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TREAVICEPVRTPIGRYNGMFKSLTAVELGVVALKGLLERTQVAPEAIEDVIVGHCYPSMEAPAIGRVIA LDAGLPVTVPGMQLDRRCGSGLQAVIQAAMQVASGTNDLVVAGGAESMSNVVFHSTDMRWGGARTGITVH DALARGRTTAGGKHYPVPGGMLETAENLRREYGISREEQDELAVRSHSKAVRAQQDGLLAETIIPVTVSG RSGDAVIDVDEHPRADTSPESLAKLKPVLAASDPEATVTAGNSSGQNDAASMCLVTTPEKAAELGLVPLV RIVSWGVAGVAPKIMGIGPVPATEVALRRAGLQLPDIDLIELNEAFAAQALACLREWKFTETDLERTNVH GSGISLGHPVGATGGRMLATLARELVRRDGRFGLETMCIGGGQGLAAVFERVEG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4368 | - | - | 100% (405) | acetyl-CoA acetyltransferase |
| M. gilvum PYR-GCK | Mflv_1347 | - | e-127 | 58.50% (400) | acetyl-CoA acetyltransferase |
| M. gilvum PYR-GCK | Mflv_2040 | - | 7e-66 | 38.31% (415) | acetyl-CoA acetyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1103c | fadA3 | 3e-67 | 38.26% (413) | acetyl-CoA acetyltransferase |
| M. tuberculosis H37Rv | Rv1074c | fadA3 | 3e-67 | 38.26% (413) | acetyl-CoA acetyltransferase |
| M. leprae Br4923 | MLBr_02162 | fadA | 2e-62 | 39.67% (426) | acetyl-CoA acetyltransferase |
| M. abscessus ATCC 19977 | MAB_1192c | - | 3e-67 | 39.13% (414) | acetyl-CoA acetyltransferase |
| M. marinum M | MMAR_4032 | - | 0.0 | 78.30% (401) | beta-ketoacyl CoA thiolase |
| M. avium 104 | MAV_1573 | - | 0.0 | 80.80% (401) | acetyl-CoA acetyltransferase |
| M. smegmatis MC2 155 | MSMEG_2207 | - | 0.0 | 81.59% (402) | acetyl-CoA acetyltransferase |
| M. thermoresistible (build 8) | TH_0255 | - | 1e-62 | 38.90% (401) | acetyl-CoA acetyltransferase |
| M. ulcerans Agy99 | MUL_0207 | fadA3 | 5e-68 | 39.71% (418) | acetyl-CoA acetyltransferase |
| M. vanbaalenii PYR-1 | Mvan_1976 | - | 0.0 | 89.33% (403) | acetyl-CoA acetyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1103c|M.bovis_AF2122/97 ----MPEAVIVSTARSPIGRAMKGSLVGMRPDDLAVQMVRAALDKVPALN
Rv1074c|M.tuberculosis_H37Rv ----MPEAVIVSTARSPIGRAMKGSLVGMRPDDLAVQMVRAALDKVPALN
MUL_0207|M.ulcerans_Agy99 ----MPEAVIVSTARSPIGRAMKASLVSMRPDDLAVQMVRAALDKVPALN
MAB_1192c|M.abscessus_ATCC_199 ----MPEAVIVSTARSPIGRAGKGSLVSMRPDDLAAQMVRAALDKVPALD
Mflv_4368|M.gilvum_PYR-GCK ---MTREAVICEPVRTPIGRYN-GMFKSLTAVELGVVALKGLLERT-QVA
Mvan_1976|M.vanbaalenii_PYR-1 ---MMRDAVVCEPVRTPIGRYN-GMFKSLTAVELGVAALQGLLART-GVA
MMAR_4032|M.marinum_M MSAAMRQAVICEPVRTPIGRYG-GMFKSHSAVDLGVVALRGLLDRT-GLA
MAV_1573|M.avium_104 -MSAVREAVICEPVRTPIGRYG-GMFKALTAVDLGVAALGGLLQRT-GLP
MSMEG_2207|M.smegmatis_MC2_155 --MSMRDAVICEPVRTPIGRYG-GMFRSLTAVDLGVTALKGLLERT-GIA
MLBr_02162|M.leprae_Br4923 ---MSEEAFIYEAIRTPRGKQKNGSLHEVKPVSLVVGLVEELRKRNPDLD
TH_0255|M.thermoresistible__bu ----MRETVIVEAVRTAVGK-RNGALADVHAADLSAVVLSELVER-AGID
::.: .. *:. *: . : . .* . : : :
