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DFGALPPEINSGRMYVGPGSGPMLAAAVVWDELAAELYATAAGYRSTLDGLTGGSWRGPASASMAAAAAP YVAWMTATAAQAELAGSQAKVAASAYETAFAATVPPPVIAANRALLMGLVFTNIFGQNTPAIAATEAHYA EMWAQDAAAMYAYAGSSATATQVTPFTEPPQITSPSGAVSQAAAVTEAATASASSDITAQLSPLIAVVPN ALQGMATSGNPAAAIAGLPDVALPAGIITDLQNFTTILDTLDGPFTIQGLTGVPGGPFLAFGQVYAFSQN MVGAQAFFSPAEPVIGGLAPLAGEANLGAAGVVGGPSVGGQASGAMGHAALVGNMSVPQGWTQEAPAIRV FVSELPTSVTAAPAATLAGESAVFNQMALSSLAGRALGTGAFGSGGGGGASKAIGGVVAEADPAAATIIV IPAIED*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_1461 | - | - | 100% (427) | PPE family protein |
| M. marinum M | MMAR_2684 | - | e-150 | 62.53% (427) | PPE family protein, PPE32 |
| M. marinum M | MMAR_2928 | - | 3e-90 | 50.87% (403) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1837 | PPE32 | 1e-128 | 58.25% (424) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 1e-31 | 36.99% (219) | PPE protein |
| M. tuberculosis H37Rv | Rv1808 | PPE32 | 1e-129 | 58.31% (427) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 5e-49 | 34.76% (420) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0669 | - | 1e-32 | 32.48% (391) | PPE-family protein |
| M. avium 104 | MAV_2910 | - | 1e-130 | 59.67% (429) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 4e-34 | 31.90% (442) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 1e-33 | 32.53% (375) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_3072 | - | 1e-150 | 62.30% (427) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 3e-34 | 31.28% (438) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1837|M.bovis_AF2122/97 -------------MDFGALPPEINSGRMYAGPGSGPLLAAAAAWDALAAE
Rv1808|M.tuberculosis_H37Rv -------------MDFGALPPEINSGRMYAGPGSGPLLAAAAAWDALAAE
MAV_2910|M.avium_104 ------------MLDFGAYPPEYNSGRMYVGAGSGPLLAAAAAWDELAAE
MUL_3072|M.ulcerans_Agy99 ------------MIDFGALPPEINSGRMYVGPGAAPLIAAAAAWDELAAE
MMAR_1461|M.marinum_M -------------MDFGALPPEINSGRMYVGPGSGPMLAAAVVWDELAAE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
MAB_0669|M.abscessus_ATCC_1997 ----------MTAPIWMAEPPEVHSALLSAGPGPGAVLAAAVQWQEIGNN
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
* .** :* : *.*...: :*. * :. :
Mb1837|M.bovis_AF2122/97 LYSAAASYGSTIEGLTVAPWMGPSSITMAAAVAPYVAWISVTAGQAEQAG
Rv1808|M.tuberculosis_H37Rv LYSAAASYGSTIEGLTVAPWMGPSSITMAAAVAPYVAWISVTAGQAEQAG
MAV_2910|M.avium_104 LQSVGASYGSTVETLTTGPWTGPSSIAMAAAAAPYVAWLQATGAQAEQAG
MUL_3072|M.ulcerans_Agy99 LQSMAASYGSTVQGLTVAPWTGASSITMAAAAAPYVTWINTTGVQAEQAA
MMAR_1461|M.marinum_M LYATAAGYRSTLDGLTGGSWRGPASASMAAAAAPYVAWMTATAAQAELAG
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
MAB_0669|M.abscessus_ATCC_1997 YANTAVELAQVLAGVRAGSWQGPSASEYVAAHLPYLAWLEQAAAESSVIA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLT-TFEGESAAALAERVTPYEKWLTQNAASAELTA
. : .: * .: . ** *: . . .
Mb1837|M.bovis_AF2122/97 AQAKIAAGVYETAFAATVPPPVIEANRALLMSLVATNIFGQNTPAIAATE
Rv1808|M.tuberculosis_H37Rv AQAKIAAGVYETAFAATVPPPVIEANRALLMSLVATNIFGQNTPAIAATE
MAV_2910|M.avium_104 AQAKLAAAAYETAFAATVPPPVIAANRALLATLVATNILGQNTPAIAATE
MUL_3072|M.ulcerans_Agy99 TQAKLAAGAYETASAATVPPPVIAANRALLMALIATNIFGQNTPAIAAAE
MMAR_1461|M.marinum_M SQAKVAASAYETAFAATVPPPVIAANRALLMGLVFTNIFGQNTPAIAATE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
MAB_0669|M.abscessus_ATCC_1997 AQHETTAAAYNSALAAMPTLAELAANHITHGVLVGTNFFGINTIPIALNE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
* :* .: :* : . : *: *: :*::* *: .** *
Mb1837|M.bovis_AF2122/97 AHYAEMWAQDAAAMYGYAGSSATASQLAPFS-EPPQTTNPSATAAQSAVV
Rv1808|M.tuberculosis_H37Rv AHYAEMWAQDAAAMYGYAGSSATASQLAPFS-EPPQTTNPSATAAQSAVV
MAV_2910|M.avium_104 AHYMEMWAQDAAAMYAYAASSASAAQLTPFT-EPPRTTNESAGPLQSAAV
MUL_3072|M.ulcerans_Agy99 AQYLEMWAQDAAAMYAYAGTAAAASALTPFT-EPPQTTNPVAGAAQSAAV
MMAR_1461|M.marinum_M AHYAEMWAQDAAAMYAYAGSSATATQVTPFT-EPPQITSPSGAVSQAAAV
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
MAB_0669|M.abscessus_ATCC_1997 ADYVRMWVQAAATMSAYQATTEAMTSAIPPTQQPPAILSPG-GEARSDQS
TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAAI
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
*.* .** * *::* * . .*
Mb1837|M.bovis_AF2122/97 AQAAGAAASSDITAQLS---------------------------------
Rv1808|M.tuberculosis_H37Rv AQAAGAAASSDITAQLS---------------------------------
MAV_2910|M.avium_104 AQSAAQSGS-NTAAHLS---------------------------------
MUL_3072|M.ulcerans_Agy99 AQASSTAASSDVVSQLA---------------------------------
MMAR_1461|M.marinum_M TEAATASASSDITAQLS---------------------------------
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLRDPI
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLRDPL
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGG-QAILDFLKDPL
MAB_0669|M.abscessus_ATCC_1997 DVPGSPDQIMKMLQG---------------------------FQQWFEKM
TH_3113|M.thermoresistible__bu TGAHVTAELRAAESRTLLDEINELIDRLFAPLFPPGFADALPDGLLGTLL
MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEAEQAIS---------------------------------
Mb1837|M.bovis_AF2122/97 -----QLISLLPSTLQSLATTAT----------------------ATSAS
Rv1808|M.tuberculosis_H37Rv -----QLISLLPSTLQSLATTAT----------------------ATSAS
MAV_2910|M.avium_104 -----QLSATAQPAAQAAGNAAS----------------------TTAAS
MUL_3072|M.ulcerans_Agy99 -----GLITSVPNALQTLATTSA----------------------APTAA
MMAR_1461|M.marinum_M -----PLIAVVPNALQGMATSGN----------------------PAAAI
Mflv_0325|M.gilvum_PYR-GCK GNTFALITDFLTNPVQALITWGP------FLLAVVYQA----VSWVGASI
Mvan_0415|M.vanbaalenii_PYR-1 GNTIKLITDFLTNPAQALITWGP------FLAAVAYQA----VSWVGASI
MSMEG_0619|M.smegmatis_MC2_155 GNLGRLLTDFMTNPAGALATWWP------FLFGVAYQVFFNLVGWPTWGM
MAB_0669|M.abscessus_ATCC_1997 G--------FNPATSAVLAVIML------FLYDLLWYP---------YYA
TH_3113|M.thermoresistible__bu APLLPGATGDGPPMATIMSFLLMGLSNPAYLFPVLVYLLFTGVVHTTVAV
MLBr_01182|M.leprae_Br4923 ------QAALDQAVNEGMEATVVP----------------------QVDQ
Mb1837|M.bovis_AF2122/97 AGWDTVLQ---------------SITTILANLTGPYSIIGLGAIP-----
Rv1808|M.tuberculosis_H37Rv AGWDTVLQ---------------SITTILANLTGPYSIIGLGAIP-----
MAV_2910|M.avium_104 TQLTTPSF-------------ITNWNEFWSVVTGVYSPQSWTTIP-----
MUL_3072|M.ulcerans_Agy99 SILPEVSLPPWLATN------LANWNTIMATLTGPFSLQGISSIP-----
MMAR_1461|M.marinum_M AGLPDVALPAGIITD------LQNFTTILDTLDGPFTIQGLTGVP-----
Mflv_0325|M.gilvum_PYR-GCK LYPSLFLLPLLATT-------LAIVAGVGQHLLSLLNTPPAEEAAEEPAP
Mvan_0415|M.vanbaalenii_PYR-1 LYPSLLLLPLVATT-------LAIVLGVGAYLLENLPAPAEDAPAEEPAA
MSMEG_0619|M.smegmatis_MC2_155 IFASPFLIPALAALG-----ITGLVLLIDHVLNNPVDVPAEDEAPQEVAA
MAB_0669|M.abscessus_ATCC_1997 SYLLPFLIPALSGLS-----GLAALMHLRPAAPGPVPA-AALSPGDRPIR
TH_3113|M.thermoresistible__bu SGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLAGLAGLTAVPAADGG
MLBr_01182|M.leprae_Br4923 QVNVDVATPQTAVPDSSSAAAPQLWGGFAQHLSPINDTLSMINN------
.
Mb1837|M.bovis_AF2122/97 --------GGWWLTFGQILGLAQNAPGVAALLG-PKAAAGALSPLAP---
Rv1808|M.tuberculosis_H37Rv --------GGWWLTFGQILGLAQNAPGVAALLG-PKAAAGALSPLAP---
MAV_2910|M.avium_104 --------GGPFLSFGQAYAWGQNGQGAAAYLAGPKAISGALAPLASGGN
MUL_3072|M.ulcerans_Agy99 --------GGPFLSFGQVYAYVQNAQGLNAFYS-PKAITGTLAPLVPEIS
MMAR_1461|M.marinum_M --------GGPFLAFGQVYAFSQNMVGAQAFFSPAEPVIGGLAPLAGEAN
Mflv_0325|M.gilvum_PYR-GCK AQSAPSRPDQQSFPATMSAPPPPSGAPIAANTVSAGSPPAPGAPAAAAAT
Mvan_0415|M.vanbaalenii_PYR-1 SSPAPTRADQPSPAIAVSAPPPPSSAAATVGTVATGTAPAPGAPAAATAS
MSMEG_0619|M.smegmatis_MC2_155 AP----RTDQP-LAVGISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAAT
MAB_0669|M.abscessus_ATCC_1997 RPTQHVEPNLAALPLPTSSVVPSGGSSVPVSTPTAPAHTVSSVPAPSAA-
TH_3113|M.thermoresistible__bu ASAAPVPAGGPSLPSGSSAPPAPTG-SAAPTTGTAPGGAGSPPPAGHSVP
MLBr_01182|M.leprae_Br4923 --------HAGMANAGLSLVNGMGSAMKSLAPTTTKAAESAFKAMGSAVQ
. .
Mb1837|M.bovis_AF2122/97 LRGGYIADITPLGGGATGGIARAIYVGSLSVPQGWAEAAPVMRAVASVLP
Rv1808|M.tuberculosis_H37Rv LRGGYIGDITPLGGGATGGIARAIYVGSLSVPQGWAEAAPVMRAVASVLP
MAV_2910|M.avium_104 AVKPMLSS-AVGAGQVSGSMGKAALVGSMSVPQGWTEAAPAIRTLAQVLP
MUL_3072|M.ulcerans_Agy99 PGGVGLTS-ASVSNSVSGTMGRAALVGSMSVPQGWTQAAPAMRLVSSVLS
MMAR_1461|M.marinum_M LGAAGVVGGPSVGGQASGAMGHAALVGNMSVPQGWTQEAPAIRVFVSELP
Mflv_0325|M.gilvum_PYR-GCK FVPYVVAGRDP-YEGFSPTVRDSTGAKAPAGTIPAAASGIAASAAERRKR
Mvan_0415|M.vanbaalenii_PYR-1 FVPYAVAGRDP-GTGFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKR
MSMEG_0619|M.smegmatis_MC2_155 FVPYAVANRDP-GEGFTPTLGNKSQVAAPASGVPAAASGVAASLASRRKR
MAB_0669|M.abscessus_ATCC_1997 -ISYAIPGLVPPGVSFGPKSTEKSSESAVDTVAAVAAARGAVAAQARRRL
TH_3113|M.thermoresistible__bu PAPHSAPPVGTSGPPYLIAAQPAPGVARRSAGARRAASIVEPAGSAAAAA
MLBr_01182|M.leprae_Br4923 STGRGLLGSSS-GGHVTAQLGRAASIGSLRVPQTWTTASQPVTAATRALS
:
Mb1837|M.bovis_AF2122/97 G-TGAAPALAAEAPGALFGEMALSSLAGRALAGTAVRS---GAGAARVAG
Rv1808|M.tuberculosis_H37Rv G-TGAAPALAAEAPGALFGEMALSSLAGRALAGTAVRS---GAGAARVAG
MAV_2910|M.avium_104 GNMAAAP-AAMAGEEGVFSQMALSSLAGRAVAAAATRPVGGAASAASSLG
MUL_3072|M.ulcerans_Agy99 TNLAAAPTAGLPGEAGVFGQMALSSLAGRAMGASTFGSSSGGAVAN-SLG
MMAR_1461|M.marinum_M TSVTAAPAATLAGESAVFNQMALSSLAGRALGTGAFGS-GGGGGASKAIG
Mflv_0325|M.gilvum_PYR-GCK RRRQKEEIKGRGYADAYADYEELPDDGPPEQPAPRVTASTRGAGPMGFAG
Mvan_0415|M.vanbaalenii_PYR-1 RRRQKDEIAGRAYADAYADYEPEPDDEPPVRQEPRIAATERGAGPMGFAG
MSMEG_0619|M.smegmatis_MC2_155 RRKKGAQIEERGYADAYMDYEE-PDEDPAPQPEPRVRASERGSDAMGFTG
MAB_0669|M.abscessus_ATCC_1997 RGKNKAEAGGR--RHEYLEETAGMGAT-ATADVPAYAATGRGTGPLGFAG
TH_3113|M.thermoresistible__bu AARESAPIRRRRGQKDGLHGHRHEHQQPASMS-AATAPSAAGIRVLGGAG
MLBr_01182|M.leprae_Br4923 PARVAVATESE----------SAPLLGGGLPMAPMVPGGGSGTGGVNTAL
.
Mb1837|M.bovis_AF2122/97 GSVTEDVASTTTIIVIPAD-------------------------------
Rv1808|M.tuberculosis_H37Rv GSVTEDVASTTTIIVIPAD-------------------------------
MAV_2910|M.avium_104 GVAAEADPAAATIIVIPCIEE-----------------------------
MUL_3072|M.ulcerans_Agy99 GVVAEADPAAATIIVIPALDE-----------------------------
MMAR_1461|M.marinum_M GVVAEADPAAATIIVIPAIED-----------------------------
Mflv_0325|M.gilvum_PYR-GCK TVSRGD-EQAGGLTTLAGDSFGGGPREPMLPGTWDPDATDDRHTDGRDGH
Mvan_0415|M.vanbaalenii_PYR-1 TVSRDA-AQAGGLTTLPGDPFGGGPKAPMLPGTWDPDTEPD------ERH
MSMEG_0619|M.smegmatis_MC2_155 TVTRHD-VTAAGLTTLTGDTFDDRPVTPMLPGTWDGDENPAP------SP
MAB_0669|M.abscessus_ATCC_1997 TAPAAASTHVAATVRLSSD--EARQVIPMLPSTWDAD-------------
TH_3113|M.thermoresistible__bu RISRTR-GSVPHAEITPGDPTEPSSPTDRAHRPAEPN-------------
MLBr_01182|M.leprae_Br4923 RLQPRAFVMPRNPAAG----------------------------------
Mb1837|M.bovis_AF2122/97 ---------
Rv1808|M.tuberculosis_H37Rv ---------
MAV_2910|M.avium_104 ---------
MUL_3072|M.ulcerans_Agy99 ---------
MMAR_1461|M.marinum_M ---------
Mflv_0325|M.gilvum_PYR-GCK DGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 NHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 DDPEGGPRR
MAB_0669|M.abscessus_ATCC_1997 ----GGDQN
TH_3113|M.thermoresistible__bu ---------
MLBr_01182|M.leprae_Br4923 ---------