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MASDSSASQVVICNPLRTPVGRMGGVLAALTAADLATSTLRELATRTGLGEGDIDDVVLGHGYPSGEAPA IGRIAALDAGLGTAVPGLQLDRRCGSGLQAVLYAAGQVATGAAGVVVAGGAESMSNVEHYALGLRTGVRQ GGVALHDRLDRARETAGGTSHPIAGGMIETAENLRREYGISRAEQDELAVRSHQRAVAAHDAGRFADELV PVTVPGKRGRPGTVVDRDEHPRADIDVETLSALRPIRGKVDAEATVTAGNASGQNDGAAMCVVTTREEAE KRGLTPMLALKSWAVTGCAPEKMGIGPVAASDAALQRAGITLDEVDLIELNEAFAAQVLAVLAEWKVDPL DERLNPNGSGISLGHPIGATGARILATAAHEALRRDARYVLETMCIGGGQGLAAVFEAVR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1896 | - | - | 100% (410) | acetyl-CoA acetyltransferase |
| M. smegmatis MC2 155 | MSMEG_2207 | - | e-137 | 61.33% (406) | acetyl-CoA acetyltransferase |
| M. smegmatis MC2 155 | MSMEG_5273 | - | 6e-65 | 38.89% (414) | acetyl-CoA acetyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1103c | fadA3 | 6e-63 | 38.16% (414) | acetyl-CoA acetyltransferase |
| M. gilvum PYR-GCK | Mflv_1347 | - | 0.0 | 82.79% (401) | acetyl-CoA acetyltransferase |
| M. tuberculosis H37Rv | Rv1074c | fadA3 | 6e-63 | 38.16% (414) | acetyl-CoA acetyltransferase |
| M. leprae Br4923 | MLBr_01158 | fadA4 | 2e-60 | 35.84% (399) | acetyl-CoA acetyltransferase |
| M. abscessus ATCC 19977 | MAB_0902 | - | 1e-65 | 39.76% (415) | beta-ketoadipyl-CoA thiolase |
| M. marinum M | MMAR_4032 | - | 1e-137 | 61.44% (402) | beta-ketoacyl CoA thiolase |
| M. avium 104 | MAV_1573 | - | 1e-139 | 61.82% (406) | acetyl-CoA acetyltransferase |
| M. thermoresistible (build 8) | TH_0255 | - | 5e-61 | 38.50% (400) | acetyl-CoA acetyltransferase |
| M. ulcerans Agy99 | MUL_0207 | fadA3 | 1e-63 | 38.16% (414) | acetyl-CoA acetyltransferase |
| M. vanbaalenii PYR-1 | Mvan_1976 | - | 1e-136 | 60.75% (400) | acetyl-CoA acetyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_01158|M.leprae_Br4923 ------MTTSVIVTGARTPIGKLM-GSLKDFSASDLGAITIAAALKKA-N
MAB_0902|M.abscessus_ATCC_1997 -----MVEQVFVVDGVRTAQGRYG-GALASVRPDDLAARVIAEVVARA-G
TH_0255|M.thermoresistible__bu ------MRETVIVEAVRTAVGKRN-GALADVHAADLSAVVLSELVERA-G
Mb1103c|M.bovis_AF2122/97 ------MPEAVIVSTARSPIGRAMKGSLVGMRPDDLAVQMVRAALDKVPA
Rv1074c|M.tuberculosis_H37Rv ------MPEAVIVSTARSPIGRAMKGSLVGMRPDDLAVQMVRAALDKVPA
MUL_0207|M.ulcerans_Agy99 ------MPEAVIVSTARSPIGRAMKASLVSMRPDDLAVQMVRAALDKVPA
MSMEG_1896|M.smegmatis_MC2_155 MASDSSASQVVICNPLRTPVGRMG-GVLAALTAADLATSTLRELATRT-G
Mflv_1347|M.gilvum_PYR-GCK -------MDVVICNPVRTPVGRMG-GALSPLTAADLATVTLRALIDRT-G
MMAR_4032|M.marinum_M --MSAAMRQAVICEPVRTPIGRYG-GMFKSHSAVDLGVVALRGLLDRT-G
MAV_1573|M.avium_104 ---MSAVREAVICEPVRTPIGRYG-GMFKALTAVDLGVAALGGLLQRT-G
Mvan_1976|M.vanbaalenii_PYR-1 -----MMRDAVVCEPVRTPIGRYN-GMFKSLTAVELGVAALQGLLART-G
.: *:. *: . : . :*.. : :.
MLBr_01158|M.leprae_Br4923 VAPSIVQYVIIGQVLTAGAG-QMPARQAAVAAGIGWDVPALTINKMCLSG
MAB_0902|M.abscessus_ATCC_1997 VPADAIGEVILGAANQAGEDNRNVARMAALLAGLPNTVPGYTVNRLCASG
TH_0255|M.thermoresistible__bu IDPELIDDVIWGCVSQVGDQSSNIGRYAVLAAGWPETIPGTTVNRACGSS
Mb1103c|M.bovis_AF2122/97 LNPHQIDDLMMGCGLPGGESGFNIARVVAVALGY-DFLPGTTVNRYCSSS
Rv1074c|M.tuberculosis_H37Rv LNPHQIDDLMMGCGLPGGESGFNIARVVAVALGY-DFLPGTTVNRYCSSS
MUL_0207|M.ulcerans_Agy99 LNPHQIDDLIMGCGLPGGESGFNIGRVVAVALGY-DFLPGTTVNRYCSSS
MSMEG_1896|M.smegmatis_MC2_155 LGEGDIDDVVLGHGYPSGEA-PAIGRIAALDAGLGTAVPGLQLDRRCGSG
Mflv_1347|M.gilvum_PYR-GCK LGEGDVDDVILGNGYANGEA-PALGRVAALDAGLGTAVPGLQIDRRCGSG
MMAR_4032|M.marinum_M LAPAAVGDVILGHCYPSSEA-PAIGRVVALDAGLPVTVPGMQVDRRCGSG
MAV_1573|M.avium_104 LPPEAVQDVILGHCYPSSEA-PAIGRVVALDSGLPVTVPGMQVDRRCGSG
Mvan_1976|M.vanbaalenii_PYR-1 VAPGAVEDVVVGHCYPSMEA-PAIGRVIALDAGLPVTVPGMQIDRRCGSG
: : :: * .* .: * :*. ::: * *.
MLBr_01158|M.leprae_Br4923 LDAIALADQLIRAGEFDVVVAGGQESMTKAPHLLMDSRS-----------
MAB_0902|M.abscessus_ATCC_1997 LTAISSAAQAIRAGEADIVVAGGVESMTRAPWVMAKPSAPWARPGEVVDT
TH_0255|M.thermoresistible__bu QQALDFAVHAVMSGQQDVVVAGGVEVMSRVPLGAARATG-----------
Mb1103c|M.bovis_AF2122/97 LQTTRMAFHAIKAGEGDAFISAGVETVSRFAKGNSDSWPDTKN----PLF
Rv1074c|M.tuberculosis_H37Rv LQTTRMAFHAIKAGEGDAFISAGVETVSRFAKGNSDSWPDTKN----PLF
MUL_0207|M.ulcerans_Agy99 LQITRVAFHAIKAGEGDAFISAGVETVSRFGKGNSDSLPDTKN----PLF
MSMEG_1896|M.smegmatis_MC2_155 LQAVLYAAGQVATGAAGVVVAGGAESMSNVEHYALGLRT-----------
Mflv_1347|M.gilvum_PYR-GCK LQAVLYAAGQVATGAARTVIAGGAESMSNVEHYALGLRT-----------
MMAR_4032|M.marinum_M LQAVIQACQQVSSGDSDLVVAGGCESMSNVTFYSTDMRW-----------
MAV_1573|M.avium_104 LQAVIQACLQVRNGDHDLVIAGGCESMSNVAFYSTDMRW-----------
Mvan_1976|M.vanbaalenii_PYR-1 LQAVIQAAMQVASGNNDLVVAGGAESMSNVVFHSTDMRW-----------
* : * .::.* * ::.
MLBr_01158|M.leprae_Br4923 --GYKYGDVTIVDH----LAYDGLHDVFTNQPMGALTEQRNDVEKFTRQE
MAB_0902|M.abscessus_ATCC_1997 SLGWRFTNPRFAQMDAGIAADAGPETVKVTLAMGETAEEVAVAEGISRED
TH_0255|M.thermoresistible__bu ---MPYG-PKVLER------YDNFG-----FNQGISAELIAERWNLSRTR
Mb1103c|M.bovis_AF2122/97 DGAQERSAAAAAGADEWHDPRTDQKLPDIYIAMGQTAENVAIMTGISREE
Rv1074c|M.tuberculosis_H37Rv DGAQERSAAAAAGADEWHDPRTDQKLPDIYIAMGQTAENVAIMTGISREE
MUL_0207|M.ulcerans_Agy99 DEAQERTAAAAAGAEEWHDPRADGNLPDVYIAMGQTAENVAIISGISRED
MSMEG_1896|M.smegmatis_MC2_155 --GVRQGGVALHDRLDRARETAGGTSHPIAGGMIETAENLRREYGISRAE
Mflv_1347|M.gilvum_PYR-GCK --GVRQGGIALQDRLDRARETAGGTSHPVAGGMIETAENLRREYGIEREE
MMAR_4032|M.marinum_M --GGARGGIRVHDGLARGRVTAGGRHYPVPGGMLETAENLRRQYGISRLE
MAV_1573|M.avium_104 --GGARSGVRVHDGLARGRTTAGGRRYPVPGGMLETAENLRRQYGISRQE
Mvan_1976|M.vanbaalenii_PYR-1 --GGARGGITVHDALARGRTTAGGKNYPVPGGMLETAENLRRDYGISRQE
. :* : *
MLBr_01158|M.leprae_Br4923 QDEFAARSHQKAAAAWKDGVFADEVVPVSIPQSKGDSLQFT-EDEGIRAN
MAB_0902|M.abscessus_ATCC_1997 SDAFALRSHVRALAAQDAGRFVKEIVPIETVDGVVD------TDEGPRRQ
TH_0255|M.thermoresistible__bu LDEYSAQSHERAAAAQSSGAFKDQIVPVFTDDAVVT------EDEGIRRG
Mb1103c|M.bovis_AF2122/97 QDRWGVRSQNRAEEAIKNGFFEREITPVTLPDGTTVS-----TDDGPRPG
Rv1074c|M.tuberculosis_H37Rv QDRWGVRSQNRAEEAIKNGFFEREITPVTLPDGTTVS-----TDDGPRPG
MUL_0207|M.ulcerans_Agy99 QDHWGVRSQNRAEEAIKGGFFEREISPVTLPDGTTVS-----TNDGPRAG
MSMEG_1896|M.smegmatis_MC2_155 QDELAVRSHQRAVAAHDAGRFADELVPVTVPGKRGRPGTVVDRDEHPRAD
Mflv_1347|M.gilvum_PYR-GCK QDELALRSHRRAVAAHENGSFVDEMVPVTVPGARGGADTVVDRDEHPRTD
MMAR_4032|M.marinum_M QDELAVTSHQRAVAAQKDGIFAEETIAVPVRTRQG--EELIDTDEHPRAD
MAV_1573|M.avium_104 QDELAVRSHQRAVAAQKDGILAQEIIAVAVPTRHG--DELIDTDEHPRAD
Mvan_1976|M.vanbaalenii_PYR-1 QDELAVLSHRRAVTAQKDGLLAETIIPVTVTSRSG--DQVIDTDEHPRAD
* . *: :* * . * : .: :: *
MLBr_01158|M.leprae_Br4923 TSAESLAGLKPAFR---CGGTITPGSASQISDGAATVVVMNKEKAQQLGL
MAB_0902|M.abscessus_ATCC_1997 TTLAKLAALRPVFR---AGGIVTAGSSSPLSDGAAAVVLAGERAVRQHGL
TH_0255|M.thermoresistible__bu TTVEKLATLKPAFT---ENGVIHAGNSSQISDGAAALLVMTAETAVTLGL
Mb1103c|M.bovis_AF2122/97 TTYEKVSELKPAFR---PNGTVTAGNACPLNDGAAAVVITSDTKAKELGL
Rv1074c|M.tuberculosis_H37Rv TTYEKVSELKPAFR---PNGTVTAGNACPLNDGAAAVVITSDTKAKELGL
MUL_0207|M.ulcerans_Agy99 TTYEKVSQLKPVFR---PNGTVTAGNACPLNDGAAAVVITSDTKAKELGL
MSMEG_1896|M.smegmatis_MC2_155 IDVETLSALRPIRGKVDAEATVTAGNASGQNDGAAMCVVTTREEAEKRGL
Mflv_1347|M.gilvum_PYR-GCK LTADKLAALRPIRSRVDAGSTVTAGNASGQNDGAAMCVVTTRAEAEKRSL
MMAR_4032|M.marinum_M TSVEALSGLKPILHQDDPEATVTAGNASGQNDAASVCVVTTPEKADEYGL
MAV_1573|M.avium_104 TSVESLSKLKPVLLEQDPEATVTAGNASGQNDAASMCVVTTPEKADEHGL
Mvan_1976|M.vanbaalenii_PYR-1 TSLESLAKLKPVLGKSDPDATVTAGNSSGQNDAASMCLVTTPQKAAELGL
:: *:* . : .*.:. .*.*: :: . .*
MLBr_01158|M.leprae_Br4923 TWLVEIGAHGVVAGPDSTLQSQPANAIKKAVDREGISVEQLDVVEINEAF
MAB_0902|M.abscessus_ATCC_1997 TVRARVVAAASAGVAPNLMGLGPVPAVRKVVDRVGWRVDAIDATEINEAF
TH_0255|M.thermoresistible__bu TPIVRYRAGAVTGADPVLMLTGPIPATEKVLRKTGLNIDDIGVFEVNEAF
Mb1103c|M.bovis_AF2122/97 TPLARIVSTGVSGLSPEIMGLGPIEASKKALERAGMAITDIDLVEINEAF
Rv1074c|M.tuberculosis_H37Rv TPLARIVSTGVSGLSPEIMGLGPIEASKKALERAGMAITDIDLVEINEAF
MUL_0207|M.ulcerans_Agy99 TPLARIVSTGVSGLSPEIMGLGPIEACKKALQRAGMSISDIDLVEINEAF
MSMEG_1896|M.smegmatis_MC2_155 TPMLALKSWAVTGCAPEKMGIGPVAASDAALQRAGITLDEVDLIELNEAF
Mflv_1347|M.gilvum_PYR-GCK EPLLTLRSWSVTGCAPETMGIGPVSAAAAALERADLTLDEIDLIEVNEAF
MMAR_4032|M.marinum_M RPLVRLVSWGLAGVAPDVMGIGPVPATEAALAKAALRLADIDLIELNEAF
MAV_1573|M.avium_104 RPLVRLVSWAVAGVAPHIMGIGPVPATEVALAKAGLSLSDIDLIELNEAF
Mvan_1976|M.vanbaalenii_PYR-1 RPLVRLVSWGVAGVAPNVMGIGPVPATEVALGNAGLALSDVDLIELNEAF
: . . : * * .: . : :. *:****
MLBr_01158|M.leprae_Br4923 AAVALASARELG---IAPELVNVNGGAIAVGHPLGMSGARITLHVALELA
MAB_0902|M.abscessus_ATCC_1997 AAQTLAVLRRLG---LDEDTVNADGGAIALGHPLGCSGARLIVTLLNRLE
TH_0255|M.thermoresistible__bu APVPLAWQAETG---ADPAKLNPLGGAIALGHPLGASGAVLMTRMVHHMR
Mb1103c|M.bovis_AF2122/97 AVQVLGSARELG---IDEDKLNISGGAIALGHPFGMTGARITTTLLNNLQ
Rv1074c|M.tuberculosis_H37Rv AVQVLGSARELG---IDEDKLNISGGAIALGHPFGMTGARITTTLLNNLQ
MUL_0207|M.ulcerans_Agy99 AVQVLGSARELG---IDEDELNVSGGAIALGHPFGMTGARITTTLLNNLQ
MSMEG_1896|M.smegmatis_MC2_155 AAQVLAVLAEWKVDPLD-ERLNPNGSGISLGHPIGATGARILATAAHEAL
Mflv_1347|M.gilvum_PYR-GCK AAQVLAVLAEWKIDPLD-DRLNPNGSGISLGHPIGATGARILATAAYEAR
MMAR_4032|M.marinum_M AAQALAVMREWNFGAADRDRTNVHGSGISLGHPVGATGARMLATLARELT
MAV_1573|M.avium_104 AAQALAVMREWKFGAADHDRTNVHGSGISLGHPVGATGGRMLATLARELT
Mvan_1976|M.vanbaalenii_PYR-1 AAQALACMREWKFTQADLERTNVHGSGISLGHPVGATGGRMLATLARELN
* *. . * *..*::***.* :*. : .
MLBr_01158|M.leprae_Br4923 RRGSGYGVAALCGAGGQGDALILRAV--
MAB_0902|M.abscessus_ATCC_1997 REGASRGLATLCVGVGQGVAILIEAP--
TH_0255|M.thermoresistible__bu ANGIRYGLQTMCEGGGTANATVVELLA-
Mb1103c|M.bovis_AF2122/97 TYDKTFGLETMCVGGGQGMAMVIERLA-
Rv1074c|M.tuberculosis_H37Rv TYDKTFGLETMCVGGGQGMAMVIERLA-
MUL_0207|M.ulcerans_Agy99 THDKTFGLETMCVGGGQGMAMVIERLS-
MSMEG_1896|M.smegmatis_MC2_155 RRDARYVLETMCIGGGQGLAAVFEAVR-
Mflv_1347|M.gilvum_PYR-GCK RRDARYVLEAMCIGGGQGLAAVFEVTR-
MMAR_4032|M.marinum_M RRQARYGLETMCIGGGQGLAAIFERVG-
MAV_1573|M.avium_104 RRQARYGLETMCIGGGQGLAAVFERVA-
Mvan_1976|M.vanbaalenii_PYR-1 RRDGRFGLETMCIGGGQGLAAVFERVTP
: ::* . * . * :..