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MFLSAPAFRVEPTRSRHSALRWARHRRFADVPRWQMLRSLQIADQIARTGHMPVRRLDLIWISARNAARR ELDLGVAALVEAVTLLTADVEGSTRLSQTRLNELAADYPTLDQNISEAVAAHGGVTRPVDQEVGSGLVVA FLRAGDAIACALELQLSTLAPMRPRVGVHTGDVRLRGDGTITGSAINESACLRDLAHEGQTLLSAATGDL VIDQLPANTWLTDVGKYPLRGLHRQERVIQLCHRDLRNEFPPLRMSVGNRSSLPAQFTTFVGRDAQINEV QEVLTNYRLVTLRGEGGVGKTRLAIQIAAASEFRDGLCFVDLAPIADPGMVSTTAAHALGLIDRPGSSTF DTLSHAIGNCHMLMVLDNCEHVLDACAELVVELLGACPELSILATSRESIGVTGEVTWVVPSLSPANEAI QLFTERARLVQPNFEIVADNFAAVSEICRRLDGMPLAIELAAARLRSLSPNEIANSLDDRFRLLTGGARS TVQRQQTLRASMDWSYALLTDTERILFRRLAVFVGGFDLTAASEVAAAGGDDFVERYSVLDQLTLLVDKS LVVAEESRGSTRYRLLETVRQYALEKLNESEEIDGVRARHRTHYATMAAGLNVPASTDYEQRLLQAEAEI DNLRAAFTWSRGNGDIAAALQLASALQPLWSQGRMREGLAWLESILEREGDNHLVPAGVWARALAEKVIL KAWPATSPMGAPDIVAQAHHALALARDAGDCAVLARALVACGCGSGCDTEAAQPYFAEAIELARAINDEW TLSQIDYWQVVGIFISGQPIPLRAAAEQARELADSIGNRFVSRQCRLFACLAQIWEGDANGALALSRDVT AEAEVANDVVTKVLGLYVEAMALSYIGDSAARTIAGAALEAATELGGIYQDLGYGAITRAALAAGDVAAI EASEASWDLRNQHNVVTAHHELMAQAALVRGDVTTARRFADEAVLASTGWHLMMALIARARVAIAQDELG KARDDAHAAVACGVGVQTYLAMPDALELLAGLAGEAGNHGQAVRLFGAAAAQRQRTGEVRHKIWDAGYEA ATAALRDAMGDEDFTAAWAEGAAAPLDEAIAYAQRGRGERKRPSNGWDALTPAEHKIVKLVTEGLVTKDI AARLFVSPRTVQTHLTHIYTKLDVTSRVQLVQEAAQHST
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1393 | - | - | 100% (1159) | transcriptional regulatory protein |
M. bovis AF2122 / 97 | Mb0914c | - | 0.0 | 65.61% (884) | LuxR family transcriptional regulator |
M. bovis AF2122 / 97 | Mb0393 | - | 0.0 | 53.54% (1087) | LuxR/UHPA family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. gilvum PYR-GCK | Mflv_4504 | - | 7e-14 | 25.54% (603) | regulatory protein, LuxR |
M. tuberculosis H37Rv | Rv1358 | - | 0.0 | 99.83% (1159) | transcriptional regulatory protein |
M. leprae Br4923 | MLBr_01753 | - | 0.0 | 58.12% (1084) | putative transcriptional regulator |
M. abscessus ATCC 19977 | MAB_3361 | - | 1e-08 | 39.53% (86) | LuxR family transcriptional regulator |
M. marinum M | MMAR_0123 | - | 0.0 | 51.85% (1107) | LuxR family transcriptional regulator |
M. avium 104 | MAV_2362 | - | 1e-11 | 23.75% (943) | TPR repeat-containing protein |
M. smegmatis MC2 155 | MSMEG_0545 | - | 3e-18 | 38.92% (167) | transcriptional regulator, LuxR family protein |
M. thermoresistible (build 8) | TH_3225 | - | 8e-13 | 27.95% (508) | PUTATIVE regulatory protein, LuxR |
M. ulcerans Agy99 | MUL_2743 | - | 4e-99 | 33.92% (846) | LuxR family transcriptional regulator |
M. vanbaalenii PYR-1 | Mvan_5928 | - | 0.0 | 53.22% (1086) | regulatory protein, LuxR |
CLUSTAL 2.0.9 multiple sequence alignment Mb1393|M.bovis_AF2122/97 MFLSAPAFRVEPTRSRHSALRWARHRRFADVPRWQMLRSLQIADQIARTG Rv1358|M.tuberculosis_H37Rv MFLSAPAFRVEPTRSRHSALRWARHRRFADGPRWQMLRSLQIADQIARTG MLBr_01753|M.leprae_Br4923 MYSLGEMQKPVPVGADYLASCLVAR-----------LRSTDVPTDLHRG- MMAR_0123|M.marinum_M --MLASMSEIDPRAEAPLVD----------------WSDVDMGELLPTG- Mvan_5928|M.vanbaalenii_PYR-1 -----------------------------------------MSELVPTG- MUL_2743|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0545|M.smegmatis_MC2_155 -----------------------------------------MTEKLSTG- MAB_3361|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3225|M.thermoresistible__bu --MSSRDGDVVLHG------------------------------------ Mflv_4504|M.gilvum_PYR-GCK --MRAALPAAMMNAMSDASP------------------------------ MAV_2362|M.avium_104 -------------------------------------------------- Mb1393|M.bovis_AF2122/97 HMPVRRLDLIWISARNAARRELDLGVAALVEAVTLLTADVEGSTRLSQTR Rv1358|M.tuberculosis_H37Rv HMPVRRLDLIWISARNAARRELDLGVAALVEAVTLLTADVEGSTRLSQTR MLBr_01753|M.leprae_Br4923 ------------------------------CTVTLFLGDVEGLAELSETQ MMAR_0123|M.marinum_M -------------------------------TVTLLLADVEGSTRLWQNQ Mvan_5928|M.vanbaalenii_PYR-1 -------------------------------TVTLLLADVQGSTQLWETQ MUL_2743|M.ulcerans_Agy99 --------------------------------MTFLFTDVEGSTRLWESD MSMEG_0545|M.smegmatis_MC2_155 -------------------------------TKTLLMARVDRAEELWQTE MAB_3361|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3225|M.thermoresistible__bu ----------------------------RAAEIATLRDVMSTARAGSSRV Mflv_4504|M.gilvum_PYR-GCK -----------------------------QAADDPQVAGFLCTATSAPTG MAV_2362|M.avium_104 -----------------------------MGREAELRRSLAALSNAEFHG Mb1393|M.bovis_AF2122/97 LNELAADYPTLDQNISEAVAAH--GGVTRPVDQEVGSGLVVAFLRAGDAI Rv1358|M.tuberculosis_H37Rv LNELAADYPTLDQNISEAVAAH--GGVTRPVDQEVGSGLVVAFLRAGDAI MLBr_01753|M.leprae_Br4923 PDEAADAIARLDCVVSEAVAAH--GGVQQVVQGVRGN-FLATFARASDAT MMAR_0123|M.marinum_M PEPMTAAVAHLDSVLATTVATH--HGVR-PVEQGEGDSFVVAFASAREAI Mvan_5928|M.vanbaalenii_PYR-1 PETMTAAVAQLDRTLTDLVSDH--DGVR-PVEQGEGDSFVVAFTRASDAV MUL_2743|M.ulcerans_Agy99 PDRMRAALAAHDAVLTRTIQTH--RGWLFKHTG---DGVCAAFASPRSAV MSMEG_0545|M.smegmatis_MC2_155 LDQTIAAIPWLRASMAHLIALN--DGTLQRDAS---DSFVAAFDRASDAV MAB_3361|M.abscessus_ATCC_1997 -MLRGQAGVGKTALLRYVLGKA--SGQLIAQASGIQSEMELAFAGLQQFC TH_3225|M.thermoresistible__bu LVLHGEAGVGKTALLGQLLGDA--AGMRCVQVAGVESDMELAYAGLHQLC Mflv_4504|M.gilvum_PYR-GCK LIIEGDAGIGKTTLWLSLLQTARMRGFQVLTARVGQAESVMAFAALADLL MAV_2362|M.avium_104 VALVGDAGVGKSTLARMLAKTVESAGRTVRFALGTQTGSAVPLGAFSHAV * . Mb1393|M.bovis_AF2122/97 ACALELQLSTLAPMRPRVGVHTGDVRLRGDGT---ITGSAINESACLRDL Rv1358|M.tuberculosis_H37Rv ACALELQLSTLAPMRPRVGVHTGDVRLRGDGT---ITGSAINESACLRDL MLBr_01753|M.leprae_Br4923 ACALDLQLAPIVPVRFRIALHTGEVQISNDDVN--NVVFMMVQAAGLLDL MMAR_0123|M.marinum_M ACALDLQRSPLGPIRLRIGVHTGDIQLRDPNDPTNYIGPTINRTARIREL Mvan_5928|M.vanbaalenii_PYR-1 ACALALQRAPLAPIRLRIGVHTGEVRLRDEG---NYVGPTINRTARLREL MUL_2743|M.ulcerans_Agy99 DAAVDAQRALELPVR--MGLATGEAEPHDAD----YFGAVLNRAARVMAT MSMEG_0545|M.smegmatis_MC2_155 MCALDLQLAPLEPFALCIGVHAVEHTDSADS----------DGAARLRDI MAB_3361|M.abscessus_ATCC_1997 APLTKYSGAIPDPQREALTIAFGTRSGPPPDR-----FLIGLAVLSLLAA TH_3225|M.thermoresistible__bu APLLDRLDDLPSPQRDVLNVAFGRGAGPAPGR-----FLVGLAVLNLLAA Mflv_4504|M.gilvum_PYR-GCK GAVSDEHFAALPPLQRLALDRVLLRAGADGPAT--DQRVVAAGFVSLLHI MAV_2362|M.avium_104 SLMAVNEPAVMLAAAHNTLSQDKN------------LVVVVDDAQLLDPL . : Mb1393|M.bovis_AF2122/97 AHEGQTLLSAATGDLVIDQLPANTWLTDVGKYPLRGLHRQERVIQLCHRD Rv1358|M.tuberculosis_H37Rv AHEGQTLLSAATGDLVIDQLPANTWLTDVGKYPLRGLHRQERVIQLCHRD MLBr_01753|M.leprae_Br4923 ACGGQTVLSSITGDLVVDGLPADTWLVDLGSHLLRDLARPVRVMQLCHRN MMAR_0123|M.marinum_M AHGGQTVISGATQLLVVDQLPDGAWLADLGLHPLRDLPRPERVMQLCHSG Mvan_5928|M.vanbaalenii_PYR-1 AHGGQTVLSGTTSDLVADLLPDGGWLSDLGTHRLRDLPRPERVVQLCHAD MUL_2743|M.ulcerans_Agy99 GHGGQILLTDSTANLIS-----GVDLLDLGSRRLRDLPAPVRVFQVRAPG MSMEG_0545|M.smegmatis_MC2_155 ARGGQTLISAAAAALVSARMPAHAALT-----PLRDRVRHEPVYQLNHPG MAB_3361|M.abscessus_ATCC_1997 AAEHQPVLCVIDDAQWLDR----VSLQTLAFVTRRLGSEPVAMLFAVRDG TH_3225|M.thermoresistible__bu AGADQPLLCVIDDAQWLDR----VSLQTLGFVARRLMAEPVAMVFALRDD Mflv_4504|M.gilvum_PYR-GCK LAADAPVLIAIDDVQWLDAS--SRTAIEFAVRRLKGAFGVVVTERCVPGD MAV_2362|M.avium_104 SATLVNQLAAWRSARLIVTIRSGEPVLDAVTALLKERLLLTVHVDPFTRE : : Mb1393|M.bovis_AF2122/97 LRNEFPPLRMS-VGNRSSLPAQFTTFVGRDAQINEVQEVLTNYRLVTLRG Rv1358|M.tuberculosis_H37Rv LRNEFPPLRMS-VGNRSSLPAQFTTFVGRDAQINEVQEVLTNYRLVTLRG MLBr_01753|M.leprae_Br4923 LRRNLHELGIRTVPGGPSLPVPLTTFVGRAAQIKELQELLTEKRLLTLVG MMAR_0123|M.marinum_M LQNDFPPLRTTKSIAVHRMPARLTRFVGRIAQMADVRSLLADNRLVTLTG Mvan_5928|M.vanbaalenii_PYR-1 LSNEFPPLRAREEIGVQRLPAQLTSFVGRVDDMAQVRGLMDANRLVTLTG MUL_2743|M.ulcerans_Agy99 LRTDFPALRAPDTSPG-NLRPALTSFVARAAEIGQVQTALQVHRLVTLTG MSMEG_0545|M.smegmatis_MC2_155 LR----------------------------TEADEVPHLPYG-RVVR--- MAB_3361|M.abscessus_ATCC_1997 TDSELAGLPELTVHG-------LRAADAGTLLDSVIPGLLDERVRDRIVA TH_3225|M.thermoresistible__bu IHEALVGVPALAVPG-------LADADARTLLEHMFPGAIDANVRDRLVA Mflv_4504|M.gilvum_PYR-GCK GTTAGWLTLERPDGLIRVSVPPMDAGRLHALISHRLGRTLTRPVVLRIAE MAV_2362|M.avium_104 QTELLAGTVLGGPVDPWVVDELLQRSSGNPLLLRGFLTAGRDTGALFRTA . Mb1393|M.bovis_AF2122/97 EGGVGKTRLAIQIAA--ASEFRDGLCFVDLAPIADPGMVSTTAAHALGLI Rv1358|M.tuberculosis_H37Rv EGGVGKTRLAIQIAA--ASEFRDGLCFVDLAPIADPGMVSTTAAHALGLI MLBr_01753|M.leprae_Br4923 PGGVGKTRLALQVVARVADEFSGELSYFDLAPDTDHDIFPIT-------- MMAR_0123|M.marinum_M AGGAGKTRLAVEIAASAVDEFGDGLWYVDLAPVSHAEAVPVTVARALGLS Mvan_5928|M.vanbaalenii_PYR-1 AGGVGKTRLATQVAVAVVEGYPGGVWYVDLAPITDPALVAITVARALGLP MUL_2743|M.ulcerans_Agy99 VGGVGKTRLALEVATRVADEFPDGVWLFELAAVSDPAAVPDAVAAVLGIT MSMEG_0545|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3361|M.abscessus_ATCC_1997 ETQGNPLALLELPRDMTAEELAGGFGWPDGGRLAG--------------- TH_3225|M.thermoresistible__bu ESRGNPLALLEVPRTYAVGELAGGFVSPGAGSAPS--------------- Mflv_4504|M.gilvum_PYR-GCK MSGGNPFYALELAHTHVNSGDSPPAAEPPLPATLADVVR----------- MAV_2362|M.avium_104 EGWQLRGPLRGDRELHDALEYRLQSLSSEER------------------- Mb1393|M.bovis_AF2122/97 DRPGSSTFDTLSHAIGNCHMLMVLDNCEHVLDACAEL-VVELLGACPELS Rv1358|M.tuberculosis_H37Rv DRPGSSTFDTLSHAIGNCHMLMVLDNCEHVLDACAEL-VVELLGACPELS MLBr_01753|M.leprae_Br4923 ------VLDNLRRCIGDRRMLMVLDNCEYLLDVCANV-MTTLLGACPSLT MMAR_0123|M.marinum_M DQPGRSTVDALARFIGEHQVLVVLDNCEHLLDATAAL-LLELTGRCPAVR Mvan_5928|M.vanbaalenii_PYR-1 DQPGRSTVDTIVRFIADRRMLVVLDNCEHLLDACATL-IDALLGACPALA MUL_2743|M.ulcerans_Agy99 QQAGKTVTQSVATALERRVRLLVFDNCEHVRDAAADL-IEAILAGSTTVR MSMEG_0545|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3361|M.abscessus_ATCC_1997 -QIEQTFLRRVQQLPAHTQTLLLAAATDPLGDVTLLARAAQQLGIPMHAI TH_3225|M.thermoresistible__bu -RIEENYVHRIRALPAQTRRLLLIAAAEPIGDSALFLRAAALMGIAVDAL Mflv_4504|M.gilvum_PYR-GCK ------RRVGLLDDATRTLLLGVACVADPTVELLARAHGASTDEITAGLE MAV_2362|M.avium_104 ------EVVEILATAGLLNWDILRDICDAEAVAALERRGLIRLVTDGSHA Mb1393|M.bovis_AF2122/97 ILATSRESIGVTGEVTWVVPSLSPAN----EAIQLFTERARLVQPNFEIV Rv1358|M.tuberculosis_H37Rv ILATSRESIGVTGEVTWVVPSLSPAN----EAIQLFTERARLVQPNFEIV MLBr_01753|M.leprae_Br4923 ILATSREPIGVAGEVIWRVSMLSPAD----EAVELFTERAALVQPGFSVT MMAR_0123|M.marinum_M LLATSREPLGVPGEVTFLVPSLSVT-----EATELFTDRARRVRPDFAVT Mvan_5928|M.vanbaalenii_PYR-1 MLATSREPIAVAGEQTWRVPPLALDD----DAIELFTDRARRARPDFIIS MUL_2743|M.ulcerans_Agy99 ILATSRERLEVPDEQLWSVPSLDVGGGVVSAAGTLFVERAQSVAPGFAPT MSMEG_0545|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3361|M.abscessus_ATCC_1997 APAEAADLVELSTRVRFRHPLVRSAVYISANPLERRRIHGVLAGATDPGA TH_3225|M.thermoresistible__bu APAEAARVIQFGPRMRFFHPLMRSAAYRAADPRDRRAVHRALAEATDPGA Mflv_4504|M.gilvum_PYR-GCK RAEAAGIVVLEGNRVRFTHPLLAGGVYTDAGPTARRAMHRAIAS---VES MAV_2362|M.avium_104 VAQLTHPMLG---EAATRHAGMVRTRQLNGKLARALQKHERTGSRHLRLP Mb1393|M.bovis_AF2122/97 AD-NFAAVSEICRRLDGMPLAIELAAARLRSLSPNEIANSLDDRFRLLTG Rv1358|M.tuberculosis_H37Rv AD-NFDAVSEICRRLDGMPLAIELAAARLRSLSPNEIANSLDDRFRLLTG MLBr_01753|M.leprae_Br4923 DG-NRQIVTEICQRLDGMPLAIELAAARIRTLSLTEIADGLDDRFRLLTG MMAR_0123|M.marinum_M DD-NTTAVTEICNRLDCMPLAIELAAARVRALSIDEIRTGLHDRFRLLTG Mvan_5928|M.vanbaalenii_PYR-1 AD-DAAAVSEICHRLDGMPLAIELAAARVRALSLTEIVDGLHDRFRLLTG MUL_2743|M.ulcerans_Agy99 DAQDAAAIGEICRRLDGIPLAIELAASRMASMTPIEVRDRLDHRFRLLVG MSMEG_0545|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3361|M.abscessus_ATCC_1997 DPDRRAWHRAHAAAGTDEAIAWELEQSAGRAQAKGGVLAAAAFLQRATEL TH_3225|M.thermoresistible__bu DPDRRAWHAANGVTGTDDAVAAELEKSAARAQQRGGIAATATFLERAVVL Mflv_4504|M.gilvum_PYR-GCK HPELRARHLALAASSGDDEIFAALDQAADSARARGAPAAAAELMDLALGL MAV_2362|M.avium_104 HLQSRIRLAEFMLHSDMEPDLDVITEAARDALAMSNVQLGEELAR--FAL Mb1393|M.bovis_AF2122/97 GARSTVQRQQTLRASMDWSYALLTDTERILFRRLAVFVGGFDLTAASEVA Rv1358|M.tuberculosis_H37Rv GARSTVQRQQTLRASMDWSYALLTDTERILFRRLAVFVGGFDLTAASEVA MLBr_01753|M.leprae_Br4923 GARTAVRRQQTLRASMDWSYALLTESERALFRRLSAISGTFDLKVA---Y MMAR_0123|M.marinum_M GARTVVRRQQTLRASVDWSHALLTEPERVLFRRIAVFLGGFDLDAA---Q Mvan_5928|M.vanbaalenii_PYR-1 GSRTAVRRQQTLRASVDWSHGLLTDPERVLFRRLAVFAGGFDLDGA---Q MUL_2743|M.ulcerans_Agy99 -SRRGLGRHQTLRHAVAWSYDHLSDAEKVLLERCSVFAGGFDLQSAC--A MSMEG_0545|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3361|M.abscessus_ATCC_1997 TADPAARGRRALAAAQSKYDAAAFDAARELLGVADMTP----------LD TH_3225|M.thermoresistible__bu TADPGLRGRRALAAAQAKRDAADSAAAHDLLAIAERAP----------LS Mflv_4504|M.gilvum_PYR-GCK GAHDPMRR---LKAAENHFLAGDTAKAAAALG------------------ MAV_2362|M.avium_104 DRGGGLPAALVLAEAVSWQGRGEEAG------------------------ Mb1393|M.bovis_AF2122/97 AAGGDDFVERYSVLDQLTLLVDKSLVVAEESRGSTRYRLLETVRQYALEK Rv1358|M.tuberculosis_H37Rv AAGGDDFVERYSVLDQLTLLVDKSLVVAEESRGSTRYRLLETVRQYALEK MLBr_01753|M.leprae_Br4923 AVGHDDLEEPDQVFDRLTMLIDKSLVIVEGRQGGSRYRLLETVRQYAMKK MMAR_0123|M.marinum_M AVAGDSQVQRYQVVDELALLVDKSLVIAESGGGPTRYRLLETVRQYAQEK Mvan_5928|M.vanbaalenii_PYR-1 AITVDGEVHRYEVVDLLTLLVDKSLLIAENTAGRTRYRLLETVRQYAQEK MUL_2743|M.ulcerans_Agy99 VAGSADTHDDYEVLDLLDALVGKSLLIVDRLSGRSRFSMLETIREFAEEQ MSMEG_0545|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3361|M.abscessus_ATCC_1997 PLARARATRLRAKIAFAESRVGAFGSVTVSEAAIGLVEAARCLENLDDNL TH_3225|M.thermoresistible__bu ALEWARAVHLRAQLEFARSRAGDAGGPPVGQTAAALLTAAQLLQDVDAPA Mflv_4504|M.gilvum_PYR-GCK ---------EVGSIEPPILRAMATSLLATVRMYDNEHRQAVDLLRSALDD MAV_2362|M.avium_104 -----------FVLAHAEPDGDDDWLIARWGCLRAANLFWGCGDAEAARR Mb1393|M.bovis_AF2122/97 LNESEEIDGVRARHRTHYATMAAGLNVPASTD-YEQRLLQAEAEIDNLRA Rv1358|M.tuberculosis_H37Rv LNESEEIDGVRARHRTHYATMAAGLNVPASTD-YEQRLLQAEAEIDNLRA MLBr_01753|M.leprae_Br4923 LEESNEVDLVLARHRDHYMALGALLDTPGDID-HEQLVEQVETELDNLRS MMAR_0123|M.marinum_M LAESGEVEAVRSRHVTYYKSVAKLLDAPTGTD-HERRLAQAEDELDNLRS Mvan_5928|M.vanbaalenii_PYR-1 LGESGEADTLRARHRDHYTARAAELDAPSVAG-HERRLNQTDIEMDNLRA MUL_2743|M.ulcerans_Agy99 LVTRGQALAARTAHARHFAQRLPDVAAVWDSPRQPEAYTWLTAELANLRL MSMEG_0545|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3361|M.abscessus_ATCC_1997 ARETYLDAVGAAMYGGRLCPRGGAVEVAEPARLAPAGAQP-ARPSDLLLD TH_3225|M.thermoresistible__bu ARESYLEAFAALMYAGRLAPSGALLEAADAVQAAFARAPEGSRAVDAFCQ Mflv_4504|M.gilvum_PYR-GCK AADNVPVQVQVLLRLSFALNSIGELDDARRYARDAVKLAEELGFPGATSA MAV_2362|M.avium_104 EADTVKKRVSSEAGLHLIDALELSMAFFRGDVETTTELGPGLCESDAVPM Mb1393|M.bovis_AF2122/97 AFTWSRGNGDIAAALQLASALQP-LWS-QGRMREGLAWLESILE------ Rv1358|M.tuberculosis_H37Rv AFTWSRGNGDIAAALQLASALQP-LWS-QGRMREGLAWLESILE------ MLBr_01753|M.leprae_Br4923 AFAWSRETGDIAGALQLASSLQP-IWFGRGHMYEGLAWFDSIFE------ MMAR_0123|M.marinum_M AFGWSLETRDFDSALELATSLHP-VWMTRGQGREGLAWLEAGLGNEAGLG Mvan_5928|M.vanbaalenii_PYR-1 AFAWSRENANTDHSLLLASSLHP-LWRARGRLQEGQAWFDAALT-----D MUL_2743|M.ulcerans_Agy99 AFRWTADNNDLDDAASIATWVGF-LGFLVNRFEP-LTWVEEAIE------ MSMEG_0545|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3361|M.abscessus_ATCC_1997 GLARRITHGAAASAQTLGEALTLIRCEAD-RPANTS-WMEQAFP------ TH_3225|M.thermoresistible__bu GMTQRIVGGISAAAAPLRVALTAMCELARSRPAEVVHWLVPAFP------ Mflv_4504|M.gilvum_PYR-GCK ALAWAVHVDFQCGRGLDETALARAMKLYDSTFDVPIIFRAPFVH------ MAV_2362|M.avium_104 ATTWAAVPTCAALAATGRYSEVGRIADIGVRAAMSCGMGLHRFN------ Mb1393|M.bovis_AF2122/97 ---REGDNHLVP-AGVWARALAEKVILKAWPATSPMGAPDIVAQAHHALA Rv1358|M.tuberculosis_H37Rv ---REGDNHLVP-AGVWARALAEKVILKAWPATSPMGAPDIVAQAHHALA MLBr_01753|M.leprae_Br4923 ---HKNIEHLVAPKEVLARAVANKVMLHAILASSPPDGSDLVTQAQQALT MMAR_0123|M.marinum_M NEAGLGNEDVQVSPSTLARALADKVTLLAWTGSMAG-----FDDAERALT Mvan_5928|M.vanbaalenii_PYR-1 YEARPG----EADPAVYARALADRAFMDGHVGITDR-----LDQAQKALA MUL_2743|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0545|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3361|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3225|M.thermoresistible__bu -------------------------------------------------- Mflv_4504|M.gilvum_PYR-GCK -------------------------------------------------- MAV_2362|M.avium_104 -------------------------------------------------- Mb1393|M.bovis_AF2122/97 LARDAGDCAVLARALVACGCGSGCDTEAAQPYFAEAIELARAINDEWTLS Rv1358|M.tuberculosis_H37Rv LARDAGDCAVLARALVACGCGSGCDTEAAQPYFAEAIELARAINDEWTLS MLBr_01753|M.leprae_Br4923 MAREIGDSAVLARALTACGFSSGYDTEVARPYFAEAVELARTQGDKWTLS MMAR_0123|M.marinum_M IARELADPALLIRALVARGVITAYDADVARPYFDEAAQLARELGDSWRLS Mvan_5928|M.vanbaalenii_PYR-1 MARDIDDPALLVRALTACGGLAAYNADVARPLLAEAVDLARSMGDKWMLA MUL_2743|M.ulcerans_Agy99 --RAVDHPKLAFLHVLASQCYTTGRVQEAIRYADEAARLLATDRYEVPFG MSMEG_0545|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3361|M.abscessus_ATCC_1997 -------------IALESATHEVWDDDMWHHLATRAVHIAREVGALSLLP TH_3225|M.thermoresistible__bu -------------VLQESAGHELWDENLVDALSEAVVRQARDAGALAGLP Mflv_4504|M.gilvum_PYR-GCK ----------------ALAMSWTGRLEQAHQELTAVRGVCLERGAESDMM MAV_2362|M.avium_104 -----------IGISEIIAATDAGDDRAAERIYKRYAAMAEGLPG--AEA Mb1393|M.bovis_AF2122/97 QIDYWQVVGIFISG-QPIPLRAAAEQARELADSIGNRFVSRQCRLFACLA Rv1358|M.tuberculosis_H37Rv QIDYWQVVGIFISG-QPIPLRAAAEQARELADSIGNRFVSRQCRLFACLA MLBr_01753|M.leprae_Br4923 QIRLWGVVGFCVSG-DPVALRAAAEAADDLAQEIGDRFVSLQCRLLLSIA MMAR_0123|M.marinum_M QILSLQTRAAMAAG-DPIALEAAGEEGLRIAEAIGDRTTSRECRGALGWV Mvan_5928|M.vanbaalenii_PYR-1 ETLAWQAYAALMGGGDPVAARTAGEEARELADEMGDGFVSRICGWLLGIA MUL_2743|M.ulcerans_Agy99 -IEGWPSGACTSSG---HPEQSVELCRTQLALGHDTHTLTLGC---LVLA MSMEG_0545|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3361|M.abscessus_ATCC_1997 AALIYRAGMHVHAG----ELDAAAELVQEADAISAATGH-APIRYHSLIL TH_3225|M.thermoresistible__bu QALVYRAGVHLLFG----EFGLADTLLTEAESITAATDHRGPVRYHRLII Mflv_4504|M.gilvum_PYR-GCK AIAGFLAINHLWRG-QITDAEAEAAEAVERAEQLGGDDVLIIPMTVRGAI MAV_2362|M.avium_104 MVDAMLGVVRLARG----EFPAACAAFTRSISLFAKGFPSPWLVVVGAFQ Mb1393|M.bovis_AF2122/97 QIWEGDANGALALSRDVTAEAEVANDVVTKVLGLYVEAMALSYIG-DSAA Rv1358|M.tuberculosis_H37Rv QIWEGDANGALALSRDVTAEAEVANDVVTKVLGLYVEAMALSYIG-DSAA MLBr_01753|M.leprae_Br4923 QLWQGDMDGAIVRSGEVVAGAEAAHDTVTRTFGLYVQTRALVHRD-VSAA MMAR_0123|M.marinum_M RAWRGDPIGALHQLGEAIAEASAAHDLLLLMISQVVQGFTYAYVGDADGA Mvan_5928|M.vanbaalenii_PYR-1 HHFQGDLDAALALADGVVSESDVAHDTLNGCCGELVLAHSLAQRGDTDAA MUL_2743|M.ulcerans_Agy99 LTIKGQCDEAEQLADALIESAEATRNPAALCYALLAYGFTFRDTN----- MSMEG_0545|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3361|M.abscessus_ATCC_1997 AAWRGSEPTAIRLIDEAMRDGAARGEGRLLGAMGYAAGVLNNSLG----- TH_3225|M.thermoresistible__bu AAWRGDAVEAARLIEAAAADGEARGEGRLMGLTGYAAALLYNGIG----- Mflv_4504|M.gilvum_PYR-GCK AAYAGRVDDARADARWVLAAVRNRKASHIADWPGMTLCFLEESLG----- MAV_2362|M.avium_104 AQAEGARGDSTAAAAALWRADRAYGPHAAVFLPELELARAWERAA----- Mb1393|M.bovis_AF2122/97 RTIAGAALEAATELGGIYQDLGYGAITRAALAAGDVAA-IEASEAS-WDL Rv1358|M.tuberculosis_H37Rv RTIAGAALEAATELGGIYQDLGYGAITRAALAAGDVAA-IEASEAS-WDL MLBr_01753|M.leprae_Br4923 LVTAGLVVEAAAELSGVYQGIGYAAMVFAALAMGDVAAAVEASEACRPHL MMAR_0123|M.marinum_M CACADAVFTSSAELVGANEGLGYATAAIACQAAGDATAAWKAYQKARELV Mvan_5928|M.vanbaalenii_PYR-1 RAAAQVSLNVAVEVSPVHAGLAHAALAVANLAAGDVTAAEAASDSATRSF MUL_2743|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0545|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3361|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3225|M.thermoresistible__bu -------------------------------------------------- Mflv_4504|M.gilvum_PYR-GCK -------------------------------------------------- MAV_2362|M.avium_104 -------------------------------------------------- Mb1393|M.bovis_AF2122/97 RNQHNVVTAH-HELMAQAALVRGDVTTARRFADEAVLASTGWHLMMALIA Rv1358|M.tuberculosis_H37Rv RNQHNVVTAH-HELMAQAALVRGDVTTARRFADEAVLASTGWHLMMALIA MLBr_01753|M.leprae_Br4923 GADHGLVAIH-LELMAAVALARGDVIVARRLADNSVSATTGWHQMAALTT MMAR_0123|M.marinum_M GMDPQMAGVFPFGALAPLVS--GDLSAARRWADDVVSTSYGCYLSVALTA Mvan_5928|M.vanbaalenii_PYR-1 GPS-EVAGIQDPNVAAQIACTRGDLDTARSLVDGAVSITRGVHRASALTT MUL_2743|M.ulcerans_Agy99 -----------------PASALAAMRRGLRIAQDTGNRNSETHLAAVLCR MSMEG_0545|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3361|M.abscessus_ATCC_1997 --------------------RYELAFMAARRACEHEDLGLYSWCLIELIE TH_3225|M.thermoresistible__bu --------------------RYREALAAARTTCEYEDLGFYSWCLHELVE Mflv_4504|M.gilvum_PYR-GCK ----------------NHREALAALDDSFIAAGPPTTELMYAWHLPDAIE MAV_2362|M.avium_104 -------------------------------AGDTQAATTHATQAAEIAR Mb1393|M.bovis_AF2122/97 RARVAIAQDELGKARDDAHAAVACGVGVQTYLAMPDALELLAGLA----G Rv1358|M.tuberculosis_H37Rv RARVAIAQDELGKARDDAHAAVACGVGVQTYLAMPDALELLAGLA----G MLBr_01753|M.leprae_Br4923 RARIAMAQGEPELARADIHAALACGADIQASLGISDSMELLAELI----S MMAR_0123|M.marinum_M RARVALAQGELGQADRDSHAALSCSAANGTTLGVADTLECLAELA----A Mvan_5928|M.vanbaalenii_PYR-1 RARIAIAQGDPEQAERNAHDALSLAAGVGARLEVPDTLECLARVV----G MUL_2743|M.ulcerans_Agy99 ---VEAKYGDPLSALDHFTLAIHNHHEAGNTTLISTPLAVLAAFF----D MSMEG_0545|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3361|M.abscessus_ATCC_1997 AAVRCGEHDTAVKAFGQLEERALAAQSDWSQGMVARSRALITVGH----D TH_3225|M.thermoresistible__bu AAARVGETDTAHRALGDIEERAGASGTPWGLGALAGARALLADGD----E Mflv_4504|M.gilvum_PYR-GCK AMVGVGRLDDAEILTAALERNGVEHDRRWMRAVGARCRAMLLAAHGDVAA MAV_2362|M.avium_104 AAGMHAAEMRTRHAAVRFGDRSQTARLERLARILDTPLAEAAADH----- Mb1393|M.bovis_AF2122/97 EAGNHGQAVRLFGAAAAQRQRTGEVRHKIWDAGYEAATAALRDAMGDEDF Rv1358|M.tuberculosis_H37Rv EAGNHGQAVRLFGAAAAQRQRTGEVRHKIWDAGYEAATAALRDAMGDEDF MLBr_01753|M.leprae_Br4923 QGDNHRQAGRLFGAASAQREKTGEVRFKVWDAGYESAVAVLRGAMGCKDF MMAR_0123|M.marinum_M TEGDRREAARLLASAEAIRHRTGEVRLKILDAHCEVVLAELRNELGEQDF Mvan_5928|M.vanbaalenii_PYR-1 DGGSHHEAARLCGAAEAIRGRTGAVRFRIYDADHETTVTTLRDALGDKAF MUL_2743|M.ulcerans_Agy99 RLGRYEAAATIAGFAFHPITEASFP-------ELRTTISHLRDALGDHAY MSMEG_0545|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3361|M.abscessus_ATCC_1997 AEPHYREAIQRLTNTRISAHLARAHLIYGEWLRRCNRRSDARTELTAAHG TH_3225|M.thermoresistible__bu ADRLFREALDHLSRSRVVVHRARVHLTYGEWLRREHRRGEARRELNEAHG Mflv_4504|M.gilvum_PYR-GCK AEQMAHRAISEHDHLPMPFERARTRLLLGQLQRRLRQKATAAKNLTDALH MAV_2362|M.avium_104 ARGLTQRDGDLLDAAAQQFADLGALACAADAAAQAAGEHARRGDRGKKFE Mb1393|M.bovis_AF2122/97 TAAWAEGAAAPLDEAIAYAQRGRGERKRPSNGWDALTPAEHKIVKLVTEG Rv1358|M.tuberculosis_H37Rv TAAWAEGAAAPLDEAIAYAQRGRGERKRPSNGWDALTPAEHKIVKLVTEG MLBr_01753|M.leprae_Br4923 DSAWAEGAAMPIDDAITYAQRGRGNRKRPTTGWESLTPAEHNVIRLVSEG MMAR_0123|M.marinum_M AAVWGQGAVISTDEVISYVRRGRGTRRRPSSGWGSLTPTEHDVVRLVQEG Mvan_5928|M.vanbaalenii_PYR-1 EAAWTEGSATSITEAIAYAQRGRGERKRPSSGWASLTPTELDVVGLVSEG MUL_2743|M.ulcerans_Agy99 ESFSQSGAAMTTAAMATYAYHQIDHARTEFQAR----------------- MSMEG_0545|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3361|M.abscessus_ATCC_1997 SFVNMGTAAFAERAERELRATGAKVRKRSASSEKALTAQEAQIARMAGQG TH_3225|M.thermoresistible__bu MFTRMGAQGFAERSRRELIAVGEKVRRQPLTSGDELTAQEAQIAGLAADG Mflv_4504|M.gilvum_PYR-GCK TFEQLGTPLWAQRARSELAR-------AVVAPAEGLTPSEQKVAEMAAAG MAV_2362|M.avium_104 SSAWAHALASRYELHT--------PAVEAAARPLPFSGRERQIVNLVAAG Mb1393|M.bovis_AF2122/97 LVTKDIAARLFVSPRTVQTHLTHIYTKLDVTSRVQLVQEAAQHST----- Rv1358|M.tuberculosis_H37Rv LVTKDIAARLFVSPRTVQTHLTHIYTKLDVTSRVQLVQEAAQHST----- MLBr_01753|M.leprae_Br4923 LDTKDIAARLFVSVRTVHTHLTRIYSKLGLTSRVQLVQEAARHN------ MMAR_0123|M.marinum_M LSNKDIAARMFISPRTVQTHLTHVYTKLGLTSRIQLVHEVARHA------ Mvan_5928|M.vanbaalenii_PYR-1 LSNKDIAARLFVSPRTVQTHLTHVYTKLCLASRVQLAQEAARHT------ MUL_2743|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0545|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3361|M.abscessus_ATCC_1997 LTNQEIAAQLFISSHTVEWHLRKVFAKRGITSRRQLRSGR---------- TH_3225|M.thermoresistible__bu LTNQEIGAQLFLSVHTVEWHLRKVFVKLGITSRRQLRAAPRVTATW---- Mflv_4504|M.gilvum_PYR-GCK ATNKDIAAAMFISSKTVEHNLTRIYRKLGISSRAELGRRMDQPGL----- MAV_2362|M.avium_104 LSNREIADRLVISVRTVEGHLYRLFTKLGINSREQLTLLVAREPRGRREL Mb1393|M.bovis_AF2122/97 ------------------- Rv1358|M.tuberculosis_H37Rv ------------------- MLBr_01753|M.leprae_Br4923 ------------------- MMAR_0123|M.marinum_M ------------------- Mvan_5928|M.vanbaalenii_PYR-1 ------------------- MUL_2743|M.ulcerans_Agy99 ------------------- MSMEG_0545|M.smegmatis_MC2_155 ------------------- MAB_3361|M.abscessus_ATCC_1997 ------------------- TH_3225|M.thermoresistible__bu ------------------- Mflv_4504|M.gilvum_PYR-GCK ------------------- MAV_2362|M.avium_104 LGHSNPSLGDQDDVHPHAG