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ELRHLRYFRAVGEELHFGRAAERLHMAQPPLSQQIRQLERELGCTLLTRTTRSVELTPAGHTYLRRAVEI LDAVDAANTEAQRIASGIQGRIAIGCVGSATYSLLPQLVRALGESLPGIEVTVRGEMLAPAQIEALLSGG IDLALLRPPVRQEAVLTHTVRRDGLVVALPADHALAIRDAVTVADLRDEDFVVHTGHGRSVMSNLVATVC ADAGFLPRIRQEVSETSTLVTLVAAGLGVAIVPDPTTALDIAGVRYVPLRPTDLGVDLVAAHTGDSPLIT NVLRVLRTLTEGPKSPTQAHPGT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1895 | - | - | 100% (304) | HTH-type transcriptional regulator AlsR |
| M. smegmatis MC2 155 | MSMEG_1909 | - | 3e-54 | 44.71% (255) | putative HTH-type transcriptional regulator YnfL |
| M. smegmatis MC2 155 | MSMEG_6125 | - | 8e-50 | 39.37% (287) | transcriptional regulatory protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0121 | oxyS | 2e-15 | 28.57% (308) | oxidative stress response regulatory protein OXYS |
| M. gilvum PYR-GCK | Mflv_1346 | - | 1e-95 | 63.57% (291) | LysR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0117 | oxyS | 2e-15 | 28.57% (308) | oxidative stress response regulatory protein OXYS |
| M. leprae Br4923 | MLBr_02041 | oxyR | 3e-19 | 28.23% (248) | putative LysR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_3208c | - | 1e-29 | 36.29% (248) | LysR family transcriptional regulator |
| M. marinum M | MMAR_2756 | oxyR | 3e-24 | 32.31% (260) | hydrogen peroxide-inducible genes activator, OxyR |
| M. avium 104 | MAV_1538 | - | 8e-29 | 30.71% (280) | transcriptional regulator, LysR family protein |
| M. thermoresistible (build 8) | TH_3504 | - | 1e-20 | 29.21% (267) | PUTATIVE putative transcriptional regulator |
| M. ulcerans Agy99 | MUL_2998 | oxyR | 6e-24 | 32.31% (260) | hydrogen peroxide-inducible genes activator, OxyR |
| M. vanbaalenii PYR-1 | Mvan_1027 | - | 1e-49 | 39.02% (287) | LysR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_1895|M.smegmatis_MC2_155 ---------------MELRHLRYFRAVGEELHFGRAAERLHMAQPPLSQQ
Mflv_1346|M.gilvum_PYR-GCK ---------------MKLRHLRYFRAVAEELHFGRAAQRLLIAQPPLSQQ
Mvan_1027|M.vanbaalenii_PYR-1 --------------MFSLARLSCFVAVAEELHFGRAAERLHMTQPPLSRQ
MMAR_2756|M.marinum_M MLATILIGMTDKSYQPTLAGLRAFVAVAEKQHFGSAANALGVSQSTLSQA
MUL_2998|M.ulcerans_Agy99 -----MIGITDKSYQPTLAGLRAFVAVAEKQHFGSAANALGVSQSTLSQA
MLBr_02041|M.leprae_Br4923 --------MSDKSYQPTIAGLRAFVAVVEKGHFSAAASFLGVRQSTLSQA
Mb0121|M.bovis_AF2122/97 ---------------MLFRQLEYFVAVAQERHFARAAEKCYVSQPALSSA
Rv0117|M.tuberculosis_H37Rv ---------------MLFRQLEYFVAVAQERHFARAAEKCYVSQPALSSA
TH_3504|M.thermoresistible__bu ----------VPSPKIDLRRLAQFVAVAELGSFTRAAATLHLSQQALSSA
MAB_3208c|M.abscessus_ATCC_199 ---------------MELRQLEYFLAVAEHANFTRAAEALHVAQPWVSAQ
MAV_1538|M.avium_104 ---------------MAVGDYEWFITLAELQHVTAAAEQLHVAQPTLTRM
. * :: : . ** : * ::
MSMEG_1895|M.smegmatis_MC2_155 IRQLERELGCTLLTRTTRSVELTPAGHTYLRRAVEILDAVDAANTEAQRI
Mflv_1346|M.gilvum_PYR-GCK IRQLEREVGADLLRRTTRSVELTEAGRAFLERTVRILDAVDDAVDQARRI
Mvan_1027|M.vanbaalenii_PYR-1 VQQLENELGVQLIDRTTRNVTLTPAGAAFLPDARRILQLAEGAAQTVKRI
MMAR_2756|M.marinum_M LAALEAGLDLHLVERSTRRVFLTTEGRSLLPHAQAAVEAVEAFTTAAAGE
MUL_2998|M.ulcerans_Agy99 LAALEAGLDLHLVERSTRRVFLTTEGRSLLPHAQAAVEAVEAFTTAAAGE
MLBr_02041|M.leprae_Br4923 LAALESGLGVQLIERSTRRVFVTTQGRHLLPRAQAAIEAMDAFTAAAAGE
Mb0121|M.bovis_AF2122/97 IAKLERELNVTLINRGHSFEGLTREGERLVVWAKRILAEHAAFKAEVDAV
Rv0117|M.tuberculosis_H37Rv IAKLERELNVTLINRGHSFEGLTREGERLVVWAKRILAEHAAFKAEVDAV
TH_3504|M.thermoresistible__bu VRALENDVGADLFTRDGRRISLTTAGRTLLAEGKPLLAAARTVAEHVRQT
MAB_3208c|M.abscessus_ATCC_199 VRRLERELGNELFDRSSRVLRLTEFGKALLPLAGAALRTVGEIRSAADAM
MAV_1538|M.avium_104 LARLEQRLGVALFDRHGRRLSLNTYGRIFYEHARRAQLELDSARRAIADL
: ** :. *. * :. *
MSMEG_1895|M.smegmatis_MC2_155 ASGIQGRIAIGCVGSATYSLLPQLVRALGESLPGIEVTVRGEMLAPAQIE
Mflv_1346|M.gilvum_PYR-GCK GTGAEGRLVVGCVGSATYSLLPRLVRELRAALPAVDLRVRGEMLAPEQLA
Mvan_1027|M.vanbaalenii_PYR-1 PAGDLGTVVVGFTAASAHAVLPRLLERARERLPDVKLDLR-EMVTAAQIE
MMAR_2756|M.marinum_M ADPLNGSIRFGIIPTVAPYVLPTVLAGLTRRLPTLTVRVI-EDQTERLLT
MUL_2998|M.ulcerans_Agy99 ADPLNGSIRFGIIPTVAPYVLPTVLAGLTRRLPTLTVRVI-EDQTERLLT
MLBr_02041|M.leprae_Br4923 SDPLRGGMRLGLIPTVAPYVLPTMLTGLTHRLPTLTLRVV-EDQTEHLLT
Mb0121|M.bovis_AF2122/97 RSGITGTLRLGTVPTAS-TTASLVLSAFCSAHPLAKVQVCSRLAATELYR
Rv0117|M.tuberculosis_H37Rv RSGITGTLRLGTVPTAS-TTASLVLSAFCSAHPLAKVQVCSRLAATELYR
TH_3504|M.thermoresistible__bu EAAAQAHYVIGHTPALSGAEAYALIEPAVTAYPSTSFTLR-QLYPDALTD
MAB_3208c|M.abscessus_ATCC_199 AGVLCGQLAIGTVPHPS-PLLAEALAAYRRAHPAVTVTLT-EARSDQLAT
MAV_1538|M.avium_104 ADPAVGEIRLAYLSSFGSTVVPRLIARFKESSPRVTFTLE-EGAAESIAD
. .. : * . : . .
MSMEG_1895|M.smegmatis_MC2_155 ALLSGGIDLALLRPPVRQEA-VLTHTVRRDGLVVALPADHALAIRD-AVT
Mflv_1346|M.gilvum_PYR-GCK ALHAKDIDLALMRPPVDDPA-LTAVSLRRDRLLVALPAGHRCADRD-EVS
Mvan_1027|M.vanbaalenii_PYR-1 GLMTGELDLGMARPPLKRPG-LVSRPLLHEQLLAALPEGHPLADMTRELT
MMAR_2756|M.marinum_M ALREGSLDTALIALPADYGG-LTEIPIYEEDFVLALPPGHPMADRH-GVP
MUL_2998|M.ulcerans_Agy99 ALREGSLDTALIALPADYGG-LTEIPIYEEDFVLALPPGHPMADRH-GVP
MLBr_02041|M.leprae_Br4923 ALREGALDAAMIALPVETAG-IAEIPIYDEDFVLALPPGHPLSGKR-RVP
Mb0121|M.bovis_AF2122/97 RLREFELDAVIVHPETQDSDDVDLVPLYEEQYVLLSPADMLPPGTS-TLV
Rv0117|M.tuberculosis_H37Rv RLREFELDAVIVHPETQDSDDVDLVPLYEEQYVLLSPADMLPPGTS-TLV
TH_3504|M.thermoresistible__bu AVFDGTVQLGLRRGVVPTPE-LATAVIGYHRVRVAFVDSHPLAARE-SVD
