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MDFGALPPEINSARIYSGPGSRPLMQAAAAWQRLANELTATAASYSSVISGLTGDDWLGPSALSMAAAAV PYVAWMRATAASAEQAAAQAVAAANAYESAYAATVPPTVIAANRRTMLSLVKTNVFGQNTPAIATSEAQY GAMWAQDIVAMEGYAGASAAASQLPPFTPPPATTSGAGSLSDAAATAAQAVVPAAAATDVSLLPTLQSFL PPPFDAIPNPIEDLDVLVAAAVAVAAGSLGVSAAQLGEIYRHDVVDEAQKAPHCPAESDQTPAGAAGDGD LPEVGGRVTSPPQPPVAALTGYSANIGGLSVPHSWNLPPAVRQVAAMFPGATPMYMTGSSDGSYAGLAAA GLAGTGLAGLAARGGSAPTPAAAAPAGAGGAGPAATRPAAQQTPAVPAAAAGSAIPGLPPGLPPGVVANL AATLAAIPGATIIVVPPSPNANQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0394c | PPE9 | - | 100% (443) | PPE family protein |
| M. bovis AF2122 / 97 | Mb1837 | PPE32 | 5e-74 | 44.39% (401) | PPE family protein |
| M. bovis AF2122 / 97 | Mb0939c | PPE14 | 6e-72 | 39.33% (445) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0325 | - | 2e-30 | 28.11% (434) | PPE protein |
| M. tuberculosis H37Rv | Rv0387c | - | 1e-138 | 100.00% (244) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 1e-41 | 31.63% (430) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0669 | - | 7e-35 | 30.19% (477) | PPE-family protein |
| M. marinum M | MMAR_0685 | - | 1e-179 | 72.32% (448) | PPE family protein |
| M. avium 104 | MAV_2906 | - | 1e-74 | 44.23% (407) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 2e-31 | 30.41% (444) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 6e-40 | 32.68% (459) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_4463 | - | 6e-69 | 39.29% (425) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 4e-35 | 30.79% (432) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0394c|M.bovis_AF2122/97 -------------MDFGALPPEINSARIYSGPGSRPLMQAAAAWQRLANE
Rv0387c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0685|M.marinum_M -------------MDFGALPPEINSARMYAGPGSAPLVQAARAWGRLANE
MAV_2906|M.avium_104 -------------MDFGALPPEVNSGRMYGGAGSGPLLAAAAAWDALGAE
MUL_4463|M.ulcerans_Agy99 ----------MLATDFGALPPEVNSGLLYAGPGAAPMLTAATAWDGLATV
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
MAB_0669|M.abscessus_ATCC_1997 ----------MTAPIWMAEPPEVHSALLSAGPGPGAVLAAAVQWQEIGNN
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
Mb0394c|M.bovis_AF2122/97 LTATAASYSSVISGLTGDDWLGPSALSMAAAAVPYVAWMRATAASAEQAA
Rv0387c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0685|M.marinum_M LNATAASYSSVIAGLGAADWQGPSALSMAAAAAPYVAWMRSTAAQAEQAA
MAV_2906|M.avium_104 LYSFAAAYTSTIAGLTVGSWLGPAATSMSAAAAPFIAWATTTAGQAEQVA
MUL_4463|M.ulcerans_Agy99 LNSAAASYASVVSGLTLESRMGPASASMAAAAAPYATWLAVANEQARQTA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
MAB_0669|M.abscessus_ATCC_1997 YANTAVELAQVLAGVRAGSWQGPSASEYVAAHLPYLAWLEQAAAESSVIA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLT-TFEGESAAALAERVTPYEKWLTQNAASAELTA
Mb0394c|M.bovis_AF2122/97 AQAVAAANAYESAYAATVPPTVIAANRRTMLSLVKTNVFGQNTPAIATSE
Rv0387c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0685|M.marinum_M AQAISAANAYESAHAAIVPPGQIAANRSTMLSLVRSNIFGQNTPAIATSE
MAV_2906|M.avium_104 TQARLAAAAYETAFAATVPPPVIAANRSLLMTLIATNILGQNTAAIAAAE
MUL_4463|M.ulcerans_Agy99 AQARAAATAFETAFAVVVPPPLIAANRSQVASLVVANVLGQNTPAIETLQ
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
MAB_0669|M.abscessus_ATCC_1997 AQHETTAAAYNSALAAMPTLAELAANHITHGVLVGTNFFGINTIPIALNE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
Mb0394c|M.bovis_AF2122/97 AQYGAMWAQDIVAMEGYAGASAAASQLPPFTPPPATTSGAGSLSDAAATA
Rv0387c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0685|M.marinum_M ADYSEMWAQDIVAMDGYAGTSAAATDLAPFTSPPATTTGTEALS---AAT
MAV_2906|M.avium_104 AEYAEMWAQDAAAMYAYAAASAAAAELTPFTEPPRTTE------------
MUL_4463|M.ulcerans_Agy99 AEYAEMWAQDAAVMYQYSAASEAASTLAAFTSPVQSTD------------
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
MAB_0669|M.abscessus_ATCC_1997 ADYVRMWVQAAATMSAYQATTEAMTSAIPPTQQPPAILSPG-GEARSDQS
TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAAI
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
Mb0394c|M.bovis_AF2122/97 AQAVVPAAAATDVSLLP-----------------------TLQSFLPPPF
Rv0387c|M.tuberculosis_H37Rv ------------MSLLP-----------------------TLQSFLPPPF
MMAR_0685|M.marinum_M VPAAAAAAAPAETSILP-----------------------LLQSFLPAPF
MAV_2906|M.avium_104 SSAAARQSAAVAQSAAS-----------------------DLPAQLSTLI
MUL_4463|M.ulcerans_Agy99 PSRAQASTAAGAAAAGT-----------------------TAQTTASQPT
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLRDPI
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLRDPL
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGG-QAILDFLKDPL
MAB_0669|M.abscessus_ATCC_1997 DVPGSPDQIMKMLQG---------------------------FQQWFEKM
TH_3113|M.thermoresistible__bu TGAHVTAELRAAESRTLLDEINELIDRLFAPLFPPGFADALPDGLLGTLL
MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEAEQAIS---------------------QAALDQAVNEGM
Mb0394c|M.bovis_AF2122/97 DAIPNPIEDLDVLVAAAVAVAAG---------------------------
Rv0387c|M.tuberculosis_H37Rv DAIPNPIEDLDVLVAAAVAVAAG---------------------------
MMAR_0685|M.marinum_M NAIPNPFEDLDLLVLAAVVVSLG---------------------------
MAV_2906|M.avium_104 DVTPTMLQGLATTPSAAAATPAA---------------------------
MUL_4463|M.ulcerans_Agy99 TAATDTAQGLA---AEVPTIPAG---------------------------
Mflv_0325|M.gilvum_PYR-GCK GNTFALITDFLTNPVQALITWGP------FLLAVVYQA----VSWVGASI
Mvan_0415|M.vanbaalenii_PYR-1 GNTIKLITDFLTNPAQALITWGP------FLAAVAYQA----VSWVGASI
MSMEG_0619|M.smegmatis_MC2_155 GNLGRLLTDFMTNPAGALATWWP------FLFGVAYQVFFNLVGWPTWGM
MAB_0669|M.abscessus_ATCC_1997 G--------FNPATSAVLAVIML------FLYDLLWYP---------YYA
TH_3113|M.thermoresistible__bu APLLPGATGDGPPMATIMSFLLMGLSNPAYLFPVLVYLLFTGVVHTTVAV
MLBr_01182|M.leprae_Br4923 EATVVPQVDQQVNVDVATPQTAVP--------------------------
Mb0394c|M.bovis_AF2122/97 ----------------------SLGVSAAQLGEIYRHDVVDEAQKAPHCP
Rv0387c|M.tuberculosis_H37Rv ----------------------SLGVSAAQLGEIYRHDVVDEAQKAPHCP
MMAR_0685|M.marinum_M ----------------------ALGVSAIQLGEVYRHDIVDEDENAPLCG
MAV_2906|M.avium_104 ----------------------SIIEAIYPITAALRPFFAAVTGAYSPIG
MUL_4463|M.ulcerans_Agy99 ----------------------SDLAAPAAISIPTPVGELDLLAAYIAVA
Mflv_0325|M.gilvum_PYR-GCK LYPSLFLLPLLATT-------LAIVAGVGQHLLSLLNTPPAEEAAEEPAP
Mvan_0415|M.vanbaalenii_PYR-1 LYPSLLLLPLVATT-------LAIVLGVGAYLLENLPAPAEDAPAEEPAA
MSMEG_0619|M.smegmatis_MC2_155 IFASPFLIPALAALG-----ITGLVLLIDHVLNNPVDVPAEDEAPQEVAA
MAB_0669|M.abscessus_ATCC_1997 SYLLPFLIPALSGLS-----GLAALMHLRPAAPGPVPA-AALSPGDRPIR
TH_3113|M.thermoresistible__bu SGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLAGLAGLTAVPAADGG
MLBr_01182|M.leprae_Br4923 ---------------------DSSSAAAPQLWGGFAQHLSPINDTLSMIN
.
Mb0394c|M.bovis_AF2122/97 AESDQTPAGAAGDGD---LPEVGG-RVTSPPQPPVAALTGYSANIGGLSV
Rv0387c|M.tuberculosis_H37Rv AESDQTPAGAAGDGD---LPEVGG-RVTSPPQPPVAALTGYSANIGGLSV
MMAR_0685|M.marinum_M GEYDELPAAGLRNPDRDAITTPGGQRLASPPSPPVAALSGYSANIGGLSV
MAV_2906|M.avium_104 AIILPGGWWLL----------------SLQALGLAQNAPGVAELLGGGKA
MUL_4463|M.ulcerans_Agy99 ATASLSLSAVN----------------TARPWSYSTNN-DHAQPNGGGVA
Mflv_0325|M.gilvum_PYR-GCK AQSAPSRPDQQSFPATMSAPPPPSGAPIAANTVSAGSPPAPGAPAAAAAT
Mvan_0415|M.vanbaalenii_PYR-1 SSPAPTRADQPSPAIAVSAPPPPSSAAATVGTVATGTAPAPGAPAAATAS
MSMEG_0619|M.smegmatis_MC2_155 AP----RTDQP-LAVGISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAAT
MAB_0669|M.abscessus_ATCC_1997 RPTQHVEPNLAALPLPTSSVVPSGGSSVPVSTPTAPAHTVSSVPAPSAA-
TH_3113|M.thermoresistible__bu ASAAPVPAGGPSLPSGSSAPPAPTG-SAAPTTGTAPGGAGSPPPAGHSVP
MLBr_01182|M.leprae_Br4923 NHAGMANAGLS------------------LVNGMGSAMKSLAPTTTKAAE
Mb0394c|M.bovis_AF2122/97 PHSWNLPPAVRQVAAMFPGATPMYMTGSSDGSYAGLAAAGLAGTGLAGLA
Rv0387c|M.tuberculosis_H37Rv PHSWNLPPAVRQVAAMFPGATPMYMTGSSDGSYAGLAAAGLAGTGLAGLA
MMAR_0685|M.marinum_M PPAWNLPPAVRQVAAMFPGATPMYLTGGSDGQYTGIAAAGIAGASLAGFA
MAV_2906|M.avium_104 IAGGLSPLAPLRGGYVSAVTPDAGGVAGSMGRSTLVGSLSVPPGWTTAAP
MUL_4463|M.ulcerans_Agy99 PTQGNTLGTERPDAEVLVSAPNVVPTSAFVGHAALVGALSVPHSWAMAAP
Mflv_0325|M.gilvum_PYR-GCK FVPYVVAGRDP-YEGFSPTVRDSTGAKAPAGTIPAAASGIAASAAERRKR
Mvan_0415|M.vanbaalenii_PYR-1 FVPYAVAGRDP-GTGFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKR
MSMEG_0619|M.smegmatis_MC2_155 FVPYAVANRDP-GEGFTPTLGNKSQVAAPASGVPAAASGVAASLASRRKR
MAB_0669|M.abscessus_ATCC_1997 -ISYAIPGLVPPGVSFGPKSTEKSSESAVDTVAAVAAARGAVAAQARRRL
TH_3113|M.thermoresistible__bu PAPHSAPPVGTSGPPYLIAAQPAPGVARRSAGARRAASIVEPAGSAAAAA
MLBr_01182|M.leprae_Br4923 SAFKAMGSAVQSTGRGLLGSSSGGHVTAQLGRAASIGSLRVPQTWTTASQ
.:
Mb0394c|M.bovis_AF2122/97 ARG-GSAPTPAAAAPAGAGGAGPAATRPAAQQTPAVPAAAAGSAIPGLPP
Rv0387c|M.tuberculosis_H37Rv ARG-GSAPTPAAAAPAGAGGAGPAATRPAAQQTPAVPAAAAGSAIPGLPP
MMAR_0685|M.marinum_M ARGSGSAPAPTTGAPSAGGGGAAAAARPAAN-TPSVPAAAAAANIPGLPS
MAV_2906|M.avium_104 VLRTVASVLPAASSATAAAMPASGG----AVFGEMAAASLAGRALAGAGV
MUL_4463|M.ulcerans_Agy99 EIRLAVESLPSAGGLSAPAGPDMGGVAPTGLLSGMALASLAGRGATGAGS
Mflv_0325|M.gilvum_PYR-GCK RRRQKEEIKGRGYADAYADYEELPDDGPPEQPAPRVTASTRGAGPMGFAG
Mvan_0415|M.vanbaalenii_PYR-1 RRRQKDEIAGRAYADAYADYEPEPDDEPPVRQEPRIAATERGAGPMGFAG
MSMEG_0619|M.smegmatis_MC2_155 RRKKGAQIEERGYADAYMDYEE-PDEDPAPQPEPRVRASERGSDAMGFTG
MAB_0669|M.abscessus_ATCC_1997 RGKNKAEAGGR--RHEYLEETAGMGAT-ATADVPAYAATGRGTGPLGFAG
TH_3113|M.thermoresistible__bu AARESAPIRRRRGQKDGLHGHRHEHQQPASMS-AATAPSAAGIRVLGGAG
MLBr_01182|M.leprae_Br4923 PVTAATRALSPARVAVATESESAPLLGGGLPMAPMVPGGGSGTGGVNTAL
. .
Mb0394c|M.bovis_AF2122/97 GLPPGV--VANLAATLAAIPGATIIVVPPSPNANQ---------------
Rv0387c|M.tuberculosis_H37Rv GLPPGV--VANLAATLAAIPGATIIVVPPSPNANQ---------------
MMAR_0685|M.marinum_M GLPPGV--VANLAATLAAIPGATIIVVPPDPNAAQ---------------
MAV_2906|M.avium_104 RTVGNG--TTGAATAAAADGAATTATIIVVPAD-----------------
MUL_4463|M.ulcerans_Agy99 RSPSES--ATNEDEQPQRK--PTVVVIQKPPPAGGPPAARP---------
Mflv_0325|M.gilvum_PYR-GCK TVSRGD-EQAGGLTTLAGDSFGGGPREPMLPGTWDPDATDDRHTDGRDGH
Mvan_0415|M.vanbaalenii_PYR-1 TVSRDA-AQAGGLTTLPGDPFGGGPKAPMLPGTWDPDTEPD------ERH
MSMEG_0619|M.smegmatis_MC2_155 TVTRHD-VTAAGLTTLTGDTFDDRPVTPMLPGTWDGDENPAP------SP
MAB_0669|M.abscessus_ATCC_1997 TAPAAASTHVAATVRLSSD--EARQVIPMLPSTWDAD-------------
TH_3113|M.thermoresistible__bu RISRTR-GSVPHAEITPGDPTEPSSPTDRAHRPAEPN-------------
MLBr_01182|M.leprae_Br4923 RLQPRA------------------FVMPRNPAAG----------------
Mb0394c|M.bovis_AF2122/97 ---------
Rv0387c|M.tuberculosis_H37Rv ---------
MMAR_0685|M.marinum_M ---------
MAV_2906|M.avium_104 ---------
MUL_4463|M.ulcerans_Agy99 ---------
Mflv_0325|M.gilvum_PYR-GCK DGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 NHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 DDPEGGPRR
MAB_0669|M.abscessus_ATCC_1997 ----GGDQN
TH_3113|M.thermoresistible__bu ---------
MLBr_01182|M.leprae_Br4923 ---------