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SAAMRQAVICEPVRTPIGRYGGMFKSHSAVDLGVVALRGLLDRTGLAPAAVGDVILGHCYPSSEAPAIGR VVALDAGLPVTVPGMQVDRRCGSGLQAVIQACQQVSSGDSDLVVAGGCESMSNVTFYSTDMRWGGARGGI RVHDGLARGRVTAGGRHYPVPGGMLETAENLRRQYGISRLEQDELAVTSHQRAVAAQKDGIFAEETIAVP VRTRQGEELIDTDEHPRADTSVEALSGLKPILHQDDPEATVTAGNASGQNDAASVCVVTTPEKADEYGLR PLVRLVSWGLAGVAPDVMGIGPVPATEAALAKAALRLADIDLIELNEAFAAQALAVMREWNFGAADRDRT NVHGSGISLGHPVGATGARMLATLARELTRRQARYGLETMCIGGGQGLAAIFERVG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4032 | - | - | 100% (407) | beta-ketoacyl CoA thiolase |
| M. marinum M | MMAR_4393 | fadA3 | 4e-69 | 40.05% (422) | beta-ketoacyl CoA thiolase FadA3 |
| M. marinum M | MMAR_1317 | fadA6_4 | 4e-65 | 39.52% (415) | acetyl-CoA acetyltransferase FadA6_4 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1103c | fadA3 | 9e-67 | 39.33% (417) | acetyl-CoA acetyltransferase |
| M. gilvum PYR-GCK | Mflv_4368 | - | 0.0 | 78.30% (401) | acetyl-CoA acetyltransferase |
| M. tuberculosis H37Rv | Rv1074c | fadA3 | 9e-67 | 39.33% (417) | acetyl-CoA acetyltransferase |
| M. leprae Br4923 | MLBr_01158 | fadA4 | 1e-62 | 36.72% (403) | acetyl-CoA acetyltransferase |
| M. abscessus ATCC 19977 | MAB_0902 | - | 4e-68 | 39.13% (414) | beta-ketoadipyl-CoA thiolase |
| M. avium 104 | MAV_1573 | - | 0.0 | 87.13% (404) | acetyl-CoA acetyltransferase |
| M. smegmatis MC2 155 | MSMEG_2207 | - | 0.0 | 82.88% (403) | acetyl-CoA acetyltransferase |
| M. thermoresistible (build 8) | TH_2071 | fadA6 | 4e-62 | 38.27% (405) | PROBABLE ACETYL-CoA ACETYLTRANSFERASE FADA6 |
| M. ulcerans Agy99 | MUL_0207 | fadA3 | 7e-67 | 39.52% (420) | acetyl-CoA acetyltransferase |
| M. vanbaalenii PYR-1 | Mvan_1976 | - | 0.0 | 79.35% (402) | acetyl-CoA acetyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1103c|M.bovis_AF2122/97 ----MPEAVIVSTARSPIGRAMKGSLVGMRPDDLAVQMVRAALDKVPALN
Rv1074c|M.tuberculosis_H37Rv ----MPEAVIVSTARSPIGRAMKGSLVGMRPDDLAVQMVRAALDKVPALN
MUL_0207|M.ulcerans_Agy99 ----MPEAVIVSTARSPIGRAMKASLVSMRPDDLAVQMVRAALDKVPALN
MMAR_4032|M.marinum_M MSAAMRQAVICEPVRTPIGRYG-GMFKSHSAVDLGVVALRGLLDRT-GLA
MAV_1573|M.avium_104 -MSAVREAVICEPVRTPIGRYG-GMFKALTAVDLGVAALGGLLQRT-GLP
MSMEG_2207|M.smegmatis_MC2_155 --MSMRDAVICEPVRTPIGRYG-GMFRSLTAVDLGVTALKGLLERT-GIA
Mflv_4368|M.gilvum_PYR-GCK ---MTREAVICEPVRTPIGRYN-GMFKSLTAVELGVVALKGLLERT-QVA
Mvan_1976|M.vanbaalenii_PYR-1 ---MMRDAVVCEPVRTPIGRYN-GMFKSLTAVELGVAALQGLLART-GVA
MLBr_01158|M.leprae_Br4923 ----MTTSVIVTGARTPIGKLM-GSLKDFSASDLGAITIAAALKKA-NVA
MAB_0902|M.abscessus_ATCC_1997 ---MVEQVFVVDGVRTAQGRYG-GALASVRPDDLAARVIAEVVARA-GVP
TH_2071|M.thermoresistible__bu --MAVSEAYVIDAVRTPTGKRN-GSLAALHPIDLGVHAFRGIFDRN-DVD
: .*:. *: . : . :*.. . . : :
Mb1103c|M.bovis_AF2122/97 PHQIDDLMMGCGLPGGESGFNIARVVAVALGYDF-LPGTTVNRYCSSSLQ
Rv1074c|M.tuberculosis_H37Rv PHQIDDLMMGCGLPGGESGFNIARVVAVALGYDF-LPGTTVNRYCSSSLQ
MUL_0207|M.ulcerans_Agy99 PHQIDDLIMGCGLPGGESGFNIGRVVAVALGYDF-LPGTTVNRYCSSSLQ
MMAR_4032|M.marinum_M PAAVGDVILGHCYPSSE-APAIGRVVALDAGLPVTVPGMQVDRRCGSGLQ
MAV_1573|M.avium_104 PEAVQDVILGHCYPSSE-APAIGRVVALDSGLPVTVPGMQVDRRCGSGLQ
MSMEG_2207|M.smegmatis_MC2_155 ADQVEDVILGHCYPNSE-APAIGRVVALDAGLPITVPGMQVDRRCGSGLQ
Mflv_4368|M.gilvum_PYR-GCK PEAIEDVIVGHCYPSME-APAIGRVIALDAGLPVTVPGMQLDRRCGSGLQ
Mvan_1976|M.vanbaalenii_PYR-1 PGAVEDVVVGHCYPSME-APAIGRVIALDAGLPVTVPGMQIDRRCGSGLQ
MLBr_01158|M.leprae_Br4923 PSIVQYVIIGQVLTAGA-GQMPARQAAVAAGIGWDVPALTINKMCLSGLD
MAB_0902|M.abscessus_ATCC_1997 ADAIGEVILGAANQAGEDNRNVARMAALLAGLPNTVPGYTVNRLCASGLT
TH_2071|M.thermoresistible__bu PAAVDDVVVGCVDAIGGQAGNIGRLMWLAAGYPEEVPGVTVDRQCGSSQQ
. : :::* .* : * :*. ::: * *.
Mb1103c|M.bovis_AF2122/97 TTRMAFHAIKAGEGDAFISAGVETVSRFAKGNSDSWPDTKNPLFDGAQER
Rv1074c|M.tuberculosis_H37Rv TTRMAFHAIKAGEGDAFISAGVETVSRFAKGNSDSWPDTKNPLFDGAQER
MUL_0207|M.ulcerans_Agy99 ITRVAFHAIKAGEGDAFISAGVETVSRFGKGNSDSLPDTKNPLFDEAQER
MMAR_4032|M.marinum_M AVIQACQQVSSGDSDLVVAGGCESMSNVTFYSTDMR---------WGGAR
MAV_1573|M.avium_104 AVIQACLQVRNGDHDLVIAGGCESMSNVAFYSTDMR---------WGGAR
MSMEG_2207|M.smegmatis_MC2_155 AVIQACLQVRSGDHDLVVAGGAESMSNVAFYSTDMR---------WGGAR
Mflv_4368|M.gilvum_PYR-GCK AVIQAAMQVASGTNDLVVAGGAESMSNVVFHSTDMR---------WGGAR
Mvan_1976|M.vanbaalenii_PYR-1 AVIQAAMQVASGNNDLVVAGGAESMSNVVFHSTDMR---------WGGAR
MLBr_01158|M.leprae_Br4923 AIALADQLIRAGEFDVVVAGGQESMTKAPHLLMDSR---------SGYKY
MAB_0902|M.abscessus_ATCC_1997 AISSAAQAIRAGEADIVVAGGVESMTRAPWVMAKPSAPWARPGEVVDTSL
TH_2071|M.thermoresistible__bu AISFGAQAIMSGTADIILAGGVQNMSQIPISSAM----------IVGKEF
. : * * .::.* :.::.
Mb1103c|M.bovis_AF2122/97 S----AAAAAGADEWHDPRTDQKLPDIYIAMGQTAENVAIMTGISREEQD
Rv1074c|M.tuberculosis_H37Rv S----AAAAAGADEWHDPRTDQKLPDIYIAMGQTAENVAIMTGISREEQD
MUL_0207|M.ulcerans_Agy99 T----AAAAAGAEEWHDPRADGNLPDVYIAMGQTAENVAIISGISREDQD
MMAR_4032|M.marinum_M G----GIRVHDGLARGRVTAGGRHYPVPGGMLETAENLRRQYGISRLEQD
MAV_1573|M.avium_104 S----GVRVHDGLARGRTTAGGRRYPVPGGMLETAENLRRQYGISRQEQD
MSMEG_2207|M.smegmatis_MC2_155 T----GVQIHDGLARGRTTAGGKFHPVPGGMLETAENLRREYHISRTEQD
Mflv_4368|M.gilvum_PYR-GCK T----GITVHDALARGRTTAGGKHYPVPGGMLETAENLRREYGISREEQD
Mvan_1976|M.vanbaalenii_PYR-1 G----GITVHDALARGRTTAGGKNYPVPGGMLETAENLRRDYGISRQEQD
MLBr_01158|M.leprae_Br4923 G----DVTIVDHLAYDGLHDVFTNQPM-GALTEQRNDVEK---FTRQEQD
MAB_0902|M.abscessus_ATCC_1997 GWRFTNPRFAQMDAGIAADAGPETVKVTLAMGETAEEVAVAEGISREDSD
TH_2071|M.thermoresistible__bu G--FTSP-TNESKYWLHRYGDQE-----ISQFRGAEMIAERWEISREDME
. . : : ::* : :
Mb1103c|M.bovis_AF2122/97 RWGVRSQNRAEEAIKNGFFEREITPVTLPDG---TTVST-DDGPRPGTTY
Rv1074c|M.tuberculosis_H37Rv RWGVRSQNRAEEAIKNGFFEREITPVTLPDG---TTVST-DDGPRPGTTY
MUL_0207|M.ulcerans_Agy99 HWGVRSQNRAEEAIKGGFFEREISPVTLPDG---TTVST-NDGPRAGTTY
MMAR_4032|M.marinum_M ELAVTSHQRAVAAQKDGIFAEETIAVPVRTRQGEELIDT-DEHPRADTSV
MAV_1573|M.avium_104 ELAVRSHQRAVAAQKDGILAQEIIAVAVPTRHGDELIDT-DEHPRADTSV
MSMEG_2207|M.smegmatis_MC2_155 ELAVRSHQRAVAAQSEGVLAEEIIPVPVRTRDGEETISV-DEHPRADTTV
Mflv_4368|M.gilvum_PYR-GCK ELAVRSHSKAVRAQQDGLLAETIIPVTVSGRSGDAVIDV-DEHPRADTSP
Mvan_1976|M.vanbaalenii_PYR-1 ELAVLSHRRAVTAQKDGLLAETIIPVTVTSRSGDQVIDT-DEHPRADTSL
MLBr_01158|M.leprae_Br4923 EFAARSHQKAAAAWKDGVFADEVVPVSIPQSKGDSLQFTEDEGIRANTSA
MAB_0902|M.abscessus_ATCC_1997 AFALRSHVRALAAQDAGRFVKEIVPIETVDG-----VVDTDEGPRRQTTL
TH_2071|M.thermoresistible__bu RYALTSHERALAAIRAGRFDNEIIGVPVDGG-----EFRIDETPR-ETSL
. *: :* * * : : :: * *:
Mb1103c|M.bovis_AF2122/97 EKVSELKPAFRPN---GTVTAGNACPLNDGAAAVVITSDTKAKELGLTPL
Rv1074c|M.tuberculosis_H37Rv EKVSELKPAFRPN---GTVTAGNACPLNDGAAAVVITSDTKAKELGLTPL
MUL_0207|M.ulcerans_Agy99 EKVSQLKPVFRPN---GTVTAGNACPLNDGAAAVVITSDTKAKELGLTPL
MMAR_4032|M.marinum_M EALSGLKPILHQDDPEATVTAGNASGQNDAASVCVVTTPEKADEYGLRPL
MAV_1573|M.avium_104 ESLSKLKPVLLEQDPEATVTAGNASGQNDAASMCVVTTPEKADEHGLRPL
MSMEG_2207|M.smegmatis_MC2_155 EALAKLKPVLLKQDPEATVTAGNSSGQNDAASMCIVTTPEKAAELGLKPL
Mflv_4368|M.gilvum_PYR-GCK ESLAKLKPVLAASDPEATVTAGNSSGQNDAASMCLVTTPEKAAELGLVPL
Mvan_1976|M.vanbaalenii_PYR-1 ESLAKLKPVLGKSDPDATVTAGNSSGQNDAASMCLVTTPQKAAELGLRPL
MLBr_01158|M.leprae_Br4923 ESLAGLKPAFRCG---GTITPGSASQISDGAATVVVMNKEKAQQLGLTWL
MAB_0902|M.abscessus_ATCC_1997 AKLAALRPVFRAG---GIVTAGSSSPLSDGAAAVVLAGERAVRQHGLTVR
TH_2071|M.thermoresistible__bu EKMAAL-PTLTEG---GRMTAAVASQISDGASAVLLASEKAVKEHKLKPR
:: * * : . :*.. :. .*.*: :: . : *
Mb1103c|M.bovis_AF2122/97 ARIVSTGVSGLSPEIMGLGPIEASKKALERAGMAITDIDLVEINEAFAVQ
Rv1074c|M.tuberculosis_H37Rv ARIVSTGVSGLSPEIMGLGPIEASKKALERAGMAITDIDLVEINEAFAVQ
MUL_0207|M.ulcerans_Agy99 ARIVSTGVSGLSPEIMGLGPIEACKKALQRAGMSISDIDLVEINEAFAVQ
MMAR_4032|M.marinum_M VRLVSWGLAGVAPDVMGIGPVPATEAALAKAALRLADIDLIELNEAFAAQ
MAV_1573|M.avium_104 VRLVSWAVAGVAPHIMGIGPVPATEVALAKAGLSLSDIDLIELNEAFAAQ
MSMEG_2207|M.smegmatis_MC2_155 VRLVSWGSAGVAPDLMGIGPVPATEVALAKAGLTLADIDLIELNEAFAAQ
Mflv_4368|M.gilvum_PYR-GCK VRIVSWGVAGVAPKIMGIGPVPATEVALRRAGLQLPDIDLIELNEAFAAQ
Mvan_1976|M.vanbaalenii_PYR-1 VRLVSWGVAGVAPNVMGIGPVPATEVALGNAGLALSDVDLIELNEAFAAQ
MLBr_01158|M.leprae_Br4923 VEIGAHGVVAGPDSTLQSQPANAIKKAVDREGISVEQLDVVEINEAFAAV
MAB_0902|M.abscessus_ATCC_1997 ARVVAAASAGVAPNLMGLGPVPAVRKVVDRVGWRVDAIDATEINEAFAAQ
TH_2071|M.thermoresistible__bu ARIHHISARGDDPVLMLTGPIPATRYALEKTGLSMDDIDVVEINEAFAPV
..: . . : * * . .: . . : :* *:*****
Mb1103c|M.bovis_AF2122/97 VLGSARELGIDE---DKLNISGGAIALGHPFGMTGARITTTLLNNLQTYD
Rv1074c|M.tuberculosis_H37Rv VLGSARELGIDE---DKLNISGGAIALGHPFGMTGARITTTLLNNLQTYD
MUL_0207|M.ulcerans_Agy99 VLGSARELGIDE---DELNVSGGAIALGHPFGMTGARITTTLLNNLQTHD
MMAR_4032|M.marinum_M ALAVMREWNFGAADRDRTNVHGSGISLGHPVGATGARMLATLARELTRRQ
MAV_1573|M.avium_104 ALAVMREWKFGAADHDRTNVHGSGISLGHPVGATGGRMLATLARELTRRQ
MSMEG_2207|M.smegmatis_MC2_155 ALAVMREWKFGEADHERTNVRGSGISLGHPVGATGGRMLATLARELHRRE
Mflv_4368|M.gilvum_PYR-GCK ALACLREWKFTETDLERTNVHGSGISLGHPVGATGGRMLATLARELVRRD
Mvan_1976|M.vanbaalenii_PYR-1 ALACMREWKFTQADLERTNVHGSGISLGHPVGATGGRMLATLARELNRRD
MLBr_01158|M.leprae_Br4923 ALASARELGIAP---ELVNVNGGAIAVGHPLGMSGARITLHVALELARRG
MAB_0902|M.abscessus_ATCC_1997 TLAVLRRLGLDE---DTVNADGGAIALGHPLGCSGARLIVTLLNRLEREG
TH_2071|M.thermoresistible__bu VIAWEKELKVDH---AKVNPNGGAIALGHPLGATGAKLFATMLNELERTG
.:. :. . * *..*::***.* :*.:: : .*
Mb1103c|M.bovis_AF2122/97 KTFGLETMCVGGGQGMAMVIERLA--
Rv1074c|M.tuberculosis_H37Rv KTFGLETMCVGGGQGMAMVIERLA--
MUL_0207|M.ulcerans_Agy99 KTFGLETMCVGGGQGMAMVIERLS--
MMAR_4032|M.marinum_M ARYGLETMCIGGGQGLAAIFERVG--
MAV_1573|M.avium_104 ARYGLETMCIGGGQGLAAVFERVA--
MSMEG_2207|M.smegmatis_MC2_155 ARYGLETMCIGGGQGLAAVFERVQEG
Mflv_4368|M.gilvum_PYR-GCK GRFGLETMCIGGGQGLAAVFERVEG-
Mvan_1976|M.vanbaalenii_PYR-1 GRFGLETMCIGGGQGLAAVFERVTP-
MLBr_01158|M.leprae_Br4923 SGYGVAALCGAGGQGDALILRAV---
MAB_0902|M.abscessus_ATCC_1997 ASRGLATLCVGVGQGVAILIEAP---
TH_2071|M.thermoresistible__bu GRYGLQTMCEGGGTANVTIIERL---
*: ::* . * . . ::.