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MFDSLVPEPGALAGLSDAELVDAAGAAARAENAVCARKLAVMAELFTRRVDLAPEDRLNWWVDPDAAVAA EIAAAVTITQGLATHQTYRAVVLRDRLPKVGALFLAGLLSELLVRAIITRTDLITDPELIAAVDADLAAD ILRWGPQSAKKTEAAIDHIVERHDPDAVRQSRQHDVGRTIEIGNPGDAPGYTTVWARMFAGDAAAGHRTL TTMAYSVCDNDPRTLDERRNDALTALFHGITTLACRCGHTDCDAATNPRPPRELTVYALTDQTAANAASE EPRGDATDADAGAVDAQPATPPVKPRRSKPTLLPGRSGYLFGSGFMPAPLFDALLDGAKIREILHPGQAG PEPRYTPSTALADFIRCRDLTCRFPGCDTPATEADIDHTVAHPVGPTHASNLKCLCRFHHLLKTFWTGPG GWHDRQDPDGTITWTAPTGHTYITHPGSRLLFPTLCKPTATLWAGDPPQVPIRERRGAMMPRRAKTRAQN RAAYITAERTHNVEHRTDSPRGNDPPF
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4099 | - | - | 100% (517) | hypothetical protein Mflv_4099 |
| M. gilvum PYR-GCK | Mflv_1180 | - | 0.0 | 93.23% (517) | hypothetical protein Mflv_1180 |
| M. gilvum PYR-GCK | Mflv_0179 | - | 0.0 | 90.72% (528) | hypothetical protein Mflv_0179 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3805 | - | 1e-111 | 44.77% (516) | hypothetical protein Mb3805 |
| M. tuberculosis H37Rv | Rv3776 | - | 1e-111 | 44.77% (516) | hypothetical protein Rv3776 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4752 | - | 5e-69 | 38.20% (445) | hypothetical protein MAB_4752 |
| M. marinum M | MMAR_5187 | - | 1e-101 | 43.57% (498) | 13e12 repeat-containing protein |
| M. avium 104 | MAV_4456 | - | 1e-100 | 42.49% (506) | 13e12 repeat-containing protein |
| M. smegmatis MC2 155 | MSMEG_0144 | - | 1e-115 | 41.78% (596) | HNH endonuclease |
| M. thermoresistible (build 8) | TH_0334 | - | 3e-66 | 37.47% (395) | HNH endonuclease |
| M. ulcerans Agy99 | MUL_2679 | - | 2e-81 | 39.79% (470) | 13e12 repeat-containing protein |
| M. vanbaalenii PYR-1 | Mvan_0728 | - | 0.0 | 74.76% (519) | hypothetical protein Mvan_0728 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_5187|M.marinum_M ----------------MFESMGVAAGVDHPCDALAERRQLRTPTAESARW
MAV_4456|M.avium_104 ----------------------MCEDATAWFDELMER-CYPSATPESAAL
MUL_2679|M.ulcerans_Agy99 ------------------------------MDQHIIEYVFDT---DDSAP
TH_0334|M.thermoresistible__bu --------------------------------------MFES--LDDGAV
MAB_4752|M.abscessus_ATCC_1997 --------------------------------------MFDE--LGDVEL
Mflv_4099|M.gilvum_PYR-GCK ------------------------------MFDSLVPEPGALAGLSDAEL
Mvan_0728|M.vanbaalenii_PYR-1 ------------------------------MFDVLVPDPADLAALSDAEL
MSMEG_0144|M.smegmatis_MC2_155 MSWGYPQTRVHPQIAVLRCRGGFTVGRFERMYEGLLVQIAEFSALSDLEL
Mb3805|M.bovis_AF2122/97 ------------------------------MFEISLSDPVELRDADDAAL
Rv3776|M.tuberculosis_H37Rv ------------------------------MFEISLSDPVELRDADDAAL
.
MMAR_5187|M.marinum_M VQRIGAAARAENRAAAAQLIEIGQLFAYRLSR--CSETEDWAVDTMEAVA
MAV_4456|M.avium_104 VQRIGVFARVENRAAAEQLAAIGELFAYRLSR--CSECEDWAVDTEAAVS
MUL_2679|M.ulcerans_Agy99 LTRITAAARAEARAAAERLAAIGDLFRLRLSQ--HGNREDWVADTCDAVA
TH_0334|M.thermoresistible__bu VDSIAAASREQSAACGREMLAIGELYARRAPED-DTERANWAIDGHANVV
MAB_4752|M.abscessus_ATCC_1997 IDLIASAQRAEAQACARKLDAIGVLVDRHADLGKPDERDHHALDRWDRVA
Mflv_4099|M.gilvum_PYR-GCK VDAAGAAARAENAVCARKLAVMAELFTRRVDLAPED-RLNWWVDPDAAVA
Mvan_0728|M.vanbaalenii_PYR-1 LDAATATTRAENAVCARKLAVMAELFIRRTTLAPQD-RLDWWVDPEAAVT
MSMEG_0144|M.smegmatis_MC2_155 EGQARGWAQAEASASAHKHAAMAELFIRATSTPSADERRWWFVDPDAAVG
Mb3805|M.bovis_AF2122/97 LAAIEDCARAEVAAGARRLSAIAELTSRRTG---NDQRADWACDGWDCAA
Rv3776|M.tuberculosis_H37Rv LAAIEDCARAEVAAGARRLSAIAELTSRRTG---NDQRADWACDGWDCAA
: : . . . :. * * .
MMAR_5187|M.marinum_M AEVAAGLRISQGLAASRLRYARALRERLPKTGAVFAAGQIDLRAFQTIVF
MAV_4456|M.avium_104 AEVAAQLRIGQGLAAAKVRYARAMRERLPRVGEVFRAGEIDFRLFATIVY
MUL_2679|M.ulcerans_Agy99 AEVAAALNTSVAMGHSNLRYARAMRERLPQLGAEFRAGGIDFRLFRTIVF
TH_0334|M.thermoresistible__bu AEISAALNISRGRAAGRLQLAIDLRERLPRVAAVFAAGDIDFRMVSALVN
MAB_4752|M.abscessus_ATCC_1997 SEVAAAQGITHALASSQMRYAQVLRHRLRAVAERFAAGDLDFRTVALIIN
Mflv_4099|M.gilvum_PYR-GCK AEIAAAVTITQGLATHQTYRAVVLRDRLPKVGALFLAGLLSELLVRAIIT
Mvan_0728|M.vanbaalenii_PYR-1 AELAAAHHITQGLATHQAYRAVVLRDRLPKIGALFLQGLLSELLVRAIIT
MSMEG_0144|M.smegmatis_MC2_155 AQLGAAQGITAWAALHQAQRGVALRDRLPKVNEVFAAGLVSEMIVRNICW
Mb3805|M.bovis_AF2122/97 AEVAAALTVSHRKASGQMHLSLTLN-RLPQVAALFLAGQLSARLVSIIAW
Rv3776|M.tuberculosis_H37Rv AEVAAALTVSHRKASGQMHLSLTLN-RLPQVAALFLAGQLSARLVSIIAW
:::.* . . . :. ** * * :. . :
MMAR_5187|M.marinum_M RTDLIVDPQVMAAVDALVALNVGRWPSMTKARLSGQIDAIVARADADAVR
MAV_4456|M.avium_104 RTDLITDRRVLAAVDAELAATAARWPSMTRARLAARVDAVVAKADADAVR
MUL_2679|M.ulcerans_Agy99 RTDLITESDALAAVDARLAIKAPRWPSMTSWKLATEVDRVVAKFDRDAVR
TH_0334|M.thermoresistible__bu RSRNVVDPDLLARLDAALAAWSPKWMKLSGPTLNERIDMWVERFDPTGVR
MAB_4752|M.abscessus_ATCC_1997 RTELVDDEAVVARVDAAIVRALPRWARWSHKRITAALDALVLHFDQDAVR
Mflv_4099|M.gilvum_PYR-GCK RTDLITDPELIAAVDADLAADILRWGPQSAKKTEAAIDHIVERHDPDAVR
Mvan_0728|M.vanbaalenii_PYR-1 RTGLITDPDLIAAVDADLATDILDWGPLSVKATEAEIDAIIDRHDPDAVR
MSMEG_0144|M.smegmatis_MC2_155 STALMLEPDKLALIDAELAAQISGWGKLTLKEIDNTIDDLILKHDPGSFR
Mb3805|M.bovis_AF2122/97 RTYLVRDPEALSLLDAALAKHATAWGPLSAPKLEKAIDSWIDRYDPAALR
Rv3776|M.tuberculosis_H37Rv RTYLVRDPEALSLLDAALAKHATAWGPLSAPKLEKAIDSWIDRYDPAALR
: : : :: :** :. * : :* : : * ..*
MMAR_5187|M.marinum_M RRKERHADREIWIGQDADG--ISRIDGSMFTIDAHALDRRLSALAATVCA
MAV_4456|M.avium_104 RTEKQAASRHVWIAEMGEG--LSHLEGTVSSPDAHALDKRLDALAATVCE
MUL_2679|M.ulcerans_Agy99 RSRRDAADRYVDCAPLEPG--MALVNRQVFSATAEALARRLDELAKTVCA
TH_0334|M.thermoresistible__bu EPRSPGEDRYVVVTPAGQG--MVDVSARLTFEAGFAFXTRLDQIAATVCR
MAB_4752|M.abscessus_ATCC_1997 RNRSATDKRHLEIRPLGNGEPVAEVWGTLQAVHAVALDKRLDLLAGTVCP
Mflv_4099|M.gilvum_PYR-GCK QSRQHDVGRTIEIGNPGDAPGYTTVWARMFAGDAAAGHRTLTTMAYSVCD
Mvan_0728|M.vanbaalenii_PYR-1 KSRAPETGRTVQFGNPGDAPGYTSMWARMYASDAAAADRTLTALAYSVCD
MSMEG_0144|M.smegmatis_MC2_155 RGRASRRGRYFDIGSPTDAPGVLTVTGRLQAHLGNAYDARIAELIEGVCP
Mb3805|M.bovis_AF2122/97 RTRISARSRDLCIGDPDEDAGTAALWGRLFATDAAMLDKRLTQLAHGVCD
Rv3776|M.tuberculosis_H37Rv RTRISARSRDLCIGDPDEDAGTAALWGRLFATDAAMLDKRLTQLAHGVCD
. . * . : : . : : **
MMAR_5187|M.marinum_M QDPRSREQRRADALGVLAAGGDRLGCRCGLPDC-AAGARPA---------
MAV_4456|M.avium_104 HDPRTGEQRRADALGALAAGADRLGCRCGRADC-AAGTRPA---------
MUL_2679|M.ulcerans_Agy99 DDPRTVVQRRADALGTLAAGQDRLICDCGRTDCPAAGAPQQ---------
TH_0334|M.thermoresistible__bu DDPRTADQRRADAMAAMSEGQNRLVCGCGSEDCPADPADTA---------
MAB_4752|M.abscessus_ATCC_1997 ADPRSKTQRRADAVGALTQGLNRMRCACGHPDC--SGRDTA---------
Mflv_4099|M.gilvum_PYR-GCK NDPRTLDERRNDALTALFHGITTLACRCGHTDCDAATNPRP---------
Mvan_0728|M.vanbaalenii_PYR-1 NDPRTLDERRNDAHTALLTGITTLACQCGNPDCHASTNPRP---------
MSMEG_0144|M.smegmatis_MC2_155 DDPRTLNELRHDALGAILD-HTTLACECEDPDCVRGREQSPRGHLVVHVI
Mb3805|M.bovis_AF2122/97 DDPRTIAQRRADALGALAAGADRLTCGCGNSDCPSSAGNHR--------Q
Rv3776|M.tuberculosis_H37Rv DDPRTIAQRRADALGALAAGADRLTCGCGNSDCPSSAGNHR--------Q
***: : * ** .: : * * **
MMAR_5187|M.marinum_M AQPVVIHVIAERATLD----------------------------------
MAV_4456|M.avium_104 AGPVVIHLIAERASVE----------------------------------
MUL_2679|M.ulcerans_Agy99 PSRVVIHVVAGCQTVD----------------------------------
TH_0334|M.thermoresistible__bu ATRLVINVIAEQATVE----------------------------------
MAB_4752|M.abscessus_ATCC_1997 DVPVVVNVVINQSTLA----------------------------------
Mflv_4099|M.gilvum_PYR-GCK PRELTVYALTDQTAANAASEEPRGDATDADAG-------------AVDAQ
Mvan_0728|M.vanbaalenii_PYR-1 PRDITVYALTDHTTT--------TDTGDADT--------------TTDTK
MSMEG_0144|M.smegmatis_MC2_155 AREDTVTAAQHAATTTNTPDDAPADTPAADTEPAEPAEPAEPAEPAEPAE
Mb3805|M.bovis_AF2122/97 ATGVVIHVVADAAALG----------AAPDPR----------------LS
Rv3776|M.tuberculosis_H37Rv ATGVVIHVVADAAALG----------AAPDPR----------------LS
.: :
MMAR_5187|M.marinum_M --------GDGGAPAWEVGA------------------------------
MAV_4456|M.avium_104 --------GTGGGPAVEVGA------------------------------
MUL_2679|M.ulcerans_Agy99 --------GAGEAPGVLPG-------------------------------
TH_0334|M.thermoresistible__bu --------GRSDNPGYLPG-------------------------------
MAB_4752|M.abscessus_ATCC_1997 --------GSDDCPAHVPG-------------------------------
Mflv_4099|M.gilvum_PYR-GCK PATPPVK-PRRSKPTLLPGR------------------------------
Mvan_0728|M.vanbaalenii_PYR-1 PPTPPAPQPRRSKPILIPGR------------------------------
MSMEG_0144|M.smegmatis_MC2_155 PAEPAEPVEPVDDPDIAPAASATETATDTTASPTGTDCDPESVSVTEFTD
Mb3805|M.bovis_AF2122/97 GPEPALAPEAPATPAVKPPA------------------------------
Rv3776|M.tuberculosis_H37Rv GPEPALAPEAPATPAVKPPA------------------------------
*
MMAR_5187|M.marinum_M ---------------------------DGLVTPELVAELAKS-AKLVPLR
MAV_4456|M.avium_104 ---------------------------EGLLPAQLVAELAAS-ARLMPLV
MUL_2679|M.ulcerans_Agy99 ---------------------------DGIIPAEIVRELAKS-AKLQPMS
TH_0334|M.thermoresistible__bu ---------------------------YGAVPASILRAKAAT-ATLRPVA
MAB_4752|M.abscessus_ATCC_1997 ---------------------------FGVLAAESARAAVAG-TPTRNLT
Mflv_4099|M.gilvum_PYR-GCK ---------------------SGYLFGSGFMPAPLFDALLDG-AKIREIL
Mvan_0728|M.vanbaalenii_PYR-1 ---------------------PAYLFGAGFMPAPLFDALLAE-ATIREII
MSMEG_0144|M.smegmatis_MC2_155 NSSDTPSAFLDPDEHPLDRVPPAVLFGGGVLPAYALAEIINN-ATIRPLK
Mb3805|M.bovis_AF2122/97 ----------------------ALISGGGVVPAPLLAELIRGGAALSRVR
Rv3776|M.tuberculosis_H37Rv ----------------------ALISGGGVVPAPLLAELIRGGAALSRMR
* :.. : :
MMAR_5187|M.marinum_M HPG-DVPPEPGYVPSKALADFVRCRDLTCRWPGCDHPALNCDLDHTIPYA
MAV_4456|M.avium_104 HPA-DAPPENRYTPSAALADFVRCRDLTCRWPGCDRPATECDLDHTIPYA
MUL_2679|M.ulcerans_Agy99 TP---ILAETGYVPSPALMDFVRARDLTCRAPGCDRPATQCDVDHTIPYS
TH_0334|M.thermoresistible__bu LP--QPCAEAGYRPSAALTRFIRCRDLTCRFPGCDAPAAVCQIDHTIPYP
MAB_4752|M.abscessus_ATCC_1997 DS-----RSTGYRPSAKLAAFVRSRDQLCRFPGCEAVADRADIDHTVPWA
Mflv_4099|M.gilvum_PYR-GCK HPG-QAGPEPRYTPSTALADFIRCRDLTCRFPGCDTPATEADIDHTVAHP
Mvan_0728|M.vanbaalenii_PYR-1 HPGNRSAPEPRYTPSQALAEFIRCRDLTCRFPGCDKPATEADIDHTVPYP
MSMEG_0144|M.smegmatis_MC2_155 HPG-DTAPEDRYIPSRALADYVRCRDLTCRFPGCDKPADRCDLDHTVPYP
Mb3805|M.bovis_AF2122/97 HPG-DLRSEPHYRPSAKLAEFVRIRDMTCRFPGCDQPTEFCDIDHTLPYP
Rv3776|M.tuberculosis_H37Rv HPG-DLRSEPHYRPSAKLAEFVRIRDMTCRFPGCDQPTEFCDIDHTLPYP
. . * ** * ::* ** ** ***: : .::***:. .
MMAR_5187|M.marinum_M QGGPTHASNLKCYCRTHHLVKTFWG----WHDQQLPDGTLILTSPAGHTY
MAV_4456|M.avium_104 EGGPTHASNLKCYCRTHHLVKTFWG----WREQQLPDATLILTSPAGRTY
MUL_2679|M.ulcerans_Agy99 DGGATHPSNLKCLCRKHHLLKTFWG----WHDEQLPDATVIWSLPDGQTY
TH_0334|M.thermoresistible__bu AG-PTHPSNLKLLCVFHCRQAELRF----THDQHKHQSSCLP------AY
MAB_4752|M.abscessus_ATCC_1997 TGGPTTGANLKALCRKHHLLKTFGQ----WTELQEPDGTVIWKSPTGHRY
Mflv_4099|M.gilvum_PYR-GCK VG-PTHASNLKCLCRFHHLLKTFWTGPGGWHDRQDPDGTITWTAPTGHTY
Mvan_0728|M.vanbaalenii_PYR-1 IG-PTHPSNLKCLCRFHHLLKTFWLGATGWHDRQHPDGTITWTAPTGHTY
MSMEG_0144|M.smegmatis_MC2_155 AG-PTHASNLKCLCRFHHLLKTFWTGPRGWTDRQHPDGTIVWTSPSGRQY
Mb3805|M.bovis_AF2122/97 LG-PTHPSNLKCLCRKHHLLKTFWTG---WRDVQLPDGTIIWTAPNGHTY
Rv3776|M.tuberculosis_H37Rv LG-PTHPSNLKCLCRKHHLLKTFWTG---WRDVQLPDGTIIWTAPNGHTY
* .* :*** * * : : : :.: *
MMAR_5187|M.marinum_M VTTPGSA--LLFPSLCHSTGGLPAAEADPPSDHCDQRSAMMPRRQRTRAQ
MAV_4456|M.avium_104 VTTPGSA--LLFPSLCVPTG-EPARPVAAGSQPCGERTAMMPTRRRTRGQ
MUL_2679|M.ulcerans_Agy99 VTTPGSA--WLLPGLFAPSPELPPP----------------PRSEATGSL
TH_0334|M.thermoresistible__bu FQRPHG-----------------------------------PATRRPPSA
MAB_4752|M.abscessus_ATCC_1997 ATTPVSW--FLFPAL---------------------------TRHHTRQQ
Mflv_4099|M.gilvum_PYR-GCK ITHPGS--RLLFPTLCKPTATL-WAGDPPQVPIRERRGAMMPRRAKTRAQ
Mvan_0728|M.vanbaalenii_PYR-1 TTHPGS--RLLFPTLCQPTATL-WTGEPPQVPQSQQRGAMMPRRRNTRAH
MSMEG_0144|M.smegmatis_MC2_155 TTVPGSHRRLSITELAAPTGALDLPATPIPTADPDLRGVKMPKRRRTRAQ
Mb3805|M.bovis_AF2122/97 TTHPDS--RIFLPSWHTTTAAL--PPAPSPPAIGPTHTLLMPRRRRTRAA
Rv3776|M.tuberculosis_H37Rv TTHPDS--RIFLPSWHTTTAAL--PPAPSPPAIGPTHTLLMPRRRRTRAA
* . .
MMAR_5187|M.marinum_M DRARRVATERRQNHHARSTQP------------------GGQPRSAAPPT
MAV_4456|M.avium_104 NRAARVAAERRANRAARLARA------------------TRPAPAASQSW
MUL_2679|M.ulcerans_Agy99 RKPRRDDAQTRPNSRPKLGR------------------------THCDRT
TH_0334|M.thermoresistible__bu RGLREAVPRQGVDPRRVSGQ------------------------------
MAB_4752|M.abscessus_ATCC_1997 ARDRRRRTERNLNREQRLQRE------------------AALAALAAKDP
Mflv_4099|M.gilvum_PYR-GCK NRAAYITAERTHNVEHRTDS--------PR----------------GNDP
Mvan_0728|M.vanbaalenii_PYR-1 NHAAYITAERRRNAQTRYATTGNTPPYLPRDHIPYQSSTGWREPDYGNDP
MSMEG_0144|M.smegmatis_MC2_155 NTARTIAAERKLNDDLVAEH---------------------------NKP
Mb3805|M.bovis_AF2122/97 ELAHRIKRERAHVTQRNKPP----------------PSGGDTAVAEGFEP
Rv3776|M.tuberculosis_H37Rv ELAHRIKRERAHVTQRNKPP----------------PSGGDTAVAEGFEP
.
MMAR_5187|M.marinum_M PPQSEPQSHPPPF-
MAV_4456|M.avium_104 PAGHGPDADPPPF-
MUL_2679|M.ulcerans_Agy99 QPQHD---------
TH_0334|M.thermoresistible__bu --------------
MAB_4752|M.abscessus_ATCC_1997 PPF-----------
Mflv_4099|M.gilvum_PYR-GCK P-F-----------
Mvan_0728|M.vanbaalenii_PYR-1 PPF-----------
MSMEG_0144|M.smegmatis_MC2_155 PPF-----------
Mb3805|M.bovis_AF2122/97 PDGVSRLSLSRRVH
Rv3776|M.tuberculosis_H37Rv PDGVSRLSLSRRVH