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TNRIQDLLGVEFPVVQAPMTYIARAELAAAVSDGGGLGMIETLTDEGRADLLRVRDLTDRPVAANLMIQG WKRDPSIVDVLAAAGVRHVFTSAGDPALFTDRLHDAGMTVVHVIGSLKGALKAADAGVDALVVEGVEGGG FKSALGASTMVLLPLVAERVDLPLICAGGICDARSAAAAVVLGAEGIQMGTRMLASAEALVHANFKDAIV AADDAGTILLDVPGNPTMRVLRTGLAARIDEQDADAKLLGRITDLYFGGDLEASVANTGQVSSRITGLAP AAEIVRQTWCEIQTVLDDTRARLG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1222 | - | - | 100% (305) | 2-nitropropane dioxygenase, NPD |
| M. gilvum PYR-GCK | Mflv_2128 | - | 1e-43 | 33.55% (304) | 2-nitropropane dioxygenase, NPD |
| M. gilvum PYR-GCK | Mflv_1487 | - | 7e-31 | 36.48% (244) | 2-nitropropane dioxygenase, NPD |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0021c | - | 1e-33 | 32.79% (305) | hypothetical protein Mb0021c |
| M. tuberculosis H37Rv | Rv0021c | - | 7e-34 | 32.79% (305) | hypothetical protein Rv0021c |
| M. leprae Br4923 | MLBr_00388 | guaB3 | 4e-09 | 24.33% (300) | inosine 5-monophosphate dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4001c | - | 5e-75 | 50.16% (307) | putative 2-nitropropane dioxygenase, NPD |
| M. marinum M | MMAR_1721 | - | 3e-32 | 30.28% (317) | hypothetical protein MMAR_1721 |
| M. avium 104 | MAV_2769 | - | 4e-92 | 61.81% (288) | oxidoreductase, 2-nitropropane dioxygenase family protein |
| M. smegmatis MC2 155 | MSMEG_5182 | - | 5e-42 | 33.55% (304) | 2-nitropropane dioxygenase |
| M. thermoresistible (build 8) | TH_3625 | - | 1e-41 | 35.46% (282) | PUTATIVE 2-Nitropropane dioxygenase |
| M. ulcerans Agy99 | MUL_1961 | - | 2e-32 | 30.28% (317) | hypothetical protein MUL_1961 |
| M. vanbaalenii PYR-1 | Mvan_5586 | - | 1e-152 | 88.82% (304) | 2-nitropropane dioxygenase, NPD |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0021c|M.bovis_AF2122/97 --------------------------MVLSTAFSQMFGIDYPIVSAPMDL
Rv0021c|M.tuberculosis_H37Rv --------------------------MVLSTAFSQMFGIDYPIVSAPMDL
MMAR_1721|M.marinum_M --------------------------MSLNTRLTEFLGVQHPILLAPMAM
MUL_1961|M.ulcerans_Agy99 --------------------------MSLNTRLTEFLGVQHPILLAPMAM
Mflv_1222|M.gilvum_PYR-GCK ----------------------------MTNRIQDLLGVEFPVVQAPMTY
