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FDVLVPDPADLAALSDAELLDAATATTRAENAVCARKLAVMAELFIRRTTLAPQDRLDWWVDPEAAVTAE LAAAHHITQGLATHQAYRAVVLRDRLPKIGALFLQGLLSELLVRAIITRTGLITDPDLIAAVDADLATDI LDWGPLSVKATEAEIDAIIDRHDPDAVRKSRAPETGRTVQFGNPGDAPGYTSMWARMYASDAAAADRTLT ALAYSVCDNDPRTLDERRNDAHTALLTGITTLACQCGNPDCHASTNPRPPRDITVYALTDHTTTTDTGDA DTTTDTKPPTPPAPQPRRSKPILIPGRPAYLFGAGFMPAPLFDALLAEATIREIIHPGNRSAPEPRYTPS QALAEFIRCRDLTCRFPGCDKPATEADIDHTVPYPIGPTHPSNLKCLCRFHHLLKTFWLGATGWHDRQHP DGTITWTAPTGHTYTTHPGSRLLFPTLCQPTATLWTGEPPQVPQSQQRGAMMPRRRNTRAHNHAAYITAE RRRNAQTRYATTGNTPPYLPRDHIPYQSSTGWREPDYGNDPPPF*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0728 | - | - | 100% (535) | hypothetical protein Mvan_0728 |
| M. vanbaalenii PYR-1 | Mvan_5774 | - | e-123 | 58.93% (375) | HNH endonuclease |
| M. vanbaalenii PYR-1 | Mvan_0426 | - | e-105 | 41.73% (532) | hypothetical protein Mvan_0426 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2126 | - | 1e-114 | 45.00% (520) | hypothetical protein Mb2126 |
| M. gilvum PYR-GCK | Mflv_1180 | - | 0.0 | 75.48% (518) | hypothetical protein Mflv_1180 |
| M. tuberculosis H37Rv | Rv2100 | - | 1e-114 | 45.00% (520) | hypothetical protein Rv2100 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4752 | - | 2e-65 | 36.70% (436) | hypothetical protein MAB_4752 |
| M. marinum M | MMAR_5187 | - | 1e-98 | 41.72% (513) | 13e12 repeat-containing protein |
| M. avium 104 | MAV_4456 | - | 1e-101 | 41.40% (541) | 13e12 repeat-containing protein |
| M. smegmatis MC2 155 | MSMEG_5106 | - | 1e-118 | 43.55% (581) | HNH endonuclease |
| M. thermoresistible (build 8) | TH_0334 | - | 2e-67 | 37.02% (389) | HNH endonuclease |
| M. ulcerans Agy99 | MUL_1813 | - | 7e-81 | 37.88% (499) | 13e12 repeat-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_5187|M.marinum_M ------------------------MFESMGVAAGVDHPCDALAERRQLRT
MAV_4456|M.avium_104 ------------------------------MCEDATAWFDELMER-CYPS
MUL_1813|M.ulcerans_Agy99 --------------------------------------------------
MAB_4752|M.abscessus_ATCC_1997 ------------------------------------------------MF
TH_0334|M.thermoresistible__bu ------------------------------------------------MF
Mvan_0728|M.vanbaalenii_PYR-1 --------------------------------------MFDVLVPDPADL
Mflv_1180|M.gilvum_PYR-GCK --------------------------------------MFDNLVPEPAAL
MSMEG_5106|M.smegmatis_MC2_155 --------------------------------------------MQIAEF
Mb2126|M.bovis_AF2122/97 MAGALFEPSFAAAHPAGLLRRPVTRTVVLSVAATSIAHMFEISLPDPTEL
Rv2100|M.tuberculosis_H37Rv MAGALFEPSFAAAHPAGLLRRPVTRTVVLSVAATSIAHMFEISLPDPTEL
MMAR_5187|M.marinum_M PTAESARWVQRIGAAARAENRAAAAQLIEIGQLFAYR--LSRCSETEDWA
MAV_4456|M.avium_104 ATPESAALVQRIGVFARVENRAAAEQLAAIGELFAYR--LSRCSECEDWA
MUL_1813|M.ulcerans_Agy99 --------MERAREASRREAAAAAERLDVVGALFVLR--CRESGDRAEWA
MAB_4752|M.abscessus_ATCC_1997 DELGDVELIDLIASAQRAEAQACARKLDAIGVLVDRHADLGKPDERDHHA
TH_0334|M.thermoresistible__bu ESLDDGAVVDSIAAASREQSAACGREMLAIGELYARR-APEDDTERANWA
Mvan_0728|M.vanbaalenii_PYR-1 AALSDAELLDAATATTRAENAVCARKLAVMAELFIRRTTLAPQD-RLDWW
Mflv_1180|M.gilvum_PYR-GCK AGLSDAELVDAAGAAARAENAVCARKLAVMAELFTRRVDLAPED-RLNWW
MSMEG_5106|M.smegmatis_MC2_155 SALSDLELEGQARGWAQAEASASAHKHAAMAEMFIRATSTPSADERRWWF
Mb2126|M.bovis_AF2122/97 CRSDDGALVAAIEDCARVEAAASARRLSAIAELTGRRTG---ADQRADWA
Rv2100|M.tuberculosis_H37Rv CRSDDGALVAAIEDCARVEAAASARRLSAIAELTGRRTG---ADQRADWA
: : ... . :. :
MMAR_5187|M.marinum_M VDTMEAVAAEVAAGLRISQGLAASRLRYARALRERLPKTGAVFAAGQIDL
MAV_4456|M.avium_104 VDTEAAVSAEVAAQLRIGQGLAAAKVRYARAMRERLPRVGEVFRAGEIDF
MUL_1813|M.ulcerans_Agy99 TDTWEAVGAQVAAALRTSVAMGSSYLRYAMAMRNRLPKVGQAFRAEDIDY
MAB_4752|M.abscessus_ATCC_1997 LDRWDRVASEVAAAQGITHALASSQMRYAQVLRHRLRAVAERFAAGDLDF
TH_0334|M.thermoresistible__bu IDGHANVVAEISAALNISRGRAAGRLQLAIDLRERLPRVAAVFAAGDIDF
Mvan_0728|M.vanbaalenii_PYR-1 VDPEAAVTAELAAAHHITQGLATHQAYRAVVLRDRLPKIGALFLQGLLSE
Mflv_1180|M.gilvum_PYR-GCK VDPDAAVAAEIAAAVTITQGLATHQTYRAVVLRDRLPKVGALFLAGLLSE
MSMEG_5106|M.smegmatis_MC2_155 VDPDAAVGAQLGAAQGITAWAALHQAQRGVALRDRLPKVNEVFAAGLVSE
Mb2126|M.bovis_AF2122/97 CDFWDCAAAEVAAALTISHGKASGQMHLSLALN-RLPQVAALFLAGHLGA
Rv2100|M.tuberculosis_H37Rv CDFWDCAAAEVAAALTISHGKASGQMHLSLALN-RLPQVAALFLAGHLGA
* . :::.* . . :. ** * :.
MMAR_5187|M.marinum_M RAFQTIVFRTDLIVDPQVMAAVDALVALNVGRWPSMTKARLSGQIDAIVA
MAV_4456|M.avium_104 RLFATIVYRTDLITDRRVLAAVDAELAATAARWPSMTRARLAARVDAVVA
MUL_1813|M.ulcerans_Agy99 RAFQTIVFRTDLITDAEVLAKVDAQLAALLARCPAVTRGRLSVAVDQVVA
MAB_4752|M.abscessus_ATCC_1997 RTVALIINRTELVDDEAVVARVDAAIVRALPRWARWSHKRITAALDALVL
TH_0334|M.thermoresistible__bu RMVSALVNRSRNVVDPDLLARLDAALAAWSPKWMKLSGPTLNERIDMWVE
Mvan_0728|M.vanbaalenii_PYR-1 LLVRAIITRTGLITDPDLIAAVDADLATDILDWGPLSVKATEAEIDAIID
Mflv_1180|M.gilvum_PYR-GCK LLVRAIITRTDLITDPELIAAVDADLAADILRWGPQSAKKTEAAIDHIVE
MSMEG_5106|M.smegmatis_MC2_155 MIVRNICWSTALMLEPDKLALIDAELAAQISGWGKLTLKEIDNTIDDLIL
Mb2126|M.bovis_AF2122/97 RLFSIIAWRTYLVRDPHALSLLDAALAEHAGAWGPLSAPKLEKAIDSWID
Rv2100|M.tuberculosis_H37Rv RLFSIIAWRTYLVRDPHALSLLDAALAEHAGAWGPLSAPKLEKAIDSWID
. : : : : :: :** :. : :* :
MMAR_5187|M.marinum_M RADADAVRRRKERHADREIWIGQDADG--ISRIDGSMFTIDAHALDRRLS
MAV_4456|M.avium_104 KADADAVRRTEKQAASRHVWIAEMGEG--LSHLEGTVSSPDAHALDKRLD
MUL_1813|M.ulcerans_Agy99 DVDRDVVRRVAEAADGRFVDVDVIADGSGLAALAGSVLATAGRAFDRRLD
MAB_4752|M.abscessus_ATCC_1997 HFDQDAVRRNRSATDKRHLEIRPLGNGEPVAEVWGTLQAVHAVALDKRLD
TH_0334|M.thermoresistible__bu RFDPTGVREPRSPGEDRYVVVTPAGQG--MVDVSARLTFEAGFAFXTRLD
Mvan_0728|M.vanbaalenii_PYR-1 RHDPDAVRKSRAPETGRTVQFGNPGDAPGYTSMWARMYASDAAAADRTLT
Mflv_1180|M.gilvum_PYR-GCK RHDPDAVRQSRAGDLDRAIEIGNPGDAPGYTTVWARMFAGDAAAGQRTLT
MSMEG_5106|M.smegmatis_MC2_155 KHDPASFRRGRASRRGRYFDIGSPTDAPGVLTVTGRLQAHLGNAYDARIA
Mb2126|M.bovis_AF2122/97 RYDPGALRRSRISARTRDLCIGDPDEDAGTAALWGRLYATDAAMLDRRLT
Rv2100|M.tuberculosis_H37Rv RYDPGALRRSRISARTRDLCIGDPDEDAGTAALWGRLYATDAAMLDRRLT
* .*. * . . : : . : . :
MMAR_5187|M.marinum_M ALAATVCAQDPRSREQRRADALGVLAAGGDRLGCRCGLPDC-AAGARPAA
MAV_4456|M.avium_104 ALAATVCEHDPRTGEQRRADALGALAAGADRLGCRCGRADC-AAGTRPAA
MUL_1813|M.ulcerans_Agy99 ELANTVCAADPRTREQRRADAVGALVAGSDRLACGCTSADC-TAAARSAP
MAB_4752|M.abscessus_ATCC_1997 LLAGTVCPADPRSKTQRRADAVGALTQGLNRMRCACGHPDC-SGRD-TAD
TH_0334|M.thermoresistible__bu QIAATVCRDDPRTADQRRADAMAAMSEGQNRLVCGCGSEDCPADPADTAA
Mvan_0728|M.vanbaalenii_PYR-1 ALAYSVCDNDPRTLDERRNDAHTALLTGITTLACQCGNPDCHAST-NPRP
Mflv_1180|M.gilvum_PYR-GCK AMAYSVCDNDPRTLDERRNDALTALFHGITTLACRCGHTDCDAAT-NPRP
MSMEG_5106|M.smegmatis_MC2_155 ELIEGVCPDDPRTLNELRHDALGAILD-QTTLACECEDPDCVRGR-EQSS
Mb2126|M.bovis_AF2122/97 EMAHGVCEDDPRTLAQRRADALGALAAGADHLACGCGKPDCPSGAGNDER
Rv2100|M.tuberculosis_H37Rv EMAHGVCEDDPRTLAQRRADALGALAAGADHLACGCGKPDCPSGAGNDER
: ** ***: : * ** .: : * * **
MMAR_5187|M.marinum_M QP-VVIHVIAERATLDG---------------------------------
MAV_4456|M.avium_104 GP-VVIHLIAERASVEG---------------------------------
MUL_1813|M.ulcerans_Agy99 SK-VVIHVVADQSTVDG---------------------------------
MAB_4752|M.abscessus_ATCC_1997 VP-VVVNVVINQSTLAG---------------------------------
TH_0334|M.thermoresistible__bu TR-LVINVIAEQATVEG---------------------------------
Mvan_0728|M.vanbaalenii_PYR-1 PRDITVYALTDHTTTT------------DTGDADTTT-DTKPPTPPAPQP
Mflv_1180|M.gilvum_PYR-GCK PRELTVYALTDQTTADSASEEPRG----DATDADASAGDAQPATPTAPKP
MSMEG_5106|M.smegmatis_MC2_155 RGHLVVHVIAREDTVTAAQHAATTTNTPDDAPSDTPAADTEPAEPAEPAE
Mb2126|M.bovis_AF2122/97 AAGVVIHVVADASALDAQPDPHLSG---DEPPSRPLTPETTLFEALTPDP
Rv2100|M.tuberculosis_H37Rv AAGVVIHVVADASALDAQPDPHLSG---DEPPSRPLTPETTLFEALTPDP
:.: : :
MMAR_5187|M.marinum_M DGGAP---------------------------------------------
MAV_4456|M.avium_104 TGGGP---------------------------------------------
MUL_1813|M.ulcerans_Agy99 TGHTP---------------------------------------------
MAB_4752|M.abscessus_ATCC_1997 SDDCP---------------------------------------------
TH_0334|M.thermoresistible__bu RSDNP---------------------------------------------
Mvan_0728|M.vanbaalenii_PYR-1 RRSKPILIPGR---------------------------------------
Mflv_1180|M.gilvum_PYR-GCK RRSKPTLLPGR---------------------------------------
MSMEG_5106|M.smegmatis_MC2_155 PVDDPDIAPAATATETATDTEPDAPAPTDTADSAATETDCDPESVSVTEF
Mb2126|M.bovis_AF2122/97 EPDPPATHAPA---------------------------------------
Rv2100|M.tuberculosis_H37Rv EPDPPATHAPA---------------------------------------
*
MMAR_5187|M.marinum_M ------------------------AWEVGADGLVTPELVAELAKSAKLVP
MAV_4456|M.avium_104 ------------------------AVEVGAEGLLPAQLVAELAASARLMP
MUL_1813|M.ulcerans_Agy99 ------------------------AVLLGAEGLIPASLIAELAKVATLRP
MAB_4752|M.abscessus_ATCC_1997 ------------------------AHVPGFG-----VLAAESARAAVAGT
TH_0334|M.thermoresistible__bu ------------------------GYLPGYG-AVPASILRAKAATATLRP
Mvan_0728|M.vanbaalenii_PYR-1 -----------------------PAYLFGAGFMPAPLFDALLAE-ATIRE
Mflv_1180|M.gilvum_PYR-GCK -----------------------SGYLFGSGFMSAPLFDALLDG-AKIRE
MSMEG_5106|M.smegmatis_MC2_155 TDNSSDTPAAFLDPDEHPLDRVPPAVLFGGGVLPAYALAEIINN-ATIRP
Mb2126|M.bovis_AF2122/97 -----------------------ELITTGGGVVPAPLLAELIRGGATISQ
Rv2100|M.tuberculosis_H37Rv -----------------------ELITTGGGVVPAPLLAELIRGGATISQ
* : *
MMAR_5187|M.marinum_M LRHPG-DVPPEPGYVPSKALADFVRCRDLTCRWPGCDHPALNCDLDHTIP
MAV_4456|M.avium_104 LVHPA-DAPPENRYTPSAALADFVRCRDLTCRWPGCDRPATECDLDHTIP
MUL_1813|M.ulcerans_Agy99 LMRPS-GRP-ESGYAPSAGLAEFVRCRDLTCRARGCDQPAVCCDLDHTVA
MAB_4752|M.abscessus_ATCC_1997 PTRNL-TDSRSTGYRPSAKLAAFVRSRDQLCRFPGCEAVADRADIDHTVP
TH_0334|M.thermoresistible__bu VALP--QPCAEAGYRPSAALTRFIRCRDLTCRFPGCDAPAAVCQIDHTIP
Mvan_0728|M.vanbaalenii_PYR-1 IIHPGNRSAPEPRYTPSQALAEFIRCRDLTCRFPGCDKPATEADIDHTVP
Mflv_1180|M.gilvum_PYR-GCK IIHPG-QAGPEPRYTPSTALADFIRCRDLTCRFPGCDTPATEADIDHTVA
MSMEG_5106|M.smegmatis_MC2_155 LKHPG-DTAPEDRYIPSRALADYVRCRDLTCRFPGCDKPADRCDLDHTVP
Mb2126|M.bovis_AF2122/97 VRHPG-DLAAEPHYRPSAKLAEFVRMRDLTCRFPGCDVPAEFCDIDHSAP
Rv2100|M.tuberculosis_H37Rv VRHPG-DLAAEPHYRPSAKLAEFVRMRDLTCRFPGCDVPAEFCDIDHSAP
. * ** *: ::* ** ** **: * .::**: .
MMAR_5187|M.marinum_M YAQGGPTHASNLKCYCRTHHLVKTFWG----WHDQQLPDGTLILTSPAGH
MAV_4456|M.avium_104 YAEGGPTHASNLKCYCRTHHLVKTFWG----WREQQLPDATLILTSPAGR
MUL_1813|M.ulcerans_Agy99 YGDGGHTHASNLKCLCRKHHLLKTFWG----WRDLQLPDGTVIWLLPDGH
MAB_4752|M.abscessus_ATCC_1997 WATGGPTTGANLKALCRKHHLLKTFGQ----WTELQEPDGTVIWKSPTGH
TH_0334|M.thermoresistible__bu YPAG-PTHPSNLKLLCVFHCRQAELRF----THDQHKHQSSCLPAYFQRP
Mvan_0728|M.vanbaalenii_PYR-1 YPIG-PTHPSNLKCLCRFHHLLKTFWLGATGWHDRQHPDGTITWTAPTGH
Mflv_1180|M.gilvum_PYR-GCK HPVG-PTHASNLKCLCRFHHLLKTFWTGPGGWHDRQHPDGTITWTSPTGH
MSMEG_5106|M.smegmatis_MC2_155 YPAG-PTHASNLKCLCRFHHLLKTFWTGPRGWTDRQHPDGTIVWTSPSGR
Mb2126|M.bovis_AF2122/97 WPLG-PTHPSNLKCACRKHHLLKTFWTG---WRDVQLPDGTVIWTAPNGH
Rv2100|M.tuberculosis_H37Rv WPLG-PTHPSNLKCACRKHHLLKTFWTG---WRDVQLPDGTVIWTAPNGH
* * :*** * * : : : :.:
MMAR_5187|M.marinum_M TYVTTPGS--ALLFPSLCHSTGGLPAAEADPP----------SDHCD---
MAV_4456|M.avium_104 TYVTTPGS--ALLFPSLCVPTG-EPARPVAAG----------SQPCG---
MUL_1813|M.ulcerans_Agy99 TYVTTPGS--ALLFPNLCVPTGELPPIVGTAGKPPRWPSGEDADPCPNPR
MAB_4752|M.abscessus_ATCC_1997 RYATTPVS--WFLFPALT--------------------------------
TH_0334|M.thermoresistible__bu HGPAT---------------------------------------------
Mvan_0728|M.vanbaalenii_PYR-1 TYTTHPGS--RLLFPTLCQPTATL-WTGEPPQVP----------------
Mflv_1180|M.gilvum_PYR-GCK TYITHPGS--RLLFPTLCKPTATL-WTGNPPQNP----------------
MSMEG_5106|M.smegmatis_MC2_155 QYTTVPGSHRRLSITELAAPTGALDLPATPIPTA----------------
Mb2126|M.bovis_AF2122/97 TYTTHPGS--RIFFPTWHTTTAEL--PQTSTAAV----------------
Rv2100|M.tuberculosis_H37Rv TYTTHPGS--RIFFPTWHTTTAEL--PQTSTAAV----------------
:
MMAR_5187|M.marinum_M --------QRSAMMP-----RRQRTR-------AQDRARRVATERRQNHH
MAV_4456|M.avium_104 --------ERTAMMP-----TRRRTR-------GQNRAARVAAERRANRA
MUL_1813|M.ulcerans_Agy99 TKPGESHRHRAPMQSQGTGSRRRRPRRPVRHPGAGNRSRRAAALLAATSL
MAB_4752|M.abscessus_ATCC_1997 ---------------------RHHTR-------QQARDRRRRTERNLNRE
TH_0334|M.thermoresistible__bu ---------------------RRPPS---------ARGLREAVPRQGVDP
Mvan_0728|M.vanbaalenii_PYR-1 -----QSQQRGAMMP-----RRRNTR-------AHNHAAYITAERRRNAQ
Mflv_1180|M.gilvum_PYR-GCK -----TNNNRGSMMP-----RRTRTR-------AQNRATYITAERTRNAA
MSMEG_5106|M.smegmatis_MC2_155 -----DPDLRGVKMP-----KRRRTR-------AQNTARTIAAERQLNDD
Mb2126|M.bovis_AF2122/97 -----NVDARGLMMP-----RRRRTR-------AAELAHRINAERALNDA
Rv2100|M.tuberculosis_H37Rv -----NVDARGLMMP-----RRRRTR-------AAELAHRINAERALNDA
* . .
MMAR_5187|M.marinum_M ARSTQPGGQPRSAAPPTPPQSEPQS-----------HPPPF---
MAV_4456|M.avium_104 ARLARATRPAPAASQSWPAGHGPDA-----------DPPPF---
MUL_1813|M.ulcerans_Agy99 GTCQIPRRIAPRPGPSRSSRGCTDSGTRMGESSMSARPRACVAG
MAB_4752|M.abscessus_ATCC_1997 QRLQREAALAALAAK---------------------DPPPF---
TH_0334|M.thermoresistible__bu RRVSGQ--------------------------------------
Mvan_0728|M.vanbaalenii_PYR-1 TRYATTGNTPPYLPRDHIPYQSSTG---WREPDYGNDPPPF---
Mflv_1180|M.gilvum_PYR-GCK HRTDSPR---------------------------GNDPPPF---
MSMEG_5106|M.smegmatis_MC2_155 LVAEHNK------------------------------PPPF---
Mb2126|M.bovis_AF2122/97 YMAERNK------------------------------PPSF---
Rv2100|M.tuberculosis_H37Rv YMAERNK------------------------------PPSF---