For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MAGALFEPSFAAAHPAGLLRRPVTRTVVLSVAATSIAHMFEISLPDPTELCRSDDGALVAAIEDCARVEA AASARRLSAIAELTGRRTGADQRADWACDFWDCAAAEVAAALTISHGKASGQMHLSLALNRLPQVAALFL AGHLGARLFSIIAWRTYLVRDPHALSLLDAALAEHAGAWGPLSAPKLEKAIDSWIDRYDPGALRRSRISA RTRDLCIGDPDEDAGTAALWGRLYATDAAMLDRRLTEMAHGVCEDDPRTLAQRRADALGALAAGADHLAC GCGKPDCPSGAGNDERAAGVVIHVVADASALDAQPDPHLSGDEPPSRPLTPETTLFEALTPDPEPDPPAT HAPAELITTGGGVVPAPLLAELIRGGATISQVRHPGDLAAEPHYRPSAKLAEFVRMRDLTCRFPGCDVPA EFCDIDHSAPWPLGPTHPSNLKCACRKHHLLKTFWTGWRDVQLPDGTVIWTAPNGHTYTTHPGSRIFFPT WHTTTAELPQTSTAAVNVDARGLMMPRRRRTRAAELAHRINAERALNDAYMAERNKPPSF
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2100 | - | - | 100% (550) | hypothetical protein Rv2100 |
| M. tuberculosis H37Rv | Rv3776 | - | 0.0 | 77.65% (510) | hypothetical protein Rv3776 |
| M. tuberculosis H37Rv | Rv0515 | - | 1e-96 | 41.33% (513) | 13E12 repeat family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2126 | - | 0.0 | 100.00% (550) | hypothetical protein Mb2126 |
| M. gilvum PYR-GCK | Mflv_5065 | - | 1e-119 | 47.47% (495) | hypothetical protein Mflv_5065 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4752 | - | 3e-72 | 38.80% (500) | hypothetical protein MAB_4752 |
| M. marinum M | MMAR_5187 | - | 2e-95 | 42.98% (484) | 13e12 repeat-containing protein |
| M. avium 104 | MAV_3457 | - | 8e-97 | 43.50% (508) | 13e12 repeat-containing protein |
| M. smegmatis MC2 155 | MSMEG_3957 | - | 1e-133 | 48.18% (521) | 13e12 repeat-containing protein |
| M. thermoresistible (build 8) | TH_0334 | - | 2e-68 | 39.70% (398) | HNH endonuclease |
| M. ulcerans Agy99 | MUL_2679 | - | 4e-85 | 42.44% (450) | 13e12 repeat-containing protein |
| M. vanbaalenii PYR-1 | Mvan_3176 | - | 1e-118 | 44.65% (551) | hypothetical protein Mvan_3176 |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2100|M.tuberculosis_H37Rv MAGALFEPSFAAAHPAGLLRRPVTRTVVLSVAATSIAHMFEISLPDPT-E
Mb2126|M.bovis_AF2122/97 MAGALFEPSFAAAHPAGLLRRPVTRTVVLSVAATSIAHMFEISLPDPT-E
MSMEG_3957|M.smegmatis_MC2_155 --------------------------------------MCET--------
Mflv_5065|M.gilvum_PYR-GCK --------------------------------------MFDTMHRG----
Mvan_3176|M.vanbaalenii_PYR-1 --------------------------------------MFGSVFAG----
MAB_4752|M.abscessus_ATCC_1997 --------------------------------------MFDE--------
MAV_3457|M.avium_104 ----------------------------------MVEHMFEYVVAS----
MUL_2679|M.ulcerans_Agy99 ----------------------------------MDQHIIEYVFDT----
MMAR_5187|M.marinum_M -------------------------MFESMGVAAGVDHPCDALAERRQLR
TH_0334|M.thermoresistible__bu --------------------------------------MFES--------
Rv2100|M.tuberculosis_H37Rv LCRSDDGALVAAIEDCARVEAAASARRLSAIAELTGRRTG---ADQRADW
Mb2126|M.bovis_AF2122/97 LCRSDDGALVAAIEDCARVEAAASARRLSAIAELTGRRTG---ADQRADW
MSMEG_3957|M.smegmatis_MC2_155 ---LDDAALIAGIAGESRAESAAAARRFAFIAEFVDRRTADS-EDTVVWW
Mflv_5065|M.gilvum_PYR-GCK ---LGEADLLAAIEQAAREEAQAGARRLAAIAELVDLTVDE--DDERGMW
Mvan_3176|M.vanbaalenii_PYR-1 ---LDESALIAVIEQCAREEAQAGARKSAAIAALVYECVTF--DDVRDGW
MAB_4752|M.abscessus_ATCC_1997 ---LGDVELIDLIASAQRAEAQACARKLDAIGVLVDRHADLGKPDERDHH
MAV_3457|M.avium_104 RSTPEAVALLDRAREAARAEARAAAARLVAVAELLVLRCRE--TGERADW
MUL_2679|M.ulcerans_Agy99 DDS----APLTRITAAARAEARAAAERLAAIGDLFRLRLSQ--HGNREDW
MMAR_5187|M.marinum_M TPTAESARWVQRIGAAARAENRAAAAQLIEIGQLFAYRLSR--CSETEDW
TH_0334|M.thermoresistible__bu ---LDDGAVVDSIAAASREQSAACGREMLAIGELYARRAPED-DTERANW
: * : * . . :. :
Rv2100|M.tuberculosis_H37Rv ACDFWDCAAAEVAAALTISHGKASGQMHLSLALN-RLPQVAALFLAGHLG
Mb2126|M.bovis_AF2122/97 ACDFWDCAAAEVAAALTISHGKASGQMHLSLALN-RLPQVAALFLAGHLG
MSMEG_3957|M.smegmatis_MC2_155 ACDDWDAASAEVAAALNIGQRSASRLMRIAVALRDRLPLVAAQFAEGAVS
Mflv_5065|M.gilvum_PYR-GCK AFDPWKNAACHIGAALSISERRASAQMCIATALRYRLPQIAALYVQGRLS
Mvan_3176|M.vanbaalenii_PYR-1 VWDSWAATACELGAALNMGHKRASGQMRIAVALRDRLPRVAALHAQGRLS
MAB_4752|M.abscessus_ATCC_1997 ALDRWDRVASEVAAAQGITHALASSQMRYAQVLRHRLRAVAERFAAGDLD
MAV_3457|M.avium_104 AADAWEAVAAQVGAALGCSVAMGHSYLRYAMAMRERLPQVGAVFAAGGID
MUL_2679|M.ulcerans_Agy99 VADTCDAVAAEVAAALNTSVAMGHSNLRYARAMRERLPQLGAEFRAGGID
MMAR_5187|M.marinum_M AVDTMEAVAAEVAAGLRISQGLAASRLRYARALRERLPKTGAVFAAGQID
TH_0334|M.thermoresistible__bu AIDGHANVVAEISAALNISRGRAAGRLQLAIDLRERLPRVAAVFAAGDID
. * . ..:.*. . : : :. ** . . * :.
Rv2100|M.tuberculosis_H37Rv ARLFSIIAWRTYLVRDPHALSLLDAALAEHAGAWGPLSAPKLEKAIDSWI
Mb2126|M.bovis_AF2122/97 ARLFSIIAWRTYLVRDPHALSLLDAALAEHAGAWGPLSAPKLEKAIDSWI
MSMEG_3957|M.smegmatis_MC2_155 TRVVETLTWRTRLIDDTQTMAAVDAQLASRIAEFGAMTIAELEGAVDKVV
Mflv_5065|M.gilvum_PYR-GCK TRLISEITWRTGLVAD-DVIATVDAALAGKAEKWGPLSEDKLIDAINTVI
Mvan_3176|M.vanbaalenii_PYR-1 ARLIGQVTWRTRLVQDPHLLALVDAEMAEKALRWEALSDDKLTAALDAVI
MAB_4752|M.abscessus_ATCC_1997 FRTVALIINRTELVDDEAVVARVDAAIVRALPRWARWSHKRITAALDALV
MAV_3457|M.avium_104 YRAFQTLVFRTDLITDAQVLARVDATLAVLVSRRPSLTRGGLAAAVDRVV
MUL_2679|M.ulcerans_Agy99 FRLFRTIVFRTDLITESDALAAVDARLAIKAPRWPSMTSWKLATEVDRVV
MMAR_5187|M.marinum_M LRAFQTIVFRTDLIVDPQVMAAVDALVALNVGRWPSMTKARLSGQIDAIV
TH_0334|M.thermoresistible__bu FRMVSALVNRSRNVVDPDLLARLDAALAAWSPKWMKLSGPTLNERIDMWV
* . : *: : : :: :** :. : : :: :
Rv2100|M.tuberculosis_H37Rv DRYDPGALRRSRISARTRDLCIGDPDEDAGTAALWGRLYATDAAMLDRRL
Mb2126|M.bovis_AF2122/97 DRYDPGALRRSRISARTRDLCIGDPDEDAGTAALWGRLYATDAAMLDRRL
MSMEG_3957|M.smegmatis_MC2_155 DSVDPAAVRRTRTAVRSRGVWFGHPDDETGITSVHARLTNVDAVALKNRV
Mflv_5065|M.gilvum_PYR-GCK ARHDPDAVRRTKEALKKRDVHIGAHEDTDDVTTIWGLLLPPDAAAYTARI
Mvan_3176|M.vanbaalenii_PYR-1 ERYDPDAVIRAREVVKGRDFHIGASDDPDALVTVWGKILGCDAAVLAARI
MAB_4752|M.abscessus_ATCC_1997 LHFDQDAVRRNRSATDKRHLEIRPLGNGEPVAEVWGTLQAVHAVALDKRL
MAV_3457|M.avium_104 AAVDADAVRRARDAVTGRYLDVRANES--GMAWVEGNVLGPDGHALDRRL
MUL_2679|M.ulcerans_Agy99 AKFDRDAVRRSRRDAADRYVDCAPLEP--GMALVNRQVFSATAEALARRL
MMAR_5187|M.marinum_M ARADADAVRRRKERHADREIWIGQDAD--GISRIDGSMFTIDAHALDRRL
TH_0334|M.thermoresistible__bu ERFDPTGVREPRSPGEDRYVVVTPAGQ--GMVDVSARLTFEAGFAFXTRL
* .: . : * . : : . *:
Rv2100|M.tuberculosis_H37Rv TEMAHGVCEDDPRTLAQRRADALGALAAGADHLACGCGKPDCPSGAGNDE
Mb2126|M.bovis_AF2122/97 TEMAHGVCEDDPRTLAQRRADALGALAAGADHLACGCGKPDCPSGAGNDE
MSMEG_3957|M.smegmatis_MC2_155 GAMSSGQCPDDPRTKGQRLSDAMGVLGHYGDRLTCRCGDPECP-AAGIDP
Mflv_5065|M.gilvum_PYR-GCK AALVKGLCDADPRSAGERRSDAMGAIGRGENQLACRCGSPNCTASGP---
Mvan_3176|M.vanbaalenii_PYR-1 AALLKGICDNDPRDMGDRRSCAVGAIIHGQDQLSCRCGSPDCTASAPPAP
MAB_4752|M.abscessus_ATCC_1997 DLLAGTVCPADPRSKTQRRADAVGALTQGLNRMRCACGHPDCS---GRDT
MAV_3457|M.avium_104 DELASGVCAGDPRSRAQRRADALGALAAGAGRLACGCGSPDCP-SAAAPA
MUL_2679|M.ulcerans_Agy99 DELAKTVCADDPRTVVQRRADALGTLAAGQDRLICDCGRTDCP-AAGAPQ
MMAR_5187|M.marinum_M SALAATVCAQDPRSREQRRADALGVLAAGGDRLGCRCGLPDCA-AGARPA
TH_0334|M.thermoresistible__bu DQIAATVCRDDPRTADQRRADAMAAMSEGQNRLVCGCGSEDCP-ADPADT
: * *** :* : *:..: .:: * ** :*.
Rv2100|M.tuberculosis_H37Rv RAAGVVIHVVADASALDAQPDPHLSGDEP--PSRPLTP------------
Mb2126|M.bovis_AF2122/97 RAAGVVIHVVADASALDAQPDPHLSGDEP--PSRPLTP------------
MSMEG_3957|M.smegmatis_MC2_155 RAANTMVHVFAEPAAVHGPVDRYLDGDHESNPIPYFEP------------
Mflv_5065|M.gilvum_PYR-GCK STSPVVITVIADQAAVDTAQQLIADQDAEQQN------------------
Mvan_3176|M.vanbaalenii_PYR-1 GSSNVVISVLADPAALEAVRRLIASQDREQQDKLTENTPPGTEPAPESEP
MAB_4752|M.abscessus_ATCC_1997 ADVPVVVNVVINQSTLAGSDD-----------------------------
MAV_3457|M.avium_104 PRSTVVIHVVAEQATVAGRGA-----------------------------
MUL_2679|M.ulcerans_Agy99 QPSRVVIHVVAGCQTVDGAGE-----------------------------
MMAR_5187|M.marinum_M AQP-VVIHVIAERATLDGDGG-----------------------------
TH_0334|M.thermoresistible__bu AATRLVINVIAEQATVEGRSD-----------------------------
:: *. ::
Rv2100|M.tuberculosis_H37Rv ------------ETTLFEALTPD-----PEPDP-----------------
Mb2126|M.bovis_AF2122/97 ------------ETTLFEALTPD-----PEPDP-----------------
MSMEG_3957|M.smegmatis_MC2_155 ------------TPTPEPEPTPEPVRKPPEPEPKPW--------------
Mflv_5065|M.gilvum_PYR-GCK ------------TTATTAEPT-----------------------------
Mvan_3176|M.vanbaalenii_PYR-1 AGEAVEPEPQPASEDESPEPTEPEPEAEPEPEPGLEVEAEAAGEAVEPEP
MAB_4752|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_3457|M.avium_104 --------------------------------------------------
MUL_2679|M.ulcerans_Agy99 --------------------------------------------------
MMAR_5187|M.marinum_M --------------------------------------------------
TH_0334|M.thermoresistible__bu --------------------------------------------------
Rv2100|M.tuberculosis_H37Rv ---------------PATHAP--AELITTGGGVVPAPLLAELIRGGATIS
Mb2126|M.bovis_AF2122/97 ---------------PATHAP--AELITTGGGVVPAPLLAELIRGGATIS
MSMEG_3957|M.smegmatis_MC2_155 --------------TPQSAHPGRGGAVVLGGGVVPAPLVAQLIADGAKVK
Mflv_5065|M.gilvum_PYR-GCK ------------------CTKDPGSALLPGAQILPIPVLAEAIRSGAKIT
Mvan_3176|M.vanbaalenii_PYR-1 QPAGDGASAGPLVPNPLACVRDSGVALLPGVKVLPLVALAEAIRAGAAIK
MAB_4752|M.abscessus_ATCC_1997 -----------------------CPAHVPGFGVLAAESARAAVAG-TPTR
MAV_3457|M.avium_104 -----------------------TPAVVAGLDGLIPAQVIAELAASARLV
MUL_2679|M.ulcerans_Agy99 -----------------------APGVLPG-DGIIPAEIVRELAKSAKLQ
MMAR_5187|M.marinum_M -----------------------APAWEVGADGLVTPELVAELAKSAKLV
TH_0334|M.thermoresistible__bu -----------------------NPGYLPGYGAVP-ASILRAKAATATLR
* : :
Rv2100|M.tuberculosis_H37Rv QVRHPGDLAAEPHYRPSAKLAEFVRMRDLTCRFPGCDVPAEFCDIDHSAP
Mb2126|M.bovis_AF2122/97 QVRHPGDLAAEPHYRPSAKLAEFVRMRDLTCRFPGCDVPAEFCDIDHSAP
MSMEG_3957|M.smegmatis_MC2_155 ELTVPDDICAS--YRPSVAMDCFVRMRDMTCRFPGCSRPADFCDVDHTTP
Mflv_5065|M.gilvum_PYR-GCK PLWLPG-PDPEPHYRPSAKLAAFIRSRDLFCRFPGCDVSADRCDIDHVVP
Mvan_3176|M.vanbaalenii_PYR-1 ILWLPG-PDPEPHYRPSAKLAAFVRARDLFCRYPGCDVPAERCDIDHVVP
MAB_4752|M.abscessus_ATCC_1997 NLTDSR----STGYRPSAKLAAFVRSRDQLCRFPGCEAVADRADIDHTVP
MAV_3457|M.avium_104 PVAVPE-GGPEPGYTPSARLADFIRCRDLTCRAPGCDRPAVDCDVDHTIP
MUL_2679|M.ulcerans_Agy99 PMSTP--ILAETGYVPSPALMDFVRARDLTCRAPGCDRPATQCDVDHTIP
MMAR_5187|M.marinum_M PLRHPGDVPPEPGYVPSKALADFVRCRDLTCRWPGCDHPALNCDLDHTIP
TH_0334|M.thermoresistible__bu PVALPQ-PCAEAGYRPSAALTRFIRCRDLTCRFPGCDAPAAVCQIDHTIP
: . . * ** : *:* ** ** ***. * .::** *
Rv2100|M.tuberculosis_H37Rv WPLG-PTHPSNLKCACRKHHLLKTFWTG---WRDVQLPDGTVIWTAPNGH
Mb2126|M.bovis_AF2122/97 WPLG-PTHPSNLKCACRKHHLLKTFWTG---WRDVQLPDGTVIWTAPNGH
MSMEG_3957|M.smegmatis_MC2_155 WPTG-VTHPSNTKCLCRIHHLLKTFWLG---WSDRQLPDGTVIWTSPTGH
Mflv_5065|M.gilvum_PYR-GCK YPFG-PTHASNMHCKCRSHHLMKTFWGGPDGWRERQLPDGTVLWTTPAGT
Mvan_3176|M.vanbaalenii_PYR-1 YPYG-PTHPSNLNCKCRTHHLGKTFAEG---WQEQQFPDGTVLWTTPAGQ
MAB_4752|M.abscessus_ATCC_1997 WATGGPTTGANLKALCRKHHLLKTFG----QWTELQEPDGTVIWKSPTGH
MAV_3457|M.avium_104 YAQGGPTHPSNLKCLCRGHHLLKTFWG----WRDRQLPDGTVIWTLPDGD
MUL_2679|M.ulcerans_Agy99 YSDGGATHPSNLKCLCRKHHLLKTFWG----WHDEQLPDATVIWSLPDGQ
MMAR_5187|M.marinum_M YAQGGPTHASNLKCYCRTHHLVKTFWG----WHDQQLPDGTLILTSPAGH
TH_0334|M.thermoresistible__bu YPAG-PTHPSNLKLLCVFHCR------------------QAELRFTHDQH
:. * * :* : * * : :
Rv2100|M.tuberculosis_H37Rv TYTTHPGSRIFFPTWHTTTAELPQTST-----AAVNVDARGLMMPRRRRT
Mb2126|M.bovis_AF2122/97 TYTTHPGSRIFFPTWHTTTAELPQTST-----AAVNVDARGLMMPRRRRT
MSMEG_3957|M.smegmatis_MC2_155 VYTTVPASRALFPQWDTTTAALPPPPTPPPPMTPSEIAARAAMMPRRRRT
Mflv_5065|M.gilvum_PYR-GCK TYTTTPGSRLFFPAWDTTTAELPPMTT------PPPGAGREIQMPKRQRS
Mvan_3176|M.vanbaalenii_PYR-1 RCTTVPGSWLFFPGWDTTTAELPPMAQ------PPPDPDRLAKMPKRRRT
MAB_4752|M.abscessus_ATCC_1997 RYATTPVSWFLFPALTRHHTRQQARDR------------------RRRTE
MAV_3457|M.avium_104 TYVTTPGSALLFPTLCTPTGAVSPAKPDT----EHRCGERTAMMPLRRHT
MUL_2679|M.ulcerans_Agy99 TYVTTPGSAWLLPGLFAPSPELPPPP---------RSEATGSLRKPRRDD
MMAR_5187|M.marinum_M TYVTTPGSALLFPSLCHSTGGLPAAEADPP---SDHCDQRSAMMPRRQRT
TH_0334|M.thermoresistible__bu KHQSSCLPAYFQRPHGPATRRPPSARG-----------------LREAVP
: . : .
Rv2100|M.tuberculosis_H37Rv RAAELAHRINAERALNDAYMAER-----NK----------------PPSF
Mb2126|M.bovis_AF2122/97 RAAELAHRINAERALNDAYMAER-----NK----------------PPSF
MSMEG_3957|M.smegmatis_MC2_155 RAAEEARRLAAERARNEAYLAQR-----DR----------------PPPD
Mflv_5065|M.gilvum_PYR-GCK RTADRAARIKAEREHNGTQRNLE-----ER------------PRRGQPPP
Mvan_3176|M.vanbaalenii_PYR-1 RAADQAARIKAEREHNAIQRALERQRALERQQAADCNRLAGLPPPVPPAP
MAB_4752|M.abscessus_ATCC_1997 RNLNREQRLQREAAL-AALAAKD-----------------------PPPF
MAV_3457|M.avium_104 RAHNRAHRITTER---NHNRRTRLTTHPATP-----------GPAPPPDP
MUL_2679|M.ulcerans_Agy99 AQTRPNSRPKLGR---THCDRT------------------------QPQH
MMAR_5187|M.marinum_M RAQDRARRVATERRQNHHARSTQPGGQPRSA-----------APPTPPQS
TH_0334|M.thermoresistible__bu RQGVDPRRVSGQ--------------------------------------
*
Rv2100|M.tuberculosis_H37Rv ---------
Mb2126|M.bovis_AF2122/97 ---------
MSMEG_3957|M.smegmatis_MC2_155 AHGPGMQ--
Mflv_5065|M.gilvum_PYR-GCK DYGNDPPPF
Mvan_3176|M.vanbaalenii_PYR-1 GYGDDLPPF
MAB_4752|M.abscessus_ATCC_1997 ---------
MAV_3457|M.avium_104 DDE--PPPF
MUL_2679|M.ulcerans_Agy99 D--------
MMAR_5187|M.marinum_M EPQSHPPPF
TH_0334|M.thermoresistible__bu ---------