Mvan_5586|M.vanbaalenii_PYR-1 ----------------------------MTNRVQELLGVEFPVVQAPMTY
MAV_2769|M.avium_104 -----------------------------------------------MTY
MAB_4001c|M.abscessus_ATCC_199 ---------------------------MITNRVTELLGVERPIVQAPMGW
MSMEG_5182|M.smegmatis_MC2_155 --------------------------MALTTKFTEAFGVTHPIAQGGMQW
TH_3625|M.thermoresistible__bu --------------------------MPLTTKFTEAFGIEHPIAQGGMQW
MLBr_00388|M.leprae_Br4923 MGRVARRTYELREISIVPSRRTRSSKDVSTAWQLDAYRFEIPVVAHPTDA
Mb0021c|M.bovis_AF2122/97 IAGGELAAAVSGAGGLGLIGGGYG----DRDWLARQFDLAAGAPVGCGFI
Rv0021c|M.tuberculosis_H37Rv IAGGELAAAVSGAGGLGLIGGGYG----DRDWLARQFDLAAGAPVGCGFI
MMAR_1721|M.marinum_M TSGGRLAAAVTAAGGLGLIGGGYG----EAEWLQRQLEQAQGQRVGCGFI
MUL_1961|M.ulcerans_Agy99 TSGGRLAAAVTAAGGLGLIGGGYG----EAEWLQRQLEQAQGQRVGCGFI
Mflv_1222|M.gilvum_PYR-GCK IARAELAAAVSDGGGLGMIETLT----DEGRADLLRVRDLTDRPVAANLM
Mvan_5586|M.vanbaalenii_PYR-1 IARAELAAAVSEGGGLGMVETLT----PEGREDLLRVRDLTDRPVAANLM
MAV_2769|M.avium_104 IAGAQLAAAVSNAGALGIIETTS----DQGRADLRRVRELTAGAVGANIA
MAB_4001c|M.abscessus_ATCC_199 IARSQLASAVCNAGGLGIIETSSGEL-DAIKDEIRAMREFTDKPFGVNIA
MSMEG_5182|M.smegmatis_MC2_155 VGRAELVAAVANAGALGFITALTQPTPADLANEIARCRDLTDKPFGVNLT
TH_3625|M.thermoresistible__bu VGRAELVAAVANAGALGFITALTQPTPKDLANEIARCRDLTDKPFGVNLT
MLBr_00388|M.leprae_Br4923 LVSPEFAIELGRLGGLGVLNGEG------------LIGRHADVGAKVAQL
.:. : *.**.:
Mb0021c|M.bovis_AF2122/97 TWSLARQP---QLLDLALQYEPVAVMLSFGDPAVFADAIKSAGTRLVCQI
Rv0021c|M.tuberculosis_H37Rv TWSLARQP---QLLDLALQYEPVAVMLSFGDPAVFADAIKSAGTRLVCQI
MMAR_1721|M.marinum_M TWSLARNP---ELLDLILAANPAAIMLSFGDPHKFAGPIHDAGIPLICQI
MUL_1961|M.ulcerans_Agy99 TWSLARNP---ELLDLILAANPAAIMLSFGDPHNFAGPIHDAGIPLICQI
Mflv_1222|M.gilvum_PYR-GCK IQGWKRDP---SIVDVLAAAGVRHVFTSAGDPALFTDRLHDAGMTVVHVI
Mvan_5586|M.vanbaalenii_PYR-1 IQGWKRDP---SIVDTLAAAGVRHVFTSAGDPALFTARLHDAGMTVVHVV
MAV_2769|M.avium_104 LL-FNRDP---AMLDLLVANDIRFVTTSAGDPALFTDRLHDAGITVFHVV
MAB_4001c|M.abscessus_ATCC_199 QA-FVRDP---SIAQFVVDQGVTFVTTSAGDPNKYTRVLKDNGLTVFHVV
MSMEG_5182|M.smegmatis_MC2_155 ILPSINPPPYDEYRQVIVDSGVKIVETAGSNPAPHLPMFHDNGIKVLHKC
TH_3625|M.thermoresistible__bu ILPTISPPPYDEYRRVIIDSGVKVVETAGSNPAPHLSHFHDNGIKVLHKC
MLBr_00388|M.leprae_Br4923 IEAAEKEP--EPATAVCLLQELHAAPLNPDLLGSAVARIREAGVTTAVRV
* . ::. *
Mb0021c|M.bovis_AF2122/97 QNRTQAER---ALQVGADVLVAQGTEAGGHGHGPRSTLTLVPEIVDLVTA
Rv0021c|M.tuberculosis_H37Rv QNRTQAER---ALQVGADVLVAQGTEAGGHGHGPRSTLTLVPEIVDLVTA
MMAR_1721|M.marinum_M HTREQALR---VLEVGPDIIVAQGSESGGHGMSVRSTFTLVPDVVDLVAQ
MUL_1961|M.ulcerans_Agy99 HTREQALR---VLEVGPDIIVAQGSESGGHGMSVRSTFTLVPDVVDLVAQ
Mflv_1222|M.gilvum_PYR-GCK GSLKGALK---AADAGVDALVVEGVEGGGF----KSALGASTMVLLPLVA
Mvan_5586|M.vanbaalenii_PYR-1 GSLKGALK---AADAGVDALVVEGVEGGGF----KSALGASTMVLLPLIA
MAV_2769|M.avium_104 GTLAAAKK---AVDAGVDGLVVEGVEGGGF----KNRFGASTMVLLPLVA
MAB_4001c|M.abscessus_ATCC_199 PTLAAALK---AVDAGVDGLVVEGVEGGGF----KDPKGASTMVLLPLVR
MSMEG_5182|M.smegmatis_MC2_155 TSVRHAVK---AQSLGVDGISIDGFECAGH----PGEDDIPGLVLIPAAA
TH_3625|M.thermoresistible__bu TSVRHAVK---AQELGVDGISIDGFECAGH----PGEDDIPGLVLIPAAA
MLBr_00388|M.leprae_Br4923 SPQNAQVLTPVLLAAGIDLLVVQGSIVSAE-----CVASGGEPLNLKTFI
* * : :* .. :
Mb0021c|M.bovis_AF2122/97 RGTDIPVIAAGGIADGRGLAAALMLGAAGVLVG---TRFYATVEALSTPQ
Rv0021c|M.tuberculosis_H37Rv RGTDIPVIAAGGIADGRGLAAALMLGAAGVLVG---TRFYATVEALSTPQ
MMAR_1721|M.marinum_M RSAETLVVAAGGIADGRGLAAALALGADGALVG---TRFWACPEALVSPR
MUL_1961|M.ulcerans_Agy99 RSAETLVVAAGGIADGRGLAAALALGADGALVG---TRFWACPEALVSPR
Mflv_1222|M.gilvum_PYR-GCK ERVDLPLICAGGICDARSAAAAVVLGAEGIQMG---TRMLASAEALVHAN
Mvan_5586|M.vanbaalenii_PYR-1 DRVDLPIICAGGVCDARSGAAAVVLGAEGVQMG---TRMLASVEAAVHTN
MAV_2769|M.avium_104 AHVDVPIVAAGGICDARSMAAAFVLGAEAVQMG---TRLLASADSPVHVN
MAB_4001c|M.abscessus_ATCC_199 SHVDIPIIAAGGICDGVSMAAAFALGAEGVQMG---TRMMSAAESPIHHN
MSMEG_5182|M.smegmatis_MC2_155 DKIEIPMIASGGFADGRGLAAALALGADGINMG---SRFMCTVESSIHQN
TH_3625|M.thermoresistible__bu KQIEIPMIASGGFADARGLVAALALGADGINMG---SRFMCTVESPVHQK
MLBr_00388|M.leprae_Br4923 SELDVPVVAGG-VLDHRTALHLMRTGAAGVIVGYGSTRGATTSDEVLGIS
: ::..* . * . ** . :* :* :
Mb0021c|M.bovis_AF2122/97 ARDPLLAATGDDMCRTTIYDQLRRYPWPQGHTMSVLSNALTDQFEDTELD
Rv0021c|M.tuberculosis_H37Rv ARDPLLAATGDDMCRTTIYDQLRRYPWPQGHTMSVLSNALTDQFEDTELD
MMAR_1721|M.marinum_M AHQRAVEASGDDTIRTRVYDIVRQRDWPAEYDLRLLSNSLIQAWHGNESE
MUL_1961|M.ulcerans_Agy99 AHQRAVEASGDDTIRTRVYDIVRQRDWPAEYDLRLLSNSLIQAWHGNESE
Mflv_1222|M.gilvum_PYR-GCK FKDAIVAA--DDAGTILLDVPGNP-------TMRVLRTGLAARIDEQDAD
Mvan_5586|M.vanbaalenii_PYR-1 FKDAIVAA--DDSGTVLLDVPGNP-------TMRVLRTGLAARIDEHPAD
MAV_2769|M.avium_104 LKQAVVAA--DETATVLLPLDGKR-------MMRVIRTPAAERLEAAGAA
MAB_4001c|M.abscessus_ATCC_199 WKAAVVAA--RETDTVLLNRLTKP-------GLRALRSARTEEMERRDLV
MSMEG_5182|M.smegmatis_MC2_155 VKEAIVAG--DERGTELIFRTLHN-------TARVASNKVSREVVEILNK
TH_3625|M.thermoresistible__bu VKEAIVAG--DERGTELIFRTLGN-------TGRVASNSVSREVVRILAD
MLBr_00388|M.leprae_Br4923 VPMATAIADAAAARREYLDETGGRYVHVLADGDIYTSGELAKAIACGADA
. :
Mb0021c|M.bovis_AF2122/97 ILHR-----EEAMARYWRAVPARDYSIANVTAGQAAGLVNAVLPAADVIT
Rv0021c|M.tuberculosis_H37Rv ILHR-----EEAMARYWRAVAARDYSIANVTAGQAAGLVNAVLPAADVIT
MMAR_1721|M.marinum_M LIRRL----PDLLGAFENAVAAEDFEMATVLVGEAVGLISRVGPAADIVS
MUL_1961|M.ulcerans_Agy99 LIRRL----PDLLGAFENAVAAEDFEMATVLVGEAVGLISRVGPAADIVS
Mflv_1222|M.gilvum_PYR-GCK ---------AKLLGRITDLYFGGDLEASVANTGQVSSRITGLAPAAEIVR
Mvan_5586|M.vanbaalenii_PYR-1 ---------AQLLGRITDLYFGGDMEASVANTGQVSSRITELRPVAEIVR
MAV_2769|M.avium_104 GE------GAAALQRVQRLYFEGDLDASVANTGQVAGRIRDLPPAADIIK
MAB_4001c|M.abscessus_ATCC_199 S--------LLETGDPLDLYFGGNMETFVPLGGQVAGRIGGVESVKDILD
MSMEG_5182|M.smegmatis_MC2_155 GGQFEDVKDLVAGVRGRKVFENGDVDAGIWTVGTAMGLIDDIPTVQDLVT
TH_3625|M.thermoresistible__bu GGRFEDVRDLVSGARGARVYETGDLEAGIWWIGTSMGLIDDIPTVGTLLS
MLBr_00388|M.leprae_Br4923 VVLGTPLAQSAEALGGGWFWPAAAAHPSLPRGALLQTAVGERPSLQQVLN
. : . ::
Mb0021c|M.bovis_AF2122/97 GMAQQAARTLTAMRAV------------------------
Rv0021c|M.tuberculosis_H37Rv GMAQQAARTLTAMRAV------------------------
MMAR_1721|M.marinum_M EMVCDATRILNRSG--------------------------
MUL_1961|M.ulcerans_Agy99 EMVCDATRILNRSG--------------------------
Mflv_1222|M.gilvum_PYR-GCK QTWCEIQTVLDDTRARLG----------------------
Mvan_5586|M.vanbaalenii_PYR-1 QTWRGIESVLDSARTRLD----------------------
MAV_2769|M.avium_104 QMWKGCREVLAATSARLDWADDA-----------------
MAB_4001c|M.abscessus_ATCC_199 ATMDEFTAVIGKLAAQYV----------------------
MSMEG_5182|M.smegmatis_MC2_155 RIVRDAEVLISGRLLNMISADEPDAEKETVPA--------
TH_3625|M.thermoresistible__bu RIIRDAEHLIEGRLQAMVRS--PAGADQ------------
MLBr_00388|M.leprae_Br4923 GPSDNPFGTLNLVGGLRRSMAKAGYCDLKEFQKVGLIVSI
: