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ITNRVTELLGVERPIVQAPMGWIARSQLASAVCNAGGLGIIETSSGELDAIKDEIRAMREFTDKPFGVNI AQAFVRDPSIAQFVVDQGVTFVTTSAGDPNKYTRVLKDNGLTVFHVVPTLAAALKAVDAGVDGLVVEGVE GGGFKDPKGASTMVLLPLVRSHVDIPIIAAGGICDGVSMAAAFALGAEGVQMGTRMMSAAESPIHHNWKA AVVAARETDTVLLNRLTKPGLRALRSARTEEMERRDLVSLLETGDPLDLYFGGNMETFVPLGGQVAGRIG GVESVKDILDATMDEFTAVIGKLAAQYV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4001c | - | - | 100% (309) | putative 2-nitropropane dioxygenase, NPD |
| M. abscessus ATCC 19977 | MAB_0603c | - | 1e-34 | 34.41% (247) | 2-nitropropane dioxygenase |
| M. abscessus ATCC 19977 | MAB_0159 | - | 1e-25 | 27.71% (314) | 2-nitropropane dioxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3583 | - | 7e-36 | 36.36% (242) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_1222 | - | 6e-75 | 50.16% (307) | 2-nitropropane dioxygenase, NPD |
| M. tuberculosis H37Rv | Rv3553 | - | 7e-36 | 36.36% (242) | oxidoreductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_5042 | - | 1e-35 | 36.36% (242) | 2-nitropropane dioxygenase |
| M. avium 104 | MAV_2769 | - | 1e-71 | 56.36% (275) | oxidoreductase, 2-nitropropane dioxygenase family protein |
| M. smegmatis MC2 155 | MSMEG_5182 | - | 3e-43 | 34.85% (307) | 2-nitropropane dioxygenase |
| M. thermoresistible (build 8) | TH_3584 | - | 3e-44 | 33.86% (319) | PUTATIVE 2-nitropropane dioxygenase, NPD |
| M. ulcerans Agy99 | MUL_4116 | - | 1e-35 | 36.36% (242) | 2-nitropropane dioxygenase |
| M. vanbaalenii PYR-1 | Mvan_5586 | - | 1e-73 | 50.83% (301) | 2-nitropropane dioxygenase, NPD |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_5042|M.marinum_M MRLRTPLTDLVGVEHPVVQTGMGWVAGARLVSATANAGGLGILASAT-MT
MUL_4116|M.ulcerans_Agy99 MRLRTPLTDLVGVEHPVVQTGMGWVAGARLVSATANAGGLGILASAT-MT
Mb3583|M.bovis_AF2122/97 MRLRTPLTELIGIEHPVVQTGMGWVAGARLVSATANAGGLGILASAT-MT
Rv3553|M.tuberculosis_H37Rv MRLRTPLTELIGIEHPVVQTGMGWVAGARLVSATANAGGLGILASAT-MT
Mflv_1222|M.gilvum_PYR-GCK --MTNRIQDLLGVEFPVVQAPMTYIARAELAAAVSDGGGLGMIETLT---
Mvan_5586|M.vanbaalenii_PYR-1 --MTNRVQELLGVEFPVVQAPMTYIARAELAAAVSEGGGLGMVETLT---
MAV_2769|M.avium_104 ---------------------MTYIAGAQLAAAVSNAGALGIIETTS---
MAB_4001c|M.abscessus_ATCC_199 -MITNRVTELLGVERPIVQAPMGWIARSQLASAVCNAGGLGIIETSSGEL
MSMEG_5182|M.smegmatis_MC2_155 MALTTKFTEAFGVTHPIAQGGMQWVGRAELVAAVANAGALGFITALTQPT
TH_3584|M.thermoresistible__bu -LIKTRFTEAFGIEHPIVQGGMQWVGRAELVAAVANAGALGFITALTQPT
* ::. :.*.:*..:.*.**:: : :
MMAR_5042|M.marinum_M LDELATAIGKVKATTDKPFGVNIRADAADASDR----VELMIREGVKVAS
MUL_4116|M.ulcerans_Agy99 LDELATAIGKVKATTDKPFGVNIRADAADASDR----VELMIREGVKVAS
Mb3583|M.bovis_AF2122/97 LDELAAAITKVKAVTDKPFGVNIRADAADAGDR----VELMIREGVRVAS
Rv3553|M.tuberculosis_H37Rv LDELAAAITKVKAVTDKPFGVNIRADAADAGDR----VELMIREGVRVAS
Mflv_1222|M.gilvum_PYR-GCK -DEGRADLLRVRDLTDRPVAANLMIQGWKRDP---SIVDVLAAAGVRHVF
Mvan_5586|M.vanbaalenii_PYR-1 -PEGREDLLRVRDLTDRPVAANLMIQGWKRDP---SIVDTLAAAGVRHVF
MAV_2769|M.avium_104 -DQGRADLRRVRELTAGAVGANIALL-FNRDP---AMLDLLVANDIRFVT
MAB_4001c|M.abscessus_ATCC_199 -DAIKDEIRAMREFTDKPFGVNIAQA-FVRDP---SIAQFVVDQGVTFVT
MSMEG_5182|M.smegmatis_MC2_155 PADLANEIARCRDLTDKPFGVNLTILPSINPPPYDEYRQVIVDSGVKIVE
TH_3584|M.thermoresistible__bu PEDLAKEIARCRELTDKPFGVNLTILPTINPPPYDEYRQVIVESGIKIVE
: : * ....*: : : .: .
MMAR_5042|M.marinum_M FALAPKPELIARLKEAGAVVIPSIGAAKHARKVAGWGADAMIVQGGEGGG
MUL_4116|M.ulcerans_Agy99 FALAPKPELIARLKEAGAVVIPSIGAAKHARKVAGWGADAMIVQGGEGGG
Mb3583|M.bovis_AF2122/97 FALAPKQQLIARLKEAGAVVIPSIGAAKHARKVAAWGADAMIVQGGEGGG
Rv3553|M.tuberculosis_H37Rv FALAPKQQLIARLKEAGAVVIPSIGAAKHARKVAAWGADAMIVQGGEGGG
Mflv_1222|M.gilvum_PYR-GCK TSAGDPALFTDRLHDAGMTVVHVIGSLKGALKAADAGVDALVVEGVEGGG
Mvan_5586|M.vanbaalenii_PYR-1 TSAGDPALFTARLHDAGMTVVHVVGSLKGALKAADAGVDALVVEGVEGGG
MAV_2769|M.avium_104 TSAGDPALFTDRLHDAGITVFHVVGTLAAAKKAVDAGVDGLVVEGVEGGG
MAB_4001c|M.abscessus_ATCC_199 TSAGDPNKYTRVLKDNGLTVFHVVPTLAAALKAVDAGVDGLVVEGVEGGG
MSMEG_5182|M.smegmatis_MC2_155 TAGSNPAPHLPMFHDNGIKVLHKCTSVRHAVKAQSLGVDGISIDGFECAG
TH_3584|M.thermoresistible__bu TAGSNPAPHLPMFHEHGVKVLHKCTSVRHAVKAQELGVDGISIDGFECAG
: . ::: * *. : * *. *.*.: ::* * .*
MMAR_5042|M.marinum_M HTGP--VATTLLLPSVLDAVKGTGIPVIAAGGFFDGRGLAAALSYGAAGV
MUL_4116|M.ulcerans_Agy99 HTGP--VATTLLLPSVLDAVKGTGIPVIAAGGFFDGHGLAAALSYGAAGV
Mb3583|M.bovis_AF2122/97 HTGP--VATTLLLPSVLDAVAGTGIPVIAAGGFFDGRGLAAALCYGAAGV
Rv3553|M.tuberculosis_H37Rv HTGP--VATTLLLPSVLDAVAGTGIPVIAAGGFFDGRGLAAALCYGAAGV
Mflv_1222|M.gilvum_PYR-GCK FKSALGASTMVLLPLVAERVD---LPLICAGGICDARSAAAAVVLGAEGI
Mvan_5586|M.vanbaalenii_PYR-1 FKSALGASTMVLLPLIADRVD---LPIICAGGVCDARSGAAAVVLGAEGV
MAV_2769|M.avium_104 FKNRFGASTMVLLPLVAAHVD---VPIVAAGGICDARSMAAAFVLGAEAV
MAB_4001c|M.abscessus_ATCC_199 FKDPKGASTMVLLPLVRSHVD---IPIIAAGGICDGVSMAAAFALGAEGV
MSMEG_5182|M.smegmatis_MC2_155 HPGEDDIPGLVLIPAAADKIE---IPMIASGGFADGRGLAAALALGADGI
TH_3584|M.thermoresistible__bu HPGEDDIPGLVLIPAAAAKIT---VPMIASGGFADARGLVAALALGADGI
. . . :*:* : :*::.:**. *. . .**. ** .:
MMAR_5042|M.marinum_M AMGTRFLLTSDSTVPEAVKRRYLQAALDGTVVTTRVDGMPHRVLRTGLVE
MUL_4116|M.ulcerans_Agy99 AMGTRFLLTSDSTVPDAVKRRYLQAALDGTVVTTRVDGMPHRVLRTGLVE
Mb3583|M.bovis_AF2122/97 AMGTRFLLTSDSTVPDAVKRRYLQAGLDGTVVTTRVDGMPHRVLRTELVE
Rv3553|M.tuberculosis_H37Rv AMGTRFLLTSDSTVPDAVKRRYLQAGLDGTVVTTRVDGMPHRVLRTELVE
Mflv_1222|M.gilvum_PYR-GCK QMGTRMLASAEALVHANFKDAIVAADDAGTILLDVPGNPTMRVLRTGLAA
Mvan_5586|M.vanbaalenii_PYR-1 QMGTRMLASVEAAVHTNFKDAIVAADDSGTVLLDVPGNPTMRVLRTGLAA
MAV_2769|M.avium_104 QMGTRLLASADSPVHVNLKQAVVAADETATVLLPLDGKRMMRVIRTPAAE
MAB_4001c|M.abscessus_ATCC_199 QMGTRMMSAAESPIHHNWKAAVVAARETDTVLLNRLTKPGLRALRSARTE
MSMEG_5182|M.smegmatis_MC2_155 NMGSRFMCTVESSIHQNVKEAIVAGDERGTELIFRTLHNTARVASNKVSR
TH_3584|M.thermoresistible__bu NMGSRFMCTVESPIHQKVKEAIVAGSELDTELIFRPLRNTGRVASNSVSR
