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SSPTKPLVAEDAEIVRRVLAHIDAGTTDEGEAWREPVENYASPERFAAELRLLRGMPSVFVPSAAIPNNG DHVERTAFGVPLFAVRGADGRARVFRNARRHRGFALVENAGCSHALVCRYHGWIYRLDGSLSHVPHAEAF PDLDMSARGLVEVESHEVDGLIVIGPLDPVDAGLIEDEGAIGWLTDGSPWRAKLVPAERLIVVESTLREI NWKVLVEQFLEGYHIRSTHKDTFFPVQYDDLNVVEAFGPNTRITFPYRNIERLRDRPEHTWTTGARVTYL YQLFPNVMLATFPDVIAMVVIDPVSVDRTAVTIYSMVTPDVAERDSLDASSNLAGAGSFIGQGLFEDNEM SEGVQRGLAAGANAFVEFGRHESAVGRFHAALGRRLARLTSAG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_4884 | - | - | 100% (394) | dioxygenase |
| M. ulcerans Agy99 | MUL_3820 | - | 2e-30 | 25.63% (394) | ring-hydroxylating dioxygenase, large terminal subunit |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3186c | - | 7e-15 | 26.25% (381) | dioxygenase |
| M. gilvum PYR-GCK | Mflv_2464 | - | 1e-13 | 28.08% (203) | Rieske (2Fe-2S) domain-containing protein |
| M. tuberculosis H37Rv | Rv3161c | - | 6e-15 | 26.25% (381) | dioxygenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4370c | - | 2e-15 | 24.43% (397) | putative large terminal subunit of phenylpropionate dioxygenase |
| M. marinum M | MMAR_0230 | - | 0.0 | 98.48% (394) | dioxygenase |
| M. avium 104 | MAV_1644 | - | 9e-34 | 26.08% (395) | Rieske (2Fe-2S) domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_0657 | - | 4e-20 | 29.45% (343) | Rieske (2Fe-2S) domain-containing protein |
| M. thermoresistible (build 8) | TH_3362 | - | 2e-14 | 29.27% (205) | PUTATIVE Rieske (2Fe-2S) domain protein |
| M. vanbaalenii PYR-1 | Mvan_4910 | - | 2e-31 | 31.15% (305) | Rieske (2Fe-2S) domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3186c|M.bovis_AF2122/97 -------MLSTDNRAELGDILTDIGDYLDDNPP---ALSLPPAAYTSSEL
Rv3161c|M.tuberculosis_H37Rv -------MLSTDNRAELGDILTDIGDYLDDNPP---ALSLPPAAYTSSEL
MUL_4884|M.ulcerans_Agy99 -MSSPTKPLVAEDAEIVRRVLAHIDAGTTDEGE---AWREPVENYASPER
MMAR_0230|M.marinum_M -MSSPTKPLVAEDAEIVRRVLAHIDAGTTDEGE---AWREPVENYVSPER
MAV_1644|M.avium_104 -------MQHDQLIDLTRRALKLARDRTTDLAPT--AHVVDARDYTCVQR
Mvan_4910|M.vanbaalenii_PYR-1 MTAIADGPVSNQDEELTRRALRHAVDKTTDMADR--ELRVPLHYYRDPKI
Mflv_2464|M.gilvum_PYR-GCK ---------------MARFPKPPEGSWTEHYPQL-GTGPVSYEDSIDPEF
TH_3362|M.thermoresistible__bu ---------------MARFPKPPEGSWTEHHPEL-GTAPVSYRDCTDPEI
MSMEG_0657|M.smegmatis_MC2_155 MDHFPAADYPDCMFKQIGPAPVPADDLAAALAPFGHSRMLPREAYVDPAV
MAB_4370c|M.abscessus_ATCC_199 -MASLPRPVAVAQGALCRPQALVRDIDVSGLVDS-HGGLLDRVIFTDGEL
Mb3186c|M.bovis_AF2122/97 WQLERERIFNRSWMLVAHVDQLAKTGDYVTVS--VAGEPVMVVRDVDGQL
Rv3161c|M.tuberculosis_H37Rv WQLERERIFNRSWMLVAHVDQVAKTGDYVTVS--VAGEPVMVVRDVDGQL
MUL_4884|M.ulcerans_Agy99 FAAELR-LLRGMPSVFVPSAAIPNNGDHVERT--AFGVPLFAVRGADGRA
MMAR_0230|M.marinum_M FAAELR-LLRGMPSVFVPSAAIPNKGDHVERT--AFGVPLFAVRGADGRA
MAV_1644|M.avium_104 HQQDRAMLLA-SPQLVGYVSELPAPGTYCTKT--VMGRSVLLTRTSDGSV
Mvan_4910|M.vanbaalenii_PYR-1 TEIEESQVLRRVPLAIVPSAQIPAVNDYVVRS--VLGDSLLVTRDRDGVS
Mflv_2464|M.gilvum_PYR-GCK YELERKAVFRRAWLNVGRVEQVPRKGSYFTKEMKVVNTSIIVVRTTSGEV
TH_3362|M.thermoresistible__bu YQKERHAIFKRAWLNVGRVERLPRKGSYFTKEIKVVNTSIIVVRTGSGEI
MSMEG_0657|M.smegmatis_MC2_155 FAWEQQAIFS-GWTCVGHAADLETPGAQRAVG--SGANGVLLVRGEDNRV
MAB_4370c|M.abscessus_ATCC_199 YRQELRRVFAPSWLFLAHADQFHRPGDFFTTY--MGEDPVIVSMDKNRRI
: :: . . . :: .
Mb3186c|M.bovis_AF2122/97 HALSPICRHRLM------LMVEPGAGRIDTLTCQYHLWRYGLDGRLRGAP
Rv3161c|M.tuberculosis_H37Rv HALSPICRHRLM------LMVEPGAGRIDTLTCQYHLWRYGLDGRLRGAP
MUL_4884|M.ulcerans_Agy99 RVFRNARRHRGF------ALVEN-AGCSHALVCRYHGWIYRLDGSLSHVP
MMAR_0230|M.marinum_M RVFRNACRHRGF------ALVEN-AGCSHALVCRYHGWIYRLDGSLSHVP
MAV_1644|M.avium_104 KAFNNVCLHRQS------QVATG-CGTASRFSCPYHAWTYDNTGRLVGLP
Mvan_4910|M.vanbaalenii_PYR-1 HVFLNYCRHRGA------KPACG-AGNTSRFTCPYHAWSYKNTGELFTVP
Mflv_2464|M.gilvum_PYR-GCK KAYHNICRHRGNKLVWNDMPLEETSGVCRQFTCKYHAWRYDLDGNLTFVQ
TH_3362|M.thermoresistible__bu KAFHNICRHRGNKLVWNDMPLEETSGVCRQFTCKYHAWRYDLDGNLTFVQ
MSMEG_0657|M.smegmatis_MC2_155 RAFANACRHRGH-----ELLSCGASAKRRSIVCPYHAWSYRLDGSVRNAP
MAB_4370c|M.abscessus_ATCC_199 RAFLNSCRHRGAR------VCRADYGVTRGFTCTYHGWAYDLEGKLISVP
:. ** . : * ** * * * :
Mb3186c|M.bovis_AF2122/97 HMAANLD-FNRRECRLPQFAVATWNGLVWINLDADAEP-IAAHLDLTDDE
Rv3161c|M.tuberculosis_H37Rv HMAANLD-FNRRECRLPQFAVATWNGLVWINLDADAEP-IAAHLDLTDDE
MUL_4884|M.ulcerans_Agy99 HAEAFPD-LDMSARGLVEVESHEVDGLIVIGPLDPVDAGLIEDEGAIGWL
MMAR_0230|M.marinum_M HAEAFPD-LDMSARGLIEVESHEVDGLIVIGPLDPVDAGLIEDEGAIGWL
MAV_1644|M.avium_104 GREGFPD-VTLRSAGLTELPATEFAGFLWVSLDPGATLDVATHLGPLADE
Mvan_4910|M.vanbaalenii_PYR-1 GKAGFDS-MDKADYGLVELPNQERHGFIWAVLTAGATIDVDAHLGAIGPE
Mflv_2464|M.gilvum_PYR-GCK QEGEFFD-LDKSRYGLVPVHCEVWEGFIFVNFAPEPEQSLREFLGPMITN
TH_3362|M.thermoresistible__bu QEEEFFD-LHKSRYGLVPVHCDVWEGFIFVNFAEQPEQSLREFLGPMITG
MSMEG_0657|M.smegmatis_MC2_155 GFKDVDG-FDPGGFGLVELRLVDWHGWLFVDPS-GQDADFATHVAGLEEV
MAB_4370c|M.abscessus_ATCC_199 NEEGYPDSFSTDDWGLVEVPHVDSYHGLIFGTWNPAPVGLRESLGDMAWY
. . * . : .
Mb3186c|M.bovis_AF2122/97 FAGYRLGE----MVQVESWSHEWR-----ANWKVAAENGH-ENYHVLGLH
Rv3161c|M.tuberculosis_H37Rv FAGYRLGE----MVQVESWSHEWR-----ANWKVAAENGH-ENYHVLGLH
MUL_4884|M.ulcerans_Agy99 TDGSPWRA----KLVPAERLIVVESTLREINWKVLVEQFL-EGYHIRSTH
MMAR_0230|M.marinum_M TDGSPWRA----KLVPAERLIVVESTLREINWKVLVEQFL-EGYHIRSTH
MAV_1644|M.avium_104 LDSWGIGR----WSPLGEKVLDCA-----INWKLAIDTFA-ENYHFATVH
Mvan_4910|M.vanbaalenii_PYR-1 LELMNYAS----YGYHTEKEFQSQ-----VSWKGALEAFA-EGYHFPFVH
Mflv_2464|M.gilvum_PYR-GCK LEGYPFDR----MTSRFHYRSEVK-----ANWKLYMDAFQ-EFYHAPVLH
TH_3362|M.thermoresistible__bu LEGYPFDR----MTSRFTYRSEVK-----ANWKLYMDAFQ-EFYHAPVLH
MSMEG_0657|M.smegmatis_MC2_155 VSPYRPED----LTIVARHSYELA-----ANWKIIAENYQ-ECYHCSSIH
MAB_4370c|M.abscessus_ATCC_199 MDAMLDHDSEGTVVVGGVHKWVLDG-----NWKLAAEQFATDWYHVNMSH
.** : : ** *
Mb3186c|M.bovis_AF2122/97 ---RQTLEPFVPGGGDLDVRQYS-------RWALRLRVPFTVPVEAKSLQ
Rv3161c|M.tuberculosis_H37Rv ---RQTLEPFVPGGGDLDVRQYS-------RWALRLRVPFTVPVEAKSLQ
MUL_4884|M.ulcerans_Agy99 ---KDTFFPVQYDDLNVVEAFGP-------NTRITFPYRNIERLRDRPEH
MMAR_0230|M.marinum_M ---KDTFFPVQYDDLNVVEAFGP-------NTRITFPYRNIERLRDRPEH
MAV_1644|M.avium_104 ---RQTFATIARSNCTVFDSYGP-------HHRLVFPLNTILELDDIPED
Mvan_4910|M.vanbaalenii_PYR-1 G--ESVIGQNTLPNTGVYDEYGK-------HHRIGFPFNWVTNLADDASG
Mflv_2464|M.gilvum_PYR-GCK A--NQSPTAYS-KAAAQAGFEAP-------HYQIDGPHRLVSTSGVRAWE
TH_3362|M.thermoresistible__bu A--NQSPTAYS-KAAAEAGFEAP-------HYRIDGPHRLVSTSGVRAWE
MSMEG_0657|M.smegmatis_MC2_155 PELSRISPPTSGENLELPGAWMG-------GWMSIIDGAETMSLDGRSGG
MAB_4370c|M.abscessus_ATCC_199 ASALMVMAPQGKAPKDEIVHRTGRQYVDPNGHGAGFPVHPKNRFDARVVH
Mb3186c|M.bovis_AF2122/97 LNEVQKS----------------------------------NLVVLWTFP
Rv3161c|M.tuberculosis_H37Rv LNEVQKS----------------------------------NLVVLWTFP
MUL_4884|M.ulcerans_Agy99 TWTTGAR----------------------------------VTYLYQLFP
MMAR_0230|M.marinum_M TWTTGAR----------------------------------VTYLYQLFP
MAV_1644|M.avium_104 QWNPFHN----------------------------------MVVIYALFP
Mvan_4910|M.vanbaalenii_PYR-1 SWDPHQN----------------------------------MGVIYWIYP
Mflv_2464|M.gilvum_PYR-GCK MADEMRKPIEDICQSGLFGPWDKPDLGEMPAGLNPAKCDPWGLDSFQLFP
TH_3362|M.thermoresistible__bu MSEEMRKPIEDICRSGLFGPWDKPDLGEMPKGLNPARCDPWGLDSFQLFP
MSMEG_0657|M.smegmatis_MC2_155 VAIAGLSEHELR-----------------------------TVMYLVGYP
MAB_4370c|M.abscessus_ATCC_199 QWTDYGALRERLGEARVQG--------------------PLTNGHATVFP
:*
Mb3186c|M.bovis_AF2122/97 NS-ALAIAGERVVWFGFIPQSIDRVQVLGGVLTTPELAADAAATAQT---
Rv3161c|M.tuberculosis_H37Rv NS-ALAIAGERVVWFGFIPQSIDRVQVLGGVLTTPELAADAAATAQT---
MUL_4884|M.ulcerans_Agy99 NV-MLATFPDVIAMVVIDPVSVDRTAVTIYSMVTPDVAERDSLDASSNLA
MMAR_0230|M.marinum_M NV-MLATFPDVIAMVVIDPVSVDRTAVTIYSMVTPDVAERDSLDASSNLA
MAV_1644|M.avium_104 NI-VLSVTIANGELFRVYPGDRPGRSITVHQNATPQDLSDESVAAGVQAV
Mvan_4910|M.vanbaalenii_PYR-1 NL-ILANSPIGVEIIDILPAGEPTRCSVRHSWMGRVPATTDEMREMYDQV
Mflv_2464|M.gilvum_PYR-GCK NF-VILFWGQGWYLTYHYWPTSHNTHIFEGTVYFPQPRTPRERIAQELAA
TH_3362|M.thermoresistible__bu NF-VILFWGQGWYLTYHYWPTSYNTHVFEGNLYFPAARTPRERVAQELAA
MSMEG_0657|M.smegmatis_MC2_155 NL-LVSLHPDYVMTHLMTPLAVDRTHVECAWAFPREAAERPGFDPAY---
MAB_4370c|M.abscessus_ATCC_199 NLSYLPVNGSVRIWHPKGPDKMEVWAWTIVDRSMPEEVRDAQRLYNLRTF
* :
Mb3186c|M.bovis_AF2122/97 -SQFVMAMINDEDRLGLEAVQVG---------AGSRFAERGHLSSKEWPG
Rv3161c|M.tuberculosis_H37Rv -SQFVMAMINDEDRLGLEAVQVG---------AGSRFAERGHLSSKEWPG
MUL_4884|M.ulcerans_Agy99 GAGSFIGQGLFEDNEMSEGVQRG---------LAAGANAFVEFGRHES-A
MMAR_0230|M.marinum_M GAGSFIGQGLSEDNEMSEGVQRG---------LAAGANAFVEFGRHES-A
MAV_1644|M.avium_104 FD-YAHATVRDEDYRLVESLQAN---------LESGARDHLVFGRNEP-G
Mvan_4910|M.vanbaalenii_PYR-1 YD-SVHAAVVDEDFAMLPQCGEG---------VRHGQHDHMIIGRNEI-G
Mflv_2464|M.gilvum_PYR-GCK VSFKEYGLQDANTLEATQSMVESRVL------DDFVLCDQEVLIRHLHTE
TH_3362|M.thermoresistible__bu ASFKEYGLQDANTLEATQSMIESGVL------DDFVLCDQEVLIRHLHKE
MSMEG_0657|M.smegmatis_MC2_155 -AVDFWDLTNRQDWAACESVQRG---------LSSPHARPGPLAPDED-G
MAB_4370c|M.abscessus_ATCC_199 GPTGIFEQDDGENWSEVQSISRGFVTNSVALNYQMGLDSEREDGRHPGLT
: . .
Mb3186c|M.bovis_AF2122/97 MLAFYRNLAMALVGDHPGAS----------
Rv3161c|M.tuberculosis_H37Rv MLAFYRNLAMALVGDHPGAS----------
MUL_4884|M.ulcerans_Agy99 VGRFHAALGRRLARLTSAG-----------
MMAR_0230|M.marinum_M VGRFHAALGRRLARLTSVG-----------
MAV_1644|M.avium_104 LQHRHITWAKALAASTG-------------
Mvan_4910|M.vanbaalenii_PYR-1 VQHMVKVFAQELGVALS-------------
Mflv_2464|M.gilvum_PYR-GCK TAAWVDDYRRKTQQVKEGV-----------
TH_3362|M.thermoresistible__bu TADWIDRYERESTGTAAGVAGR--------
MSMEG_0657|M.smegmatis_MC2_155 VYQFVTRVARAYQGA---------------
MAB_4370c|M.abscessus_ATCC_199 SELYSDAAGRSFYARWRDLMNTKAWHEEHV