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VLSTAFSQMFGIDYPIVSAPMDLIAGGELAAAVSGAGGLGLIGGGYGDRDWLARQFDLAAGAPVGCGFIT WSLARQPQLLDLALQYEPVAVMLSFGDPAVFADAIKSAGTRLVCQIQNRTQAERALQVGADVLVAQGTEA GGHGHGPRSTLTLVPEIVDLVTARGTDIPVIAAGGIADGRGLAAALMLGAAGVLVGTRFYATVEALSTPQ ARDPLLAATGDDMCRTTIYDQLRRYPWPQGHTMSVLSNALTDQFEDTELDILHREEAMARYWRAVAARDY SIANVTAGQAAGLVNAVLPAADVITGMAQQAARTLTAMRAV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0021c | - | - | 100% (322) | hypothetical protein Rv0021c |
| M. tuberculosis H37Rv | Rv3553 | - | 7e-27 | 34.48% (232) | oxidoreductase |
| M. tuberculosis H37Rv | Rv1533 | - | 8e-22 | 32.30% (257) | hypothetical protein Rv1533 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0021c | - | 0.0 | 99.69% (322) | hypothetical protein Mb0021c |
| M. gilvum PYR-GCK | Mflv_5156 | - | 8e-54 | 42.01% (319) | 2-nitropropane dioxygenase, NPD |
| M. leprae Br4923 | MLBr_00388 | guaB3 | 3e-07 | 27.67% (206) | inosine 5-monophosphate dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0159 | - | 3e-83 | 49.69% (322) | 2-nitropropane dioxygenase |
| M. marinum M | MMAR_1721 | - | 7e-92 | 53.00% (317) | hypothetical protein MMAR_1721 |
| M. avium 104 | MAV_2791 | - | 1e-89 | 54.29% (315) | oxidoreductase, 2-nitropropane dioxygenase family protein |
| M. smegmatis MC2 155 | MSMEG_1660 | - | 3e-46 | 37.62% (319) | oxidoreductase, 2-nitropropane dioxygenase family protein |
| M. thermoresistible (build 8) | TH_1976 | - | 1e-45 | 38.44% (307) | oxidoreductase, 2-nitropropane dioxygenase family protein |
| M. ulcerans Agy99 | MUL_1961 | - | 6e-92 | 53.00% (317) | hypothetical protein MUL_1961 |
| M. vanbaalenii PYR-1 | Mvan_4537 | - | 2e-57 | 42.49% (313) | 2-nitropropane dioxygenase, NPD |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0021c|M.tuberculosis_H37Rv --------------------------MVLSTAFSQMFGIDYPIVSAPMDL
Mb0021c|M.bovis_AF2122/97 --------------------------MVLSTAFSQMFGIDYPIVSAPMDL
MMAR_1721|M.marinum_M --------------------------MSLNTRLTEFLGVQHPILLAPMAM
MUL_1961|M.ulcerans_Agy99 --------------------------MSLNTRLTEFLGVQHPILLAPMAM
MAV_2791|M.avium_104 ----------------------MSAATGLPTRLTDLFGIEQPILLAPMAL
MAB_0159|M.abscessus_ATCC_1997 --------------------------MTFNTRLTDRFGIEHPVVLAPMDD
Mflv_5156|M.gilvum_PYR-GCK -------------------------MDTLSTPWSAELGLDVPIVNAPMGG
Mvan_4537|M.vanbaalenii_PYR-1 -------------------------MKATSTQWSQAMGLAAPIVNAPMGG
MSMEG_1660|M.smegmatis_MC2_155 --------------------------MSLATTWSKAMGIDVPIVNAPMGG
TH_1976|M.thermoresistible__bu ------------------------------------MGIEVPIVNAPMGG
MLBr_00388|M.leprae_Br4923 MGRVARRTYELREISIVPSRRTRSSKDVSTAWQLDAYRFEIPVVAHPTDA
. *:: *
Rv0021c|M.tuberculosis_H37Rv IAGGELAAAVSGAGGLGLIGGG-YGDRDWLARQFDLAAG---APVGCGFI
Mb0021c|M.bovis_AF2122/97 IAGGELAAAVSGAGGLGLIGGG-YGDRDWLARQFDLAAG---APVGCGFI
MMAR_1721|M.marinum_M TSGGRLAAAVTAAGGLGLIGGG-YGEAEWLQRQLEQAQG---QRVGCGFI
MUL_1961|M.ulcerans_Agy99 TSGGRLAAAVTAAGGLGLIGGG-YGEAEWLQRQLEQAQG---QRVGCGFI
MAV_2791|M.avium_104 VSGGRLAAAVTRAGGLGLIGGG-YPDAEWLQTQIDRAEG---ARVGYGFI
MAB_0159|M.abscessus_ATCC_1997 VADARLASAVSAAGGLGLLGGG-YADADWVRQQFDQVS----AAVGCGFI
Mflv_5156|M.gilvum_PYR-GCK AAGGTLAAAVSRAGGLGMVGMGSSASAAQLRAQLAELGELK-RPFGIGVI
Mvan_4537|M.vanbaalenii_PYR-1 VAGGALAAAVSRAGGLGMIGIGSAGSADRLHTELRHVSDLVDRPFGIGLI
MSMEG_1660|M.smegmatis_MC2_155 AAGARLAAAVSEAGGLGMVGMGSSATPEQLRRELADLAKPS-RPFGIGLV
TH_1976|M.thermoresistible__bu TAGAELAAAVSAAGGLGMIGMGSSATAAVLRRELAGPIT---RPFGIGLV
MLBr_00388|M.leprae_Br4923 LVSPEFAIELGRLGGLGVLNGE-----GLIGRHADVGAK------VAQLI
. :* : ****::. : . .:
Rv0021c|M.tuberculosis_H37Rv TWSLARQPQLLDLALQYEPVAVMLSFGDPAVFADAIKSAGTRLVCQIQNR
Mb0021c|M.bovis_AF2122/97 TWSLARQPQLLDLALQYEPVAVMLSFGDPAVFADAIKSAGTRLVCQIQNR
MMAR_1721|M.marinum_M TWSLARNPELLDLILAANPAAIMLSFGDPHKFAGPIHDAGIPLICQIHTR
MUL_1961|M.ulcerans_Agy99 TWSLARNPELLDLILAANPAAIMLSFGDPHNFAGPIHDAGIPLICQIHTR
MAV_2791|M.avium_104 TWSLARNPGVLDLALDRGPAAVMLSFGELAPFADRIHAAGVPLIAQVQNL
MAB_0159|M.abscessus_ATCC_1997 TWTLKGNEHVLEHALARGPAALFLSFGDPAPYAPRIRAAGVPLICQVHNI
Mflv_5156|M.gilvum_PYR-GCK DWVIRKEPELLTTALDARPTALSVSFGTEWDWVARARDAGCVSVTQVADV
Mvan_4537|M.vanbaalenii_PYR-1 SWAVAEQPRLLEAALAARPALLSVSFGDDWAWVRRAHDAGCVTATQVADV
MSMEG_1660|M.smegmatis_MC2_155 HWVMTERPDLFDIALEARPALLSVSFGDDWAWVRRAHDVGVTVATQVATV
TH_1976|M.thermoresistible__bu QWVVDAEPELLDVALAARPTLLSVSFGADYGWVERAHAEGISAAAQVADV
MLBr_00388|M.leprae_Br4923 EAAEKEPEPATAVCLLQELHAAPLNPDLLGSAVARIREAGVTTAVRVSPQ
* :. . . : * ::
Rv0021c|M.tuberculosis_H37Rv TQAER---ALQVGADVLVAQG----TEAGGHGHGPRSTLTLVPEIVDLVT
Mb0021c|M.bovis_AF2122/97 TQAER---ALQVGADVLVAQG----TEAGGHGHGPRSTLTLVPEIVDLVT
MMAR_1721|M.marinum_M EQALR---VLEVGPDIIVAQG----SESGGHGMSVRSTFTLVPDVVDLVA
MUL_1961|M.ulcerans_Agy99 EQALR---VLEVGPDIIVAQG----SESGGHGMSVRSTFTLVPDVVDLVA
MAV_2791|M.avium_104 DQARR---ALDAGAEVIVAQG----GEAGGHGMSVRSTFTLVPEVVDVVA
MAB_0159|M.abscessus_ATCC_1997 RQAAR---AIEVGADVIVAQG----GEAGGHGEGRRSTFTLVPEVVDLVA
Mflv_5156|M.gilvum_PYR-GCK EAALR---AVDAGVQVLVARG----AEAGGHGTPAVATLPLLAAILDRVE
Mvan_4537|M.vanbaalenii_PYR-1 DGAQR---AADAGVDVLVTRG----AEAGGHGQPRVGTLPLLVEVLDRVA
MSMEG_1660|M.smegmatis_MC2_155 GDALR---AAEAGVDVLVARG----AEAGGHGRPALGTLPLLTQVLDAVE
TH_1976|M.thermoresistible__bu ESGVR---AQDAGVDVVVARG----AEGGGHGEPRLGTLPLLTELLDRLT
MLBr_00388|M.leprae_Br4923 NAQVLTPVLLAAGIDLLVVQGSIVSAECVASGGEPLNLKTFISELDVPVV
.* :::*.:* * . * .:: : :
Rv0021c|M.tuberculosis_H37Rv A-----RGTDIPVIAAGGIADGRGLAAALMLGAAGVLVGTRFYATVEALS
Mb0021c|M.bovis_AF2122/97 A-----RGTDIPVIAAGGIADGRGLAAALMLGAAGVLVGTRFYATVEALS
MMAR_1721|M.marinum_M Q-----RSAETLVVAAGGIADGRGLAAALALGADGALVGTRFWACPEALV
MUL_1961|M.ulcerans_Agy99 Q-----RSAETLVVAAGGIADGRGLAAALALGADGALVGTRFWACPEALV
MAV_2791|M.avium_104 D-----RSPATLVAAAGGVGDGRGLAAALALGADGAVVGTRFWATPEALV
MAB_0159|M.abscessus_ATCC_1997 G-----TAPQILVLAAGGVTDGRGLAASLALGADGVLVGTRFWAAGEAAI
Mflv_5156|M.gilvum_PYR-GCK ----------VPVLAAGGIASGRALAAVLAAGAAGAWIGTAFATCPESLF
Mvan_4537|M.vanbaalenii_PYR-1 ----------VPVLAAGGIASGRGLAAALAAGASGGWLGTAFAACPESTL
MSMEG_1660|M.smegmatis_MC2_155 ----------LPVLAAGGVASPRGLAAVLAAGAAAAWLGTVFTTCVEAST
TH_1976|M.thermoresistible__bu ----------VPVLAAGGITSGRGLAAVLAAGAAGAWLGTVFTACAEALT
MLBr_00388|M.leprae_Br4923 AGGVLDHRTALHLMRTGAAGVIVGYGSTRGATTSDEVLGISVPMATAIAD
: :*. . .: : :* .
Rv0021c|M.tuberculosis_H37Rv TPQARDPLLAATG---------DDMCRTTIYDQLRRYPWPQGHTMSVLSN
Mb0021c|M.bovis_AF2122/97 TPQARDPLLAATG---------DDMCRTTIYDQLRRYPWPQGHTMSVLSN
MMAR_1721|M.marinum_M SPRAHQRAVEASG---------DDTIRTRVYDIVRQRDWPAEYDLRLLSN
MUL_1961|M.ulcerans_Agy99 SPRAHQRAVEASG---------DDTIRTRVYDIVRQRDWPAEYDLRLLSN
MAV_2791|M.avium_104 SPKAQQRAVAAGG---------DDTVRTRVYDVVRRLDWPAGYTVRALNN
MAB_0159|M.abscessus_ATCC_1997 SRAAQRHALQVGG---------DDTIRQHVYDIVRGKRWPSAYSGRVLRN
Mflv_5156|M.gilvum_PYR-GCK PDEARRALLTADA---------TDTLTTRVFDVALGYPWPAHFPERVLRN
Mvan_4537|M.vanbaalenii_PYR-1 PDAAAEVMLAARN---------TDTVTTRVFDIALGYPWPPTIPERVLRN
MSMEG_1660|M.smegmatis_MC2_155 PAAARDRLLAANG---------ENTMLTSEFDIRAGYRWPADVPERVLT-
TH_1976|M.thermoresistible__bu APDARAALLAAPS---------TATTTTREFDIAAGYRWPATIPERVLT-
MLBr_00388|M.leprae_Br4923 AAAARREYLDETGGRYVHVLADGDIYTSGELAKAIACGADAVVLGTPLAQ
. * : *
Rv0021c|M.tuberculosis_H37Rv ALTDQFEDTELDILHR--EEAMARYWRAVAARDYSIANVTAGQAAGLVNA
Mb0021c|M.bovis_AF2122/97 ALTDQFEDTELDILHR--EEAMARYWRAVPARDYSIANVTAGQAAGLVNA
MMAR_1721|M.marinum_M SLIQAWHGNESELIRRL-PDLLGAFENAVAAEDFEMATVLVGEAVGLISR
MUL_1961|M.ulcerans_Agy99 SLIQAWHGNESELIRRL-PDLLGAFENAVAAEDFEMATVLVGEAVGLISR
MAV_2791|M.avium_104 AFLGTWHGNEAELSARL-PEAIDAYEKAVAAEDFDTAAILVGEGVGRIRE
MAB_0159|M.abscessus_ATCC_1997 DFVDKWHRREAELAQHL-DQARSEYQSGVAAEDYRTANLIVGEGIGQVRS
Mflv_5156|M.gilvum_PYR-GCK AFTAAWDGR----TPD--DDARARLAEAIADDDFRVAPVNAGQGVDDITA
Mvan_4537|M.vanbaalenii_PYR-1 AFTDSWHGRESELAAD--TEAVTELRAAIAADDYRLAPVNVGQGVSELTA
MSMEG_1660|M.smegmatis_MC2_155 ------------------------------DENGAATPVNAGQGVGMVNQ
TH_1976|M.thermoresistible__bu ------------------------------DPAGDPTPVNAGQGVGMVTA
MLBr_00388|M.leprae_Br4923 SAEALGGGWFWPAAAAHPSLPRGALLQTAVGERPSLQQVLNGPSDNPFGT
: * . . .
Rv0021c|M.tuberculosis_H37Rv VLPAADVITGMAQQAARTLTAMRAV------
Mb0021c|M.bovis_AF2122/97 VLPAADVITGMAQQAARTLTAMRAV------
MMAR_1721|M.marinum_M VGPAADIVSEMVCDATRILNRSG--------
MUL_1961|M.ulcerans_Agy99 VGPAADIVSEMVCDATRILNRSG--------
MAV_2791|M.avium_104 IRPAAEIVAEMVGDAKRILNRDAAP------
MAB_0159|M.abscessus_ATCC_1997 VESVADIIESMVAQAAAINSTSRS-------
Mflv_5156|M.gilvum_PYR-GCK VEPAAMVIARLCDDARRLLAKPPTR------
Mvan_4537|M.vanbaalenii_PYR-1 IEPAARVIQRLCDEAREVGQQ----------
MSMEG_1660|M.smegmatis_MC2_155 SLTVAETMSRLCWGAEALLRRWS--------
TH_1976|M.thermoresistible__bu AQPAAAVIERLCSRAEQLLTRWGG-------
MLBr_00388|M.leprae_Br4923 LNLVGGLRRSMAKAGYCDLKEFQKVGLIVSI
.. : .