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VMRDAVVCEPVRTPIGRYNGMFKSLTAVELGVAALQGLLARTGVAPGAVEDVVVGHCYPSMEAPAIGRVI ALDAGLPVTVPGMQIDRRCGSGLQAVIQAAMQVASGNNDLVVAGGAESMSNVVFHSTDMRWGGARGGITV HDALARGRTTAGGKNYPVPGGMLETAENLRRDYGISRQEQDELAVLSHRRAVTAQKDGLLAETIIPVTVT SRSGDQVIDTDEHPRADTSLESLAKLKPVLGKSDPDATVTAGNSSGQNDAASMCLVTTPQKAAELGLRPL VRLVSWGVAGVAPNVMGIGPVPATEVALGNAGLALSDVDLIELNEAFAAQALACMREWKFTQADLERTNV HGSGISLGHPVGATGGRMLATLARELNRRDGRFGLETMCIGGGQGLAAVFERVTP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1976 | - | - | 100% (405) | acetyl-CoA acetyltransferase |
| M. vanbaalenii PYR-1 | Mvan_2617 | - | 5e-68 | 39.37% (414) | acetyl-CoA acetyltransferases |
| M. vanbaalenii PYR-1 | Mvan_4677 | - | 2e-66 | 37.29% (421) | acetyl-CoA acetyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1103c | fadA3 | 3e-66 | 36.87% (415) | acetyl-CoA acetyltransferase |
| M. gilvum PYR-GCK | Mflv_4368 | - | 0.0 | 89.33% (403) | acetyl-CoA acetyltransferase |
| M. tuberculosis H37Rv | Rv1074c | fadA3 | 3e-66 | 36.87% (415) | acetyl-CoA acetyltransferase |
| M. leprae Br4923 | MLBr_01158 | fadA4 | 7e-61 | 35.73% (403) | acetyl-CoA acetyltransferase |
| M. abscessus ATCC 19977 | MAB_3455c | - | 2e-67 | 39.14% (419) | putative acyl-CoA thiolase |
| M. marinum M | MMAR_4032 | - | 0.0 | 79.35% (402) | beta-ketoacyl CoA thiolase |
| M. avium 104 | MAV_1573 | - | 0.0 | 81.34% (402) | acetyl-CoA acetyltransferase |
| M. smegmatis MC2 155 | MSMEG_2207 | - | 0.0 | 80.85% (402) | acetyl-CoA acetyltransferase |
| M. thermoresistible (build 8) | TH_0255 | - | 2e-61 | 37.31% (402) | acetyl-CoA acetyltransferase |
| M. ulcerans Agy99 | MUL_0207 | fadA3 | 5e-67 | 38.39% (422) | acetyl-CoA acetyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1103c|M.bovis_AF2122/97 ----MPEAVIVSTARSPIGRAMK-GSLVGMRPDDLAVQMVRAALDKVPAL
Rv1074c|M.tuberculosis_H37Rv ----MPEAVIVSTARSPIGRAMK-GSLVGMRPDDLAVQMVRAALDKVPAL
MUL_0207|M.ulcerans_Agy99 ----MPEAVIVSTARSPIGRAMK-ASLVSMRPDDLAVQMVRAALDKVPAL
Mvan_1976|M.vanbaalenii_PYR-1 ---MMRDAVVCEPVRTPIGR-YN-GMFKSLTAVELGVAALQGLLART-GV
Mflv_4368|M.gilvum_PYR-GCK ---MTREAVICEPVRTPIGR-YN-GMFKSLTAVELGVVALKGLLERT-QV
MMAR_4032|M.marinum_M MSAAMRQAVICEPVRTPIGR-YG-GMFKSHSAVDLGVVALRGLLDRT-GL
MAV_1573|M.avium_104 -MSAVREAVICEPVRTPIGR-YG-GMFKALTAVDLGVAALGGLLQRT-GL
MSMEG_2207|M.smegmatis_MC2_155 --MSMRDAVICEPVRTPIGR-YG-GMFRSLTAVDLGVTALKGLLERT-GI
MAB_3455c|M.abscessus_ATCC_199 ----MRDAVIIDAVRTPVGKGKPGGSLSGVHPVDLHAHAIRELVERA-GI
TH_0255|M.thermoresistible__bu ----MRETVIVEAVRTAVGKRN--GALADVHAADLSAVVLSELVERA-GI
MLBr_01158|M.leprae_Br4923 ----MTTSVIVTGARTPIGKLMG--SLKDFSASDLGAITIAAALKKA-NV
:*: .*:.:*: : . :* . : : :. :
Mb1103c|M.bovis_AF2122/97 NPHQIDDLMMGCGLPGGESGFNIARVVAVALGYDF-LPGTTVNRYCSSSL
Rv1074c|M.tuberculosis_H37Rv NPHQIDDLMMGCGLPGGESGFNIARVVAVALGYDF-LPGTTVNRYCSSSL
MUL_0207|M.ulcerans_Agy99 NPHQIDDLIMGCGLPGGESGFNIGRVVAVALGYDF-LPGTTVNRYCSSSL
Mvan_1976|M.vanbaalenii_PYR-1 APGAVEDVVVGHCYPSME-APAIGRVIALDAGLPVTVPGMQIDRRCGSGL
Mflv_4368|M.gilvum_PYR-GCK APEAIEDVIVGHCYPSME-APAIGRVIALDAGLPVTVPGMQLDRRCGSGL
MMAR_4032|M.marinum_M APAAVGDVILGHCYPSSE-APAIGRVVALDAGLPVTVPGMQVDRRCGSGL
MAV_1573|M.avium_104 PPEAVQDVILGHCYPSSE-APAIGRVVALDSGLPVTVPGMQVDRRCGSGL
MSMEG_2207|M.smegmatis_MC2_155 AADQVEDVILGHCYPNSE-APAIGRVVALDAGLPITVPGMQVDRRCGSGL
MAB_3455c|M.abscessus_ATCC_199 DPALIDDVISGAVGQVGEQSSNTARWAALAAGLPETVPAVTVDRQCGSSQ
TH_0255|M.thermoresistible__bu DPELIDDVIWGCVSQVGDQSSNIGRYAVLAAGWPETIPGTTVNRACGSSQ
MLBr_01158|M.leprae_Br4923 APSIVQYVIIGQVLTAGA-GQMPARQAAVAAGIGWDVPALTINKMCLSGL
. : :: * . .* .: * :*. ::: * *.
Mb1103c|M.bovis_AF2122/97 QTTRMAFHAIKAGEGDAFISAGVETVSRFAKGNSDS-WPDTKNPLFDGAQ
Rv1074c|M.tuberculosis_H37Rv QTTRMAFHAIKAGEGDAFISAGVETVSRFAKGNSDS-WPDTKNPLFDGAQ
MUL_0207|M.ulcerans_Agy99 QITRVAFHAIKAGEGDAFISAGVETVSRFGKGNSDS-LPDTKNPLFDEAQ
Mvan_1976|M.vanbaalenii_PYR-1 QAVIQAAMQVASGNNDLVVAGGAESMSNVVFHSTDMRWGGARGGITVHDA
Mflv_4368|M.gilvum_PYR-GCK QAVIQAAMQVASGTNDLVVAGGAESMSNVVFHSTDMRWGGARTGITVHDA
MMAR_4032|M.marinum_M QAVIQACQQVSSGDSDLVVAGGCESMSNVTFYSTDMRWGGARGGIRVHDG
MAV_1573|M.avium_104 QAVIQACLQVRNGDHDLVIAGGCESMSNVAFYSTDMRWGGARSGVRVHDG
MSMEG_2207|M.smegmatis_MC2_155 QAVIQACLQVRSGDHDLVVAGGAESMSNVAFYSTDMRWGGARTGVQIHDG
MAB_3455c|M.abscessus_ATCC_199 QAIHFAAQGVIAGAYDVVIASGIESMSRVPMGSQSL--GKDFFGSEVARR
TH_0255|M.thermoresistible__bu QALDFAVHAVMSGQQDVVVAGGVEVMSRVPLGAARA--TGMPYGPKVLER
MLBr_01158|M.leprae_Br4923 DAIALADQLIRAGEFDVVVAGGQESMTKAPHLLMDSRSGYKYGDVTIVDH
: * : * * .::.* * ::.
