For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
STPTADSPTINQVNRGPVLLLLFASVVAAIGNGVSIVALPWLVLQRNGSAADAAIVAAAGTLPLVFSTLI SGTAVDYFGRRVMSIFSDVLSLVSVSAIPILAMTTGLNVPLLAALAALGAIFDPAGITARESMLPAAAKS AGWSLDKMNSMYEATFNVAYIVGPGLGGLLIASVGGVNTMWVTAASFVVSIIAIALLKVDGAGKPAHETR PTGVFSGVLEGLRFFWNIKILRTIALVDMAITALYLPIESVLLPKHFSDIGAPQQLGWMLMAISVGGLLG ALGYATMVRHFQRRTIMLCATFTAGITTLGMSLLPPIAVLLVLAACLGFIYGPVAPIANFVMQTRSPEHL RGRVVGVMTSTAYCAGPLGFMLAGPIADKFGVATTLVILGAPMLLIAIASTRMRVLRELDQDEPQPDKEP TR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_1409c | - | - | 100% (423) | putative drug antiporter protein precursor |
| M. abscessus ATCC 19977 | MAB_0880 | - | 4e-18 | 25.66% (378) | hypothetical protein MAB_0880 |
| M. abscessus ATCC 19977 | MAB_0940 | - | 2e-12 | 24.50% (347) | hypothetical protein MAB_0940 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1288c | - | 1e-133 | 56.27% (407) | integral membrane transport protein |
| M. gilvum PYR-GCK | Mflv_2234 | - | 1e-142 | 58.88% (411) | H+ antiporter protein |
| M. tuberculosis H37Rv | Rv1258c | - | 1e-133 | 56.27% (407) | integral membrane transport protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_4182 | - | 1e-135 | 56.97% (409) | hypothetical protein MMAR_4182 |
| M. avium 104 | MAV_1406 | - | 1e-130 | 56.68% (404) | transporter, major facilitator family protein |
| M. smegmatis MC2 155 | MSMEG_0357 | - | 7e-18 | 24.55% (391) | transmembrane transport protein |
| M. thermoresistible (build 8) | TH_2406 | - | 1e-131 | 56.75% (400) | PROBABLE CONSERVED INTEGRAL MEMBRANE TRANSPORT PROTEIN |
| M. ulcerans Agy99 | MUL_4170 | - | 4e-07 | 27.41% (197) | integral membrane transport protein |
| M. vanbaalenii PYR-1 | Mvan_4461 | - | 1e-142 | 60.00% (405) | H+ antiporter protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1288c|M.bovis_AF2122/97 -------------MRNSNRGPAFLILFATLMAAAGDGVSIVAFPWLVLQR
Rv1258c|M.tuberculosis_H37Rv -------------MRNSNRGPAFLILFATLMAAAGDGVSIVAFPWLVLQR
MMAR_4182|M.marinum_M -------------MRNSSRGPAFLILFATLAACAGNGISIVAFPWLVLER
MAV_1406|M.avium_104 -----------------------MILFATLLATAGTGISIVAFPWLALQH
Mflv_2234|M.gilvum_PYR-GCK ---------MTPDTTPRSRTPLLLIMFAALMAGAGNGISIVAFPWLVLQR
Mvan_4461|M.vanbaalenii_PYR-1 ---------MTPNEAPSRRGPLLLILFAALMAGAGNGISLVAFPWLVLQR
TH_2406|M.thermoresistible__bu -------------MSTSTRGPVLLIYSAALTAGAGNGISIIAFPWLVLQR
MAB_1409c|M.abscessus_ATCC_199 ---MSTPTADSPTINQVNRGPVLLLLFASVVAAIGNGVSIVALPWLVLQR
MSMEG_0357|M.smegmatis_MC2_155 MTTATPAMGATSTWAPLASPIYRALWIAQFVSNLGTWMQTVGAQWMLVGD
MUL_4170|M.ulcerans_Agy99 ----------MNRGNVRPKLVLGVIVLGSFIASIDLTIVNVALPTLSRAL
: . . : . : :. :
Mb1288c|M.bovis_AF2122/97 EGSAGQASIVASATMLPLLFATLVAGTAVDYFGRRRVSMVADALSGAAVA
Rv1258c|M.tuberculosis_H37Rv EGSAGQASIVASATMLPLLFATLVAGTAVDYFGRRRVSMVADALSGAAVA
MMAR_4182|M.marinum_M EGSAGQASIVAGAITLPLLFSTLVAGTAVDYFGRRPVSMVSDALSGSAVA
MAV_1406|M.avium_104 RHSATDASIVAAAMTLPLVLATLIAGTAVDFFGRRRVSLVCDWLSGAAVT
Mflv_2234|M.gilvum_PYR-GCK TGSALDASIVAMAGTLPLLAATLIAGAAVDFLGRRRVSMISDALSALSVA
Mvan_4461|M.vanbaalenii_PYR-1 TGSALDASIVAMAGTLPLLAATLIAGAAVDFLGRRRVSMISDALSALSVA
TH_2406|M.thermoresistible__bu NGSALEASVVAMAATXPLLVATLFAGVAVDYLGRRRVSMISDLLSALSVA
MAB_1409c|M.abscessus_ATCC_199 NGSAADAAIVAAAGTLPLVFSTLISGTAVDYFGRRVMSIFSDVLSLVSVS
MSMEG_0357|M.smegmatis_MC2_155 PRAAVLVPLVQTATTLPVMLLALPSGVLADLVDRRRLLIAAQGATAAGVA
MUL_4170|M.ulcerans_Agy99 QASNAELQWIVDSYAIAAAGLLLAAGNLGDRYGRRGWLTIGLVIVGASSA
: : : . * :* * .** . :
Mb1288c|M.bovis_AF2122/97 GVP-LVAWGYGGDAVNVLVLAVLAALAAAFGPAGMTARDSMLPEAAARAG
Rv1258c|M.tuberculosis_H37Rv GVP-LVAWGYGGDAVNVLVLAVLAALAAAFGPAGMTARDSMLPEAAARAG
MMAR_4182|M.marinum_M IVP-LIAWAFGDDAVSVAVLAALGACSATFDPAGITARQSMLPEAAARAG
MAV_1406|M.avium_104 AVP-LTAWIFGAAAIDVAELAVLAFCAAAFDPAGMTARQSMLPEAAARAG
Mflv_2234|M.gilvum_PYR-GCK AVP-VIALVFGADAVNVAVLAALAALGAFFDPAGMTARETMLPEAAHRAG
Mvan_4461|M.vanbaalenii_PYR-1 AVP-VLALAFGTDVINVAVLAGLAALGAIFDPAGMTARETMLPEAANRAG
TH_2406|M.thermoresistible__bu AVP-VIALTFGVQAVNVAVLAALAALGAFFDPAGMTARETMLPEAAARAG
MAB_1409c|M.abscessus_ATCC_199 AIP-ILAMTTG---LNVPLLAALAALGAIFDPAGITARESMLPAAAKSAG
MSMEG_0357|M.smegmatis_MC2_155 SLATLTGAGLATPTVLLTLLFLIGCGQALTAPAWQAIQPDLVPREQIPAA
MUL_4170|M.ulcerans_Agy99 VAA-----SAGSAQAVIGARAVMGVGAAIIFPTSLALVTNVFVDSTHRA-
. . : :. * *: : :. *
Mb1288c|M.bovis_AF2122/97 WSLDRINGAYEAILNLAFIVGPAIGGLMIATVGGITTMWITATAFGLSIL
Rv1258c|M.tuberculosis_H37Rv WSLDRINGAYEAILNLAFIVGPAIGGLMIATVGGITTMWITATAFGLSIL
MMAR_4182|M.marinum_M WSLDRINSSYEAILNLAFVVGPGIGGLMIATVGGITTMWITAGAFGLSLL
MAV_1406|M.avium_104 WSLDRTNSSYEAMLNLAFIVGPGLGGLLIATLGGINTMWVTAGCFALSFL
Mflv_2234|M.gilvum_PYR-GCK WTLDRANSFFEAVFNLAYIVGPGIGGLLIATLGGIDTMWVTAGAFVLSIA
Mvan_4461|M.vanbaalenii_PYR-1 WTLDHANSVFEAIFNLAYIVGPGIGGLLIATLGGIDTMWVTAGAFGLSIF
TH_2406|M.thermoresistible__bu WTLDKTNSGYEAIFNLAYIVGPGIGGLLIATLGGVNTMWVTAALFVVSIV
MAB_1409c|M.abscessus_ATCC_199 WSLDKMNSMYEATFNVAYIVGPGLGGLLIASVGGVNTMWVTAASFVVSII
MSMEG_0357|M.smegmatis_MC2_155 AALGSMS------MNGARAIGPAIAGALVSLSGPTLVFALNAVSFVGIVA
MUL_4170|M.ulcerans_Agy99 ----RAIGVWSAVTGIAVVIGPILGGWLIEHFSVGSVFWVNVPIAVVAIV
. * :** :.* :: . .: :.. .
Mb1288c|M.bovis_AF2122/97 AIAALQLEGAGKPHHTSRPQGLVSGIAEGLRFVWNLRVLRTLGMIDLTVT
Rv1258c|M.tuberculosis_H37Rv AIAALQLEGAGKPHHTSRPQGLVSGIAEGLRFVWNLRVLRTLGMIDLTVT
MMAR_4182|M.marinum_M AIGALRLEGAGRPHHETRPDGLVSGVTQGLRFVWNLRVLRALALIDLTVT
MAV_1406|M.avium_104 AIGALRLEGAGKPPRATRPVGLVTGIAEGVRFVWNLRVLRTLGLIDLAVT
Mflv_2234|M.gilvum_PYR-GCK AIAVLRLEGTARPDPSTMSDGVWAGILEGLRFVWNNKVLRTLAFVDLAAT
Mvan_4461|M.vanbaalenii_PYR-1 AIAALKLEGAGRPDPTAMSDGVWAGIIEGLRFVWRNKVLRTLALVDLVAT
TH_2406|M.thermoresistible__bu TIAALRLEGAGLPDRALLTDSVLAGIVEGLRFVWRTPVLRALLIVDLVVT
MAB_1409c|M.abscessus_ATCC_199 AIALLKVDGAGKPAHETRPTGVFSGVLEGLRFFWNIKILRTIALVDMAIT
MSMEG_0357|M.smegmatis_MC2_155 VLLLWRRPAAERMLPAERP---LAALSAGGRYIRSAPIVRRILLRTVLFI
MUL_4170|M.ulcerans_Agy99 SVNMFVPTSRNPDRPPLDLPGLLVSTVGVTVLTYTLIETPNIGWASARTA
: . . :
Mb1288c|M.bovis_AF2122/97 ALYLPMESVLFPKYFTDHQQP-VQLGWALMA---IAGGGLVGALGYAVLA
Rv1258c|M.tuberculosis_H37Rv ALYLPMESVLFPKYFTDHQQP-VQLGWALMA---IAGGGLVGALGYAVLA
MMAR_4182|M.marinum_M ALYLPMESVLFPTYFSDRQQP-AQLGSVLVA---LSLGSLVGALGYGMLS
MAV_1406|M.avium_104 ALYLPMESVLFPKYFADQHQP-AQLGWALMA---LALGGVAGALGYAVLS
Mflv_2234|M.gilvum_PYR-GCK GLYMPMESVLFPKYFTDRDEP-AQLGWVLMA---LSIGGLLGALGFAVLS
Mvan_4461|M.vanbaalenii_PYR-1 GLYVPMESVLFPKYFTDRNEP-AQLGWVLMA---LSIGGLIGALGYAVMS
TH_2406|M.thermoresistible__bu GLYMPMESVLFPKYFTDRDEP-AHLGWVLMA---LSIGGLTGALAYAWVS
MAB_1409c|M.abscessus_ATCC_199 ALYLPIESVLLPKHFSDIGAP-QQLGWMLMA---ISVGGLLGALGYATMV
MSMEG_0357|M.smegmatis_MC2_155 APGSALWGLLAVIAKDQLDLTSSGYGVLLGA---LGLGAVCGAFVLGRLQ
MUL_4170|M.ulcerans_Agy99 AGFALAVVLLAVFLWLERRTWHPILDLSIFANRRFSGGTAAVTTAYLVMC
. :* : . : * :. * : :
Mb1288c|M.bovis_AF2122/97 IRVPRRVTMSTAVLTLGLASMVIAFLPPLPVIMVLCAVV-----------
Rv1258c|M.tuberculosis_H37Rv IRVPRRVTMSTAVLTLGLASMVIAFLPPLPVIMVLCAVV-----------
MMAR_4182|M.marinum_M NYVSRRTIMLTAVLTLGAATTGIALLPPLPVILVLCALI-----------
MAV_1406|M.avium_104 ARLRRRTAVLTATLTFGATTAGIAVLPPLPVILGLCAVT-----------
Mflv_2234|M.gilvum_PYR-GCK KYLKRRTVMLTAVLTLGVAMTVIAFLPPLPIILVLCALV-----------
Mvan_4461|M.vanbaalenii_PYR-1 RYMKRRTVMLTAVLTLGVAMTVIAFLPPLPIILVLCAIV-----------
TH_2406|M.thermoresistible__bu RFVSRRATLITAVLTLGATMTVIAFLPPLPLILAMAAVG-----------
MAB_1409c|M.abscessus_ATCC_199 RHFQRRTIMLCATFTAGITTLGMSLLPPIAVLLVLAACL-----------
MSMEG_0357|M.smegmatis_MC2_155 KMFELNTLLVVAAIGFGGATVVLALVHQVAVVVIALVLG-----------
MUL_4170|M.ulcerans_Agy99 GFIFVATQYLQFVAAYRAFDTGVRLVPLAFSYAGLSVIAPRIVERVGTTA
. . . : .: .
Mb1288c|M.bovis_AF2122/97 ----GLVYGPIQPIYNYVIQTRAAQHLRGRVVGVMTS-LAYAAGPLGLLL
Rv1258c|M.tuberculosis_H37Rv ----GLVYGPIQPIYNYVIQTRAAQHLRGRVVGVMTS-LAYAAGPLGLLL
MMAR_4182|M.marinum_M ----GVVYGPIQPIYNYVMQTRAPHYLRGRVVGVMTS-LAYAAGPLGLLL
MAV_1406|M.avium_104 ----GVVYGPIQPIYNFVMQTRAPHHLRGRVVGVMAG-LTYAAGPLGLLV
Mflv_2234|M.gilvum_PYR-GCK ----GFVYGPIAPIYNYVMQTRAPQHLRGRVVGVMGS-LAYAAGPLGLIL
Mvan_4461|M.vanbaalenii_PYR-1 ----GFVYGPIAPIYNYVMQTRAPQHLRGRVVGVMGS-LAYAAGPLGLIL
TH_2406|M.thermoresistible__bu ----GFAYGPIQPIYNYVMQTRAPQHLRGRVVGVMGS-LAYAAGPLGLVI
MAB_1409c|M.abscessus_ATCC_199 ----GFIYGPVAPIANFVMQTRSPEHLRGRVVGVMTS-TAYCAGPLGFML
MSMEG_0357|M.smegmatis_MC2_155 ----GTAWLLALSTLNASMQLSLPGWVRARGLSVYQL-VFMGGQALGSLL
MUL_4170|M.ulcerans_Agy99 VVTSGLVMVAVSVACAGGFDAGTPYWLIAAVMAALGSGLGLTMAPASEAI
* :: . : . :.. . . :
Mb1288c|M.bovis_AF2122/97 AGPLTDAAG---------LHATFLALALPIVCTGLVAIRLPALR------
Rv1258c|M.tuberculosis_H37Rv AGPLTDAAG---------LHATFLALALPIVCTGLVAIRLPALR------
MMAR_4182|M.marinum_M AGPVADAAG---------LKVAFFALALPIAITGLMCIRLPSLR------
MAV_1406|M.avium_104 AGPLADAAG---------LKATFLTLAVPILAIGVVACGLPSLR------
Mflv_2234|M.gilvum_PYR-GCK AGPLADSAG---------LHVTFLALSLPMLALGIVSVFLPALR------
Mvan_4461|M.vanbaalenii_PYR-1 AGPLADATG---------LRTTFLALSLPMLALGIVAVFLPALR------
TH_2406|M.thermoresistible__bu AGPLADSAG---------LRVTFLALSLPMVALGLIAIGLPVLT------
MAB_1409c|M.abscessus_ATCC_199 AGPIADKFG---------VATTLVILGAPMLLIAIASTRMRVLR------
MSMEG_0357|M.smegmatis_MC2_155 WGLIAGAAG---------SVTALLVSAGLMGVCAVSAIWWPLHAR---TG
MUL_4170|M.ulcerans_Agy99 MGSLSPTAAGVGSAVTGVARQLGACLGVAIVGSVFASVYLRSMSSNAALH
* :: . . : . .
Mb1288c|M.bovis_AF2122/97 ELDLAPQADIDRPVGSAQ--------------------------------
Rv1258c|M.tuberculosis_H37Rv ELDLAPQADIDRPVGSAQ--------------------------------
MMAR_4182|M.marinum_M ELDHAPTQDISETSLL----------------------------------
MAV_1406|M.avium_104 ELDRAPQFADDPGA------------------------------------
Mflv_2234|M.gilvum_PYR-GCK ELDTPHP-------------------------------------------
Mvan_4461|M.vanbaalenii_PYR-1 DLDRPAAGP-----------------------------------------
TH_2406|M.thermoresistible__bu TLNQPAADQIDLQFDD----------------------------------
MAB_1409c|M.abscessus_ATCC_199 ELDQDEPQPDKEPTR-----------------------------------
MSMEG_0357|M.smegmatis_MC2_155 NLDMTPSAHWPEPALIFEPEPLDGPVVVLVSYRVEPAQETGFFEAMAALG
MUL_4170|M.ulcerans_Agy99 GLDPAARAAMRQSMAAAKQVLDQLPVGEAPAIRHAVESAFLESFGVGCLA
*:
Mb1288c|M.bovis_AF2122/97 --------------------------------------------------
Rv1258c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4182|M.marinum_M --------------------------------------------------
MAV_1406|M.avium_104 --------------------------------------------------
Mflv_2234|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4461|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2406|M.thermoresistible__bu --------------------------------------------------
MAB_1409c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_0357|M.smegmatis_MC2_155 RSRQRTGASQWQLFRSGEHAGTFVEAFIVRSWEEHLRQHHTRLTGHDLLV
MUL_4170|M.ulcerans_Agy99 CAVFAAVGAVVVAFLLPARGEVRDDVAVSVAASAIGPAEGGK--------
Mb1288c|M.bovis_AF2122/97 -----------------------
Rv1258c|M.tuberculosis_H37Rv -----------------------
MMAR_4182|M.marinum_M -----------------------
MAV_1406|M.avium_104 -----------------------
Mflv_2234|M.gilvum_PYR-GCK -----------------------
Mvan_4461|M.vanbaalenii_PYR-1 -----------------------
TH_2406|M.thermoresistible__bu -----------------------
MAB_1409c|M.abscessus_ATCC_199 -----------------------
MSMEG_0357|M.smegmatis_MC2_155 EETVRRFTVGEPTSQHLIAAKTH
MUL_4170|M.ulcerans_Agy99 -----------------------