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MTITTKFTETFGVEHPIAQGGMQWVGRAELVAAVANAGALGFITALTQPTPADLANEIARTRDLTDKPFG VNLTILPAINPPPYDEYRQVIVDAGIKIVETAGSNPAPHLPMFHDNGIKVLHKCTSVRHAVKAQSLGVDG ISIDGFECAGHPGEDDVPGLVLIPAAADKIEIPMIASGGFADGRGLAAALALGADGVNMGSRFMCTVESC IHQNVKEAIVAGDERGTELIFRSLHNTARVASNVVSREVVQILKEGGQFEDVKDLVAGVRGRKVFDDGDI DAGIWTVGTAMGLINDIPTVGDLVSRIVGDAEEIISGRLAGMVSPVAQRV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2128 | - | - | 100% (330) | 2-nitropropane dioxygenase, NPD |
| M. gilvum PYR-GCK | Mflv_1222 | - | 1e-43 | 33.55% (304) | 2-nitropropane dioxygenase, NPD |
| M. gilvum PYR-GCK | Mflv_1487 | - | 2e-36 | 29.01% (355) | 2-nitropropane dioxygenase, NPD |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3583 | - | 2e-37 | 30.86% (350) | oxidoreductase |
| M. tuberculosis H37Rv | Rv3553 | - | 2e-37 | 30.86% (350) | oxidoreductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4001c | - | 4e-45 | 34.98% (323) | putative 2-nitropropane dioxygenase, NPD |
| M. marinum M | MMAR_5042 | - | 8e-38 | 31.25% (352) | 2-nitropropane dioxygenase |
| M. avium 104 | MAV_2769 | - | 3e-39 | 32.11% (299) | oxidoreductase, 2-nitropropane dioxygenase family protein |
| M. smegmatis MC2 155 | MSMEG_5182 | - | 1e-172 | 91.36% (324) | 2-nitropropane dioxygenase |
| M. thermoresistible (build 8) | TH_2580 | - | 1e-159 | 83.69% (325) | PUTATIVE 2-nitropropane dioxygenase, NPD |
| M. ulcerans Agy99 | MUL_4116 | - | 3e-37 | 30.97% (352) | 2-nitropropane dioxygenase |
| M. vanbaalenii PYR-1 | Mvan_4576 | - | 0.0 | 94.85% (330) | 2-nitropropane dioxygenase, NPD |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2128|M.gilvum_PYR-GCK MTITTKFTETFGVEHPIAQGGMQWVGRAELVAAVANAGALGFITALTQPT
Mvan_4576|M.vanbaalenii_PYR-1 MTIRTKFTETFGVEHPIAQGGMQWVGRAELVAAVANAGALGFITALTQPT
MSMEG_5182|M.smegmatis_MC2_155 MALTTKFTEAFGVTHPIAQGGMQWVGRAELVAAVANAGALGFITALTQPT
TH_2580|M.thermoresistible__bu MALKTKFTEAFGVEHPIVQGGMQWVGRAELVAAVANAGALGFLTALTQPT
MAB_4001c|M.abscessus_ATCC_199 -MITNRVTELLGVERPIVQAPMGWIARSQLASAVCNAGGLGIIETSSGEL
MAV_2769|M.avium_104 ---------------------MTYIAGAQLAAAVSNAGALGIIETTS---
Mb3583|M.bovis_AF2122/97 MRLRTPLTELIGIEHPVVQTGMGWVAGARLVSATANAGGLGILASAT-MT
Rv3553|M.tuberculosis_H37Rv MRLRTPLTELIGIEHPVVQTGMGWVAGARLVSATANAGGLGILASAT-MT
MMAR_5042|M.marinum_M MRLRTPLTDLVGVEHPVVQTGMGWVAGARLVSATANAGGLGILASAT-MT
MUL_4116|M.ulcerans_Agy99 MRLRTPLTDLVGVEHPVVQTGMGWVAGARLVSATANAGGLGILASAT-MT
* ::. :.*.:*..***.**:: : :
Mflv_2128|M.gilvum_PYR-GCK PADLANEIARTRDLTDKPFGVNLTILPAINPPPYDEYRQVIVDAGIKIVE
Mvan_4576|M.vanbaalenii_PYR-1 PADLANEIAKTRDLTDKPFGVNLTILPAINPPPYDEYRQVIVDAGIKIVE
MSMEG_5182|M.smegmatis_MC2_155 PADLANEIARCRDLTDKPFGVNLTILPSINPPPYDEYRQVIVDSGVKIVE
TH_2580|M.thermoresistible__bu PEALAKEIARTREMTDKPFGVNLTILPTINPPPYDEYRQVIVESGIKIVE
MAB_4001c|M.abscessus_ATCC_199 -DAIKDEIRAMREFTDKPFGVNIAQAFVRDPS----IAQFVVDQGVTFVT
MAV_2769|M.avium_104 -DQGRADLRRVRELTAGAVGANIALLFNRDPA----MLDLLVANDIRFVT
Mb3583|M.bovis_AF2122/97 LDELAAAITKVKAVTDKPFGVNIRADAADAGDR----VELMIREGVRVAS
Rv3553|M.tuberculosis_H37Rv LDELAAAITKVKAVTDKPFGVNIRADAADAGDR----VELMIREGVRVAS
MMAR_5042|M.marinum_M LDELATAIGKVKATTDKPFGVNIRADAADASDR----VELMIREGVKVAS
MUL_4116|M.ulcerans_Agy99 LDELATAIGKVKATTDKPFGVNIRADAADASDR----VELMIREGVKVAS
: : * ..*.*: :.:: .: ..