**:*:: : :: : * : . * : *. .
MMAR_5042|M.marinum_M KLEGGSRARGFTAAIRNAAKFKQMSQMSWASMIKDGLAMRHGKELTWSQV
MUL_4116|M.ulcerans_Agy99 KLEGGSRARGFTAAIRNAAKFKQMSQMSWASMIKDGLAMRHGKELTWSQV
Mb3583|M.bovis_AF2122/97 KLESGSRARGFAAALRNAGKFRRMSQMTWRSMIRDGLTMRHGKELTWSQV
Rv3553|M.tuberculosis_H37Rv KLESGSRARGFAAALRNAGKFRRMSQMTWRSMIRDGLTMRHGKELTWSQV
Mflv_1222|M.gilvum_PYR-GCK RIDEQDAD---------AKLLGRITDLYFG--------------------
Mvan_5586|M.vanbaalenii_PYR-1 RIDEHPAD---------AQLLGRITDLYFG--------------------
MAV_2769|M.avium_104 RLEAAGAAGE------GAAALQRVQRLYFE--------------------
MAB_4001c|M.abscessus_ATCC_199 EMERRDLVS--------LLETGDPLDLYFG--------------------
MSMEG_5182|M.smegmatis_MC2_155 EVVEILNKGGQFEDVKDLVAGVRGRKVFEN--------------------
TH_3584|M.thermoresistible__bu EVVEILDKGGKFEDVAHLVSGKRGAKVYET--------------------
.: :
MMAR_5042|M.marinum_M VMAANTPMLLKAGLVDGNPEAGVLASGQVAGILDDLPSCAQLVESIVHDA
MUL_4116|M.ulcerans_Agy99 LMAANTPMLLKAGLVDGNPEAGVLASGQVAGILDDLPSCAQLVESIVHDA
Mb3583|M.bovis_AF2122/97 LMAANTPMLLKAGLVDGNTEAGVLASGQVAGILDDLPSCKELIESIVLDA
Rv3553|M.tuberculosis_H37Rv LMAANTPMLLKAGLVDGNTEAGVLASGQVAGILDDLPSCKELIESIVLDA
Mflv_1222|M.gilvum_PYR-GCK ----------------GDLEASVANTGQVSSRITGLAPAAEIVRQTWCEI
Mvan_5586|M.vanbaalenii_PYR-1 ----------------GDMEASVANTGQVSSRITELRPVAEIVRQTWRGI
MAV_2769|M.avium_104 ----------------GDLDASVANTGQVAGRIRDLPPAADIIKQMWKGC
MAB_4001c|M.abscessus_ATCC_199 ----------------GNMETFVPLGGQVAGRIGGVESVKDILDATMDEF
MSMEG_5182|M.smegmatis_MC2_155 ----------------GDVDAGIWTVGTAMGLIDDIPTVQDLVTRIVRDA
TH_3584|M.thermoresistible__bu ----------------GDLEAGIWWIGTAMGLINDIPTVGELVSRMVSEA
*: :: : * . . : : . :::
MMAR_5042|M.marinum_M IEHLRAAAALVE--------------
MUL_4116|M.ulcerans_Agy99 IEHLRAAAALVE--------------
Mb3583|M.bovis_AF2122/97 ITHLQTASALVE--------------
Rv3553|M.tuberculosis_H37Rv ITHLQTASALVE--------------
Mflv_1222|M.gilvum_PYR-GCK QTVLDDTRARLG--------------
Mvan_5586|M.vanbaalenii_PYR-1 ESVLDSARTRLD--------------
MAV_2769|M.avium_104 REVLAATSARLDWADDA---------
MAB_4001c|M.abscessus_ATCC_199 TAVIGKLAAQYV--------------
MSMEG_5182|M.smegmatis_MC2_155 EVLISGRLLNMISADEPDAEKETVPA
TH_3584|M.thermoresistible__bu EEIINGRLAGALR-------------
: