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VVEQVFVVDGVRTAQGRYGGALASVRPDDLAARVIAEVVARAGVPADAIGEVILGAANQAGEDNRNVARM AALLAGLPNTVPGYTVNRLCASGLTAISSAAQAIRAGEADIVVAGGVESMTRAPWVMAKPSAPWARPGEV VDTSLGWRFTNPRFAQMDAGIAADAGPETVKVTLAMGETAEEVAVAEGISREDSDAFALRSHVRALAAQD AGRFVKEIVPIETVDGVVDTDEGPRRQTTLAKLAALRPVFRAGGIVTAGSSSPLSDGAAAVVLAGERAVR QHGLTVRARVVAAASAGVAPNLMGLGPVPAVRKVVDRVGWRVDAIDATEINEAFAAQTLAVLRRLGLDED TVNADGGAIALGHPLGCSGARLIVTLLNRLEREGASRGLATLCVGVGQGVAILIEAP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_0902 | - | - | 100% (407) | beta-ketoadipyl-CoA thiolase |
| M. abscessus ATCC 19977 | MAB_1192c | - | 5e-77 | 41.39% (418) | acetyl-CoA acetyltransferase |
| M. abscessus ATCC 19977 | MAB_0850 | - | 6e-75 | 40.05% (427) | acetyl-CoA acetyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1103c | fadA3 | 6e-78 | 41.77% (419) | acetyl-CoA acetyltransferase |
| M. gilvum PYR-GCK | Mflv_1691 | - | 7e-77 | 40.42% (428) | acetyl-CoA acetyltransferase |
| M. tuberculosis H37Rv | Rv1074c | fadA3 | 7e-78 | 41.77% (419) | acetyl-CoA acetyltransferase |
| M. leprae Br4923 | MLBr_02162 | fadA | 9e-72 | 38.55% (428) | acetyl-CoA acetyltransferase |
| M. marinum M | MMAR_4393 | fadA3 | 8e-80 | 42.28% (421) | beta-ketoacyl CoA thiolase FadA3 |
| M. avium 104 | MAV_1198 | - | 6e-80 | 43.20% (419) | acetyl-CoA acetyltransferase |
| M. smegmatis MC2 155 | MSMEG_5721 | - | 1e-77 | 40.89% (428) | acetyl-CoA acetyltransferase |
| M. thermoresistible (build 8) | TH_0166 | fadA6 | 3e-76 | 41.79% (402) | PROBABLE ACETYL-CoA ACETYLTRANSFERASE FADA6 |
| M. ulcerans Agy99 | MUL_0207 | fadA3 | 7e-78 | 41.87% (418) | acetyl-CoA acetyltransferase |
| M. vanbaalenii PYR-1 | Mvan_4677 | - | 2e-77 | 41.49% (417) | acetyl-CoA acetyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1103c|M.bovis_AF2122/97 -----MPEAVIVSTARSPIGRAMKGSLVGMRPDDLAVQMVRAALDKVPAL
Rv1074c|M.tuberculosis_H37Rv -----MPEAVIVSTARSPIGRAMKGSLVGMRPDDLAVQMVRAALDKVPAL
MMAR_4393|M.marinum_M MEGAVMPEAVIVSTARSPIGRAMKGSLVSMRPDDLAVQMVRAALDKVPAL
MUL_0207|M.ulcerans_Agy99 -----MPEAVIVSTARSPIGRAMKASLVSMRPDDLAVQMVRAALDKVPAL
MAV_1198|M.avium_104 -----MPEAVIVSTARSPIGRAMKGSLVSMRPDDLAVQIVRAALDKVPAL
Mvan_4677|M.vanbaalenii_PYR-1 -----MPEAVIVATARSPIGRAGKGSLVSMRPDDLAAQMVRAALDKVPSL
Mflv_1691|M.gilvum_PYR-GCK ----MSEEAFIYEAIRTPRGKQRGGALNEIKPVNLVVGLIDEMRTRFPDL
MSMEG_5721|M.smegmatis_MC2_155 ----MSEEAFIYEAIRTPRGKQRGGALNEIKPVNLVVGLIDELRVRFPNL
MLBr_02162|M.leprae_Br4923 ----MSEEAFIYEAIRTPRGKQKNGSLHEVKPVSLVVGLVEELRKRNPDL
TH_0166|M.thermoresistible__bu ---MAMTEAYIVDAVRTPVGK-RNGGLSGAHPADMAAHVIKTLVGR-HDF
MAB_0902|M.abscessus_ATCC_1997 ----MVEQVFVVDGVRTAQGR-YGGALASVRPDDLAARVIAEVVAR-AGV
:. : *:. *: ..* :* .:.. :: : .
Mb1103c|M.bovis_AF2122/97 NPHQIDDLMMGCGLPGGESGFNIARVVAVALGY-DFLPGTTVNRYCSSSL
Rv1074c|M.tuberculosis_H37Rv NPHQIDDLMMGCGLPGGESGFNIARVVAVALGY-DFLPGTTVNRYCSSSL
MMAR_4393|M.marinum_M NPHQIDDLIMGCGLPGGESGFNIGRVVAVALGY-DFLPGTTVNRYCSSSL
MUL_0207|M.ulcerans_Agy99 NPHQIDDLIMGCGLPGGESGFNIGRVVAVALGY-DFLPGTTVNRYCSSSL
MAV_1198|M.avium_104 NPHQIDDLILGCGQPGGESGFNLARVVAVELGF-DFLPGTTVNRYCSSSL
Mvan_4677|M.vanbaalenii_PYR-1 DPRDIDDLMMGCAQPAGEAGYNIGRAVAIELGY-DFLPGTTVNRYCSSSL
Mflv_1691|M.gilvum_PYR-GCK DENLISDLILGVVSPVGDQGGDIARTAGLVAKLPETTGGVQLNRFCASGL
MSMEG_5721|M.smegmatis_MC2_155 DETLISDLVLGVVSPVGDQGGDIARTATLVANLPETTGGVQLNRFCASGL
MLBr_02162|M.leprae_Br4923 DENLISDVILGCVSPVGDQGGDIARATVLAAGLPVTAGGVQLNRFCASGL
TH_0166|M.thermoresistible__bu DPAAIDDVIFGCLDNIGSQAGDIARTAALAAGLPESVPGVTIDRQCGSAQ
MAB_0902|M.abscessus_ATCC_1997 PADAIGEVILGAANQAGEDNRNVARMAALLAGLPNTVPGYTVNRLCASGL
*.::::* *. ::.* . : * ::* *.*.
Mb1103c|M.bovis_AF2122/97 QTTRMAFHAIKAGEGDAFISAGVETVSRFAKGNSDSWPDTKNPLFDGAQE
Rv1074c|M.tuberculosis_H37Rv QTTRMAFHAIKAGEGDAFISAGVETVSRFAKGNSDSWPDTKNPLFDGAQE
MMAR_4393|M.marinum_M QTTRMAFHAIKAGEGDAFISAGVETVSRFGKGNSDSLPDTKNPLFDEAQE
MUL_0207|M.ulcerans_Agy99 QITRVAFHAIKAGEGDAFISAGVETVSRFGKGNSDSLPDTKNPLFDEAQE
MAV_1198|M.avium_104 QTSRMAFHAIKAGEGDAFISAGVETVSRFPKGSADSWPDTKNPLFSEAQE
Mvan_4677|M.vanbaalenii_PYR-1 QTTRMAFHAIKAGEGSAFISAGVETVSRFGKGAADGAPDSKNPMFDEAQA
Mflv_1691|M.gilvum_PYR-GCK EAVNMAAQKVRSGWDDLVLAGGVESMSRVPMGSDGGA---------WAAD
MSMEG_5721|M.smegmatis_MC2_155 EAVNIAAQKVRSGWDDLVLAGGVESMSRVPMGSDGGA---------WAGD
MLBr_02162|M.leprae_Br4923 EAVNTAAQKVRSGWDDLVLAGGVESMSRVPMGSDGGA---------MGLD
TH_0166|M.thermoresistible__bu QAVHFAAQGVMSGTVDLIVAGGVQKMSQFPILSAFAAGEPY-----GATD
MAB_0902|M.abscessus_ATCC_1997 TAISSAAQAIRAGEADIVVAGGVESMTRAPWVMAKPSAP-------WARP
* : : :* . .::.**:.::: .
Mb1103c|M.bovis_AF2122/97 RSAAAAAGADEWHDPRTDQKLP-----------DIYIAMGQTAENVAIMT
Rv1074c|M.tuberculosis_H37Rv RSAAAAAGADEWHDPRTDQKLP-----------DIYIAMGQTAENVAIMT
MMAR_4393|M.marinum_M RTAAAAAGAEEWHDPRADGNLP-----------DVYIAMGQTAENVAIIS
MUL_0207|M.ulcerans_Agy99 RTAAAAAGAEEWHDPRADGNLP-----------DVYIAMGQTAENVAIIS
MAV_1198|M.avium_104 RSAAAAEGAEEWHDPRADGKLP-----------DIYIAMGQTAENVALLT
Mvan_4677|M.vanbaalenii_PYR-1 RTEQGAAGATEWHDPREDGLLP-----------DVYIAMGQTAENVANFT
Mflv_1691|M.gilvum_PYR-GCK PET-------NYRIGFVPQGIG--------------------ADLIATIE
MSMEG_5721|M.smegmatis_MC2_155 PET-------NYRIGFVPQGIG--------------------ADLIATIE
MLBr_02162|M.leprae_Br4923 PAT-------NYDVMFVPQGIG--------------------ADLIATIE
TH_0166|M.thermoresistible__bu PWTGCEGWQARYGDQEISQFRG--------------------AEMIAEHW
MAB_0902|M.abscessus_ATCC_1997 GEVVDTSLGWRFTNPRFAQMDAGIAADAGPETVKVTLAMGETAEEVAVAE
.: *: :*
Mb1103c|M.bovis_AF2122/97 GISREEQDRWGVRSQNRAEEAIKNGFFEREITPVTLPDG-TTVSTDDGPR
Rv1074c|M.tuberculosis_H37Rv GISREEQDRWGVRSQNRAEEAIKNGFFEREITPVTLPDG-TTVSTDDGPR
MMAR_4393|M.marinum_M GISREDQDHWGVRSQNRAEEAIKSGFFEREISPVTLPDG-TTVSTDDGPR
MUL_0207|M.ulcerans_Agy99 GISREDQDHWGVRSQNRAEEAIKGGFFEREISPVTLPDG-TTVSTNDGPR
MAV_1198|M.avium_104 GISREDQDHWGVRSQNRAEEAIKSGFFEREITPVTLPDG-TTVSTDDGPR
Mvan_4677|M.vanbaalenii_PYR-1 GISREDQDHWGVRSQNRAEEAINSGFFAREISPVTLPDG-TVVSTDDGPR
Mflv_1691|M.gilvum_PYR-GCK GFSREDVDAYAARSQERAAAAWSGGYFAKSVVPVKDQNGLVVLDHDEHIR
MSMEG_5721|M.smegmatis_MC2_155 GFSREDVDAYAARSQERAAAAWSGGYFSKSVVPVKDQNGLVVLDHDEHMR
MLBr_02162|M.leprae_Br4923 GFSRDDVDVYALRSQEKAAAAWSGGYFAKSVVPVRDQNGLLILDHDEHMR
TH_0166|M.thermoresistible__bu KLSREDNEKFALESHRRAVAAIEAGYFDKEITPYADAT------VDEGPR
MAB_0902|M.abscessus_ATCC_1997 GISREDSDAFALRSHVRALAAQDAGRFVKEIVPIETVDG--VVDTDEGPR
:**:: : :. .*: :* * . * * :.: * :: *
Mb1103c|M.bovis_AF2122/97 PGTTYEKVSELKPAFRPNG---------------------TVTAGNACPL
Rv1074c|M.tuberculosis_H37Rv PGTTYEKVSELKPAFRPNG---------------------TVTAGNACPL
MMAR_4393|M.marinum_M AGTTYEKVSQLKPVFRPNG---------------------TVTAGNACPL
MUL_0207|M.ulcerans_Agy99 AGTTYEKVSQLKPVFRPNG---------------------TVTAGNACPL
MAV_1198|M.avium_104 PGTTYEKIRELKPVFRPNG---------------------TVTAGNACPL
Mvan_4677|M.vanbaalenii_PYR-1 AGTTYDKISQLKPVFRPNG---------------------TITAGNACPL
Mflv_1691|M.gilvum_PYR-GCK PGTTIESLGKLKSAFEGVGAMGGFDDVALQKYHFVEKINHVHTGGNSSGI
MSMEG_5721|M.smegmatis_MC2_155 PGTTVESLGKLKPAFEGVGAMGGFDDVALQKYHSIEKINHVHTGGNSSGI
MLBr_02162|M.leprae_Br4923 PDTSKEGLAKLKPAFEGLAAMGGFDDVALQKYHWVEKINHVHTGGNSSGI
TH_0166|M.thermoresistible__bu PDTSLEKMASLPTLIEGG----------------------VLTAAVASQI
MAB_0902|M.abscessus_ATCC_1997 RQTTLAKLAALRPVFRAGG---------------------IVTAGSSSPL
*: : * . :. *.. :. :
Mb1103c|M.bovis_AF2122/97 NDGAAAVVITSDTKAKELGLTPLARIVSTGVSGLSPEIMGLGPIEASKKA
Rv1074c|M.tuberculosis_H37Rv NDGAAAVVITSDTKAKELGLTPLARIVSTGVSGLSPEIMGLGPIEASKKA
MMAR_4393|M.marinum_M NDGAAAVVITSDTKAKELGLTPLARIVSTGVSGLSPEIMGLGPIEACKKA
MUL_0207|M.ulcerans_Agy99 NDGAAAVVITSDTKAKELGLTPLARIVSTGVSGLSPEIMGLGPIEACKKA
MAV_1198|M.avium_104 NDGAAAVVITSDTKAKELGLTPLARIVSTGVSGLSPEIMGLGPIEATKKA
Mvan_4677|M.vanbaalenii_PYR-1 NDGAAAVVIMSDTKAKELGLTPLARIVSTGVSGLSPEIMGLGPIEAVKKA
Mflv_1691|M.gilvum_PYR-GCK VDGAALVLIGSESAGTSQGLTPRARIVATATSGADPVIMLTGPTPATKKV
MSMEG_5721|M.smegmatis_MC2_155 VDGAALVLIGSESAGKAAGLTPRARVVATATSGADPVIMLTGPTPATRKV
MLBr_02162|M.leprae_Br4923 VDGAALVMIGSEAVGKSQGLTPRARMVATATSGADPVIMLTGPTPATRKV
TH_0166|M.thermoresistible__bu SDGAAALLVASKDAVDRFNLTPRARIHHMSVRGADPVMMLTAPIPATQHA
MAB_0902|M.abscessus_ATCC_1997 SDGAAAVVLAGERAVRQHGLTVRARVVAAASAGVAPNLMGLGPVPAVRKV
**** ::: .. .** **: . * * :* .* * ::.
Mb1103c|M.bovis_AF2122/97 LERAGMAITDIDLVEINEAFAVQVLGSARELGIDEDKLNISGGAIALGHP
Rv1074c|M.tuberculosis_H37Rv LERAGMAITDIDLVEINEAFAVQVLGSARELGIDEDKLNISGGAIALGHP
MMAR_4393|M.marinum_M LQRAGMSISDIDLVEINEAFAVQVLGSARELGIDEDKLNVSGGAIALGHP
MUL_0207|M.ulcerans_Agy99 LQRAGMSISDIDLVEINEAFAVQVLGSARELGIDEDELNVSGGAIALGHP
MAV_1198|M.avium_104 LARAKMSVSDIDLFEINEAFAVQVLGSARELGIDEDKLNVSGGAIALGHP
Mvan_4677|M.vanbaalenii_PYR-1 LANAKMSIGDIDLYEINEAFAVQVLGSARELGMDEDKLNVSGGAIALGHP
Mflv_1691|M.gilvum_PYR-GCK LDRAGLTVDDIDLFELNEAFASVVLKFQKDLGIPDEKLNVNGGAIAMGHP
MSMEG_5721|M.smegmatis_MC2_155 LDRAGLTVDDIDLFELNEAFASVVLKFQKDLGIPDEKLNVNGGAIAMGHP
MLBr_02162|M.leprae_Br4923 LDRAGLTVDDIDLFELNEAFASVVLKFQKDLNIPDEKLNVNGGAIAMGHP
TH_0166|M.thermoresistible__bu LKRAGMSIDDIDAVEINEAFAPVVLAWLAELGADPARVNPNGGAIALGHP
MAB_0902|M.abscessus_ATCC_1997 VDRVGWRVDAIDATEINEAFAAQTLAVLRRLGLDEDTVNADGGAIALGHP
: .. : ** *:***** .* *. :* .*****:***
Mb1103c|M.bovis_AF2122/97 FGMTGARITTTLLNNLQTYDKTFGLETMCVGGGQGMAMVIERLA
Rv1074c|M.tuberculosis_H37Rv FGMTGARITTTLLNNLQTYDKTFGLETMCVGGGQGMAMVIERLA
MMAR_4393|M.marinum_M FGMTGARITTTLLNNLQTHDKTFGLETMCVGGGQGMAMVIERLS
MUL_0207|M.ulcerans_Agy99 FGMTGARITTTLLNNLQTHDKTFGLETMCVGGGQGMAMVIERLS
MAV_1198|M.avium_104 FGMTGARITTTLLNNLQTHDKTFGLETMCVGGGQGMAMVIERLS
Mvan_4677|M.vanbaalenii_PYR-1 FGMTGARITATLLNNLTTHDKTFGIETMCVGGGQGMAMVLERLS
Mflv_1691|M.gilvum_PYR-GCK LGATGAMITGTMVDELERRGARRALITLCVGGGMGVATIIERV-
MSMEG_5721|M.smegmatis_MC2_155 LGATGAMITGTMVDELERRGARRALITLCVGGGMGVATIIERV-
MLBr_02162|M.leprae_Br4923 LGATGAMILGTMVDELERCNARRALVTLCIGAGMGVATIIERV-
TH_0166|M.thermoresistible__bu IGCTGARLMTSLLHHLERTGGRYGLQTMCEGGGQANVTIIERL-
MAB_0902|M.abscessus_ATCC_1997 LGCSGARLIVTLLNRLEREGASRGLATLCVGVGQGVAILIEAP-
:* :** : :::..* . .: *:* * * . . ::*