Mflv_2128|M.gilvum_PYR-GCK TAGSNPAPHLPMFHDNGIKVLHKCTSVRHAVKAQSLGVDGISIDGFECAG
Mvan_4576|M.vanbaalenii_PYR-1 TAGSNPAPHLPMFHDNGIKVLHKCTSVRHAVKAQSLGVDGISIDGFECAG
MSMEG_5182|M.smegmatis_MC2_155 TAGSNPAPHLPMFHDNGIKVLHKCTSVRHAVKAQSLGVDGISIDGFECAG
TH_2580|M.thermoresistible__bu TAGSNPAPHLPMFHENGVKVLHKCTSVRHAVKAQSLGVDGISIDGFECAG
MAB_4001c|M.abscessus_ATCC_199 TSAGDPNKYTRVLKDNGLTVFHVVPTLAAALKAVDAGVDGLVVEGVEGGG
MAV_2769|M.avium_104 TSAGDPALFTDRLHDAGITVFHVVGTLAAAKKAVDAGVDGLVVEGVEGGG
Mb3583|M.bovis_AF2122/97 FALAPKQQLIARLKEAGAVVIPSIGAAKHARKVAAWGADAMIVQGGEGGG
Rv3553|M.tuberculosis_H37Rv FALAPKQQLIARLKEAGAVVIPSIGAAKHARKVAAWGADAMIVQGGEGGG
MMAR_5042|M.marinum_M FALAPKPELIARLKEAGAVVIPSIGAAKHARKVAGWGADAMIVQGGEGGG
MUL_4116|M.ulcerans_Agy99 FALAPKPELIARLKEAGAVVIPSIGAAKHARKVAGWGADAMIVQGGEGGG
: . ::: * *: : * *. *.*.: ::* * .*
Mflv_2128|M.gilvum_PYR-GCK HPGEDDVPGLVLIPAAADKIE---IPMIASGGFADGRGLAAALALGADGV
Mvan_4576|M.vanbaalenii_PYR-1 HPGEDDVPGLVLIPAAADKIE---IPMIASGGFADARGLVAALALGADGI
MSMEG_5182|M.smegmatis_MC2_155 HPGEDDIPGLVLIPAAADKIE---IPMIASGGFADGRGLAAALALGADGI
TH_2580|M.thermoresistible__bu HPGEDDIPGLVLIPAAADKIT---IPMIASGGFADARGLVAALALGADGI
MAB_4001c|M.abscessus_ATCC_199 FKDPKGASTMVLLPLVRSHVD---IPIIAAGGICDGVSMAAAFALGAEGV
MAV_2769|M.avium_104 FKNRFGASTMVLLPLVAAHVD---VPIVAAGGICDARSMAAAFVLGAEAV
Mb3583|M.bovis_AF2122/97 HTGP--VATTLLLPSVLDAVAGTGIPVIAAGGFFDGRGLAAALCYGAAGV
Rv3553|M.tuberculosis_H37Rv HTGP--VATTLLLPSVLDAVAGTGIPVIAAGGFFDGRGLAAALCYGAAGV
MMAR_5042|M.marinum_M HTGP--VATTLLLPSVLDAVKGTGIPVIAAGGFFDGRGLAAALSYGAAGV
MUL_4116|M.ulcerans_Agy99 HTGP--VATTLLLPSVLDAVKGTGIPVIAAGGFFDGHGLAAALSYGAAGV
. . . :*:* . : :*::*:**: *. .:.**: ** .:
Mflv_2128|M.gilvum_PYR-GCK NMGSRFMCTVESCIHQNVKEAIVAGDERGTELIFRSLHNTARVASNVVSR
Mvan_4576|M.vanbaalenii_PYR-1 NMGSRFMCTVESCIHQNVKEAIVAGDERGTELIFRSLHNTARVASNEVSR
MSMEG_5182|M.smegmatis_MC2_155 NMGSRFMCTVESSIHQNVKEAIVAGDERGTELIFRTLHNTARVASNKVSR
TH_2580|M.thermoresistible__bu NMGSRFMCTVESPIHQKVKEAIVAGTELDTELIFRPLRNTSRVASNAVSR
MAB_4001c|M.abscessus_ATCC_199 QMGTRMMSAAESPIHHNWKAAVVAARETDTVLLNRLTKPGLRALRSARTE
MAV_2769|M.avium_104 QMGTRLLASADSPVHVNLKQAVVAADETATVLLPLDGKRMMRVIRTPAAE
Mb3583|M.bovis_AF2122/97 AMGTRFLLTSDSTVPDAVKRRYLQAGLDGTVVTTRVDGMPHRVLRTELVE
Rv3553|M.tuberculosis_H37Rv AMGTRFLLTSDSTVPDAVKRRYLQAGLDGTVVTTRVDGMPHRVLRTELVE
MMAR_5042|M.marinum_M AMGTRFLLTSDSTVPEAVKRRYLQAALDGTVVTTRVDGMPHRVLRTGLVE
MUL_4116|M.ulcerans_Agy99 AMGTRFLLTSDSTVPDAVKRRYLQAALDGTVVTTRVDGMPHRVLRTGLVE
**:*:: : :* : * : . * : *. . .
Mflv_2128|M.gilvum_PYR-GCK EVVQILKEGGQFEDVKDLVAGVRGRKVFD---------------------
Mvan_4576|M.vanbaalenii_PYR-1 EVVQILKDGGQFEDVKDLVAGVRGRKVFD---------------------
MSMEG_5182|M.smegmatis_MC2_155 EVVEILNKGGQFEDVKDLVAGVRGRKVFE---------------------
TH_2580|M.thermoresistible__bu EVVEILNRGGKFEDVKDLVAGTRGAKVYE---------------------
MAB_4001c|M.abscessus_ATCC_199 EMERRDLVS------LLETGDP--LDLYF---------------------
MAV_2769|M.avium_104 RLEAAGAAG------EGAAALQRVQRLYF---------------------
Mb3583|M.bovis_AF2122/97 KLESGSRARGFAAALRNAGKFRRMSQMTWRSMIRDGLTMRHGKELTWSQV
Rv3553|M.tuberculosis_H37Rv KLESGSRARGFAAALRNAGKFRRMSQMTWRSMIRDGLTMRHGKELTWSQV
MMAR_5042|M.marinum_M KLEGGSRARGFTAAIRNAAKFKQMSQMSWASMIKDGLAMRHGKELTWSQV
MUL_4116|M.ulcerans_Agy99 KLEGGSRARGFTAAIRNAAKFKQMSQMSWASMIKDGLAMRHGKELTWSQV
.: :
Mflv_2128|M.gilvum_PYR-GCK ---------------DGDIDAGIWTVGTAMGLINDIPTVGDLVSRIVGDA
Mvan_4576|M.vanbaalenii_PYR-1 ---------------DGDIDAGIWTVGTAMGLINDIPTVGELVSRIVGEA
MSMEG_5182|M.smegmatis_MC2_155 ---------------NGDVDAGIWTVGTAMGLIDDIPTVQDLVTRIVRDA
TH_2580|M.thermoresistible__bu ---------------TGDLDAGIWWVGTSMGLINDIPTVGELVSRMVAEA
MAB_4001c|M.abscessus_ATCC_199 ---------------GGNMETFVPLGGQVAGRIGGVESVKDILDATMDEF
MAV_2769|M.avium_104 ---------------EGDLDASVANTGQVAGRIRDLPPAADIIKQMWKGC
Mb3583|M.bovis_AF2122/97 LMAANTPMLLKAGLVDGNTEAGVLASGQVAGILDDLPSCKELIESIVLDA
Rv3553|M.tuberculosis_H37Rv LMAANTPMLLKAGLVDGNTEAGVLASGQVAGILDDLPSCKELIESIVLDA
MMAR_5042|M.marinum_M VMAANTPMLLKAGLVDGNPEAGVLASGQVAGILDDLPSCAQLVESIVHDA
MUL_4116|M.ulcerans_Agy99 LMAANTPMLLKAGLVDGNPEAGVLASGQVAGILDDLPSCAQLVESIVHDA
*: :: : * * : .: . :::
Mflv_2128|M.gilvum_PYR-GCK EEIISGRLAGMVS---PVAQRV----
Mvan_4576|M.vanbaalenii_PYR-1 EQLITGRLGEMVT---PTAARV----
MSMEG_5182|M.smegmatis_MC2_155 EVLISGRLLNMISADEPDAEKETVPA
TH_2580|M.thermoresistible__bu EDLIAGRLAELIEPSVDEAGSA----
MAB_4001c|M.abscessus_ATCC_199 TAVIGKLAAQYV--------------
MAV_2769|M.avium_104 REVLAATSARLDWADDA---------
Mb3583|M.bovis_AF2122/97 ITHLQTASALVE--------------
Rv3553|M.tuberculosis_H37Rv ITHLQTASALVE--------------
MMAR_5042|M.marinum_M IEHLRAAAALVE--------------
MUL_4116|M.ulcerans_Agy99 IEHLRAAAALVE--------------
: