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M. bovis AF2122 / 97 Mb1103c (fadA3)

annotation: acetyl-CoA acetyltransferase
coordinates: 1199516 - 1200733
length: 405

MPEAVIVSTARSPIGRAMKGSLVGMRPDDLAVQMVRAALDKVPALNPHQIDDLMMGCGLPGGESGFNIAR
VVAVALGYDFLPGTTVNRYCSSSLQTTRMAFHAIKAGEGDAFISAGVETVSRFAKGNSDSWPDTKNPLFD
GAQERSAAAAAGADEWHDPRTDQKLPDIYIAMGQTAENVAIMTGISREEQDRWGVRSQNRAEEAIKNGFF
EREITPVTLPDGTTVSTDDGPRPGTTYEKVSELKPAFRPNGTVTAGNACPLNDGAAAVVITSDTKAKELG
LTPLARIVSTGVSGLSPEIMGLGPIEASKKALERAGMAITDIDLVEINEAFAVQVLGSARELGIDEDKLN
ISGGAIALGHPFGMTGARITTTLLNNLQTYDKTFGLETMCVGGGQGMAMVIERLA
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1103cfadA3-100% (405)acetyl-CoA acetyltransferase
M. bovis AF2122 / 97Mb0882fadA3e-6736.47% (425) acetyl-CoA acetyltransferase
M. bovis AF2122 / 97Mb3586cfadA61e-6237.19% (406) acetyl-CoA acetyltransferase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. gilvum PYR-GCKMflv_2040-0.083.70% (405) acetyl-CoA acetyltransferase
M. tuberculosis H37RvRv1074cfadA30.0100.00% (405) acetyl-CoA acetyltransferase
M. leprae Br4923MLBr_02162fadA3e-6635.53% (425) acetyl-CoA acetyltransferase
M. abscessus ATCC 19977MAB_1192c-0.083.21% (405) acetyl-CoA acetyltransferase
M. marinum MMMAR_4393fadA30.093.09% (405) beta-ketoacyl CoA thiolase FadA3
M. avium 104MAV_1198-0.091.11% (405) acetyl-CoA acetyltransferase
M. smegmatis MC2 155MSMEG_5273-0.084.44% (405) acetyl-CoA acetyltransferase
M. thermoresistible (build 8)TH_0255-2e-6737.19% (406) acetyl-CoA acetyltransferase
M. ulcerans Agy99MUL_0207fadA30.091.85% (405) acetyl-CoA acetyltransferase
M. vanbaalenii PYR-1Mvan_4677-0.083.46% (405) acetyl-CoA acetyltransferase

CLUSTAL 2.0.9 multiple sequence alignment


Mb1103c|M.bovis_AF2122/97           -----MPEAVIVSTARSPIGRAMKGSLVGMRPDDLAVQMVRAALDKVPAL
Rv1074c|M.tuberculosis_H37Rv        -----MPEAVIVSTARSPIGRAMKGSLVGMRPDDLAVQMVRAALDKVPAL
MMAR_4393|M.marinum_M               MEGAVMPEAVIVSTARSPIGRAMKGSLVSMRPDDLAVQMVRAALDKVPAL
MUL_0207|M.ulcerans_Agy99           -----MPEAVIVSTARSPIGRAMKASLVSMRPDDLAVQMVRAALDKVPAL
MAV_1198|M.avium_104                -----MPEAVIVSTARSPIGRAMKGSLVSMRPDDLAVQIVRAALDKVPAL
MAB_1192c|M.abscessus_ATCC_199      -----MPEAVIVSTARSPIGRAGKGSLVSMRPDDLAAQMVRAALDKVPAL
MSMEG_5273|M.smegmatis_MC2_155      -----MPEAVIVATARSPIGRAGKGSLVEMRPDDLAAQMVKAVLDKVPAL
Mflv_2040|M.gilvum_PYR-GCK          -----MPEAVIVATARSPIGRANKGSLVAMRPDDLAAQMVRAALDKVPSL
Mvan_4677|M.vanbaalenii_PYR-1       -----MPEAVIVATARSPIGRAGKGSLVSMRPDDLAAQMVRAALDKVPSL
MLBr_02162|M.leprae_Br4923          ----MSEEAFIYEAIRTPRGKQKNGSLHEVKPVSLVVGLVEELRKRNPDL
TH_0255|M.thermoresistible__bu      -----MRETVIVEAVRTAVGK-RNGALADVHAADLSAVVLSELVER-AGI
                                           *:.*  : *:. *:  :.:*  ::. .* . ::    .: . :

Mb1103c|M.bovis_AF2122/97           NPHQIDDLMMGCGLPGGESGFNIARVVAVALGY-DFLPGTTVNRYCSSSL
Rv1074c|M.tuberculosis_H37Rv        NPHQIDDLMMGCGLPGGESGFNIARVVAVALGY-DFLPGTTVNRYCSSSL
MMAR_4393|M.marinum_M               NPHQIDDLIMGCGLPGGESGFNIGRVVAVALGY-DFLPGTTVNRYCSSSL
MUL_0207|M.ulcerans_Agy99           NPHQIDDLIMGCGLPGGESGFNIGRVVAVALGY-DFLPGTTVNRYCSSSL
MAV_1198|M.avium_104                NPHQIDDLILGCGQPGGESGFNLARVVAVELGF-DFLPGTTVNRYCSSSL
MAB_1192c|M.abscessus_ATCC_199      DPKDVDDLMLGCGQPGGEAGFNIGRAVAVQLGY-DFLPGTTVNRYCSSSL
MSMEG_5273|M.smegmatis_MC2_155      DPRDIDDLIMGCGQPGGEAGFNIGRAVAVQLGY-DFLPGTTVNRYCSSSL
Mflv_2040|M.gilvum_PYR-GCK          DPRDIDDLMMGCAQPAGEAGYNIARAVAVELGY-DFLPGTTVNRYCSSSL
Mvan_4677|M.vanbaalenii_PYR-1       DPRDIDDLMMGCAQPAGEAGYNIGRAVAIELGY-DFLPGTTVNRYCSSSL
MLBr_02162|M.leprae_Br4923          DENLISDVILGCVSPVGDQGGDIARATVLAAGLPVTAGGVQLNRFCASGL
TH_0255|M.thermoresistible__bu      DPELIDDVIWGCVSQVGDQSSNIGRYAVLAAGWPETIPGTTVNRACGSSQ
                                    : . :.*:: **    *: . ::.* ..:  *      *. :** *.*. 

Mb1103c|M.bovis_AF2122/97           QTTRMAFHAIKAGEGDAFISAGVETVSRFAKGNSDSWPDTKNPLFDGAQE
Rv1074c|M.tuberculosis_H37Rv        QTTRMAFHAIKAGEGDAFISAGVETVSRFAKGNSDSWPDTKNPLFDGAQE
MMAR_4393|M.marinum_M               QTTRMAFHAIKAGEGDAFISAGVETVSRFGKGNSDSLPDTKNPLFDEAQE
MUL_0207|M.ulcerans_Agy99           QITRVAFHAIKAGEGDAFISAGVETVSRFGKGNSDSLPDTKNPLFDEAQE
MAV_1198|M.avium_104                QTSRMAFHAIKAGEGDAFISAGVETVSRFPKGSADSWPDTKNPLFSEAQE
MAB_1192c|M.abscessus_ATCC_199      QTTRMAFHAIKAGEGHAFISAGVETVSRFPKGTSDGWPDSHNPLYADAEA
MSMEG_5273|M.smegmatis_MC2_155      QTTRMAFHAIKAGEGHAFISAGVETVSRFAKGNADGWPDTKNPLYADAMK
Mflv_2040|M.gilvum_PYR-GCK          QTTRMAFHAIKAGEGHAFISAGVETVSRFGKGAADGAPDSKNPIFADAQE
Mvan_4677|M.vanbaalenii_PYR-1       QTTRMAFHAIKAGEGSAFISAGVETVSRFGKGAADGAPDSKNPMFDEAQA
MLBr_02162|M.leprae_Br4923          EAVNTAAQKVRSGWDDLVLAGGVESMSRVPMGSD----------------
TH_0255|M.thermoresistible__bu      QALDFAVHAVMSGQQDVVVAGGVEVMSRVPLGAAR---------------
                                    :    * : : :*    .::.*** :**.  *                  

Mb1103c|M.bovis_AF2122/97           RSAAAAAGADEWHDPRTDQKLPDIYIAMGQTAENVAIMTGISREEQDRWG
Rv1074c|M.tuberculosis_H37Rv        RSAAAAAGADEWHDPRTDQKLPDIYIAMGQTAENVAIMTGISREEQDRWG
MMAR_4393|M.marinum_M               RTAAAAAGAEEWHDPRADGNLPDVYIAMGQTAENVAIISGISREDQDHWG
MUL_0207|M.ulcerans_Agy99           RTAAAAAGAEEWHDPRADGNLPDVYIAMGQTAENVAIISGISREDQDHWG
MAV_1198|M.avium_104                RSAAAAEGAEEWHDPRADGKLPDIYIAMGQTAENVALLTGISREDQDHWG
MAB_1192c|M.abscessus_ATCC_199      RTATAAQGATEWHDPRNDGLTPDVYIAMGQTAENVALHTGISREDQDHWG
MSMEG_5273|M.smegmatis_MC2_155      RSDEAAAGTEEWHDPREDGALPDVYIAMGQTAENVALHTGISREDQDHWG
Mflv_2040|M.gilvum_PYR-GCK          RSAKAAEGAEEWHDPREDGLLPDVYIAMGQTAENVAAFTGISREDQDHWG
Mvan_4677|M.vanbaalenii_PYR-1       RTEQGAAGATEWHDPREDGLLPDVYIAMGQTAENVANFTGISREDQDHWG
MLBr_02162|M.leprae_Br4923          -------GGAMGLDPATN--YDVMFVPQGIGADLIATIEGFSRDDVDVYA
TH_0255|M.thermoresistible__bu      -----ATGMPYGPKVLER--YDNFGFNQGISAELIAERWNLSRTRLDEYS
                                           *     .         . .  *  *: :*   .:**   * :.

Mb1103c|M.bovis_AF2122/97           VRSQNRAEEAIKNGFFEREITPVTLPDG-TTVSTDDGPRPGTTYEKVSEL
Rv1074c|M.tuberculosis_H37Rv        VRSQNRAEEAIKNGFFEREITPVTLPDG-TTVSTDDGPRPGTTYEKVSEL
MMAR_4393|M.marinum_M               VRSQNRAEEAIKSGFFEREISPVTLPDG-TTVSTDDGPRAGTTYEKVSQL
MUL_0207|M.ulcerans_Agy99           VRSQNRAEEAIKGGFFEREISPVTLPDG-TTVSTNDGPRAGTTYEKVSQL
MAV_1198|M.avium_104                VRSQNRAEEAIKSGFFEREITPVTLPDG-TTVSTDDGPRPGTTYEKIREL
MAB_1192c|M.abscessus_ATCC_199      VRSQNRAEKAIADGFFEREITPVTLADG-TVVAKDDGPRAGTTYEAISQL
MSMEG_5273|M.smegmatis_MC2_155      VRSQNRAEEAINSGFFEREITPVTLPDG-TVVSKDDGPRAGTTYEKISQL
Mflv_2040|M.gilvum_PYR-GCK          VRSQNRAEEAINSGFFDREIVPVTLPDG-TVVSKDDGPRAGTSYDKISQL
Mvan_4677|M.vanbaalenii_PYR-1       VRSQNRAEEAINSGFFAREISPVTLPDG-TVVSTDDGPRAGTTYDKISQL
MLBr_02162|M.leprae_Br4923          LRSQEKAAAAWSGGYFAKSVVPVRDQNGLLILDHDEHMRPDTSKEGLAKL
TH_0255|M.thermoresistible__bu      AQSHERAAAAQSSGAFKDQIVPVFTDD--AVVTEDEGIRRGTTVEKLATL
                                     :*:::*  *  .* *  .: **   :    :  ::  * .*: : :  *

Mb1103c|M.bovis_AF2122/97           KPAFR---------------------PNGTVTAGNACPLNDGAAAVVITS
Rv1074c|M.tuberculosis_H37Rv        KPAFR---------------------PNGTVTAGNACPLNDGAAAVVITS
MMAR_4393|M.marinum_M               KPVFR---------------------PNGTVTAGNACPLNDGAAAVVITS
MUL_0207|M.ulcerans_Agy99           KPVFR---------------------PNGTVTAGNACPLNDGAAAVVITS
MAV_1198|M.avium_104                KPVFR---------------------PNGTVTAGNACPLNDGAAAVVITS
MAB_1192c|M.abscessus_ATCC_199      KPVFR---------------------PNGTITAGNACPLNDGAAALVVMS
MSMEG_5273|M.smegmatis_MC2_155      KPVFR---------------------PNGTVTAGNACPLNDGAAALVVMS
Mflv_2040|M.gilvum_PYR-GCK          KPVFR---------------------PNGTITAGNACPLNDGAAAVVIMS
Mvan_4677|M.vanbaalenii_PYR-1       KPVFR---------------------PNGTITAGNACPLNDGAAAVVIMS
MLBr_02162|M.leprae_Br4923          KPAFEGLAAMGGFDDVALQKYHWVEKINHVHTGGNSSGIVDGAALVMIGS
TH_0255|M.thermoresistible__bu      KPAFT---------------------ENGVIHAGNSSQISDGAAALLVMT
                                    **.*                       * .  .**:. : **** ::: :

Mb1103c|M.bovis_AF2122/97           DTKAKELGLTPLARIVSTGVSGLSPEIMGLGPIEASKKALERAGMAITDI
Rv1074c|M.tuberculosis_H37Rv        DTKAKELGLTPLARIVSTGVSGLSPEIMGLGPIEASKKALERAGMAITDI
MMAR_4393|M.marinum_M               DTKAKELGLTPLARIVSTGVSGLSPEIMGLGPIEACKKALQRAGMSISDI
MUL_0207|M.ulcerans_Agy99           DTKAKELGLTPLARIVSTGVSGLSPEIMGLGPIEACKKALQRAGMSISDI
MAV_1198|M.avium_104                DTKAKELGLTPLARIVSTGVSGLSPEIMGLGPIEATKKALARAKMSVSDI
MAB_1192c|M.abscessus_ATCC_199      DVRAKELGLTPLARIVSTGVSGLSPEIMGLGPIEAVKRALANAGKSIGDI
MSMEG_5273|M.smegmatis_MC2_155      DVRAKELGLTPLARIVSTGVSGLSPEIMGLGPIEAVKKALANANMTIGDI
Mflv_2040|M.gilvum_PYR-GCK          DTKAKELGLTPLARIVSTGVSGLSPEIMGLGPIEAVKKALANAKMSISDI
Mvan_4677|M.vanbaalenii_PYR-1       DTKAKELGLTPLARIVSTGVSGLSPEIMGLGPIEAVKKALANAKMSIGDI
MLBr_02162|M.leprae_Br4923          EAVGKSQGLTPRARMVATATSGADPVIMLTGPTPATRKVLDRAGLTVDDI
TH_0255|M.thermoresistible__bu      AETAVTLGLTPIVRYRAGAVTGADPVLMLTGPIPATEKVLRKTGLNIDDI
                                       .   **** .*  : ..:* .* :*  **  * .:.* .:   : **

Mb1103c|M.bovis_AF2122/97           DLVEINEAFAVQVLGSARELGIDEDKLNISGGAIALGHPFGMTGARITTT
Rv1074c|M.tuberculosis_H37Rv        DLVEINEAFAVQVLGSARELGIDEDKLNISGGAIALGHPFGMTGARITTT
MMAR_4393|M.marinum_M               DLVEINEAFAVQVLGSARELGIDEDKLNVSGGAIALGHPFGMTGARITTT
MUL_0207|M.ulcerans_Agy99           DLVEINEAFAVQVLGSARELGIDEDELNVSGGAIALGHPFGMTGARITTT
MAV_1198|M.avium_104                DLFEINEAFAVQVLGSARELGIDEDKLNVSGGAIALGHPFGMTGARITTT
MAB_1192c|M.abscessus_ATCC_199      DLFEINEAFAVQVLGSARALGIDEDKLNVSGGAIALGHPFGMTGARITAT
MSMEG_5273|M.smegmatis_MC2_155      DLYEINEAFAVQVLGSARALGMDEDKLNVSGGAIALGHPFGMTGARITAT
Mflv_2040|M.gilvum_PYR-GCK          DLYEINEAFAVQVLGSARELGMDEDKLNVSGGAIALGHPFGMTGARITAT
Mvan_4677|M.vanbaalenii_PYR-1       DLYEINEAFAVQVLGSARELGMDEDKLNVSGGAIALGHPFGMTGARITAT
MLBr_02162|M.leprae_Br4923          DLFELNEAFASVVLKFQKDLNIPDEKLNVNGGAIAMGHPLGATGAMILGT
TH_0255|M.thermoresistible__bu      GVFEVNEAFAPVPLAWQAETGADPAKLNPLGGAIALGHPLGASGAVLMTR
                                    .: *:*****   *      .    :**  *****:***:* :** :   

Mb1103c|M.bovis_AF2122/97           LLNNLQTYDKTFGLETMCVGGGQGMAMVIERLA
Rv1074c|M.tuberculosis_H37Rv        LLNNLQTYDKTFGLETMCVGGGQGMAMVIERLA
MMAR_4393|M.marinum_M               LLNNLQTHDKTFGLETMCVGGGQGMAMVIERLS
MUL_0207|M.ulcerans_Agy99           LLNNLQTHDKTFGLETMCVGGGQGMAMVIERLS
MAV_1198|M.avium_104                LLNNLQTHDKTFGLETMCVGGGQGMAMVIERLS
MAB_1192c|M.abscessus_ATCC_199      LLNNLTTYDKTFGVETMCVGGGQGMAMVIERLA
MSMEG_5273|M.smegmatis_MC2_155      LLNNLQTHDKTFGIETMCVGGGQGMAMVVERLS
Mflv_2040|M.gilvum_PYR-GCK          LLNNLATHDKTFGIESMCVGGGQGMAMVVERLS
Mvan_4677|M.vanbaalenii_PYR-1       LLNNLTTHDKTFGIETMCVGGGQGMAMVLERLS
MLBr_02162|M.leprae_Br4923          MVDELERCNARRALVTLCIGAGMGVATIIERV-
TH_0255|M.thermoresistible__bu      MVHHMRANGIRYGLQTMCEGGGTANATVVELLA
                                    ::..:   .   .: ::* *.* . * ::* :