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MDVVICNPVRTPVGRMGGALSPLTAADLATVTLRALIDRTGLGEGDVDDVILGNGYANGEAPALGRVAAL DAGLGTAVPGLQIDRRCGSGLQAVLYAAGQVATGAARTVIAGGAESMSNVEHYALGLRTGVRQGGIALQD RLDRARETAGGTSHPVAGGMIETAENLRREYGIEREEQDELALRSHRRAVAAHENGSFVDEMVPVTVPGA RGGADTVVDRDEHPRTDLTADKLAALRPIRSRVDAGSTVTAGNASGQNDGAAMCVVTTRAEAEKRSLEPL LTLRSWSVTGCAPETMGIGPVSAAAAALERADLTLDEIDLIEVNEAFAAQVLAVLAEWKIDPLDDRLNPN GSGISLGHPIGATGARILATAAYEARRRDARYVLEAMCIGGGQGLAAVFEVTR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1347 | - | - | 100% (403) | acetyl-CoA acetyltransferase |
| M. gilvum PYR-GCK | Mflv_4368 | - | e-127 | 58.50% (400) | acetyl-CoA acetyltransferase |
| M. gilvum PYR-GCK | Mflv_2040 | - | 2e-62 | 36.71% (414) | acetyl-CoA acetyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1103c | fadA3 | 6e-63 | 37.92% (414) | acetyl-CoA acetyltransferase |
| M. tuberculosis H37Rv | Rv1074c | fadA3 | 6e-63 | 37.92% (414) | acetyl-CoA acetyltransferase |
| M. leprae Br4923 | MLBr_01158 | fadA4 | 1e-61 | 35.19% (395) | acetyl-CoA acetyltransferase |
| M. abscessus ATCC 19977 | MAB_0902 | - | 1e-62 | 38.83% (412) | beta-ketoadipyl-CoA thiolase |
| M. marinum M | MMAR_4032 | - | 1e-129 | 59.55% (398) | beta-ketoacyl CoA thiolase |
| M. avium 104 | MAV_1573 | - | 1e-129 | 59.25% (400) | acetyl-CoA acetyltransferase |
| M. smegmatis MC2 155 | MSMEG_1896 | - | 0.0 | 82.79% (401) | acetyl-CoA acetyltransferase |
| M. thermoresistible (build 8) | TH_0166 | fadA6 | 7e-61 | 37.22% (403) | PROBABLE ACETYL-CoA ACETYLTRANSFERASE FADA6 |
| M. ulcerans Agy99 | MUL_0357 | - | 8e-63 | 39.95% (403) | beta-ketoacyl CoA thiolase |
| M. vanbaalenii PYR-1 | Mvan_1976 | - | 1e-129 | 58.25% (400) | acetyl-CoA acetyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1103c|M.bovis_AF2122/97 ----------------MPEAVIVSTARSPIGRAMKGSLVGMRPDDLAVQM
Rv1074c|M.tuberculosis_H37Rv ----------------MPEAVIVSTARSPIGRAMKGSLVGMRPDDLAVQM
Mflv_1347|M.gilvum_PYR-GCK -----------------MDVVICNPVRTPVGRMG-GALSPLTAADLATVT
MSMEG_1896|M.smegmatis_MC2_155 ----------MASDSSASQVVICNPLRTPVGRMG-GVLAALTAADLATST
MMAR_4032|M.marinum_M ------------MSAAMRQAVICEPVRTPIGRYG-GMFKSHSAVDLGVVA
MAV_1573|M.avium_104 -------------MSAVREAVICEPVRTPIGRYG-GMFKALTAVDLGVAA
Mvan_1976|M.vanbaalenii_PYR-1 ---------------MMRDAVVCEPVRTPIGRYN-GMFKSLTAVELGVAA
MUL_0357|M.ulcerans_Agy99 MCGRLLASAPPKWRKPVPEAVIVAALRTPIGTARKGTLRDTNAFDLAHHV
MLBr_01158|M.leprae_Br4923 ----------------MTTSVIVTGARTPIGKLM-GSLKDFSASDLGAIT
MAB_0902|M.abscessus_ATCC_1997 ---------------MVEQVFVVDGVRTAQGRYG-GALASVRPDDLAARV
TH_0166|M.thermoresistible__bu --------------MAMTEAYIVDAVRTPVGKRN-GGLSGAHPADMAAHV
: *:. * * : . ::.
Mb1103c|M.bovis_AF2122/97 VRAALDKVPALNPHQIDDLMMGCGLPGGESGFNIARVVAVALGYD-FLPG
Rv1074c|M.tuberculosis_H37Rv VRAALDKVPALNPHQIDDLMMGCGLPGGESGFNIARVVAVALGYD-FLPG
Mflv_1347|M.gilvum_PYR-GCK LRALIDRTG-LGEGDVDDVILGNGYANGEA-PALGRVAALDAGLGTAVPG
MSMEG_1896|M.smegmatis_MC2_155 LRELATRTG-LGEGDIDDVVLGHGYPSGEA-PAIGRIAALDAGLGTAVPG
MMAR_4032|M.marinum_M LRGLLDRTG-LAPAAVGDVILGHCYPSSEA-PAIGRVVALDAGLPVTVPG
MAV_1573|M.avium_104 LGGLLQRTG-LPPEAVQDVILGHCYPSSEA-PAIGRVVALDSGLPVTVPG
Mvan_1976|M.vanbaalenii_PYR-1 LQGLLARTG-VAPGAVEDVVVGHCYPSMEA-PAIGRVIALDAGLPVTVPG
MUL_0357|M.ulcerans_Agy99 VS--EATAD-LDPGQIDDVILGEGLYGG---GVIARHAAITAGLG-HVPG
MLBr_01158|M.leprae_Br4923 IAAALKKAN-VAPSIVQYVIIGQVLTAGAG-QMPARQAAVAAGIGWDVPA
MAB_0902|M.abscessus_ATCC_1997 IAEVVARAG-VPADAIGEVILGAANQAGEDNRNVARMAALLAGLPNTVPG
TH_0166|M.thermoresistible__bu IKTLVGRHD-FDPAAIDDVIFGCLDNIGSQAGDIARTAALAAGLPESVPG
: . : ::.* .* *: * :*.
Mb1103c|M.bovis_AF2122/97 TTVNRYCSSSLQTTRMAFHAIKAGEGDAFISAGVETVSRFAKGNSDSWPD
Rv1074c|M.tuberculosis_H37Rv TTVNRYCSSSLQTTRMAFHAIKAGEGDAFISAGVETVSRFAKGNSDSWPD
Mflv_1347|M.gilvum_PYR-GCK LQIDRRCGSGLQAVLYAAGQVATGAARTVIAGGAESMSNVEHYALGLRTG
MSMEG_1896|M.smegmatis_MC2_155 LQLDRRCGSGLQAVLYAAGQVATGAAGVVVAGGAESMSNVEHYALGLRTG
MMAR_4032|M.marinum_M MQVDRRCGSGLQAVIQACQQVSSGDSDLVVAGGCESMSNVTFYSTDMRWG
MAV_1573|M.avium_104 MQVDRRCGSGLQAVIQACLQVRNGDHDLVIAGGCESMSNVAFYSTDMRWG
Mvan_1976|M.vanbaalenii_PYR-1 MQIDRRCGSGLQAVIQAAMQVASGNNDLVVAGGAESMSNVVFHSTDMRWG
MUL_0357|M.ulcerans_Agy99 LAQNRHCAAGQAAVQGAAASVRAGMDQLIIAGGVNSAS----TSPRPRMQ
MLBr_01158|M.leprae_Br4923 LTINKMCLSGLDAIALADQLIRAGEFDVVVAGGQESMTKAPHLLMDSRS-
MAB_0902|M.abscessus_ATCC_1997 YTVNRLCASGLTAISSAAQAIRAGEADIVVAGGVESMTRAPWVMAKPSAP
TH_0166|M.thermoresistible__bu VTIDRQCGSAQQAVHFAAQGVMSGTVDLIVAGGVQKMSQFPILSAFAAG-
:: * :. : * : * .::.* :. :
Mb1103c|M.bovis_AF2122/97 -----------TKNPLFDGAQERSAAAAAGADEWHDPRTDQKLPDIYIAM
Rv1074c|M.tuberculosis_H37Rv -----------TKNPLFDGAQERSAAAAAGADEWHDPRTDQKLPDIYIAM
Mflv_1347|M.gilvum_PYR-GCK -----------VRQGGIA-LQDRLDRARETAGGTSHPVAGGMI-------
MSMEG_1896|M.smegmatis_MC2_155 -----------VRQGGVA-LHDRLDRARETAGGTSHPIAGGMI-------
MMAR_4032|M.marinum_M -----------GARGGIR-VHDGLARGRVTAGGRHYPVPGGML-------
MAV_1573|M.avium_104 -----------GARSGVR-VHDGLARGRTTAGGRRYPVPGGML-------
Mvan_1976|M.vanbaalenii_PYR-1 -----------GARGGIT-VHDALARGRTTAGGKNYPVPGGML-------
MUL_0357|M.ulcerans_Agy99 -----------IDGEWVD-WFPPTHPDRPDAPNMDMSIT-----------
MLBr_01158|M.leprae_Br4923 ------------GYKYGDVTIVDH----LAYDGLHDVFTNQPMGAL----
MAB_0902|M.abscessus_ATCC_1997 WARPGEVVDTSLGWRFTNPRFAQMDAGIAADAGPETVKVTLAMGET----
TH_0166|M.thermoresistible__bu -----------EPYGATDP--------WTGCEGWQARYGDQEISQFR---
Mb1103c|M.bovis_AF2122/97 GQTAENVAIMTGISREEQDRWGVRSQNRAEEAIKNGFFEREITPVTLP--
Rv1074c|M.tuberculosis_H37Rv GQTAENVAIMTGISREEQDRWGVRSQNRAEEAIKNGFFEREITPVTLP--
Mflv_1347|M.gilvum_PYR-GCK -ETAENLRREYGIEREEQDELALRSHRRAVAAHENGSFVDEMVPVTVPGA
MSMEG_1896|M.smegmatis_MC2_155 -ETAENLRREYGISRAEQDELAVRSHQRAVAAHDAGRFADELVPVTVPGK
MMAR_4032|M.marinum_M -ETAENLRRQYGISRLEQDELAVTSHQRAVAAQKDGIFAEETIAVPVRTR
MAV_1573|M.avium_104 -ETAENLRRQYGISRQEQDELAVRSHQRAVAAQKDGILAQEIIAVAVPTR
Mvan_1976|M.vanbaalenii_PYR-1 -ETAENLRRDYGISRQEQDELAVLSHRRAVTAQKDGLLAETIIPVTVTSR
MUL_0357|M.ulcerans_Agy99 --VGWNAAVAAGVSRAEMDAWALRSHRNAIAAIDEGRFKEEIVPIPTP--
MLBr_01158|M.leprae_Br4923 ---TEQRNDVEKFTRQEQDEFAARSHQKAAAAWKDGVFADEVVPVSIPQS
MAB_0902|M.abscessus_ATCC_1997 ---AEEVAVAEGISREDSDAFALRSHVRALAAQDAGRFVKEIVPIETVDG
TH_0166|M.thermoresistible__bu --GAEMIAEHWKLSREDNEKFALESHRRAVAAIEAGYFDKEITPYADAT-
. * : : . *: .* * . * : .
Mb1103c|M.bovis_AF2122/97 DG---TTVSTDDGPRPGTTYEKVSELKPAFR---PNGTVTAGNACPLNDG
Rv1074c|M.tuberculosis_H37Rv DG---TTVSTDDGPRPGTTYEKVSELKPAFR---PNGTVTAGNACPLNDG
Mflv_1347|M.gilvum_PYR-GCK RGGADTVVDRDEHPRTDLTADKLAALRPIRSRVDAGSTVTAGNASGQNDG
MSMEG_1896|M.smegmatis_MC2_155 RGRPGTVVDRDEHPRADIDVETLSALRPIRGKVDAEATVTAGNASGQNDG
MMAR_4032|M.marinum_M QG--EELIDTDEHPRADTSVEALSGLKPILHQDDPEATVTAGNASGQNDA
MAV_1573|M.avium_104 HG--DELIDTDEHPRADTSVESLSKLKPVLLEQDPEATVTAGNASGQNDA
Mvan_1976|M.vanbaalenii_PYR-1 SG--DQVIDTDEHPRADTSLESLAKLKPVLGKSDPDATVTAGNSSGQNDA
MUL_0357|M.ulcerans_Agy99 HG----LFCVDEHPRRDTTMEKLAALKPLHPEIDG-FSITAGNACGANDG
MLBr_01158|M.leprae_Br4923 KGD-SLQFTEDEGIRANTSAESLAGLKPAFRCG---GTITPGSASQISDG
MAB_0902|M.abscessus_ATCC_1997 VVD------TDEGPRRQTTLAKLAALRPVFRAG---GIVTAGSSSPLSDG
TH_0166|M.thermoresistible__bu ---------VDEGPRPDTSLEKMASL-PTLIEG---GVLTAAVASQISDG
*: * :: * * :*.. :. .*.