Mb1103c|M.bovis_AF2122/97 ERSAAAAAGADEWHDPRTDQKLPDIYIAMGQTAENVAIMTGISREEQDRW
Rv1074c|M.tuberculosis_H37Rv ERSAAAAAGADEWHDPRTDQKLPDIYIAMGQTAENVAIMTGISREEQDRW
MUL_0207|M.ulcerans_Agy99 ERTAAAAAGAEEWHDPRADGNLPDVYIAMGQTAENVAIISGISREDQDHW
Mvan_1976|M.vanbaalenii_PYR-1 LARGRTTAGGKNYPVPG----------GMLETAENLRRDYGISRQEQDEL
Mflv_4368|M.gilvum_PYR-GCK LARGRTTAGGKHYPVPG----------GMLETAENLRREYGISREEQDEL
MMAR_4032|M.marinum_M LARGRVTAGGRHYPVPG----------GMLETAENLRRQYGISRLEQDEL
MAV_1573|M.avium_104 LARGRTTAGGRRYPVPG----------GMLETAENLRRQYGISRQEQDEL
MSMEG_2207|M.smegmatis_MC2_155 LARGRTTAGGKFHPVPG----------GMLETAENLRREYHISRTEQDEL
MAB_3455c|M.abscessus_ATCC_199 YPEGLVPQG---------------------ISAELIAAKWNLSREQLDTF
TH_0255|M.thermoresistible__bu YDNFGFNQG---------------------ISAELIAERWNLSRTRLDEY
MLBr_01158|M.leprae_Br4923 LAYDGLHDVFTNQP--------------MGALTEQRNDVEKFTRQEQDEF
:* ::* *
Mb1103c|M.bovis_AF2122/97 GVRSQNRAEEAIKNGFFEREITPVTLPDG----TTVSTDDGPRPGTTYEK
Rv1074c|M.tuberculosis_H37Rv GVRSQNRAEEAIKNGFFEREITPVTLPDG----TTVSTDDGPRPGTTYEK
MUL_0207|M.ulcerans_Agy99 GVRSQNRAEEAIKGGFFEREISPVTLPDG----TTVSTNDGPRAGTTYEK
Mvan_1976|M.vanbaalenii_PYR-1 AVLSHRRAVTAQKDGLLAETIIPVTVTSRSGD-QVIDTDEHPRADTSLES
Mflv_4368|M.gilvum_PYR-GCK AVRSHSKAVRAQQDGLLAETIIPVTVSGRSGD-AVIDVDEHPRADTSPES
MMAR_4032|M.marinum_M AVTSHQRAVAAQKDGIFAEETIAVPVRTRQGE-ELIDTDEHPRADTSVEA
MAV_1573|M.avium_104 AVRSHQRAVAAQKDGILAQEIIAVAVPTRHGD-ELIDTDEHPRADTSVES
MSMEG_2207|M.smegmatis_MC2_155 AVRSHQRAVAAQSEGVLAEEIIPVPVRTRDGE-ETISVDEHPRADTTVEA
MAB_3455c|M.abscessus_ATCC_199 AAESHRRAAQAWSEGRFARDVVPIKAPDVNGDLVEVSTDESVRPSTTVEV
TH_0255|M.thermoresistible__bu SAQSHERAAAAQSSGAFKDQIVPVFTDDA-----VVTEDEGIRRGTTVEK
MLBr_01158|M.leprae_Br4923 AARSHQKAAAAWKDGVFADEVVPVSIPQSKGDSLQFTEDEGIRANTSAES
.. *: :* * . * : .: . :: * .*: *
Mb1103c|M.bovis_AF2122/97 VSELKPAFR----------PNGTVTAGNACPLNDGAAAVVITSDTKAKEL
Rv1074c|M.tuberculosis_H37Rv VSELKPAFR----------PNGTVTAGNACPLNDGAAAVVITSDTKAKEL
MUL_0207|M.ulcerans_Agy99 VSQLKPVFR----------PNGTVTAGNACPLNDGAAAVVITSDTKAKEL
Mvan_1976|M.vanbaalenii_PYR-1 LAKLKPVLGKS-------DPDATVTAGNSSGQNDAASMCLVTTPQKAAEL
Mflv_4368|M.gilvum_PYR-GCK LAKLKPVLAAS-------DPEATVTAGNSSGQNDAASMCLVTTPEKAAEL
MMAR_4032|M.marinum_M LSGLKPILHQD-------DPEATVTAGNASGQNDAASVCVVTTPEKADEY
MAV_1573|M.avium_104 LSKLKPVLLEQ-------DPEATVTAGNASGQNDAASMCVVTTPEKADEH
MSMEG_2207|M.smegmatis_MC2_155 LAKLKPVLLKQ-------DPEATVTAGNSSGQNDAASMCIVTTPEKAAEL
MAB_3455c|M.abscessus_ATCC_199 LAGLKPAFRNELWQQRFPGLDWKVTAGNSSPINDGASAVLITSSETAHRL
TH_0255|M.thermoresistible__bu LATLKPAFT----------ENGVIHAGNSSQISDGAAALLVMTAETAVTL
MLBr_01158|M.leprae_Br4923 LAGLKPAFRCG----------GTITPGSASQISDGAATVVVMNKEKAQQL
:: *** : : .*.:. .*.*: :: . .*
Mb1103c|M.bovis_AF2122/97 GLTPLARIVSTGVSGLSPEIMGLGPIEASKKALERAGMAITDIDLVEINE
Rv1074c|M.tuberculosis_H37Rv GLTPLARIVSTGVSGLSPEIMGLGPIEASKKALERAGMAITDIDLVEINE
MUL_0207|M.ulcerans_Agy99 GLTPLARIVSTGVSGLSPEIMGLGPIEACKKALQRAGMSISDIDLVEINE
Mvan_1976|M.vanbaalenii_PYR-1 GLRPLVRLVSWGVAGVAPNVMGIGPVPATEVALGNAGLALSDVDLIELNE
Mflv_4368|M.gilvum_PYR-GCK GLVPLVRIVSWGVAGVAPKIMGIGPVPATEVALRRAGLQLPDIDLIELNE
MMAR_4032|M.marinum_M GLRPLVRLVSWGLAGVAPDVMGIGPVPATEAALAKAALRLADIDLIELNE
MAV_1573|M.avium_104 GLRPLVRLVSWAVAGVAPHIMGIGPVPATEVALAKAGLSLSDIDLIELNE
MSMEG_2207|M.smegmatis_MC2_155 GLKPLVRLVSWGSAGVAPDLMGIGPVPATEVALAKAGLTLADIDLIELNE
MAB_3455c|M.abscessus_ATCC_199 GLTPRARVHSVAVVGDDPLYMLTGIIPATAKVLDRAGLSLADIDAFEVNE
TH_0255|M.thermoresistible__bu GLTPIVRYRAGAVTGADPVLMLTGPIPATEKVLRKTGLNIDDIGVFEVNE
MLBr_01158|M.leprae_Br4923 GLTWLVEIGAHGVVAGPDSTLQSQPANAIKKAVDREGISVEQLDVVEINE
** .. : . . : * .: . .: : ::. .*:**
Mb1103c|M.bovis_AF2122/97 AFAVQVLGSARELG---IDEDKLNISGGAIALGHPFGMTGARITTTLLNN
Rv1074c|M.tuberculosis_H37Rv AFAVQVLGSARELG---IDEDKLNISGGAIALGHPFGMTGARITTTLLNN
MUL_0207|M.ulcerans_Agy99 AFAVQVLGSARELG---IDEDELNVSGGAIALGHPFGMTGARITTTLLNN
Mvan_1976|M.vanbaalenii_PYR-1 AFAAQALACMREWKFTQADLERTNVHGSGISLGHPVGATGGRMLATLARE
Mflv_4368|M.gilvum_PYR-GCK AFAAQALACLREWKFTETDLERTNVHGSGISLGHPVGATGGRMLATLARE
MMAR_4032|M.marinum_M AFAAQALAVMREWNFGAADRDRTNVHGSGISLGHPVGATGARMLATLARE
MAV_1573|M.avium_104 AFAAQALAVMREWKFGAADHDRTNVHGSGISLGHPVGATGGRMLATLARE
MSMEG_2207|M.smegmatis_MC2_155 AFAAQALAVMREWKFGEADHERTNVRGSGISLGHPVGATGGRMLATLARE
MAB_3455c|M.abscessus_ATCC_199 AFASVVLAWQAETG---ADLSKVNVNGGATAIGHPLGASGGRLMTTLVSV
TH_0255|M.thermoresistible__bu AFAPVPLAWQAETG---ADPAKLNPLGGAIALGHPLGASGAVLMTRMVHH
MLBr_01158|M.leprae_Br4923 AFAAVALASARELG---IAPELVNVNGGAIAVGHPLGMSGARITLHVALE
*** *. * * *.. ::***.* :*. : :
Mb1103c|M.bovis_AF2122/97 LQTYDKTFGLETMCVGGGQGMAMVIERLA--
Rv1074c|M.tuberculosis_H37Rv LQTYDKTFGLETMCVGGGQGMAMVIERLA--
MUL_0207|M.ulcerans_Agy99 LQTHDKTFGLETMCVGGGQGMAMVIERLS--
Mvan_1976|M.vanbaalenii_PYR-1 LNRRDGRFGLETMCIGGGQGLAAVFERVTP-
Mflv_4368|M.gilvum_PYR-GCK LVRRDGRFGLETMCIGGGQGLAAVFERVEG-
MMAR_4032|M.marinum_M LTRRQARYGLETMCIGGGQGLAAIFERVG--
MAV_1573|M.avium_104 LTRRQARYGLETMCIGGGQGLAAVFERVA--
MSMEG_2207|M.smegmatis_MC2_155 LHRREARYGLETMCIGGGQGLAAVFERVQEG
MAB_3455c|M.abscessus_ATCC_199 LEQGGGRYGLQTMCEAGGLANATILERL---
TH_0255|M.thermoresistible__bu MRANGIRYGLQTMCEGGGTANATVVELLA--
MLBr_01158|M.leprae_Br4923 LARRGSGYGVAALCGAGGQGDALILRAV---
: :*: ::* .** . * :.. :