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DRETYERGRQIREAVLGSEYVERATAGADEFSAPLQDLVTEYCWGAVWGRDGLSRKTRSMLNLAMIATLN RPHELATHIRGALGNGVTREEIREIFLHVGVYAGIPAAVDSFRIAKATFAELEGE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1912 | - | - | 100% (126) | carboxymuconolactone decarboxylase |
| M. gilvum PYR-GCK | Mflv_0527 | - | 6e-24 | 37.19% (121) | 4-carboxymuconolactone decarboxylase |
| M. gilvum PYR-GCK | Mflv_1906 | - | 7e-09 | 33.33% (90) | carboxymuconolactone decarboxylase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0794 | - | 5e-05 | 28.57% (70) | 4-carboxymuconolactone decarboxylase |
| M. tuberculosis H37Rv | Rv0771 | - | 5e-05 | 28.57% (70) | 4-carboxymuconolactone decarboxylase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_4925 | - | 1e-05 | 29.58% (71) | 4-carboxymuconolactone decarboxylase |
| M. avium 104 | MAV_3552 | pcaC | 7e-10 | 34.44% (90) | hypothetical protein MAV_3552 |
| M. smegmatis MC2 155 | MSMEG_2604 | pcaC | 1e-27 | 45.08% (122) | 4-carboxymuconolactone decarboxylase |
| M. thermoresistible (build 8) | TH_0621 | - | 4e-14 | 37.36% (91) | 4-carboxymuconolactone decarboxylase |
| M. ulcerans Agy99 | MUL_0480 | - | 6e-05 | 28.17% (71) | 4-carboxymuconolactone decarboxylase |
| M. vanbaalenii PYR-1 | Mvan_4821 | - | 2e-55 | 80.16% (126) | carboxymuconolactone decarboxylase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0794|M.bovis_AF2122/97 ----MMDELRRTGLDKMNEVYAWDMPD--------MPG-EFFALTVDHLF
Rv0771|M.tuberculosis_H37Rv ----MMDELRRTGLDKMNEVYAWDMPD--------MPG-EFFALTVDHLF
MMAR_4925|M.marinum_M -----MDELRRKGLDKMNEVYGWEMPN--------IEGDAYFDLTVDHLF
MUL_0480|M.ulcerans_Agy99 -----MDELRRKGLDKMNEVYGWEMPN--------IEGDAYFDLTVDHLF
TH_0621|M.thermoresistible__bu --------MREQGLQVFRELLPGVLPDGDVDFRDGSFGDELLEIGIDNVF
MAV_3552|M.avium_104 MSRSDSAARHQRGVRTFAEVMTFDPPD---------DASPCASGLIDFVF
Mflv_1912|M.gilvum_PYR-GCK ----MDRETYERGRQIREAVLGSEYVER-ATAGADEFSAPLQDLVTEYCW
Mvan_4821|M.vanbaalenii_PYR-1 ----MDPQTYELGRQIRTTVLGADYVQR-AASDADDFSQPLQDLVTEYCW
MSMEG_2604|M.smegmatis_MC2_155 -MTTMRDETHAAGSQVRRAVLGDDHVDR-AVAATTGFTADFQDLITRYAW
* : : :
Mb0794|M.bovis_AF2122/97 GRIWTRPGLSMRDRRMAVIAVLTAQGQSDLLEVQVNAVLHNDELTIDELR
Rv0771|M.tuberculosis_H37Rv GRIWTRPGLSMRDRRMAVIAVLTAQGQSDLLEVQVNAVLHNDELTIDELR
MMAR_4925|M.marinum_M GTIWTRPGLSMRDRRLMTLTAVTAIGNRDLAEIQINAALLNGELTEAELK
MUL_0480|M.ulcerans_Agy99 GTIWTRPGLSMRDRRLMTLTAVTAIGNRDLAEIQINAAPLNGELTEAELK
TH_0621|M.thermoresistible__bu GRLWTRDGLSRRDRSLVTLGILIALRATDELRFHVQIARNN-GLTEDEIA
MAV_3552|M.avium_104 GEVWSRPGLSRRDRRFVTLACVAAADAQAPLEQHVYAALNSGDLSITEMR
Mflv_1912|M.gilvum_PYR-GCK GAVWGRDGLSRKTRSMLNLAMIATLNRPHELATHIRGALGN-GVTREEIR
Mvan_4821|M.vanbaalenii_PYR-1 GAVWGRDGLPLKTRSMLNLAMIAVLNRPQELATHIRGALNN-GVTRDEIR
MSMEG_2604|M.smegmatis_MC2_155 GEIWTRPGLDRRSRSMITLTAMIARGHHDELAMHVRAARRN-GLSVDEIK
* :* * ** : * : : : . :: . . :: *:
Mb0794|M.bovis_AF2122/97 ELAVFITHYVGFPLGSRLNSAIERVAAKRKQAAENGSLPDT-----KANV
Rv0771|M.tuberculosis_H37Rv ELAVFITHYVGFPLGSRLNSAIERVAAKRKQAAENGSLPDT-----KANV
MMAR_4925|M.marinum_M EMAVFLTHYLGFPLGSGLNGAVDTVVARRKKAAAKGAGEDK-----KGNV
MUL_0480|M.ulcerans_Agy99 EMAVFLTHYLGFPLGSGLNGAVDTVVARRKKAAAKGAGEDK-----KGNV
TH_0621|M.thermoresistible__bu EVIYHATGYAGFPNASTAMKVAKEVLAEEHSRAADADKQSR-----LGES
MAV_3552|M.avium_104 EAVLHFAVYAGWPKASRFNIVVDQQWARIAAERGEPTPDPEPLLPLVTAA
Mflv_1912|M.gilvum_PYR-GCK EIFLHVGVYAGIPAAVDSFRIAKATFAELEGE------------------
Mvan_4821|M.vanbaalenii_PYR-1 EIFLQVGIYAGIPAAVDSFRVAKTAFAELEAE------------------
MSMEG_2604|M.smegmatis_MC2_155 EVLLQSAIYCGVPEANTAFRIAGAVLAEEAQEPGDER-------------
* * * * . *.
Mb0794|M.bovis_AF2122/97 AEVLAKESGKSS--------------------------------------
Rv0771|M.tuberculosis_H37Rv AEVLAKESGKSS--------------------------------------
MMAR_4925|M.marinum_M DDALKMHSGGKPD-------------------------------------
MUL_0480|M.ulcerans_Agy99 DDALKMHSGSKPD-------------------------------------
TH_0621|M.thermoresistible__bu NP------------------------------------------------
MAV_3552|M.avium_104 DPEQRLRGGERSFKDINCLPFAPPRDNPYSGAGILNFVFGEMWLRPGLGM
Mflv_1912|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4821|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2604|M.smegmatis_MC2_155 --------------------------------------------------
Mb0794|M.bovis_AF2122/97 --------------------------------------------------
Rv0771|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4925|M.marinum_M --------------------------------------------------
MUL_0480|M.ulcerans_Agy99 --------------------------------------------------
TH_0621|M.thermoresistible__bu --------------------------------------------------
MAV_3552|M.avium_104 KERRLITVACVAFQDAEIPIMSHVYAALKSGDVSFREMDEVALQFAAYYG
Mflv_1912|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4821|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2604|M.smegmatis_MC2_155 --------------------------------------------------
Mb0794|M.bovis_AF2122/97 ------------------------------
Rv0771|M.tuberculosis_H37Rv ------------------------------
MMAR_4925|M.marinum_M ------------------------------
MUL_0480|M.ulcerans_Agy99 ------------------------------
TH_0621|M.thermoresistible__bu ------------------------------
MAV_3552|M.avium_104 CAKADHLNQALAEQKQRVIAENHSDATPVG
Mflv_1912|M.gilvum_PYR-GCK ------------------------------
Mvan_4821|M.vanbaalenii_PYR-1 ------------------------------
MSMEG_2604|M.smegmatis_MC2_155 ------------------------------