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MTYIAGAQLAAAVSNAGALGIIETTSDQGRADLRRVRELTAGAVGANIALLFNRDPAMLDLLVANDIRFV TTSAGDPALFTDRLHDAGITVFHVVGTLAAAKKAVDAGVDGLVVEGVEGGGFKNRFGASTMVLLPLVAAH VDVPIVAAGGICDARSMAAAFVLGAEAVQMGTRLLASADSPVHVNLKQAVVAADETATVLLPLDGKRMMR VIRTPAAERLEAAGAAGEGAAALQRVQRLYFEGDLDASVANTGQVAGRIRDLPPAADIIKQMWKGCREVL AATSARLDWADDA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2769 | - | - | 100% (293) | oxidoreductase, 2-nitropropane dioxygenase family protein |
| M. avium 104 | MAV_0607 | - | 6e-28 | 28.27% (336) | oxidoreductase, 2-nitropropane dioxygenase family protein |
| M. avium 104 | MAV_2791 | - | 3e-27 | 30.87% (311) | oxidoreductase, 2-nitropropane dioxygenase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3583 | - | 1e-28 | 29.06% (320) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_1222 | - | 4e-92 | 61.81% (288) | 2-nitropropane dioxygenase, NPD |
| M. tuberculosis H37Rv | Rv3553 | - | 1e-28 | 29.06% (320) | oxidoreductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4001c | - | 9e-72 | 56.36% (275) | putative 2-nitropropane dioxygenase, NPD |
| M. marinum M | MMAR_2084 | - | 1e-27 | 34.93% (292) | hypothetical protein MMAR_2084 |
| M. smegmatis MC2 155 | MSMEG_5182 | - | 6e-39 | 31.05% (306) | 2-nitropropane dioxygenase |
| M. thermoresistible (build 8) | TH_3584 | - | 1e-39 | 32.31% (294) | PUTATIVE 2-nitropropane dioxygenase, NPD |
| M. ulcerans Agy99 | MUL_4116 | - | 2e-26 | 27.38% (336) | 2-nitropropane dioxygenase |
| M. vanbaalenii PYR-1 | Mvan_5586 | - | 5e-90 | 59.86% (289) | 2-nitropropane dioxygenase, NPD |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3583|M.bovis_AF2122/97 MRLRTPLTELIGIEHPVVQTGMGWVAGARLVSATANAGGLGILASAT-MT
Rv3553|M.tuberculosis_H37Rv MRLRTPLTELIGIEHPVVQTGMGWVAGARLVSATANAGGLGILASAT-MT
MUL_4116|M.ulcerans_Agy99 MRLRTPLTDLVGVEHPVVQTGMGWVAGARLVSATANAGGLGILASAT-MT
Mflv_1222|M.gilvum_PYR-GCK --MTNRIQDLLGVEFPVVQAPMTYIARAELAAAVSDGGGLGMIETLT---
Mvan_5586|M.vanbaalenii_PYR-1 --MTNRVQELLGVEFPVVQAPMTYIARAELAAAVSEGGGLGMVETLT---
MAV_2769|M.avium_104 ---------------------MTYIAGAQLAAAVSNAGALGIIETTS---
MAB_4001c|M.abscessus_ATCC_199 -MITNRVTELLGVERPIVQAPMGWIARSQLASAVCNAGGLGIIETSSGEL
MSMEG_5182|M.smegmatis_MC2_155 MALTTKFTEAFGVTHPIAQGGMQWVGRAELVAAVANAGALGFITALTQPT
TH_3584|M.thermoresistible__bu -LIKTRFTEAFGIEHPIVQGGMQWVGRAELVAAVANAGALGFITALTQPT
MMAR_2084|M.marinum_M -MLATGWSRGFGLRVPIVNAPMGGVAGGRLAAAVTAAGGLGMIGMGS---
* :. ..*.:*. .*.**:: :
Mb3583|M.bovis_AF2122/97 LDELAAAITKVKAVTDKPFGVNIRADAADAGDR----VELMIREGVRVAS
Rv3553|M.tuberculosis_H37Rv LDELAAAITKVKAVTDKPFGVNIRADAADAGDR----VELMIREGVRVAS
MUL_4116|M.ulcerans_Agy99 LDELATAIGKVKATTDKPFGVNIRADAADASDR----VELMIREGVKVAS
Mflv_1222|M.gilvum_PYR-GCK -DEGRADLLRVRDLTDRPVAANLMIQGWKRDP---SIVDVLAAAGVRHVF
Mvan_5586|M.vanbaalenii_PYR-1 -PEGREDLLRVRDLTDRPVAANLMIQGWKRDP---SIVDTLAAAGVRHVF
MAV_2769|M.avium_104 -DQGRADLRRVRELTAGAVGANIALL-FNRDP---AMLDLLVANDIRFVT
MAB_4001c|M.abscessus_ATCC_199 -DAIKDEIRAMREFTDKPFGVNIAQA-FVRDP---SIAQFVVDQGVTFVT
MSMEG_5182|M.smegmatis_MC2_155 PADLANEIARCRDLTDKPFGVNLTILPSINPPPYDEYRQVIVDSGVKIVE
TH_3584|M.thermoresistible__bu PEDLAKEIARCRELTDKPFGVNLTILPTINPPPYDEYRQVIVESGIKIVE
MMAR_2084|M.marinum_M -RATRAALAEQLRQVSGRFGIGLVDWVMRSEAG---LLEDALAAGPALLS
: . .. .: : .