MAB_3208c|M.abscessus_ATCC_199 AVVERRLDMAVMAWLAQPPSQLRERILAKENIVAVVHRDDPLAGRE-SVA
MAV_1538|M.avium_104 RVRSGGVDIGVVSPRPVERT-LAWRSLFRQRLGVAVPDGHRFARGA-AVS
: :: : : : . . . :
MSMEG_1895|M.smegmatis_MC2_155 VADLRDEDFVVHTGHGRSVMSNLVATVCADAGFLPRIR-QEVSETSTLVT
Mflv_1346|M.gilvum_PYR-GCK LADLRDEDFISHAGGGRSRMSALLAALCADAGFSPRIR-DEVDETSTLVT
Mvan_1027|M.vanbaalenii_PYR-1 LIDLDGQDFVMYSPVQARYFNELLISTFTIAGTTPRYV-QYVTQVHTMLV
MMAR_2756|M.marinum_M VAALSELPLLLLDEG--HCLRDQALDVCQNAGVRAELADTRAASLATAVQ
MUL_2998|M.ulcerans_Agy99 VAALSELPLLLLDEG--HCLRDQALDVCQNAGVRAEHADTRADSLATAVQ
MLBr_02041|M.leprae_Br4923 TTALAQLPLLLLDEG--HCLRDQTLDICRKSGVQAELANTRAASLATAVQ
Mb0121|M.bovis_AF2122/97 WRDAAQLPLALLTAD---MRDRQVIDAAFADHAVSAIPQVETDSVASLFA
Rv0117|M.tuberculosis_H37Rv WRDAAQLPLALLTAD---MRDRQVIDAAFADHAVSAIPQVETDSVASLFA
TH_3504|M.thermoresistible__bu ITELAREQVALWAPPGTSYYSDFLMGACRRAGFEPDYVVSRVQGAATVAA
MAB_3208c|M.abscessus_ATCC_199 LAELRDRALISHPQG--CEIRTALDQACLATGFTPRVV-FETSSADMMRH
MAV_1538|M.avium_104 MVDLADEPFVTMHPG--FGMRRLLDELCAAAQFRPRVA-LQAPNLTTAAS
. . .
MSMEG_1895|M.smegmatis_MC2_155 LVAAGLGVAIVPDP----TTALDIAG-----VRYVPLRPTD-LGVDLVAA
Mflv_1346|M.gilvum_PYR-GCK LVAGGLGVALVPEP----TAALEIGG-----VTYRPLAAKAGATIELLAV
Mvan_1027|M.vanbaalenii_PYR-1 LVRSGIGIALVPAS----AATLHPEG-----VVFRTIGAFRERPVELDAV
MMAR_2756|M.marinum_M CVNGGLGVTLIPQS----AVSVEAARSRVGLAHFAAPTPGRRIGLVYRAS
MUL_2998|M.ulcerans_Agy99 CVNGGLGVTLIPQS----AVSVEAARSRVGLTHFAAPTPGRRIGLVYRAS
MLBr_02041|M.leprae_Br4923 CVTGGLGVTLLPQS----AAPVESVRSKLGLAQFAAPCPGRRIGLAFRSA
Mb0121|M.bovis_AF2122/97 QVATGNWASIVPHTWLWAMPMSGPTGGEIRAVELVDPVLKAQIALATNAL
Rv0117|M.tuberculosis_H37Rv QVATGNWASIVPHTWLWAMPMSGPTGGEIRAVELVDPVLKAQIALATNAL
TH_3504|M.thermoresistible__bu PLTTG-GIAFVTAA-----AGPTMNG------RVQVVDLTPPLLVPVQAL
MAB_3208c|M.abscessus_ATCC_199 LVVRDLGVAVTPRLP---REQLGRLR----QIDLSDRAMSGRLSLLWRGK
MAV_1538|M.avium_104 LVAAGLGISLVPID-----GSSYPSG--VSVKPLADADAYRDVGMIWDSG
: . :. . : .
MSMEG_1895|M.smegmatis_MC2_155 H--TGDSPLITNVLRVLRTLTEGPKSPTQAHPGT
Mflv_1346|M.gilvum_PYR-GCK YRSADASPLTAKVVDVLRATV-------------
Mvan_1027|M.vanbaalenii_PYR-1 WRGDSTNPALLRVLKDVLPQQEWTT---------
MMAR_2756|M.marinum_M SGRDEAYRQLAAIMGESISNEQQVRLVN------
MUL_2998|M.ulcerans_Agy99 SGRDEAYRQLAAIMGESISNEQQVRLVN------
MLBr_02041|M.leprae_Br4923 SGRSASYRQIAKIIGELISTEHHVRLVA------
Mb0121|M.bovis_AF2122/97 GPGSPVARALITCAQALALNEFFDTQLRGITRRR
Rv0117|M.tuberculosis_H37Rv GPGSPVARALITCAQALALNEFFDTQLRGITRRR
TH_3504|M.thermoresistible__bu WQRHTLSAIRDRILEGLG----------------
MAB_3208c|M.abscessus_ATCC_199 GATLEAVAFAACIDELCRKDANLVS---------
MAV_1538|M.avium_104 RPLPRSARDFIAGAAAVGHGGW------------