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M. bovis AF2122 / 97 Mb1393 (-)

annotation: transcriptional regulatory protein
coordinates: 1524647 - 1528126
length: 1159

MFLSAPAFRVEPTRSRHSALRWARHRRFADVPRWQMLRSLQIADQIARTGHMPVRRLDLIWISARNAARR
ELDLGVAALVEAVTLLTADVEGSTRLSQTRLNELAADYPTLDQNISEAVAAHGGVTRPVDQEVGSGLVVA
FLRAGDAIACALELQLSTLAPMRPRVGVHTGDVRLRGDGTITGSAINESACLRDLAHEGQTLLSAATGDL
VIDQLPANTWLTDVGKYPLRGLHRQERVIQLCHRDLRNEFPPLRMSVGNRSSLPAQFTTFVGRDAQINEV
QEVLTNYRLVTLRGEGGVGKTRLAIQIAAASEFRDGLCFVDLAPIADPGMVSTTAAHALGLIDRPGSSTF
DTLSHAIGNCHMLMVLDNCEHVLDACAELVVELLGACPELSILATSRESIGVTGEVTWVVPSLSPANEAI
QLFTERARLVQPNFEIVADNFAAVSEICRRLDGMPLAIELAAARLRSLSPNEIANSLDDRFRLLTGGARS
TVQRQQTLRASMDWSYALLTDTERILFRRLAVFVGGFDLTAASEVAAAGGDDFVERYSVLDQLTLLVDKS
LVVAEESRGSTRYRLLETVRQYALEKLNESEEIDGVRARHRTHYATMAAGLNVPASTDYEQRLLQAEAEI
DNLRAAFTWSRGNGDIAAALQLASALQPLWSQGRMREGLAWLESILEREGDNHLVPAGVWARALAEKVIL
KAWPATSPMGAPDIVAQAHHALALARDAGDCAVLARALVACGCGSGCDTEAAQPYFAEAIELARAINDEW
TLSQIDYWQVVGIFISGQPIPLRAAAEQARELADSIGNRFVSRQCRLFACLAQIWEGDANGALALSRDVT
AEAEVANDVVTKVLGLYVEAMALSYIGDSAARTIAGAALEAATELGGIYQDLGYGAITRAALAAGDVAAI
EASEASWDLRNQHNVVTAHHELMAQAALVRGDVTTARRFADEAVLASTGWHLMMALIARARVAIAQDELG
KARDDAHAAVACGVGVQTYLAMPDALELLAGLAGEAGNHGQAVRLFGAAAAQRQRTGEVRHKIWDAGYEA
ATAALRDAMGDEDFTAAWAEGAAAPLDEAIAYAQRGRGERKRPSNGWDALTPAEHKIVKLVTEGLVTKDI
AARLFVSPRTVQTHLTHIYTKLDVTSRVQLVQEAAQHST
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1393--100% (1159)transcriptional regulatory protein
M. bovis AF2122 / 97Mb0914c-0.065.61% (884) LuxR family transcriptional regulator
M. bovis AF2122 / 97Mb0393-0.053.54% (1087) LuxR/UHPA family transcriptional regulator

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. gilvum PYR-GCKMflv_4504-7e-1425.54% (603) regulatory protein, LuxR
M. tuberculosis H37RvRv1358-0.099.83% (1159) transcriptional regulatory protein
M. leprae Br4923MLBr_01753-0.058.12% (1084) putative transcriptional regulator
M. abscessus ATCC 19977MAB_3361-1e-0839.53% (86) LuxR family transcriptional regulator
M. marinum MMMAR_0123-0.051.85% (1107) LuxR family transcriptional regulator
M. avium 104MAV_2362-1e-1123.75% (943) TPR repeat-containing protein
M. smegmatis MC2 155MSMEG_0545-3e-1838.92% (167) transcriptional regulator, LuxR family protein
M. thermoresistible (build 8)TH_3225-8e-1327.95% (508) PUTATIVE regulatory protein, LuxR
M. ulcerans Agy99MUL_2743-4e-9933.92% (846) LuxR family transcriptional regulator
M. vanbaalenii PYR-1Mvan_5928-0.053.22% (1086) regulatory protein, LuxR

CLUSTAL 2.0.9 multiple sequence alignment


Mb1393|M.bovis_AF2122/97            MFLSAPAFRVEPTRSRHSALRWARHRRFADVPRWQMLRSLQIADQIARTG
Rv1358|M.tuberculosis_H37Rv         MFLSAPAFRVEPTRSRHSALRWARHRRFADGPRWQMLRSLQIADQIARTG
MLBr_01753|M.leprae_Br4923          MYSLGEMQKPVPVGADYLASCLVAR-----------LRSTDVPTDLHRG-
MMAR_0123|M.marinum_M               --MLASMSEIDPRAEAPLVD----------------WSDVDMGELLPTG-
Mvan_5928|M.vanbaalenii_PYR-1       -----------------------------------------MSELVPTG-
MUL_2743|M.ulcerans_Agy99           --------------------------------------------------
MSMEG_0545|M.smegmatis_MC2_155      -----------------------------------------MTEKLSTG-
MAB_3361|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3225|M.thermoresistible__bu      --MSSRDGDVVLHG------------------------------------
Mflv_4504|M.gilvum_PYR-GCK          --MRAALPAAMMNAMSDASP------------------------------
MAV_2362|M.avium_104                --------------------------------------------------
                                                                                      

Mb1393|M.bovis_AF2122/97            HMPVRRLDLIWISARNAARRELDLGVAALVEAVTLLTADVEGSTRLSQTR
Rv1358|M.tuberculosis_H37Rv         HMPVRRLDLIWISARNAARRELDLGVAALVEAVTLLTADVEGSTRLSQTR
MLBr_01753|M.leprae_Br4923          ------------------------------CTVTLFLGDVEGLAELSETQ
MMAR_0123|M.marinum_M               -------------------------------TVTLLLADVEGSTRLWQNQ
Mvan_5928|M.vanbaalenii_PYR-1       -------------------------------TVTLLLADVQGSTQLWETQ
MUL_2743|M.ulcerans_Agy99           --------------------------------MTFLFTDVEGSTRLWESD
MSMEG_0545|M.smegmatis_MC2_155      -------------------------------TKTLLMARVDRAEELWQTE
MAB_3361|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3225|M.thermoresistible__bu      ----------------------------RAAEIATLRDVMSTARAGSSRV
Mflv_4504|M.gilvum_PYR-GCK          -----------------------------QAADDPQVAGFLCTATSAPTG
MAV_2362|M.avium_104                -----------------------------MGREAELRRSLAALSNAEFHG
                                                                                      

Mb1393|M.bovis_AF2122/97            LNELAADYPTLDQNISEAVAAH--GGVTRPVDQEVGSGLVVAFLRAGDAI
Rv1358|M.tuberculosis_H37Rv         LNELAADYPTLDQNISEAVAAH--GGVTRPVDQEVGSGLVVAFLRAGDAI
MLBr_01753|M.leprae_Br4923          PDEAADAIARLDCVVSEAVAAH--GGVQQVVQGVRGN-FLATFARASDAT
MMAR_0123|M.marinum_M               PEPMTAAVAHLDSVLATTVATH--HGVR-PVEQGEGDSFVVAFASAREAI
Mvan_5928|M.vanbaalenii_PYR-1       PETMTAAVAQLDRTLTDLVSDH--DGVR-PVEQGEGDSFVVAFTRASDAV
MUL_2743|M.ulcerans_Agy99           PDRMRAALAAHDAVLTRTIQTH--RGWLFKHTG---DGVCAAFASPRSAV
MSMEG_0545|M.smegmatis_MC2_155      LDQTIAAIPWLRASMAHLIALN--DGTLQRDAS---DSFVAAFDRASDAV
MAB_3361|M.abscessus_ATCC_1997      -MLRGQAGVGKTALLRYVLGKA--SGQLIAQASGIQSEMELAFAGLQQFC
TH_3225|M.thermoresistible__bu      LVLHGEAGVGKTALLGQLLGDA--AGMRCVQVAGVESDMELAYAGLHQLC
Mflv_4504|M.gilvum_PYR-GCK          LIIEGDAGIGKTTLWLSLLQTARMRGFQVLTARVGQAESVMAFAALADLL
MAV_2362|M.avium_104                VALVGDAGVGKSTLARMLAKTVESAGRTVRFALGTQTGSAVPLGAFSHAV
                                                             *               .        

Mb1393|M.bovis_AF2122/97            ACALELQLSTLAPMRPRVGVHTGDVRLRGDGT---ITGSAINESACLRDL
Rv1358|M.tuberculosis_H37Rv         ACALELQLSTLAPMRPRVGVHTGDVRLRGDGT---ITGSAINESACLRDL
MLBr_01753|M.leprae_Br4923          ACALDLQLAPIVPVRFRIALHTGEVQISNDDVN--NVVFMMVQAAGLLDL
MMAR_0123|M.marinum_M               ACALDLQRSPLGPIRLRIGVHTGDIQLRDPNDPTNYIGPTINRTARIREL
Mvan_5928|M.vanbaalenii_PYR-1       ACALALQRAPLAPIRLRIGVHTGEVRLRDEG---NYVGPTINRTARLREL
MUL_2743|M.ulcerans_Agy99           DAAVDAQRALELPVR--MGLATGEAEPHDAD----YFGAVLNRAARVMAT
MSMEG_0545|M.smegmatis_MC2_155      MCALDLQLAPLEPFALCIGVHAVEHTDSADS----------DGAARLRDI
MAB_3361|M.abscessus_ATCC_1997      APLTKYSGAIPDPQREALTIAFGTRSGPPPDR-----FLIGLAVLSLLAA
TH_3225|M.thermoresistible__bu      APLLDRLDDLPSPQRDVLNVAFGRGAGPAPGR-----FLVGLAVLNLLAA
Mflv_4504|M.gilvum_PYR-GCK          GAVSDEHFAALPPLQRLALDRVLLRAGADGPAT--DQRVVAAGFVSLLHI
MAV_2362|M.avium_104                SLMAVNEPAVMLAAAHNTLSQDKN------------LVVVVDDAQLLDPL
                                                .                                 :   

Mb1393|M.bovis_AF2122/97            AHEGQTLLSAATGDLVIDQLPANTWLTDVGKYPLRGLHRQERVIQLCHRD
Rv1358|M.tuberculosis_H37Rv         AHEGQTLLSAATGDLVIDQLPANTWLTDVGKYPLRGLHRQERVIQLCHRD
MLBr_01753|M.leprae_Br4923          ACGGQTVLSSITGDLVVDGLPADTWLVDLGSHLLRDLARPVRVMQLCHRN
MMAR_0123|M.marinum_M               AHGGQTVISGATQLLVVDQLPDGAWLADLGLHPLRDLPRPERVMQLCHSG
Mvan_5928|M.vanbaalenii_PYR-1       AHGGQTVLSGTTSDLVADLLPDGGWLSDLGTHRLRDLPRPERVVQLCHAD
MUL_2743|M.ulcerans_Agy99           GHGGQILLTDSTANLIS-----GVDLLDLGSRRLRDLPAPVRVFQVRAPG
MSMEG_0545|M.smegmatis_MC2_155      ARGGQTLISAAAAALVSARMPAHAALT-----PLRDRVRHEPVYQLNHPG
MAB_3361|M.abscessus_ATCC_1997      AAEHQPVLCVIDDAQWLDR----VSLQTLAFVTRRLGSEPVAMLFAVRDG
TH_3225|M.thermoresistible__bu      AGADQPLLCVIDDAQWLDR----VSLQTLGFVARRLMAEPVAMVFALRDD
Mflv_4504|M.gilvum_PYR-GCK          LAADAPVLIAIDDVQWLDAS--SRTAIEFAVRRLKGAFGVVVTERCVPGD
MAV_2362|M.avium_104                SATLVNQLAAWRSARLIVTIRSGEPVLDAVTALLKERLLLTVHVDPFTRE
                                           :                          :               

Mb1393|M.bovis_AF2122/97            LRNEFPPLRMS-VGNRSSLPAQFTTFVGRDAQINEVQEVLTNYRLVTLRG
Rv1358|M.tuberculosis_H37Rv         LRNEFPPLRMS-VGNRSSLPAQFTTFVGRDAQINEVQEVLTNYRLVTLRG
MLBr_01753|M.leprae_Br4923          LRRNLHELGIRTVPGGPSLPVPLTTFVGRAAQIKELQELLTEKRLLTLVG
MMAR_0123|M.marinum_M               LQNDFPPLRTTKSIAVHRMPARLTRFVGRIAQMADVRSLLADNRLVTLTG
Mvan_5928|M.vanbaalenii_PYR-1       LSNEFPPLRAREEIGVQRLPAQLTSFVGRVDDMAQVRGLMDANRLVTLTG
MUL_2743|M.ulcerans_Agy99           LRTDFPALRAPDTSPG-NLRPALTSFVARAAEIGQVQTALQVHRLVTLTG
MSMEG_0545|M.smegmatis_MC2_155      LR----------------------------TEADEVPHLPYG-RVVR---
MAB_3361|M.abscessus_ATCC_1997      TDSELAGLPELTVHG-------LRAADAGTLLDSVIPGLLDERVRDRIVA
TH_3225|M.thermoresistible__bu      IHEALVGVPALAVPG-------LADADARTLLEHMFPGAIDANVRDRLVA
Mflv_4504|M.gilvum_PYR-GCK          GTTAGWLTLERPDGLIRVSVPPMDAGRLHALISHRLGRTLTRPVVLRIAE
MAV_2362|M.avium_104                QTELLAGTVLGGPVDPWVVDELLQRSSGNPLLLRGFLTAGRDTGALFRTA
                                                                       .              

Mb1393|M.bovis_AF2122/97            EGGVGKTRLAIQIAA--ASEFRDGLCFVDLAPIADPGMVSTTAAHALGLI
Rv1358|M.tuberculosis_H37Rv         EGGVGKTRLAIQIAA--ASEFRDGLCFVDLAPIADPGMVSTTAAHALGLI
MLBr_01753|M.leprae_Br4923          PGGVGKTRLALQVVARVADEFSGELSYFDLAPDTDHDIFPIT--------
MMAR_0123|M.marinum_M               AGGAGKTRLAVEIAASAVDEFGDGLWYVDLAPVSHAEAVPVTVARALGLS
Mvan_5928|M.vanbaalenii_PYR-1       AGGVGKTRLATQVAVAVVEGYPGGVWYVDLAPITDPALVAITVARALGLP
MUL_2743|M.ulcerans_Agy99           VGGVGKTRLALEVATRVADEFPDGVWLFELAAVSDPAAVPDAVAAVLGIT
MSMEG_0545|M.smegmatis_MC2_155      --------------------------------------------------
MAB_3361|M.abscessus_ATCC_1997      ETQGNPLALLELPRDMTAEELAGGFGWPDGGRLAG---------------
TH_3225|M.thermoresistible__bu      ESRGNPLALLEVPRTYAVGELAGGFVSPGAGSAPS---------------
Mflv_4504|M.gilvum_PYR-GCK          MSGGNPFYALELAHTHVNSGDSPPAAEPPLPATLADVVR-----------
MAV_2362|M.avium_104                EGWQLRGPLRGDRELHDALEYRLQSLSSEER-------------------
                                                                                      

Mb1393|M.bovis_AF2122/97            DRPGSSTFDTLSHAIGNCHMLMVLDNCEHVLDACAEL-VVELLGACPELS
Rv1358|M.tuberculosis_H37Rv         DRPGSSTFDTLSHAIGNCHMLMVLDNCEHVLDACAEL-VVELLGACPELS
MLBr_01753|M.leprae_Br4923          ------VLDNLRRCIGDRRMLMVLDNCEYLLDVCANV-MTTLLGACPSLT
MMAR_0123|M.marinum_M               DQPGRSTVDALARFIGEHQVLVVLDNCEHLLDATAAL-LLELTGRCPAVR
Mvan_5928|M.vanbaalenii_PYR-1       DQPGRSTVDTIVRFIADRRMLVVLDNCEHLLDACATL-IDALLGACPALA
MUL_2743|M.ulcerans_Agy99           QQAGKTVTQSVATALERRVRLLVFDNCEHVRDAAADL-IEAILAGSTTVR
MSMEG_0545|M.smegmatis_MC2_155      --------------------------------------------------
MAB_3361|M.abscessus_ATCC_1997      -QIEQTFLRRVQQLPAHTQTLLLAAATDPLGDVTLLARAAQQLGIPMHAI
TH_3225|M.thermoresistible__bu      -RIEENYVHRIRALPAQTRRLLLIAAAEPIGDSALFLRAAALMGIAVDAL
Mflv_4504|M.gilvum_PYR-GCK          ------RRVGLLDDATRTLLLGVACVADPTVELLARAHGASTDEITAGLE
MAV_2362|M.avium_104                ------EVVEILATAGLLNWDILRDICDAEAVAALERRGLIRLVTDGSHA
                                                                                      

Mb1393|M.bovis_AF2122/97            ILATSRESIGVTGEVTWVVPSLSPAN----EAIQLFTERARLVQPNFEIV
Rv1358|M.tuberculosis_H37Rv         ILATSRESIGVTGEVTWVVPSLSPAN----EAIQLFTERARLVQPNFEIV
MLBr_01753|M.leprae_Br4923          ILATSREPIGVAGEVIWRVSMLSPAD----EAVELFTERAALVQPGFSVT
MMAR_0123|M.marinum_M               LLATSREPLGVPGEVTFLVPSLSVT-----EATELFTDRARRVRPDFAVT
Mvan_5928|M.vanbaalenii_PYR-1       MLATSREPIAVAGEQTWRVPPLALDD----DAIELFTDRARRARPDFIIS
MUL_2743|M.ulcerans_Agy99           ILATSRERLEVPDEQLWSVPSLDVGGGVVSAAGTLFVERAQSVAPGFAPT
MSMEG_0545|M.smegmatis_MC2_155      --------------------------------------------------
MAB_3361|M.abscessus_ATCC_1997      APAEAADLVELSTRVRFRHPLVRSAVYISANPLERRRIHGVLAGATDPGA
TH_3225|M.thermoresistible__bu      APAEAARVIQFGPRMRFFHPLMRSAAYRAADPRDRRAVHRALAEATDPGA
Mflv_4504|M.gilvum_PYR-GCK          RAEAAGIVVLEGNRVRFTHPLLAGGVYTDAGPTARRAMHRAIAS---VES
MAV_2362|M.avium_104                VAQLTHPMLG---EAATRHAGMVRTRQLNGKLARALQKHERTGSRHLRLP
                                                                                      

Mb1393|M.bovis_AF2122/97            AD-NFAAVSEICRRLDGMPLAIELAAARLRSLSPNEIANSLDDRFRLLTG
Rv1358|M.tuberculosis_H37Rv         AD-NFDAVSEICRRLDGMPLAIELAAARLRSLSPNEIANSLDDRFRLLTG
MLBr_01753|M.leprae_Br4923          DG-NRQIVTEICQRLDGMPLAIELAAARIRTLSLTEIADGLDDRFRLLTG
MMAR_0123|M.marinum_M               DD-NTTAVTEICNRLDCMPLAIELAAARVRALSIDEIRTGLHDRFRLLTG
Mvan_5928|M.vanbaalenii_PYR-1       AD-DAAAVSEICHRLDGMPLAIELAAARVRALSLTEIVDGLHDRFRLLTG
MUL_2743|M.ulcerans_Agy99           DAQDAAAIGEICRRLDGIPLAIELAASRMASMTPIEVRDRLDHRFRLLVG
MSMEG_0545|M.smegmatis_MC2_155      --------------------------------------------------
MAB_3361|M.abscessus_ATCC_1997      DPDRRAWHRAHAAAGTDEAIAWELEQSAGRAQAKGGVLAAAAFLQRATEL
TH_3225|M.thermoresistible__bu      DPDRRAWHAANGVTGTDDAVAAELEKSAARAQQRGGIAATATFLERAVVL
Mflv_4504|M.gilvum_PYR-GCK          HPELRARHLALAASSGDDEIFAALDQAADSARARGAPAAAAELMDLALGL
MAV_2362|M.avium_104                HLQSRIRLAEFMLHSDMEPDLDVITEAARDALAMSNVQLGEELAR--FAL
                                                                                      

Mb1393|M.bovis_AF2122/97            GARSTVQRQQTLRASMDWSYALLTDTERILFRRLAVFVGGFDLTAASEVA
Rv1358|M.tuberculosis_H37Rv         GARSTVQRQQTLRASMDWSYALLTDTERILFRRLAVFVGGFDLTAASEVA
MLBr_01753|M.leprae_Br4923          GARTAVRRQQTLRASMDWSYALLTESERALFRRLSAISGTFDLKVA---Y
MMAR_0123|M.marinum_M               GARTVVRRQQTLRASVDWSHALLTEPERVLFRRIAVFLGGFDLDAA---Q
Mvan_5928|M.vanbaalenii_PYR-1       GSRTAVRRQQTLRASVDWSHGLLTDPERVLFRRLAVFAGGFDLDGA---Q
MUL_2743|M.ulcerans_Agy99           -SRRGLGRHQTLRHAVAWSYDHLSDAEKVLLERCSVFAGGFDLQSAC--A
MSMEG_0545|M.smegmatis_MC2_155      --------------------------------------------------
MAB_3361|M.abscessus_ATCC_1997      TADPAARGRRALAAAQSKYDAAAFDAARELLGVADMTP----------LD
TH_3225|M.thermoresistible__bu      TADPGLRGRRALAAAQAKRDAADSAAAHDLLAIAERAP----------LS
Mflv_4504|M.gilvum_PYR-GCK          GAHDPMRR---LKAAENHFLAGDTAKAAAALG------------------
MAV_2362|M.avium_104                DRGGGLPAALVLAEAVSWQGRGEEAG------------------------
                                                                                      

Mb1393|M.bovis_AF2122/97            AAGGDDFVERYSVLDQLTLLVDKSLVVAEESRGSTRYRLLETVRQYALEK
Rv1358|M.tuberculosis_H37Rv         AAGGDDFVERYSVLDQLTLLVDKSLVVAEESRGSTRYRLLETVRQYALEK
MLBr_01753|M.leprae_Br4923          AVGHDDLEEPDQVFDRLTMLIDKSLVIVEGRQGGSRYRLLETVRQYAMKK
MMAR_0123|M.marinum_M               AVAGDSQVQRYQVVDELALLVDKSLVIAESGGGPTRYRLLETVRQYAQEK
Mvan_5928|M.vanbaalenii_PYR-1       AITVDGEVHRYEVVDLLTLLVDKSLLIAENTAGRTRYRLLETVRQYAQEK
MUL_2743|M.ulcerans_Agy99           VAGSADTHDDYEVLDLLDALVGKSLLIVDRLSGRSRFSMLETIREFAEEQ
MSMEG_0545|M.smegmatis_MC2_155      --------------------------------------------------
MAB_3361|M.abscessus_ATCC_1997      PLARARATRLRAKIAFAESRVGAFGSVTVSEAAIGLVEAARCLENLDDNL
TH_3225|M.thermoresistible__bu      ALEWARAVHLRAQLEFARSRAGDAGGPPVGQTAAALLTAAQLLQDVDAPA
Mflv_4504|M.gilvum_PYR-GCK          ---------EVGSIEPPILRAMATSLLATVRMYDNEHRQAVDLLRSALDD
MAV_2362|M.avium_104                -----------FVLAHAEPDGDDDWLIARWGCLRAANLFWGCGDAEAARR
                                                                                      

Mb1393|M.bovis_AF2122/97            LNESEEIDGVRARHRTHYATMAAGLNVPASTD-YEQRLLQAEAEIDNLRA
Rv1358|M.tuberculosis_H37Rv         LNESEEIDGVRARHRTHYATMAAGLNVPASTD-YEQRLLQAEAEIDNLRA
MLBr_01753|M.leprae_Br4923          LEESNEVDLVLARHRDHYMALGALLDTPGDID-HEQLVEQVETELDNLRS
MMAR_0123|M.marinum_M               LAESGEVEAVRSRHVTYYKSVAKLLDAPTGTD-HERRLAQAEDELDNLRS
Mvan_5928|M.vanbaalenii_PYR-1       LGESGEADTLRARHRDHYTARAAELDAPSVAG-HERRLNQTDIEMDNLRA
MUL_2743|M.ulcerans_Agy99           LVTRGQALAARTAHARHFAQRLPDVAAVWDSPRQPEAYTWLTAELANLRL
MSMEG_0545|M.smegmatis_MC2_155      --------------------------------------------------
MAB_3361|M.abscessus_ATCC_1997      ARETYLDAVGAAMYGGRLCPRGGAVEVAEPARLAPAGAQP-ARPSDLLLD
TH_3225|M.thermoresistible__bu      ARESYLEAFAALMYAGRLAPSGALLEAADAVQAAFARAPEGSRAVDAFCQ
Mflv_4504|M.gilvum_PYR-GCK          AADNVPVQVQVLLRLSFALNSIGELDDARRYARDAVKLAEELGFPGATSA
MAV_2362|M.avium_104                EADTVKKRVSSEAGLHLIDALELSMAFFRGDVETTTELGPGLCESDAVPM
                                                                                      

Mb1393|M.bovis_AF2122/97            AFTWSRGNGDIAAALQLASALQP-LWS-QGRMREGLAWLESILE------
Rv1358|M.tuberculosis_H37Rv         AFTWSRGNGDIAAALQLASALQP-LWS-QGRMREGLAWLESILE------
MLBr_01753|M.leprae_Br4923          AFAWSRETGDIAGALQLASSLQP-IWFGRGHMYEGLAWFDSIFE------
MMAR_0123|M.marinum_M               AFGWSLETRDFDSALELATSLHP-VWMTRGQGREGLAWLEAGLGNEAGLG
Mvan_5928|M.vanbaalenii_PYR-1       AFAWSRENANTDHSLLLASSLHP-LWRARGRLQEGQAWFDAALT-----D
MUL_2743|M.ulcerans_Agy99           AFRWTADNNDLDDAASIATWVGF-LGFLVNRFEP-LTWVEEAIE------
MSMEG_0545|M.smegmatis_MC2_155      --------------------------------------------------
MAB_3361|M.abscessus_ATCC_1997      GLARRITHGAAASAQTLGEALTLIRCEAD-RPANTS-WMEQAFP------
TH_3225|M.thermoresistible__bu      GMTQRIVGGISAAAAPLRVALTAMCELARSRPAEVVHWLVPAFP------
Mflv_4504|M.gilvum_PYR-GCK          ALAWAVHVDFQCGRGLDETALARAMKLYDSTFDVPIIFRAPFVH------
MAV_2362|M.avium_104                ATTWAAVPTCAALAATGRYSEVGRIADIGVRAAMSCGMGLHRFN------
                                                                                      

Mb1393|M.bovis_AF2122/97            ---REGDNHLVP-AGVWARALAEKVILKAWPATSPMGAPDIVAQAHHALA
Rv1358|M.tuberculosis_H37Rv         ---REGDNHLVP-AGVWARALAEKVILKAWPATSPMGAPDIVAQAHHALA
MLBr_01753|M.leprae_Br4923          ---HKNIEHLVAPKEVLARAVANKVMLHAILASSPPDGSDLVTQAQQALT
MMAR_0123|M.marinum_M               NEAGLGNEDVQVSPSTLARALADKVTLLAWTGSMAG-----FDDAERALT
Mvan_5928|M.vanbaalenii_PYR-1       YEARPG----EADPAVYARALADRAFMDGHVGITDR-----LDQAQKALA
MUL_2743|M.ulcerans_Agy99           --------------------------------------------------
MSMEG_0545|M.smegmatis_MC2_155      --------------------------------------------------
MAB_3361|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3225|M.thermoresistible__bu      --------------------------------------------------
Mflv_4504|M.gilvum_PYR-GCK          --------------------------------------------------
MAV_2362|M.avium_104                --------------------------------------------------
                                                                                      

Mb1393|M.bovis_AF2122/97            LARDAGDCAVLARALVACGCGSGCDTEAAQPYFAEAIELARAINDEWTLS
Rv1358|M.tuberculosis_H37Rv         LARDAGDCAVLARALVACGCGSGCDTEAAQPYFAEAIELARAINDEWTLS
MLBr_01753|M.leprae_Br4923          MAREIGDSAVLARALTACGFSSGYDTEVARPYFAEAVELARTQGDKWTLS
MMAR_0123|M.marinum_M               IARELADPALLIRALVARGVITAYDADVARPYFDEAAQLARELGDSWRLS
Mvan_5928|M.vanbaalenii_PYR-1       MARDIDDPALLVRALTACGGLAAYNADVARPLLAEAVDLARSMGDKWMLA
MUL_2743|M.ulcerans_Agy99           --RAVDHPKLAFLHVLASQCYTTGRVQEAIRYADEAARLLATDRYEVPFG
MSMEG_0545|M.smegmatis_MC2_155      --------------------------------------------------
MAB_3361|M.abscessus_ATCC_1997      -------------IALESATHEVWDDDMWHHLATRAVHIAREVGALSLLP
TH_3225|M.thermoresistible__bu      -------------VLQESAGHELWDENLVDALSEAVVRQARDAGALAGLP
Mflv_4504|M.gilvum_PYR-GCK          ----------------ALAMSWTGRLEQAHQELTAVRGVCLERGAESDMM
MAV_2362|M.avium_104                -----------IGISEIIAATDAGDDRAAERIYKRYAAMAEGLPG--AEA
                                                                                      

Mb1393|M.bovis_AF2122/97            QIDYWQVVGIFISG-QPIPLRAAAEQARELADSIGNRFVSRQCRLFACLA
Rv1358|M.tuberculosis_H37Rv         QIDYWQVVGIFISG-QPIPLRAAAEQARELADSIGNRFVSRQCRLFACLA
MLBr_01753|M.leprae_Br4923          QIRLWGVVGFCVSG-DPVALRAAAEAADDLAQEIGDRFVSLQCRLLLSIA
MMAR_0123|M.marinum_M               QILSLQTRAAMAAG-DPIALEAAGEEGLRIAEAIGDRTTSRECRGALGWV
Mvan_5928|M.vanbaalenii_PYR-1       ETLAWQAYAALMGGGDPVAARTAGEEARELADEMGDGFVSRICGWLLGIA
MUL_2743|M.ulcerans_Agy99           -IEGWPSGACTSSG---HPEQSVELCRTQLALGHDTHTLTLGC---LVLA
MSMEG_0545|M.smegmatis_MC2_155      --------------------------------------------------
MAB_3361|M.abscessus_ATCC_1997      AALIYRAGMHVHAG----ELDAAAELVQEADAISAATGH-APIRYHSLIL
TH_3225|M.thermoresistible__bu      QALVYRAGVHLLFG----EFGLADTLLTEAESITAATDHRGPVRYHRLII
Mflv_4504|M.gilvum_PYR-GCK          AIAGFLAINHLWRG-QITDAEAEAAEAVERAEQLGGDDVLIIPMTVRGAI
MAV_2362|M.avium_104                MVDAMLGVVRLARG----EFPAACAAFTRSISLFAKGFPSPWLVVVGAFQ
                                                                                      

Mb1393|M.bovis_AF2122/97            QIWEGDANGALALSRDVTAEAEVANDVVTKVLGLYVEAMALSYIG-DSAA
Rv1358|M.tuberculosis_H37Rv         QIWEGDANGALALSRDVTAEAEVANDVVTKVLGLYVEAMALSYIG-DSAA
MLBr_01753|M.leprae_Br4923          QLWQGDMDGAIVRSGEVVAGAEAAHDTVTRTFGLYVQTRALVHRD-VSAA
MMAR_0123|M.marinum_M               RAWRGDPIGALHQLGEAIAEASAAHDLLLLMISQVVQGFTYAYVGDADGA
Mvan_5928|M.vanbaalenii_PYR-1       HHFQGDLDAALALADGVVSESDVAHDTLNGCCGELVLAHSLAQRGDTDAA
MUL_2743|M.ulcerans_Agy99           LTIKGQCDEAEQLADALIESAEATRNPAALCYALLAYGFTFRDTN-----
MSMEG_0545|M.smegmatis_MC2_155      --------------------------------------------------
MAB_3361|M.abscessus_ATCC_1997      AAWRGSEPTAIRLIDEAMRDGAARGEGRLLGAMGYAAGVLNNSLG-----
TH_3225|M.thermoresistible__bu      AAWRGDAVEAARLIEAAAADGEARGEGRLMGLTGYAAALLYNGIG-----
Mflv_4504|M.gilvum_PYR-GCK          AAYAGRVDDARADARWVLAAVRNRKASHIADWPGMTLCFLEESLG-----
MAV_2362|M.avium_104                AQAEGARGDSTAAAAALWRADRAYGPHAAVFLPELELARAWERAA-----
                                                                                      

Mb1393|M.bovis_AF2122/97            RTIAGAALEAATELGGIYQDLGYGAITRAALAAGDVAA-IEASEAS-WDL
Rv1358|M.tuberculosis_H37Rv         RTIAGAALEAATELGGIYQDLGYGAITRAALAAGDVAA-IEASEAS-WDL
MLBr_01753|M.leprae_Br4923          LVTAGLVVEAAAELSGVYQGIGYAAMVFAALAMGDVAAAVEASEACRPHL
MMAR_0123|M.marinum_M               CACADAVFTSSAELVGANEGLGYATAAIACQAAGDATAAWKAYQKARELV
Mvan_5928|M.vanbaalenii_PYR-1       RAAAQVSLNVAVEVSPVHAGLAHAALAVANLAAGDVTAAEAASDSATRSF
MUL_2743|M.ulcerans_Agy99           --------------------------------------------------
MSMEG_0545|M.smegmatis_MC2_155      --------------------------------------------------
MAB_3361|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3225|M.thermoresistible__bu      --------------------------------------------------
Mflv_4504|M.gilvum_PYR-GCK          --------------------------------------------------
MAV_2362|M.avium_104                --------------------------------------------------
                                                                                      

Mb1393|M.bovis_AF2122/97            RNQHNVVTAH-HELMAQAALVRGDVTTARRFADEAVLASTGWHLMMALIA
Rv1358|M.tuberculosis_H37Rv         RNQHNVVTAH-HELMAQAALVRGDVTTARRFADEAVLASTGWHLMMALIA
MLBr_01753|M.leprae_Br4923          GADHGLVAIH-LELMAAVALARGDVIVARRLADNSVSATTGWHQMAALTT
MMAR_0123|M.marinum_M               GMDPQMAGVFPFGALAPLVS--GDLSAARRWADDVVSTSYGCYLSVALTA
Mvan_5928|M.vanbaalenii_PYR-1       GPS-EVAGIQDPNVAAQIACTRGDLDTARSLVDGAVSITRGVHRASALTT
MUL_2743|M.ulcerans_Agy99           -----------------PASALAAMRRGLRIAQDTGNRNSETHLAAVLCR
MSMEG_0545|M.smegmatis_MC2_155      --------------------------------------------------
MAB_3361|M.abscessus_ATCC_1997      --------------------RYELAFMAARRACEHEDLGLYSWCLIELIE
TH_3225|M.thermoresistible__bu      --------------------RYREALAAARTTCEYEDLGFYSWCLHELVE
Mflv_4504|M.gilvum_PYR-GCK          ----------------NHREALAALDDSFIAAGPPTTELMYAWHLPDAIE
MAV_2362|M.avium_104                -------------------------------AGDTQAATTHATQAAEIAR
                                                                                      

Mb1393|M.bovis_AF2122/97            RARVAIAQDELGKARDDAHAAVACGVGVQTYLAMPDALELLAGLA----G
Rv1358|M.tuberculosis_H37Rv         RARVAIAQDELGKARDDAHAAVACGVGVQTYLAMPDALELLAGLA----G
MLBr_01753|M.leprae_Br4923          RARIAMAQGEPELARADIHAALACGADIQASLGISDSMELLAELI----S
MMAR_0123|M.marinum_M               RARVALAQGELGQADRDSHAALSCSAANGTTLGVADTLECLAELA----A
Mvan_5928|M.vanbaalenii_PYR-1       RARIAIAQGDPEQAERNAHDALSLAAGVGARLEVPDTLECLARVV----G
MUL_2743|M.ulcerans_Agy99           ---VEAKYGDPLSALDHFTLAIHNHHEAGNTTLISTPLAVLAAFF----D
MSMEG_0545|M.smegmatis_MC2_155      --------------------------------------------------
MAB_3361|M.abscessus_ATCC_1997      AAVRCGEHDTAVKAFGQLEERALAAQSDWSQGMVARSRALITVGH----D
TH_3225|M.thermoresistible__bu      AAARVGETDTAHRALGDIEERAGASGTPWGLGALAGARALLADGD----E
Mflv_4504|M.gilvum_PYR-GCK          AMVGVGRLDDAEILTAALERNGVEHDRRWMRAVGARCRAMLLAAHGDVAA
MAV_2362|M.avium_104                AAGMHAAEMRTRHAAVRFGDRSQTARLERLARILDTPLAEAAADH-----
                                                                                      