Mb1103c|M.bovis_AF2122/97 AAAVVITSDTKAKELGLTPLARIVSTGVSGLSPEIMGLGPIEASKKALER
Rv1074c|M.tuberculosis_H37Rv AAAVVITSDTKAKELGLTPLARIVSTGVSGLSPEIMGLGPIEASKKALER
Mflv_1347|M.gilvum_PYR-GCK AAMCVVTTRAEAEKRSLEPLLTLRSWSVTGCAPETMGIGPVSAAAAALER
MSMEG_1896|M.smegmatis_MC2_155 AAMCVVTTREEAEKRGLTPMLALKSWAVTGCAPEKMGIGPVAASDAALQR
MMAR_4032|M.marinum_M ASVCVVTTPEKADEYGLRPLVRLVSWGLAGVAPDVMGIGPVPATEAALAK
MAV_1573|M.avium_104 ASMCVVTTPEKADEHGLRPLVRLVSWAVAGVAPHIMGIGPVPATEVALAK
Mvan_1976|M.vanbaalenii_PYR-1 ASMCLVTTPQKAAELGLRPLVRLVSWGVAGVAPNVMGIGPVPATEVALGN
MUL_0357|M.ulcerans_Agy99 AAVLTIASDRMAQGLGMPALARVLSWASVGVDPAATGLAPVEAIPKALAR
MLBr_01158|M.leprae_Br4923 AATVVVMNKEKAQQLGLTWLVEIGAHGVVAGPDSTLQSQPANAIKKAVDR
MAB_0902|M.abscessus_ATCC_1997 AAAVVLAGERAVRQHGLTVRARVVAAASAGVAPNLMGLGPVPAVRKVVDR
TH_0166|M.thermoresistible__bu AAALLVASKDAVDRFNLTPRARIHHMSVRGADPVMMLTAPIPATQHALKR
*: : . .: : . . * * .: .
Mb1103c|M.bovis_AF2122/97 AGMAITDIDLVEINEAFAVQVLGSAR---ELGIDEDKLNISGGAIALGHP
Rv1074c|M.tuberculosis_H37Rv AGMAITDIDLVEINEAFAVQVLGSAR---ELGIDEDKLNISGGAIALGHP
Mflv_1347|M.gilvum_PYR-GCK ADLTLDEIDLIEVNEAFAAQVLAVLAEWKIDPLD-DRLNPNGSGISLGHP
MSMEG_1896|M.smegmatis_MC2_155 AGITLDEVDLIELNEAFAAQVLAVLAEWKVDPLD-ERLNPNGSGISLGHP
MMAR_4032|M.marinum_M AALRLADIDLIELNEAFAAQALAVMREWNFGAADRDRTNVHGSGISLGHP
MAV_1573|M.avium_104 AGLSLSDIDLIELNEAFAAQALAVMREWKFGAADHDRTNVHGSGISLGHP
Mvan_1976|M.vanbaalenii_PYR-1 AGLALSDVDLIELNEAFAAQALACMREWKFTQADLERTNVHGSGISLGHP
MUL_0357|M.ulcerans_Agy99 GHLSISDVDLFEINEAFASMCVATV---KLLELDADRVNVSGSGCSLGHP
MLBr_01158|M.leprae_Br4923 EGISVEQLDVVEINEAFAAVALASAR---ELGIAPELVNVNGGAIAVGHP
MAB_0902|M.abscessus_ATCC_1997 VGWRVDAIDATEINEAFAAQTLAVLR---RLGLDEDTVNADGGAIALGHP
TH_0166|M.thermoresistible__bu AGMSIDDIDAVEINEAFAPVVLAWLA---ELGADPARVNPNGGAIALGHP
: :* *:***** :. * *.. ::***
Mb1103c|M.bovis_AF2122/97 FGMTGARITTTLLNNLQTYDKTFGLETMCVGGGQGMAMVIERLA-
Rv1074c|M.tuberculosis_H37Rv FGMTGARITTTLLNNLQTYDKTFGLETMCVGGGQGMAMVIERLA-
Mflv_1347|M.gilvum_PYR-GCK IGATGARILATAAYEARRRDARYVLEAMCIGGGQGLAAVFEVTR-
MSMEG_1896|M.smegmatis_MC2_155 IGATGARILATAAHEALRRDARYVLETMCIGGGQGLAAVFEAVR-
MMAR_4032|M.marinum_M VGATGARMLATLARELTRRQARYGLETMCIGGGQGLAAIFERVG-
MAV_1573|M.avium_104 VGATGGRMLATLARELTRRQARYGLETMCIGGGQGLAAVFERVA-
Mvan_1976|M.vanbaalenii_PYR-1 VGATGGRMLATLARELNRRDGRFGLETMCIGGGQGLAAVFERVTP
MUL_0357|M.ulcerans_Agy99 VAATGARMLVTLVHELRRRGGGIGLAAMCAGGGMGSATVIEVAAP
MLBr_01158|M.leprae_Br4923 LGMSGARITLHVALELARRGSGYGVAALCGAGGQGDALILRAV--
MAB_0902|M.abscessus_ATCC_1997 LGCSGARLIVTLLNRLEREGASRGLATLCVGVGQGVAILIEAP--
TH_0166|M.thermoresistible__bu IGCTGARLMTSLLHHLERTGGRYGLQTMCEGGGQANVTIIERL--
.. :*.*: . : ::* . * . . ::.