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TAIADGPVSNQDEELTRRALRHAVDKTTDMADRELRVPLHYYRDPKITEIEESQVLRRVPLAIVPSAQIP AVNDYVVRSVLGDSLLVTRDRDGVSHVFLNYCRHRGAKPACGAGNTSRFTCPYHAWSYKNTGELFTVPGK AGFDSMDKADYGLVELPNQERHGFIWAVLTAGATIDVDAHLGAIGPELELMNYASYGYHTEKEFQSQVSW KGALEAFAEGYHFPFVHGESVIGQNTLPNTGVYDEYGKHHRIGFPFNWVTNLADDASGSWDPHQNMGVIY WIYPNLILANSPIGVEIIDILPAGEPTRCSVRHSWMGRVPATTDEMREMYDQVYDSVHAAVVDEDFAMLP QCGEGVRHGQHDHMIIGRNEIGVQHMVKVFAQELGVALS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4910 | - | - | 100% (390) | Rieske (2Fe-2S) domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_0488 | - | 4e-22 | 32.64% (242) | ring hydroxylating dioxygenase, alpha subunit |
| M. vanbaalenii PYR-1 | Mvan_0463 | - | 9e-22 | 33.33% (207) | ring hydroxylating dioxygenase, alpha subunit |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3186c | - | 3e-17 | 25.56% (360) | dioxygenase |
| M. gilvum PYR-GCK | Mflv_0685 | - | 2e-22 | 34.30% (207) | ring hydroxylating dioxygenase, alpha subunit |
| M. tuberculosis H37Rv | Rv3161c | - | 3e-17 | 25.56% (360) | dioxygenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4370c | - | 6e-16 | 30.80% (224) | putative large terminal subunit of phenylpropionate dioxygenase |
| M. marinum M | MMAR_3964 | - | 3e-64 | 36.12% (371) | ring-hydroxylating dioxygenase, large terminal subunit |
| M. avium 104 | MAV_1116 | - | 0.0 | 79.48% (385) | Rieske (2Fe-2S) domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_4840 | - | 6e-21 | 31.00% (200) | Rieske (2Fe-2S) domain-containing protein |
| M. thermoresistible (build 8) | TH_3820 | - | 4e-23 | 28.63% (234) | PUTATIVE Rieske [2Fe-2S] domain protein |
| M. ulcerans Agy99 | MUL_3820 | - | 2e-63 | 35.58% (371) | ring-hydroxylating dioxygenase, large terminal subunit |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_4910|M.vanbaalenii_PYR-1 MTAIADGPVSNQDEELTRRALRHAVDKTTDMADRELRVPLHYYRDPKITE
MAV_1116|M.avium_104 MAPINS-PVSGTDEALTRRGLRHALDKTTDLAERELRVPLHYYRDPKITE
MMAR_3964|M.marinum_M -------MDRDQLIDLTRRALKLARDKTTDLAPHQHAVDACEYTSLDRHE
MUL_3820|M.ulcerans_Agy99 -------MDRDQLIDLTRRALKLARDKTTDLAPHQHAVDAREYTSLDRHE
MSMEG_4840|M.smegmatis_MC2_155 ------------MAHFPKPAVGSWTENWPELG--TAPVDYTDSIDPEQWK
TH_3820|M.thermoresistible__bu ------------VAHFPKPAVGSWTENWPELG--TAPVDYTDSIDPEQWK
Mb3186c|M.bovis_AF2122/97 ---MLSTDNRAELGDILTDIGDYLDDNPPALS--LPPAAYTS---SELWQ
Rv3161c|M.tuberculosis_H37Rv ---MLSTDNRAELGDILTDIGDYLDDNPPALS--LPPAAYTS---SELWQ
Mflv_0685|M.gilvum_PYR-GCK --------------------MQDHGEVLEAVR--TGMIPAHVYNDKQIFS
MAB_4370c|M.abscessus_ATCC_199 MASLPRPVAVAQGALCRPQALVRDIDVSGLVDSHGGLLDRVIFTDGELYR
: : .
Mvan_4910|M.vanbaalenii_PYR-1 IEESQVLRRVPLAIVPSAQIPAVNDYVVRSV----LGDSLLVTRDRDGVS
MAV_1116|M.avium_104 IEEGQILRRVPLAIVPSAQLPNTNDYMVRSV----LGDSLLVTRDRSGAS
MMAR_3964|M.marinum_M RDRAMVLD-SPQLVGYSSELPGPGTYCTKTV----MGRSILLTRAADGAV
MUL_3820|M.ulcerans_Agy99 RDRAMVLD-SPQLVGYSSELPGPDTYRTKTI----MGRSILLTRAADRAV
MSMEG_4840|M.smegmatis_MC2_155 LEQQAIFRRTWLHVGRVERLPKTGSYFTREMPSVGKGTSIIVVKDKDGAV
TH_3820|M.thermoresistible__bu LEQQAIFRRLWLHVGRVERLPKAGSYFTREMPSVGAGTSIIVNRDKDGTI
Mb3186c|M.bovis_AF2122/97 LERERIFNRSWMLVAHVDQLAKTGDYVTVSV----AGEPVMVVRDVDGQL
Rv3161c|M.tuberculosis_H37Rv LERERIFNRSWMLVAHVDQVAKTGDYVTVSV----AGEPVMVVRDVDGQL
Mflv_0685|M.gilvum_PYR-GCK LEKERLFSRAWLFVAHESEIPQPGDYVVRQV----LQDSFIVARDSAGEV
MAB_4370c|M.abscessus_ATCC_199 QELRRVFAPSWLFLAHADQFHRPGDFFTTYMG----EDPVIVSMDKNRRI
: :: : .. . : . : ..::
Mvan_4910|M.vanbaalenii_PYR-1 HVFLNYCRHRGA----KPACG---AGNTSRFTCPYHAWSYKNTGELFTVP
MAV_1116|M.avium_104 HVLLNYCRHRGA----MPACG---SGNAARFVCPYHAWTYKNTGELFSVP
MMAR_3964|M.marinum_M RAFDNVCLHRQS----RVATG---CGTALRFTCPYHGWTYDNGGRLVGLP
MUL_3820|M.ulcerans_Agy99 RAFDNVCLHRQS----RVATG---CGTALRFTCPYHGWTYDNGGRLVGLP
MSMEG_4840|M.smegmatis_MC2_155 RAFYNMCRHRGNKLVWNDYPGEEVSGTCRQFTCKYHAWRYALNGDLTFIQ
TH_3820|M.thermoresistible__bu RAFYNLCRHRGNKLVWNDYPGEEVSGTCRQFTCKYHGWRYALNGDLTFIQ
Mb3186c|M.bovis_AF2122/97 HALSPICRHR---LMLMVEPG---AGRIDTLTCQYHLWRYGLDGRLRGAP
Rv3161c|M.tuberculosis_H37Rv HALSPICRHR---LMLMVEPG---AGRIDTLTCQYHLWRYGLDGRLRGAP
Mflv_0685|M.gilvum_PYR-GCK RVMFNMCLHRG------MQVCRAEMGNASNFRCPYHGWSYRNDGRIIGLP
MAB_4370c|M.abscessus_ATCC_199 RAFLNSCRHRG------ARVCRADYGVTRGFTCTYHGWAYDLEGKLISVP
:.: * ** * : * ** * * * :
Mvan_4910|M.vanbaalenii_PYR-1 GKAGFDSMDK-----ADYGLVELP-NQERHGFIWAVLTAGATIDVDAHLG
MAV_1116|M.avium_104 GKAGFDSMNT-----KDYGLVELP-SEERHGFIWAVLTADATIDLDAHLG
MMAR_3964|M.marinum_M GREGFPGIAV-----GSDGLTELP-ATEFAGFLWVSLHPAARLDVPAHLG
MUL_3820|M.ulcerans_Agy99 GREGFPGIAV-----GSDGLTELP-ATEFAGFLWVSLHPAARLDVPAHLG
MSMEG_4840|M.smegmatis_MC2_155 QEDEFFDVDK-----ADYPLKPVR-CEIWEGFIFVNFDDDAMP-LEEYLG
TH_3820|M.thermoresistible__bu QEDEFFDVDK-----ADYGLKPIR-CEVWEGFIFVNFDDDAEP-LEDYLG
Mb3186c|M.bovis_AF2122/97 HMAANLDFNR-----RECRLPQFA-VATWNGLVWINLDADAEP-IAAHLD
Rv3161c|M.tuberculosis_H37Rv HMAANLDFNR-----RECRLPQFA-VATWNGLVWINLDADAEP-IAAHLD
Mflv_0685|M.gilvum_PYR-GCK FHQEAYGGDAGFNKAGQTLLPAPS-VASYNGLIFLSMDPDAES-LEEYLG
MAB_4370c|M.abscessus_ATCC_199 NEEGYPDSFS----TDDWGLVEVPHVDSYHGLIFGTWNPAPVG-LRESLG
. . * *::: . : *.
Mvan_4910|M.vanbaalenii_PYR-1 AIGPELELMN----YASYGYHTEKEFQSQVSWKGALEAFA-EGYHFPFVH
MAV_1116|M.avium_104 DFGAELALWN----YSSYGYHTQREFTSEVSWKGALEAFA-EGYHFPYVH
MMAR_3964|M.marinum_M PLAGELQSWG----IGRWSPLGEKVLDSPINWKLAADTFA-ENYHFATVH
MUL_3820|M.ulcerans_Agy99 PLAGELQSWG----IGRWSPLGEKVLGSPIDWKLATDTFA-ENYHFATVH
MSMEG_4840|M.smegmatis_MC2_155 EFGQGLKGYP----FHEMTEVYSYRAEINSNWKLFIDAFV-EFYHAPILH
TH_3820|M.thermoresistible__bu EFGQNLKGYP----FHEMTEVYSYRAEVNANWKLFIDAFT-EFYHAPVLH
Mb3186c|M.bovis_AF2122/97 LTDDEFAGYR----LGEMVQVESWSHEWRANWKVAAENGH-ENYHVLGLH
Rv3161c|M.tuberculosis_H37Rv LTDDEFAGYR----LGEMVQVESWSHEWRANWKVAAENGH-ENYHVLGLH
Mflv_0685|M.gilvum_PYR-GCK DFRFYLDFYTRQ-GPNGLEVRGPQRWRVKANWKIAAENFAGDMYHTPQTH
MAB_4370c|M.abscessus_ATCC_199 DMAWYMDAMLDHDSEGTVVVGGVHKWVLDGNWKLAAEQFATDWYHVNMSH
: .** : : ** *
Mvan_4910|M.vanbaalenii_PYR-1 GESVIGQNTL----------------PNTGVYDEYGKHHRIGFPFNWVTN
MAV_1116|M.avium_104 GQSLIGQNTL----------------ANTMVYDEFGKHHRIGFPFTWITN
MMAR_3964|M.marinum_M RR-TFATIAR----------------SNCTVFDSYGPHHRLIFPLNTILE
MUL_3820|M.ulcerans_Agy99 RR-TFATIAR----------------SNCTVFDSYGPHHRLIFPLNTILE
MSMEG_4840|M.smegmatis_MC2_155 MKQATPEEAAKLAKIGFEALHYDIKGDHSMISSWGGMSPPKDLNMVKPIE
TH_3820|M.thermoresistible__bu NKQAVKEEAEKLAKYGYEALHYDIKGPHSMISSWGGMAPPKDPSMVKPIE
Mb3186c|M.bovis_AF2122/97 RQTLEPFVPG---------------GGDLDVRQYSRWALRLRVPFTVPVE
Rv3161c|M.tuberculosis_H37Rv RQTLEPFVPG---------------GGDLDVRQYSRWALRLRVPFTVPVE
Mflv_0685|M.gilvum_PYR-GCK TSVVEIGLFREP--------KANKRKDGATYWAGRGGGTTYKLPEGSFED
MAB_4370c|M.abscessus_ATCC_199 ASALMVMAPQGK-----------APKDEIVHRTGRQYVDPNGHGAGFPVH
.
Mvan_4910|M.vanbaalenii_PYR-1 ---------------LADDASGSWDP--HQNMGVIYW----------IYP
MAV_1116|M.avium_104 ---------------AATDPAASLEP--LANMGVIYW----------VYP
MMAR_3964|M.marinum_M ---------------LENVPEGQWDP--FHHMVVIYA----------LFP
MUL_3820|M.ulcerans_Agy99 ---------------LENVPEGQWDP--FHHMVVIYA----------LFP
MSMEG_4840|M.smegmatis_MC2_155 RILHSGLFGPWDRPDIKGILPDELPPAVNPARQPTWGQDSF-----EFFP
TH_3820|M.thermoresistible__bu RILNSGLFGPWDRPDIKGIAPDELPPAINPSRQPFWGQDSF-----EFFP
Mb3186c|M.bovis_AF2122/97 ---------------AKSLQLNEVQ---KSNLVVLWT-----------FP
Rv3161c|M.tuberculosis_H37Rv ---------------AKSLQLNEVQ---KSNLVVLWT-----------FP
Mflv_0685|M.gilvum_PYR-GCK RMSYVGYPAEMISRAKATWTEQQQQVVGTDGFMISAATCFPNISFVHNWP
MAB_4370c|M.abscessus_ATCC_199 PKNRFDARVVHQWTDYGALRERLGEARVQGPLTNGHAT---------VFP
:*
Mvan_4910|M.vanbaalenii_PYR-1 NLILANSPIGVEIIDILPAGEPTRCSVRHSWMGRVPATTDEMREMYDQVY
MAV_1116|M.avium_104 NLILANSPVGVEIIDMLPAGAPTRCTVRHSWMARVPAADDEMRAAYDAVF
MMAR_3964|M.marinum_M NVVLSVTIANGELFRIYPGDRPGSSITVHQNSTPLDLSDESVATGAQAVF
MUL_3820|M.ulcerans_Agy99 NVVLSVTIANGELFRIYPGDRPGSSITVHQNSTPLDLSDESVATGAQAVF
MSMEG_4840|M.smegmatis_MC2_155 NFTLLLWVPGWYLTYNYWPTDVDKHIFECNLYFVPPKNTRQRLAQELAAV
TH_3820|M.thermoresistible__bu NFTLLIWAPGWYLTYNYWPTDVTKHIFEASLYFVPPKTTRQRLAQELAAV
Mb3186c|M.bovis_AF2122/97 NSALAIAG-ERVVWFGFIPQSIDRVQVLGGVLTTPELAADAAATAQTSQF
Rv3161c|M.tuberculosis_H37Rv NSALAIAG-ERVVWFGFIPQSIDRVQVLGGVLTTPELAADAAATAQTSQF
Mflv_0685|M.gilvum_PYR-GCK KVEDGEHVLPFISIRVWQPISENETEVLSWFAVDSDAPEAFKADSYKAYL
MAB_4370c|M.abscessus_ATCC_199 NLS---YLPVNGSVRIWHPKGPDKMEVWAWTIVDRSMPEEVRDAQRLYNL
:
Mvan_4910|M.vanbaalenii_PYR-1 DSVHAA----VVDEDFAMLPQCGEG-------------------VRHGQH
MAV_1116|M.avium_104 EGVHAA----VRDEDFAMLPQCGEG-------------------VRHGQH
MMAR_3964|M.marinum_M DYAHAT----VRDEDYRLAETLQTN-------------------FESGAR
MUL_3820|M.ulcerans_Agy99 DYAHAT----VRDEDYRLAETLQTN-------------------LESGAR
MSMEG_4840|M.smegmatis_MC2_155 TFKEYA----LQDANTLEATQTQIN-------------------TRAVTE
TH_3820|M.thermoresistible__bu TFKEYA----LQDANTLEATQTQIG-------------------TRAVTE
Mb3186c|M.bovis_AF2122/97 VMAMIN----DEDRLGLEAVQVGAG-------------------SRFAER
Rv3161c|M.tuberculosis_H37Rv VMAMIN----DEDRLGLEAVQVGAG-------------------SRFAER
Mflv_0685|M.gilvum_PYR-GCK MCFGSTGMFEQDDVENWVSLTNTAGGSMARRLRLNSRMGLLADDARVVDT
MAB_4370c|M.abscessus_ATCC_199 RTFGPTGIFEQDDGENWSEVQSISRG----------------FVTNSVAL
* .
Mvan_4910|M.vanbaalenii_PYR-1 D---------HMIIGRNEIGVQHMVKVFAQELGVALS-------------
MAV_1116|M.avium_104 D---------HMIIGRNEIAVQHMIRVFAHELGVALA-------------
MMAR_3964|M.marinum_M Q---------RLVFGRNEPGLQHRHITWAQALKTPG--------------
MUL_3820|M.ulcerans_Agy99 Q---------RLVFGRNEPGLQHRHITWAQALETPG--------------
MSMEG_4840|M.smegmatis_MC2_155 FPLCDQEVLLRHLHHTAHKYVDAYKAELAEKTQKAESNGSAVTSEKDAAH
TH_3820|M.thermoresistible__bu FPLCDQEVLLRHLHHTAHQYVDKYKEELAQKAQQT--NGSKKEGARSTAH
Mb3186c|M.bovis_AF2122/97 G----------HLSSKEWPGMLAFYRNLAMALVGDHPGAS----------
Rv3161c|M.tuberculosis_H37Rv G----------HLSSKEWPGMLAFYRNLAMALVGDHPGAS----------
Mflv_0685|M.gilvum_PYR-GCK LSSAQFHGPGYAQLGYNENNQRELLRLWADYLDMPPLRVDPATVLTDNPQ
MAB_4370c|M.abscessus_ATCC_199 N----------YQMGLDSEREDGRHPGLTSELYSDAAGRSFYARWRDLMN
:
Mvan_4910|M.vanbaalenii_PYR-1 ---------------------------
MAV_1116|M.avium_104 ---------------------------
MMAR_3964|M.marinum_M ---------------------------
MUL_3820|M.ulcerans_Agy99 ---------------------------
MSMEG_4840|M.smegmatis_MC2_155 V--------------------------
TH_3820|M.thermoresistible__bu V--------------------------
Mb3186c|M.bovis_AF2122/97 ---------------------------
Rv3161c|M.tuberculosis_H37Rv ---------------------------
Mflv_0685|M.gilvum_PYR-GCK GIEPMVQTNGGAVAGIDSESATTSVTL
MAB_4370c|M.abscessus_ATCC_199 TKAWHEEHV------------------