Mb1393|M.bovis_AF2122/97            EAGNHGQAVRLFGAAAAQRQRTGEVRHKIWDAGYEAATAALRDAMGDEDF
Rv1358|M.tuberculosis_H37Rv         EAGNHGQAVRLFGAAAAQRQRTGEVRHKIWDAGYEAATAALRDAMGDEDF
MLBr_01753|M.leprae_Br4923          QGDNHRQAGRLFGAASAQREKTGEVRFKVWDAGYESAVAVLRGAMGCKDF
MMAR_0123|M.marinum_M               TEGDRREAARLLASAEAIRHRTGEVRLKILDAHCEVVLAELRNELGEQDF
Mvan_5928|M.vanbaalenii_PYR-1       DGGSHHEAARLCGAAEAIRGRTGAVRFRIYDADHETTVTTLRDALGDKAF
MUL_2743|M.ulcerans_Agy99           RLGRYEAAATIAGFAFHPITEASFP-------ELRTTISHLRDALGDHAY
MSMEG_0545|M.smegmatis_MC2_155      --------------------------------------------------
MAB_3361|M.abscessus_ATCC_1997      AEPHYREAIQRLTNTRISAHLARAHLIYGEWLRRCNRRSDARTELTAAHG
TH_3225|M.thermoresistible__bu      ADRLFREALDHLSRSRVVVHRARVHLTYGEWLRREHRRGEARRELNEAHG
Mflv_4504|M.gilvum_PYR-GCK          AEQMAHRAISEHDHLPMPFERARTRLLLGQLQRRLRQKATAAKNLTDALH
MAV_2362|M.avium_104                ARGLTQRDGDLLDAAAQQFADLGALACAADAAAQAAGEHARRGDRGKKFE
                                                                                      

Mb1393|M.bovis_AF2122/97            TAAWAEGAAAPLDEAIAYAQRGRGERKRPSNGWDALTPAEHKIVKLVTEG
Rv1358|M.tuberculosis_H37Rv         TAAWAEGAAAPLDEAIAYAQRGRGERKRPSNGWDALTPAEHKIVKLVTEG
MLBr_01753|M.leprae_Br4923          DSAWAEGAAMPIDDAITYAQRGRGNRKRPTTGWESLTPAEHNVIRLVSEG
MMAR_0123|M.marinum_M               AAVWGQGAVISTDEVISYVRRGRGTRRRPSSGWGSLTPTEHDVVRLVQEG
Mvan_5928|M.vanbaalenii_PYR-1       EAAWTEGSATSITEAIAYAQRGRGERKRPSSGWASLTPTELDVVGLVSEG
MUL_2743|M.ulcerans_Agy99           ESFSQSGAAMTTAAMATYAYHQIDHARTEFQAR-----------------
MSMEG_0545|M.smegmatis_MC2_155      --------------------------------------------------
MAB_3361|M.abscessus_ATCC_1997      SFVNMGTAAFAERAERELRATGAKVRKRSASSEKALTAQEAQIARMAGQG
TH_3225|M.thermoresistible__bu      MFTRMGAQGFAERSRRELIAVGEKVRRQPLTSGDELTAQEAQIAGLAADG
Mflv_4504|M.gilvum_PYR-GCK          TFEQLGTPLWAQRARSELAR-------AVVAPAEGLTPSEQKVAEMAAAG
MAV_2362|M.avium_104                SSAWAHALASRYELHT--------PAVEAAARPLPFSGRERQIVNLVAAG
                                                                                      

Mb1393|M.bovis_AF2122/97            LVTKDIAARLFVSPRTVQTHLTHIYTKLDVTSRVQLVQEAAQHST-----
Rv1358|M.tuberculosis_H37Rv         LVTKDIAARLFVSPRTVQTHLTHIYTKLDVTSRVQLVQEAAQHST-----
MLBr_01753|M.leprae_Br4923          LDTKDIAARLFVSVRTVHTHLTRIYSKLGLTSRVQLVQEAARHN------
MMAR_0123|M.marinum_M               LSNKDIAARMFISPRTVQTHLTHVYTKLGLTSRIQLVHEVARHA------
Mvan_5928|M.vanbaalenii_PYR-1       LSNKDIAARLFVSPRTVQTHLTHVYTKLCLASRVQLAQEAARHT------
MUL_2743|M.ulcerans_Agy99           --------------------------------------------------
MSMEG_0545|M.smegmatis_MC2_155      --------------------------------------------------
MAB_3361|M.abscessus_ATCC_1997      LTNQEIAAQLFISSHTVEWHLRKVFAKRGITSRRQLRSGR----------
TH_3225|M.thermoresistible__bu      LTNQEIGAQLFLSVHTVEWHLRKVFVKLGITSRRQLRAAPRVTATW----
Mflv_4504|M.gilvum_PYR-GCK          ATNKDIAAAMFISSKTVEHNLTRIYRKLGISSRAELGRRMDQPGL-----
MAV_2362|M.avium_104                LSNREIADRLVISVRTVEGHLYRLFTKLGINSREQLTLLVAREPRGRREL
                                                                                      

Mb1393|M.bovis_AF2122/97            -------------------
Rv1358|M.tuberculosis_H37Rv         -------------------
MLBr_01753|M.leprae_Br4923          -------------------
MMAR_0123|M.marinum_M               -------------------
Mvan_5928|M.vanbaalenii_PYR-1       -------------------
MUL_2743|M.ulcerans_Agy99           -------------------
MSMEG_0545|M.smegmatis_MC2_155      -------------------
MAB_3361|M.abscessus_ATCC_1997      -------------------
TH_3225|M.thermoresistible__bu      -------------------
Mflv_4504|M.gilvum_PYR-GCK          -------------------
MAV_2362|M.avium_104                LGHSNPSLGDQDDVHPHAG