For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MFDSSVPEPAALAGLSDAELVDAAGAAARAENAVCARKLAVMAELFTRRVDLAPEDRLNWWVDPDAAVAA EIAAAVTITQGLATHQTYRAVVLRDRLPKVGALFLQGLLSELLVRAIITRTDLITDPELIAAVDADLAAD ILRWGPQSAKKTEAAIDHIVERHDPDAVRQTRQHDVGRTIEIGNPGDAPGYTTVWARMFAGDAAAGHRTL TTMAYSVCDNDPRTLDERRNDALTALFHGITTLACRCGNGDCDAATNPRPPRELTVYALTDQTTANIEET TANDADADGGRNAGNGDGDAQPPAPKPRRSKPTLLPGRSGYLFGSGFMPAPLFDALLDDALLDGAKIREI LHPGQAGPEPRYTPSTALADFIRCRDLTCRFPGCDTPATEADIDHTVAHPVGPTHASNLKCLCRFHHLLK TFWTGRGGWHDRQHPDGTITWTSPTGHTYITHPGSRLLFPTLCKPTATLWTGDPPQVPIRERRGAMMPRR AKTRAHSRAVYITAQRRRNAAERADGPRGNDPPF
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0179 | - | - | 100% (524) | hypothetical protein Mflv_0179 |
| M. gilvum PYR-GCK | Mflv_4099 | - | 0.0 | 90.72% (528) | hypothetical protein Mflv_4099 |
| M. gilvum PYR-GCK | Mflv_1180 | - | 0.0 | 88.78% (526) | hypothetical protein Mflv_1180 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2126 | - | 1e-108 | 43.51% (524) | hypothetical protein Mb2126 |
| M. tuberculosis H37Rv | Rv2100 | - | 1e-108 | 43.51% (524) | hypothetical protein Rv2100 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4752 | - | 2e-66 | 37.83% (452) | hypothetical protein MAB_4752 |
| M. marinum M | MMAR_5187 | - | 1e-100 | 42.77% (505) | 13e12 repeat-containing protein |
| M. avium 104 | MAV_4456 | - | 7e-98 | 40.22% (547) | 13e12 repeat-containing protein |
| M. smegmatis MC2 155 | MSMEG_5106 | - | 1e-108 | 40.89% (587) | HNH endonuclease |
| M. thermoresistible (build 8) | TH_0334 | - | 2e-63 | 37.06% (402) | HNH endonuclease |
| M. ulcerans Agy99 | MUL_2679 | - | 2e-77 | 38.99% (477) | 13e12 repeat-containing protein |
| M. vanbaalenii PYR-1 | Mvan_0728 | - | 0.0 | 74.48% (525) | hypothetical protein Mvan_0728 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_5187|M.marinum_M ------------------------MFESMGVAAGVDHPCDALAERRQLRT
MAV_4456|M.avium_104 ------------------------------MCEDATAWFDELMER-CYPS
MUL_2679|M.ulcerans_Agy99 --------------------------------------MDQHIIEYVFDT
TH_0334|M.thermoresistible__bu ----------------------------------------------MFES
MAB_4752|M.abscessus_ATCC_1997 ----------------------------------------------MFDE
Mflv_0179|M.gilvum_PYR-GCK --------------------------------------MFDSSVPEPAAL
Mvan_0728|M.vanbaalenii_PYR-1 --------------------------------------MFDVLVPDPADL
MSMEG_5106|M.smegmatis_MC2_155 --------------------------------------------MQIAEF
Mb2126|M.bovis_AF2122/97 MAGALFEPSFAAAHPAGLLRRPVTRTVVLSVAATSIAHMFEISLPDPTEL
Rv2100|M.tuberculosis_H37Rv MAGALFEPSFAAAHPAGLLRRPVTRTVVLSVAATSIAHMFEISLPDPTEL
MMAR_5187|M.marinum_M PTAESARWVQRIGAAARAENRAAAAQLIEIGQLFAYRLSR--CSETEDWA
MAV_4456|M.avium_104 ATPESAALVQRIGVFARVENRAAAEQLAAIGELFAYRLSR--CSECEDWA
MUL_2679|M.ulcerans_Agy99 ---DDSAPLTRITAAARAEARAAAERLAAIGDLFRLRLSQ--HGNREDWV
TH_0334|M.thermoresistible__bu --LDDGAVVDSIAAASREQSAACGREMLAIGELYARRAPED-DTERANWA
MAB_4752|M.abscessus_ATCC_1997 --LGDVELIDLIASAQRAEAQACARKLDAIGVLVDRHADLGKPDERDHHA
Mflv_0179|M.gilvum_PYR-GCK AGLSDAELVDAAGAAARAENAVCARKLAVMAELFTRRVDLAPED-RLNWW
Mvan_0728|M.vanbaalenii_PYR-1 AALSDAELLDAATATTRAENAVCARKLAVMAELFIRRTTLAPQD-RLDWW
MSMEG_5106|M.smegmatis_MC2_155 SALSDLELEGQARGWAQAEASASAHKHAAMAEMFIRATSTPSADERRWWF
Mb2126|M.bovis_AF2122/97 CRSDDGALVAAIEDCARVEAAASARRLSAIAELTGRRTG---ADQRADWA
Rv2100|M.tuberculosis_H37Rv CRSDDGALVAAIEDCARVEAAASARRLSAIAELTGRRTG---ADQRADWA
. : : ... . :. :
MMAR_5187|M.marinum_M VDTMEAVAAEVAAGLRISQGLAASRLRYARALRERLPKTGAVFAAGQIDL
MAV_4456|M.avium_104 VDTEAAVSAEVAAQLRIGQGLAAAKVRYARAMRERLPRVGEVFRAGEIDF
MUL_2679|M.ulcerans_Agy99 ADTCDAVAAEVAAALNTSVAMGHSNLRYARAMRERLPQLGAEFRAGGIDF
TH_0334|M.thermoresistible__bu IDGHANVVAEISAALNISRGRAAGRLQLAIDLRERLPRVAAVFAAGDIDF
MAB_4752|M.abscessus_ATCC_1997 LDRWDRVASEVAAAQGITHALASSQMRYAQVLRHRLRAVAERFAAGDLDF
Mflv_0179|M.gilvum_PYR-GCK VDPDAAVAAEIAAAVTITQGLATHQTYRAVVLRDRLPKVGALFLQGLLSE
Mvan_0728|M.vanbaalenii_PYR-1 VDPEAAVTAELAAAHHITQGLATHQAYRAVVLRDRLPKIGALFLQGLLSE
MSMEG_5106|M.smegmatis_MC2_155 VDPDAAVGAQLGAAQGITAWAALHQAQRGVALRDRLPKVNEVFAAGLVSE
Mb2126|M.bovis_AF2122/97 CDFWDCAAAEVAAALTISHGKASGQMHLSLALN-RLPQVAALFLAGHLGA
Rv2100|M.tuberculosis_H37Rv CDFWDCAAAEVAAALTISHGKASGQMHLSLALN-RLPQVAALFLAGHLGA
* . :::.* . . . :. ** * * :.
MMAR_5187|M.marinum_M RAFQTIVFRTDLIVDPQVMAAVDALVALNVGRWPSMTKARLSGQIDAIVA
MAV_4456|M.avium_104 RLFATIVYRTDLITDRRVLAAVDAELAATAARWPSMTRARLAARVDAVVA
MUL_2679|M.ulcerans_Agy99 RLFRTIVFRTDLITESDALAAVDARLAIKAPRWPSMTSWKLATEVDRVVA
TH_0334|M.thermoresistible__bu RMVSALVNRSRNVVDPDLLARLDAALAAWSPKWMKLSGPTLNERIDMWVE
MAB_4752|M.abscessus_ATCC_1997 RTVALIINRTELVDDEAVVARVDAAIVRALPRWARWSHKRITAALDALVL
Mflv_0179|M.gilvum_PYR-GCK LLVRAIITRTDLITDPELIAAVDADLAADILRWGPQSAKKTEAAIDHIVE
Mvan_0728|M.vanbaalenii_PYR-1 LLVRAIITRTGLITDPDLIAAVDADLATDILDWGPLSVKATEAEIDAIID
MSMEG_5106|M.smegmatis_MC2_155 MIVRNICWSTALMLEPDKLALIDAELAAQISGWGKLTLKEIDNTIDDLIL
Mb2126|M.bovis_AF2122/97 RLFSIIAWRTYLVRDPHALSLLDAALAEHAGAWGPLSAPKLEKAIDSWID
Rv2100|M.tuberculosis_H37Rv RLFSIIAWRTYLVRDPHALSLLDAALAEHAGAWGPLSAPKLEKAIDSWID
. : : : : :: :** :. * : :* :
MMAR_5187|M.marinum_M RADADAVRRRKERHADREIWIGQDADG--ISRIDGSMFTIDAHALDRRLS
MAV_4456|M.avium_104 KADADAVRRTEKQAASRHVWIAEMGEG--LSHLEGTVSSPDAHALDKRLD
MUL_2679|M.ulcerans_Agy99 KFDRDAVRRSRRDAADRYVDCAPLEPG--MALVNRQVFSATAEALARRLD
TH_0334|M.thermoresistible__bu RFDPTGVREPRSPGEDRYVVVTPAGQG--MVDVSARLTFEAGFAFXTRLD
MAB_4752|M.abscessus_ATCC_1997 HFDQDAVRRNRSATDKRHLEIRPLGNGEPVAEVWGTLQAVHAVALDKRLD
Mflv_0179|M.gilvum_PYR-GCK RHDPDAVRQTRQHDVGRTIEIGNPGDAPGYTTVWARMFAGDAAAGHRTLT
Mvan_0728|M.vanbaalenii_PYR-1 RHDPDAVRKSRAPETGRTVQFGNPGDAPGYTSMWARMYASDAAAADRTLT
MSMEG_5106|M.smegmatis_MC2_155 KHDPASFRRGRASRRGRYFDIGSPTDAPGVLTVTGRLQAHLGNAYDARIA
Mb2126|M.bovis_AF2122/97 RYDPGALRRSRISARTRDLCIGDPDEDAGTAALWGRLYATDAAMLDRRLT
Rv2100|M.tuberculosis_H37Rv RYDPGALRRSRISARTRDLCIGDPDEDAGTAALWGRLYATDAAMLDRRLT
: * ..*. . * . : : . :
MMAR_5187|M.marinum_M ALAATVCAQDPRSREQRRADALGVLAAGGDRLGCRCGLPDC-AAGARPAA
MAV_4456|M.avium_104 ALAATVCEHDPRTGEQRRADALGALAAGADRLGCRCGRADC-AAGTRPAA
MUL_2679|M.ulcerans_Agy99 ELAKTVCADDPRTVVQRRADALGTLAAGQDRLICDCGRTDCPAAGAPQQP
TH_0334|M.thermoresistible__bu QIAATVCRDDPRTADQRRADAMAAMSEGQNRLVCGCGSEDCPADPADTAA
MAB_4752|M.abscessus_ATCC_1997 LLAGTVCPADPRSKTQRRADAVGALTQGLNRMRCACGHPDC--SGRDTAD
Mflv_0179|M.gilvum_PYR-GCK TMAYSVCDNDPRTLDERRNDALTALFHGITTLACRCGNGDCDAAT-NPRP
Mvan_0728|M.vanbaalenii_PYR-1 ALAYSVCDNDPRTLDERRNDAHTALLTGITTLACQCGNPDCHAST-NPRP
MSMEG_5106|M.smegmatis_MC2_155 ELIEGVCPDDPRTLNELRHDALGAILD-QTTLACECEDPDCVRGR-EQSS
Mb2126|M.bovis_AF2122/97 EMAHGVCEDDPRTLAQRRADALGALAAGADHLACGCGKPDCPSGAGNDER
Rv2100|M.tuberculosis_H37Rv EMAHGVCEDDPRTLAQRRADALGALAAGADHLACGCGKPDCPSGAGNDER
: ** ***: : * ** .: : * * **
MMAR_5187|M.marinum_M QP-VVIHVIA---------------------------------ERATLDG
MAV_4456|M.avium_104 GP-VVIHLIA---------------------------------ERASVEG
MUL_2679|M.ulcerans_Agy99 SR-VVIHVVA---------------------------------GCQTVDG
TH_0334|M.thermoresistible__bu TR-LVINVIA---------------------------------EQATVEG
MAB_4752|M.abscessus_ATCC_1997 VP-VVVNVVI---------------------------------NQSTLAG
Mflv_0179|M.gilvum_PYR-GCK PRELTVYALT---DQTTANIEETTANDADADGGRNAGNGDGDAQPPAPKP
Mvan_0728|M.vanbaalenii_PYR-1 PRDITVYALT---DHTTT----TDTGDADTTTDTKP------PTPPAPQP
MSMEG_5106|M.smegmatis_MC2_155 RGHLVVHVIAREDTVTAAQHAATTTNTPDDAPSDTPAADTEPAEPAEPAE
Mb2126|M.bovis_AF2122/97 AAGVVIHVVA---DASALDAQPDPHLSGDEPPSRPLTPETTLFEALTPDP
Rv2100|M.tuberculosis_H37Rv AAGVVIHVVA---DASALDAQPDPHLSGDEPPSRPLTPETTLFEALTPDP
:.: :
MMAR_5187|M.marinum_M DGGAPAWEVGA---------------------------------------
MAV_4456|M.avium_104 TGGGPAVEVGA---------------------------------------
MUL_2679|M.ulcerans_Agy99 AGEAPGVLPG----------------------------------------
TH_0334|M.thermoresistible__bu RSDNPGYLPG----------------------------------------
MAB_4752|M.abscessus_ATCC_1997 SDDCPAHVPG----------------------------------------
Mflv_0179|M.gilvum_PYR-GCK RRSKPTLLPGR---------------------------------------
Mvan_0728|M.vanbaalenii_PYR-1 RRSKPILIPGR---------------------------------------
MSMEG_5106|M.smegmatis_MC2_155 PVDDPDIAPAATATETATDTEPDAPAPTDTADSAATETDCDPESVSVTEF
Mb2126|M.bovis_AF2122/97 EPDPPATHAPA---------------------------------------
Rv2100|M.tuberculosis_H37Rv EPDPPATHAPA---------------------------------------
*
MMAR_5187|M.marinum_M -----------------------------DGLVTPELVAELAKSAK----
MAV_4456|M.avium_104 -----------------------------EGLLPAQLVAELAASAR----
MUL_2679|M.ulcerans_Agy99 -----------------------------DGIIPAEIVRELAKSAK----
TH_0334|M.thermoresistible__bu -----------------------------YGAVPASILRAKAATAT----
MAB_4752|M.abscessus_ATCC_1997 -----------------------------FGVLAAESARAAVAGTP----
Mflv_0179|M.gilvum_PYR-GCK -----------------------SGYLFGSGFMPAPLFDALLDDALLDGA
Mvan_0728|M.vanbaalenii_PYR-1 -----------------------PAYLFGAGFMPAPLFDALLAEAT----
MSMEG_5106|M.smegmatis_MC2_155 TDNSSDTPAAFLDPDEHPLDRVPPAVLFGGGVLPAYALAEIINNAT----
Mb2126|M.bovis_AF2122/97 -----------------------ELITTGGGVVPAPLLAELIRGGAT---
Rv2100|M.tuberculosis_H37Rv -----------------------ELITTGGGVVPAPLLAELIRGGAT---
* :..
MMAR_5187|M.marinum_M -LVPLRHPG-DVPPEPGYVPSKALADFVRCRDLTCRWPGCDHPALNCDLD
MAV_4456|M.avium_104 -LMPLVHPA-DAPPENRYTPSAALADFVRCRDLTCRWPGCDRPATECDLD
MUL_2679|M.ulcerans_Agy99 -LQPMSTP---ILAETGYVPSPALMDFVRARDLTCRAPGCDRPATQCDVD
TH_0334|M.thermoresistible__bu -LRPVALP--QPCAEAGYRPSAALTRFIRCRDLTCRFPGCDAPAAVCQID
MAB_4752|M.abscessus_ATCC_1997 -TRNLTDS-----RSTGYRPSAKLAAFVRSRDQLCRFPGCEAVADRADID
Mflv_0179|M.gilvum_PYR-GCK KIREILHPG-QAGPEPRYTPSTALADFIRCRDLTCRFPGCDTPATEADID
Mvan_0728|M.vanbaalenii_PYR-1 -IREIIHPGNRSAPEPRYTPSQALAEFIRCRDLTCRFPGCDKPATEADID
MSMEG_5106|M.smegmatis_MC2_155 -IRPLKHPG-DTAPEDRYIPSRALADYVRCRDLTCRFPGCDKPADRCDLD
Mb2126|M.bovis_AF2122/97 -ISQVRHPG-DLAAEPHYRPSAKLAEFVRMRDLTCRFPGCDVPAEFCDID
Rv2100|M.tuberculosis_H37Rv -ISQVRHPG-DLAAEPHYRPSAKLAEFVRMRDLTCRFPGCDVPAEFCDID
: . . * ** * ::* ** ** ***: * .::*
MMAR_5187|M.marinum_M HTIPYAQGGPTHASNLKCYCRTHHLVKTFWG----WHDQQLPDGTLILTS
MAV_4456|M.avium_104 HTIPYAEGGPTHASNLKCYCRTHHLVKTFWG----WREQQLPDATLILTS
MUL_2679|M.ulcerans_Agy99 HTIPYSDGGATHPSNLKCLCRKHHLLKTFWG----WHDEQLPDATVIWSL
TH_0334|M.thermoresistible__bu HTIPYPAG-PTHPSNLKLLCVFHCRQAELRF----THDQHKHQSSCLP--