Mb3583|M.bovis_AF2122/97 FALAPKQQLIARLKEAGAVVIPSIGAAKHARKVAAWGADAMIVQGGEGGG
Rv3553|M.tuberculosis_H37Rv FALAPKQQLIARLKEAGAVVIPSIGAAKHARKVAAWGADAMIVQGGEGGG
MUL_4116|M.ulcerans_Agy99 FALAPKPELIARLKEAGAVVIPSIGAAKHARKVAGWGADAMIVQGGEGGG
Mflv_1222|M.gilvum_PYR-GCK TSAGDPALFTDRLHDAGMTVVHVIGSLKGALKAADAGVDALVVEGVEGGG
Mvan_5586|M.vanbaalenii_PYR-1 TSAGDPALFTARLHDAGMTVVHVVGSLKGALKAADAGVDALVVEGVEGGG
MAV_2769|M.avium_104 TSAGDPALFTDRLHDAGITVFHVVGTLAAAKKAVDAGVDGLVVEGVEGGG
MAB_4001c|M.abscessus_ATCC_199 TSAGDPNKYTRVLKDNGLTVFHVVPTLAAALKAVDAGVDGLVVEGVEGGG
MSMEG_5182|M.smegmatis_MC2_155 TAGSNPAPHLPMFHDNGIKVLHKCTSVRHAVKAQSLGVDGISIDGFECAG
TH_3584|M.thermoresistible__bu TAGSNPAPHLPMFHEHGVKVLHKCTSVRHAVKAQELGVDGISIDGFECAG
MMAR_2084|M.marinum_M VSFGTDWSWVGPARDAGIPTVTQVYDALGARRAADAGVDIVVARGAEGGG
: . :: * .. * :. *.* : * * .*
Mb3583|M.bovis_AF2122/97 HTGP--VATTLLLPSVLDAVAGTGIPVIAAGGFFDGRGLAAALCYGAAGV
Rv3553|M.tuberculosis_H37Rv HTGP--VATTLLLPSVLDAVAGTGIPVIAAGGFFDGRGLAAALCYGAAGV
MUL_4116|M.ulcerans_Agy99 HTGP--VATTLLLPSVLDAVKGTGIPVIAAGGFFDGHGLAAALSYGAAGV
Mflv_1222|M.gilvum_PYR-GCK FKSALGASTMVLLPLVAERVD---LPLICAGGICDARSAAAAVVLGAEGI
Mvan_5586|M.vanbaalenii_PYR-1 FKSALGASTMVLLPLIADRVD---LPIICAGGVCDARSGAAAVVLGAEGV
MAV_2769|M.avium_104 FKNRFGASTMVLLPLVAAHVD---VPIVAAGGICDARSMAAAFVLGAEAV
MAB_4001c|M.abscessus_ATCC_199 FKDPKGASTMVLLPLVRSHVD---IPIIAAGGICDGVSMAAAFALGAEGV
MSMEG_5182|M.smegmatis_MC2_155 HPGEDDIPGLVLIPAAADKIE---IPMIASGGFADGRGLAAALALGADGI
TH_3584|M.thermoresistible__bu HPGEDDIPGLVLIPAAAAKIT---VPMIASGGFADARGLVAALALGADGI
MMAR_2084|M.marinum_M HGEVR-LGTLPLLDAVLAAVS---VPVLAGGGIASPRSLAAVLAAGAAGA
. *: : :*::..**. . . .*.. ** .