Mb1103c|M.bovis_AF2122/97 PHQIDDLMMGCGLPGGESGFNIARVVAVALGYDF-LPGTTVNRYCSSSLQ
Rv1074c|M.tuberculosis_H37Rv PHQIDDLMMGCGLPGGESGFNIARVVAVALGYDF-LPGTTVNRYCSSSLQ
MUL_0207|M.ulcerans_Agy99 PHQIDDLIMGCGLPGGESGFNIGRVVAVALGYDF-LPGTTVNRYCSSSLQ
MAB_1192c|M.abscessus_ATCC_199 PKDVDDLMLGCGQPGGEAGFNIGRAVAVQLGYDF-LPGTTVNRYCSSSLQ
Mflv_4368|M.gilvum_PYR-GCK PEAIEDVIVGHCYPSME-APAIGRVIALDAGLPVTVPGMQLDRRCGSGLQ
Mvan_1976|M.vanbaalenii_PYR-1 PGAVEDVVVGHCYPSME-APAIGRVIALDAGLPVTVPGMQIDRRCGSGLQ
MMAR_4032|M.marinum_M PAAVGDVILGHCYPSSE-APAIGRVVALDAGLPVTVPGMQVDRRCGSGLQ
MAV_1573|M.avium_104 PEAVQDVILGHCYPSSE-APAIGRVVALDSGLPVTVPGMQVDRRCGSGLQ
MSMEG_2207|M.smegmatis_MC2_155 ADQVEDVILGHCYPNSE-APAIGRVVALDAGLPITVPGMQVDRRCGSGLQ
MLBr_02162|M.leprae_Br4923 ENLISDVILGCVSPVGDQGGDIARATVLAAGLPVTAGGVQLNRFCASGLE
TH_0255|M.thermoresistible__bu PELIDDVIWGCVSQVGDQSSNIGRYAVLAAGWPETIPGTTVNRACGSSQQ
: *:: * : . *.* .: * * ::* *.*. :
Mb1103c|M.bovis_AF2122/97 TTRMAFHAIKAGEGDAFISAGVETVSRFAKGNSDS-WPDTKNPLFDGAQE
Rv1074c|M.tuberculosis_H37Rv TTRMAFHAIKAGEGDAFISAGVETVSRFAKGNSDS-WPDTKNPLFDGAQE
MUL_0207|M.ulcerans_Agy99 ITRVAFHAIKAGEGDAFISAGVETVSRFGKGNSDS-LPDTKNPLFDEAQE
MAB_1192c|M.abscessus_ATCC_199 TTRMAFHAIKAGEGHAFISAGVETVSRFPKGTSDG-WPDSHNPLYADAEA
Mflv_4368|M.gilvum_PYR-GCK AVIQAAMQVASGTNDLVVAGGAESMSNVVFHSTDMRWGGARTGITVHDAL
Mvan_1976|M.vanbaalenii_PYR-1 AVIQAAMQVASGNNDLVVAGGAESMSNVVFHSTDMRWGGARGGITVHDAL
MMAR_4032|M.marinum_M AVIQACQQVSSGDSDLVVAGGCESMSNVTFYSTDMRWGGARGGIRVHDGL
MAV_1573|M.avium_104 AVIQACLQVRNGDHDLVIAGGCESMSNVAFYSTDMRWGGARSGVRVHDGL
MSMEG_2207|M.smegmatis_MC2_155 AVIQACLQVRSGDHDLVVAGGAESMSNVAFYSTDMRWGGARTGVQIHDGL
MLBr_02162|M.leprae_Br4923 AVNTAAQKVRSGWDDLVLAGGVESMSRVPMGSD-----GGAMGLDPATNY
TH_0255|M.thermoresistible__bu ALDFAVHAVMSGQQDVVVAGGVEVMSRVPLGAARA--TGMPYGPKVLERY
* : * . .::.* * :*.. .
Mb1103c|M.bovis_AF2122/97 RSAAAAAGADEWHDPRTDQKLPDIYIAMGQTAENVAIMTGISREEQDRWG
Rv1074c|M.tuberculosis_H37Rv RSAAAAAGADEWHDPRTDQKLPDIYIAMGQTAENVAIMTGISREEQDRWG
MUL_0207|M.ulcerans_Agy99 RTAAAAAGAEEWHDPRADGNLPDVYIAMGQTAENVAIISGISREDQDHWG
MAB_1192c|M.abscessus_ATCC_199 RTATAAQGATEWHDPRNDGLTPDVYIAMGQTAENVALHTGISREDQDHWG
Mflv_4368|M.gilvum_PYR-GCK ARGRTTAGGKHYPVPG----------GMLETAENLRREYGISREEQDELA
Mvan_1976|M.vanbaalenii_PYR-1 ARGRTTAGGKNYPVPG----------GMLETAENLRRDYGISRQEQDELA
MMAR_4032|M.marinum_M ARGRVTAGGRHYPVPG----------GMLETAENLRRQYGISRLEQDELA
MAV_1573|M.avium_104 ARGRTTAGGRRYPVPG----------GMLETAENLRRQYGISRQEQDELA
MSMEG_2207|M.smegmatis_MC2_155 ARGRTTAGGKFHPVPG----------GMLETAENLRREYHISRTEQDELA
MLBr_02162|M.leprae_Br4923 DVMFVPQG---------------------IGADLIATIEGFSRDDVDVYA
TH_0255|M.thermoresistible__bu DNFGFNQG---------------------ISAELIAERWNLSRTRLDEYS
* *: : :** * .
Mb1103c|M.bovis_AF2122/97 VRSQNRAEEAIKNGFFEREITPVTLPDG---TTVSTDDGPRPGTTYEKVS
Rv1074c|M.tuberculosis_H37Rv VRSQNRAEEAIKNGFFEREITPVTLPDG---TTVSTDDGPRPGTTYEKVS
MUL_0207|M.ulcerans_Agy99 VRSQNRAEEAIKGGFFEREISPVTLPDG---TTVSTNDGPRAGTTYEKVS
MAB_1192c|M.abscessus_ATCC_199 VRSQNRAEKAIADGFFEREITPVTLADG---TVVAKDDGPRAGTTYEAIS
Mflv_4368|M.gilvum_PYR-GCK VRSHSKAVRAQQDGLLAETIIPVTVSGRSGDAVIDVDEHPRADTSPESLA
Mvan_1976|M.vanbaalenii_PYR-1 VLSHRRAVTAQKDGLLAETIIPVTVTSRSGDQVIDTDEHPRADTSLESLA
MMAR_4032|M.marinum_M VTSHQRAVAAQKDGIFAEETIAVPVRTRQGEELIDTDEHPRADTSVEALS
MAV_1573|M.avium_104 VRSHQRAVAAQKDGILAQEIIAVAVPTRHGDELIDTDEHPRADTSVESLS
MSMEG_2207|M.smegmatis_MC2_155 VRSHQRAVAAQSEGVLAEEIIPVPVRTRDGEETISVDEHPRADTTVEALA
MLBr_02162|M.leprae_Br4923 LRSQEKAAAAWSGGYFAKSVVPVRDQNGL--LILDHDEHMRPDTSKEGLA
TH_0255|M.thermoresistible__bu AQSHERAAAAQSSGAFKDQIVPVFTDD----AVVTEDEGIRRGTTVEKLA
*: :* * * : .* : :: * .*: * ::
Mb1103c|M.bovis_AF2122/97 ELKPAFR---------------------PNGTVTAGNACPLNDGAAAVVI
Rv1074c|M.tuberculosis_H37Rv ELKPAFR---------------------PNGTVTAGNACPLNDGAAAVVI
MUL_0207|M.ulcerans_Agy99 QLKPVFR---------------------PNGTVTAGNACPLNDGAAAVVI
MAB_1192c|M.abscessus_ATCC_199 QLKPVFR---------------------PNGTITAGNACPLNDGAAALVV
Mflv_4368|M.gilvum_PYR-GCK KLKPVLAA------------------SDPEATVTAGNSSGQNDAASMCLV
Mvan_1976|M.vanbaalenii_PYR-1 KLKPVLGK------------------SDPDATVTAGNSSGQNDAASMCLV
MMAR_4032|M.marinum_M GLKPILHQ------------------DDPEATVTAGNASGQNDAASVCVV
MAV_1573|M.avium_104 KLKPVLLE------------------QDPEATVTAGNASGQNDAASMCVV
MSMEG_2207|M.smegmatis_MC2_155 KLKPVLLK------------------QDPEATVTAGNSSGQNDAASMCIV
MLBr_02162|M.leprae_Br4923 KLKPAFEGLAAMGGFDDVALQKYHWVEKINHVHTGGNSSGIVDGAALVMI
TH_0255|M.thermoresistible__bu TLKPAFT---------------------ENGVIHAGNSSQISDGAAALLV
*** : : . .**:. *.*: ::
Mb1103c|M.bovis_AF2122/97 TSDTKAKELGLTPLARIVSTGVSGLSPEIMGLGPIEASKKALERAGMAIT
Rv1074c|M.tuberculosis_H37Rv TSDTKAKELGLTPLARIVSTGVSGLSPEIMGLGPIEASKKALERAGMAIT
MUL_0207|M.ulcerans_Agy99 TSDTKAKELGLTPLARIVSTGVSGLSPEIMGLGPIEACKKALQRAGMSIS
MAB_1192c|M.abscessus_ATCC_199 MSDVRAKELGLTPLARIVSTGVSGLSPEIMGLGPIEAVKRALANAGKSIG
Mflv_4368|M.gilvum_PYR-GCK TTPEKAAELGLVPLVRIVSWGVAGVAPKIMGIGPVPATEVALRRAGLQLP
Mvan_1976|M.vanbaalenii_PYR-1 TTPQKAAELGLRPLVRLVSWGVAGVAPNVMGIGPVPATEVALGNAGLALS
MMAR_4032|M.marinum_M TTPEKADEYGLRPLVRLVSWGLAGVAPDVMGIGPVPATEAALAKAALRLA
MAV_1573|M.avium_104 TTPEKADEHGLRPLVRLVSWAVAGVAPHIMGIGPVPATEVALAKAGLSLS
MSMEG_2207|M.smegmatis_MC2_155 TTPEKAAELGLKPLVRLVSWGSAGVAPDLMGIGPVPATEVALAKAGLTLA
MLBr_02162|M.leprae_Br4923 GSEAVGKSQGLTPRARMVATATSGADPVIMLTGPTPATRKVLDRAGLTVD
TH_0255|M.thermoresistible__bu MTAETAVTLGLTPIVRYRAGAVTGADPVLMLTGPIPATEKVLRKTGLNID
: . ** * .* : . :* * :* ** * . .* .:. :
Mb1103c|M.bovis_AF2122/97 DIDLVEINEAFAVQVLGSARELG---IDEDKLNISGGAIALGHPFGMTGA
Rv1074c|M.tuberculosis_H37Rv DIDLVEINEAFAVQVLGSARELG---IDEDKLNISGGAIALGHPFGMTGA
MUL_0207|M.ulcerans_Agy99 DIDLVEINEAFAVQVLGSARELG---IDEDELNVSGGAIALGHPFGMTGA
MAB_1192c|M.abscessus_ATCC_199 DIDLFEINEAFAVQVLGSARALG---IDEDKLNVSGGAIALGHPFGMTGA
Mflv_4368|M.gilvum_PYR-GCK DIDLIELNEAFAAQALACLREWKFTETDLERTNVHGSGISLGHPVGATGG
Mvan_1976|M.vanbaalenii_PYR-1 DVDLIELNEAFAAQALACMREWKFTQADLERTNVHGSGISLGHPVGATGG
MMAR_4032|M.marinum_M DIDLIELNEAFAAQALAVMREWNFGAADRDRTNVHGSGISLGHPVGATGA
MAV_1573|M.avium_104 DIDLIELNEAFAAQALAVMREWKFGAADHDRTNVHGSGISLGHPVGATGG
MSMEG_2207|M.smegmatis_MC2_155 DIDLIELNEAFAAQALAVMREWKFGEADHERTNVRGSGISLGHPVGATGG
MLBr_02162|M.leprae_Br4923 DIDLFELNEAFASVVLKFQKDLN---IPDEKLNVNGGAIAMGHPLGATGA
TH_0255|M.thermoresistible__bu DIGVFEVNEAFAPVPLAWQAETG---ADPAKLNPLGGAIALGHPLGASGA
*:.:.*:***** * . * *..*::***.* :*.
Mb1103c|M.bovis_AF2122/97 RITTTLLNNLQTYDKTFGLETMCVGGGQGMAMVIERLA--
Rv1074c|M.tuberculosis_H37Rv RITTTLLNNLQTYDKTFGLETMCVGGGQGMAMVIERLA--
MUL_0207|M.ulcerans_Agy99 RITTTLLNNLQTHDKTFGLETMCVGGGQGMAMVIERLS--
MAB_1192c|M.abscessus_ATCC_199 RITATLLNNLTTYDKTFGVETMCVGGGQGMAMVIERLA--
Mflv_4368|M.gilvum_PYR-GCK RMLATLARELVRRDGRFGLETMCIGGGQGLAAVFERVEG-
Mvan_1976|M.vanbaalenii_PYR-1 RMLATLARELNRRDGRFGLETMCIGGGQGLAAVFERVTP-
MMAR_4032|M.marinum_M RMLATLARELTRRQARYGLETMCIGGGQGLAAIFERVG--
MAV_1573|M.avium_104 RMLATLARELTRRQARYGLETMCIGGGQGLAAVFERVA--
MSMEG_2207|M.smegmatis_MC2_155 RMLATLARELHRREARYGLETMCIGGGQGLAAVFERVQEG
MLBr_02162|M.leprae_Br4923 MILGTMVDELERCNARRALVTLCIGAGMGVATIIERV---
TH_0255|M.thermoresistible__bu VLMTRMVHHMRANGIRYGLQTMCEGGGTANATVVELLA--
: : .: .: *:* *.* . * :.* :