MAB_4752|M.abscessus_ATCC_1997 HTVPWATGGPTTGANLKALCRKHHLLKTFGQ----WTELQEPDGTVIWKS
Mflv_0179|M.gilvum_PYR-GCK HTVAHPVG-PTHASNLKCLCRFHHLLKTFWTGRGGWHDRQHPDGTITWTS
Mvan_0728|M.vanbaalenii_PYR-1 HTVPYPIG-PTHPSNLKCLCRFHHLLKTFWLGATGWHDRQHPDGTITWTA
MSMEG_5106|M.smegmatis_MC2_155 HTVPYPAG-PTHASNLKCLCRFHHLLKTFWTGPRGWTDRQHPDGTIVWTS
Mb2126|M.bovis_AF2122/97 HSAPWPLG-PTHPSNLKCACRKHHLLKTFWTG---WRDVQLPDGTVIWTA
Rv2100|M.tuberculosis_H37Rv HSAPWPLG-PTHPSNLKCACRKHHLLKTFWTG---WRDVQLPDGTVIWTA
*: . . * .* :*** * * : : : :.:
MMAR_5187|M.marinum_M PAGHTYVTTPGSA--LLFPSLCHSTGGLPAAEADPPSDHCDQRSAMMPRR
MAV_4456|M.avium_104 PAGRTYVTTPGSA--LLFPSLCVPTG-EPARPVAAGSQPCGERTAMMPTR
MUL_2679|M.ulcerans_Agy99 PDGQTYVTTPGSA--WLLPGLFAPSPELPPP----------------PRS
TH_0334|M.thermoresistible__bu ----AYFQRPHG-----------------------------------PAT
MAB_4752|M.abscessus_ATCC_1997 PTGHRYATTPVSW--FLFPAL---------------------------TR
Mflv_0179|M.gilvum_PYR-GCK PTGHTYITHPGS--RLLFPTLCKPTATL-WTGDPPQVPIRERRGAMMPRR
Mvan_0728|M.vanbaalenii_PYR-1 PTGHTYTTHPGS--RLLFPTLCQPTATL-WTGEPPQVPQSQQRGAMMPRR
MSMEG_5106|M.smegmatis_MC2_155 PSGRQYTTVPGSHRRLSITELAAPTGALDLPATPIPTADPDLRGVKMPKR
Mb2126|M.bovis_AF2122/97 PNGHTYTTHPGS--RIFFPTWHTTTAEL--PQTSTAAVNVDARGLMMPRR
Rv2100|M.tuberculosis_H37Rv PNGHTYTTHPGS--RIFFPTWHTTTAEL--PQTSTAAVNVDARGLMMPRR
* * .
MMAR_5187|M.marinum_M QRTRAQDRARRVATERRQNHHARSTQP------------------GGQPR
MAV_4456|M.avium_104 RRTRGQNRAARVAAERRANRAARLARA------------------TRPAP
MUL_2679|M.ulcerans_Agy99 EATGSLRKPRRDDAQTRPNSRPKLGR------------------------
TH_0334|M.thermoresistible__bu RRPPSARGLREAVPRQGVDPRRVSGQ------------------------
MAB_4752|M.abscessus_ATCC_1997 HHTRQQARDRRRRTERNLNREQRLQRE------------------AALAA
Mflv_0179|M.gilvum_PYR-GCK AKTRAHSRAVYITAQRRRNAAER--------------------ADGPR--
Mvan_0728|M.vanbaalenii_PYR-1 RNTRAHNHAAYITAERRRNAQTRYATTGNTPPYLPRDHIPYQSSTGWREP
MSMEG_5106|M.smegmatis_MC2_155 RRTRAQNTARTIAAERQLNDDLVA--------------------------
Mb2126|M.bovis_AF2122/97 RRTRAAELAHRINAERALNDAYMAE-------------------------
Rv2100|M.tuberculosis_H37Rv RRTRAAELAHRINAERALNDAYMAE-------------------------
. .. :
MMAR_5187|M.marinum_M SAAPPTPPQSEPQSHPPPF
MAV_4456|M.avium_104 AASQSWPAGHGPDADPPPF
MUL_2679|M.ulcerans_Agy99 THCDRTQPQHD--------
TH_0334|M.thermoresistible__bu -------------------
MAB_4752|M.abscessus_ATCC_1997 LAAKDPPPF----------
Mflv_0179|M.gilvum_PYR-GCK --GNDPP-F----------
Mvan_0728|M.vanbaalenii_PYR-1 DYGNDPPPF----------
MSMEG_5106|M.smegmatis_MC2_155 -EHNKPPPF----------
Mb2126|M.bovis_AF2122/97 --RNKPPSF----------
Rv2100|M.tuberculosis_H37Rv --RNKPPSF----------