Mb3583|M.bovis_AF2122/97 AMGTRFLLTSDSTVPDAVKRRYLQAGLDGTVVTTRVDGMPHRVLRTELVE
Rv3553|M.tuberculosis_H37Rv AMGTRFLLTSDSTVPDAVKRRYLQAGLDGTVVTTRVDGMPHRVLRTELVE
MUL_4116|M.ulcerans_Agy99 AMGTRFLLTSDSTVPDAVKRRYLQAALDGTVVTTRVDGMPHRVLRTGLVE
Mflv_1222|M.gilvum_PYR-GCK QMGTRMLASAEALVHANFKDAIVAADDAGTILLDVPGNPTMRVLRTGLAA
Mvan_5586|M.vanbaalenii_PYR-1 QMGTRMLASVEAAVHTNFKDAIVAADDSGTVLLDVPGNPTMRVLRTGLAA
MAV_2769|M.avium_104 QMGTRLLASADSPVHVNLKQAVVAADETATVLLPLDGKRMMRVIRTPAAE
MAB_4001c|M.abscessus_ATCC_199 QMGTRMMSAAESPIHHNWKAAVVAARETDTVLLNRLTKPGLRALRSARTE
MSMEG_5182|M.smegmatis_MC2_155 NMGSRFMCTVESSIHQNVKEAIVAGDERGTELIFRTLHNTARVASNKVSR
TH_3584|M.thermoresistible__bu NMGSRFMCTVESPIHQKVKEAIVAGSELDTELIFRPLRNTGRVASNSVSR
MMAR_2084|M.marinum_M WVGTRLAACPEALTGEPSRQALIAARETDTSTTRVFDVADGLPWPQRFPS
:*:*: :: : : . *
Mb3583|M.bovis_AF2122/97 KLESGSRARGFAAALRNAGKFRRMSQMTWRSMIRDGLTMRHGKELTWSQV
Rv3553|M.tuberculosis_H37Rv KLESGSRARGFAAALRNAGKFRRMSQMTWRSMIRDGLTMRHGKELTWSQV
MUL_4116|M.ulcerans_Agy99 KLEGGSRARGFTAAIRNAAKFKQMSQMSWASMIKDGLAMRHGKELTWSQV
Mflv_1222|M.gilvum_PYR-GCK RIDEQDAD---------AKLLGRITDLYF---------------------
Mvan_5586|M.vanbaalenii_PYR-1 RIDEHPAD---------AQLLGRITDLYF---------------------
MAV_2769|M.avium_104 RLEAAGAAGE------GAAALQRVQRLYF---------------------
MAB_4001c|M.abscessus_ATCC_199 EMERRDLVS--------LLETGDPLDLYF---------------------
MSMEG_5182|M.smegmatis_MC2_155 EVVEILNKGGQFEDVKDLVAGVRGRKVFE---------------------
TH_3584|M.thermoresistible__bu EVVEILDKGGKFEDVAHLVSGKRGAKVYE---------------------
MMAR_2084|M.marinum_M RVLTNDFVARWNGNETALAADADARAELAAAS------------------
.:
Mb3583|M.bovis_AF2122/97 LMAANTPMLLKAGLVDGNTEAGVLASGQVAGILDDLPSCKELIESIVLDA
Rv3553|M.tuberculosis_H37Rv LMAANTPMLLKAGLVDGNTEAGVLASGQVAGILDDLPSCKELIESIVLDA
MUL_4116|M.ulcerans_Agy99 LMAANTPMLLKAGLVDGNPEAGVLASGQVAGILDDLPSCAQLVESIVHDA
Mflv_1222|M.gilvum_PYR-GCK ---------------GGDLEASVANTGQVSSRITGLAPAAEIVRQTWCEI
Mvan_5586|M.vanbaalenii_PYR-1 ---------------GGDMEASVANTGQVSSRITELRPVAEIVRQTWRGI
MAV_2769|M.avium_104 ---------------EGDLDASVANTGQVAGRIRDLPPAADIIKQMWKGC
MAB_4001c|M.abscessus_ATCC_199 ---------------GGNMETFVPLGGQVAGRIGGVESVKDILDATMDEF
MSMEG_5182|M.smegmatis_MC2_155 ---------------NGDVDAGIWTVGTAMGLIDDIPTVQDLVTRIVRDA
TH_3584|M.thermoresistible__bu ---------------TGDLEAGIWWIGTAMGLINDIPTVGELVSRMVSEA
MMAR_2084|M.marinum_M --------------AAEDLRVAPVDAGQGVGMIPDGAPAGEVIEQMCSGA
: . * . : . :::
Mb3583|M.bovis_AF2122/97 ITHLQTASALVE--------------
Rv3553|M.tuberculosis_H37Rv ITHLQTASALVE--------------
MUL_4116|M.ulcerans_Agy99 IEHLRAAAALVE--------------
Mflv_1222|M.gilvum_PYR-GCK QTVLDDTRARLG--------------
Mvan_5586|M.vanbaalenii_PYR-1 ESVLDSARTRLD--------------
MAV_2769|M.avium_104 REVLAATSARLDWADDA---------
MAB_4001c|M.abscessus_ATCC_199 TAVIGKLAAQYV--------------
MSMEG_5182|M.smegmatis_MC2_155 EVLISGRLLNMISADEPDAEKETVPA
TH_3584|M.thermoresistible__bu EEIINGRLAGALR-------------
MMAR_2084|M.marinum_M RELLARWA------------------
: