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QHDQLIDLTRRALKLARDRTTDLAPTAHVVDARDYTCVQRHQQDRAMLLASPQLVGYVSELPAPGTYCTK TVMGRSVLLTRTSDGSVKAFNNVCLHRQSQVATGCGTASRFSCPYHAWTYDNTGRLVGLPGREGFPDVTL RSAGLTELPATEFAGFLWVSLDPGATLDVATHLGPLADELDSWGIGRWSPLGEKVLDCAINWKLAIDTFA ENYHFATVHRQTFATIARSNCTVFDSYGPHHRLVFPLNTILELDDIPEDQWNPFHNMVVIYALFPNIVLS VTIANGELFRVYPGDRPGRSITVHQNATPQDLSDESVAAGVQAVFDYAHATVRDEDYRLVESLQANLESG ARDHLVFGRNEPGLQHRHITWAKALAASTG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1644 | - | - | 100% (381) | Rieske (2Fe-2S) domain-containing protein |
| M. avium 104 | MAV_1116 | - | 2e-64 | 35.12% (373) | Rieske (2Fe-2S) domain-containing protein |
| M. avium 104 | MAV_0905 | - | 2e-25 | 31.53% (203) | Rieske (2Fe-2S) domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3186c | - | 2e-24 | 26.52% (362) | dioxygenase |
| M. gilvum PYR-GCK | Mflv_0685 | - | 2e-22 | 36.96% (184) | ring hydroxylating dioxygenase, alpha subunit |
| M. tuberculosis H37Rv | Rv3161c | - | 4e-24 | 26.24% (362) | dioxygenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4370c | - | 4e-15 | 29.06% (203) | putative large terminal subunit of phenylpropionate dioxygenase |
| M. marinum M | MMAR_3964 | - | 0.0 | 82.45% (376) | ring-hydroxylating dioxygenase, large terminal subunit |
| M. smegmatis MC2 155 | MSMEG_5627 | - | 3e-20 | 31.63% (215) | Rieske (2Fe-2S) domain-containing protein |
| M. thermoresistible (build 8) | TH_3362 | - | 1e-23 | 29.52% (227) | PUTATIVE Rieske (2Fe-2S) domain protein |
| M. ulcerans Agy99 | MUL_3820 | - | 0.0 | 81.38% (376) | ring-hydroxylating dioxygenase, large terminal subunit |
| M. vanbaalenii PYR-1 | Mvan_4910 | - | 5e-67 | 35.83% (374) | Rieske (2Fe-2S) domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3964|M.marinum_M -------MDRDQLIDLTRRALKLARDKTTDLAPHQHAVDACEYTSLDRHE
MUL_3820|M.ulcerans_Agy99 -------MDRDQLIDLTRRALKLARDKTTDLAPHQHAVDAREYTSLDRHE
MAV_1644|M.avium_104 -------MQHDQLIDLTRRALKLARDRTTDLAPTAHVVDARDYTCVQRHQ
Mvan_4910|M.vanbaalenii_PYR-1 MTAIADGPVSNQDEELTRRALRHAVDKTTDMADRELRVPLHYYRDPKITE
Mb3186c|M.bovis_AF2122/97 ------MLSTDNRAELG--DILTDIGDYLDDNPPALSLPPAAYTSSELWQ
Rv3161c|M.tuberculosis_H37Rv ------MLSTDNRAELG--DILTDIGDYLDDNPPALSLPPAAYTSSELWQ
Mflv_0685|M.gilvum_PYR-GCK ----------------------MQDHGEVLEAVRTGMIPAHVYNDKQIFS
MAB_4370c|M.abscessus_ATCC_199 MASLPRPVAVAQGALCRPQALVRDIDVSGLVDSHGGLLDRVIFTDGELYR
MSMEG_5627|M.smegmatis_MC2_155 --------------------MTDTQPRTDEALATPMTIGVEAYTSEAYAR
TH_3362|M.thermoresistible__bu --------------MARFPKPPEGSWTEHHPELGTAPVSYRDCTDPEIYQ
:
MMAR_3964|M.marinum_M RDRAMVLD-SPQLVGYSSELPGPGTYCTKTVMGR--SILLTR----AADG
MUL_3820|M.ulcerans_Agy99 RDRAMVLD-SPQLVGYSSELPGPDTYRTKTIMGR--SILLTR----AADR
MAV_1644|M.avium_104 QDRAMLLA-SPQLVGYVSELPAPGTYCTKTVMGR--SVLLTR----TSDG
Mvan_4910|M.vanbaalenii_PYR-1 IEESQVLRRVPLAIVPSAQIPAVNDYVVRSVLGD--SLLVTR----DRDG
Mb3186c|M.bovis_AF2122/97 LERERIFNRSWMLVAHVDQLAKTGDYVTVSVAGE--PVMVVR----DVDG
Rv3161c|M.tuberculosis_H37Rv LERERIFNRSWMLVAHVDQVAKTGDYVTVSVAGE--PVMVVR----DVDG
Mflv_0685|M.gilvum_PYR-GCK LEKERLFSRAWLFVAHESEIPQPGDYVVRQVLQD--SFIVAR----DSAG
MAB_4370c|M.abscessus_ATCC_199 QELRRVFAPSWLFLAHADQFHRPGDFFTTYMGED--PVIVSM----DKNR
MSMEG_5627|M.smegmatis_MC2_155 AERDRLWRRVWQQVGRVEELPEVGSYLTYDILDD--SILVVRTGPGDSGG
TH_3362|M.thermoresistible__bu KERHAIFKRAWLNVGRVERLPRKGSYFTKEIKVVNTSIIVVR----TGSG
: : : .. . : . : ..::
MMAR_3964|M.marinum_M AVRAFDNVCLHR-QSRVATGCG-------TALRFTCPYHGWTYDNGGRLV
MUL_3820|M.ulcerans_Agy99 AVRAFDNVCLHR-QSRVATGCG-------TALRFTCPYHGWTYDNGGRLV
MAV_1644|M.avium_104 SVKAFNNVCLHR-QSQVATGCG-------TASRFSCPYHAWTYDNTGRLV
Mvan_4910|M.vanbaalenii_PYR-1 VSHVFLNYCRHR-GAKPACGAG-------NTSRFTCPYHAWSYKNTGELF
Mb3186c|M.bovis_AF2122/97 QLHALSPICRHRLMLMVEPGAG-------RIDTLTCQYHLWRYGLDGRLR
Rv3161c|M.tuberculosis_H37Rv QLHALSPICRHRLMLMVEPGAG-------RIDTLTCQYHLWRYGLDGRLR
Mflv_0685|M.gilvum_PYR-GCK EVRVMFNMCLHRGMQVCRAEMG-------NASNFRCPYHGWSYRNDGRII
MAB_4370c|M.abscessus_ATCC_199 RIRAFLNSCRHRGARVCRADYG-------VTRGFTCTYHGWAYDLEGKLI
MSMEG_5627|M.smegmatis_MC2_155 SFAAHHNVCMHRGRRLVDTPAGAKNACARTRKSFMCGFHGWTYDLTGACT
TH_3362|M.thermoresistible__bu EIKAFHNICRHRGNKLVWNDMPLEETSG-VCRQFTCKYHAWRYDLDGNLT
. * ** : * :* * * *
MMAR_3964|M.marinum_M GLPGREGFPGIAV-----GSDGLTELPATEFAGFLWVSLHPAARLDVPAH
MUL_3820|M.ulcerans_Agy99 GLPGREGFPGIAV-----GSDGLTELPATEFAGFLWVSLHPAARLDVPAH
MAV_1644|M.avium_104 GLPGREGFPDVTL-----RSAGLTELPATEFAGFLWVSLDPGATLDVATH
Mvan_4910|M.vanbaalenii_PYR-1 TVPGKAGFDSMDK-----ADYGLVELPNQERHGFIWAVLTAGATIDVDAH
Mb3186c|M.bovis_AF2122/97 GAPHMAANLDFNR-----RECRLPQFAVATWNGLVWINLDADAEP-IAAH
Rv3161c|M.tuberculosis_H37Rv GAPHMAANLDFNR-----RECRLPQFAVATWNGLVWINLDADAEP-IAAH
Mflv_0685|M.gilvum_PYR-GCK GLPFHQEAYGGDAGFNKAGQTLLPAPSVASYNGLIFLSMDPDAES-LEEY
MAB_4370c|M.abscessus_ATCC_199 SVPNEEGYPDSFS---TDDWGLVEVPHVDSYHGLIFGTWNPAPVG-LRES
MSMEG_5627|M.smegmatis_MC2_155 HIREQDDWQGTLTP----ENTHLPRVHVDTWGGWLFINMDPDPEP-LADY
TH_3362|M.thermoresistible__bu FVQQEEEFFDLHK-----SRYGLVPVHCDVWEGFIFVNFAEQPEQSLREF
. : * :: . :
MMAR_3964|M.marinum_M LGPLAGELQSWG----IGRWSPLGEKVLDSPINWKLAADTFA-ENYHFAT
MUL_3820|M.ulcerans_Agy99 LGPLAGELQSWG----IGRWSPLGEKVLGSPIDWKLATDTFA-ENYHFAT
MAV_1644|M.avium_104 LGPLADELDSWG----IGRWSPLGEKVLDCAINWKLAIDTFA-ENYHFAT
Mvan_4910|M.vanbaalenii_PYR-1 LGAIGPELELMN----YASYGYHTEKEFQSQVSWKGALEAFA-EGYHFPF
Mb3186c|M.bovis_AF2122/97 LDLTDDEFAGYR----LGEMVQVESWSHEWRANWKVAAENGH-ENYHVLG
Rv3161c|M.tuberculosis_H37Rv LDLTDDEFAGYR----LGEMVQVESWSHEWRANWKVAAENGH-ENYHVLG
Mflv_0685|M.gilvum_PYR-GCK LGDFRFYLDFYTRQ-GPNGLEVRGPQRWRVKANWKIAAENFAGDMYHTPQ
MAB_4370c|M.abscessus_ATCC_199 LGDMAWYMDAMLDHDSEGTVVVGGVHKWVLDGNWKLAAEQFATDWYHVNM
MSMEG_5627|M.smegmatis_MC2_155 LFPAAKILDPFG----LENMRYKWRKWLYFDCNWKVALEAFN-ETYHVFT
TH_3362|M.thermoresistible__bu LGPMITGLEGYP----FDRMTSRFTYRSEVKANWKLYMDAFQ-EFYHAPV
* : .** : : **
MMAR_3964|M.marinum_M VH---------------RRTFATIARSNCTVFDSYGPHHRLIFP------
MUL_3820|M.ulcerans_Agy99 VH---------------RRTFATIARSNCTVFDSYGPHHRLIFP------
MAV_1644|M.avium_104 VH---------------RQTFATIARSNCTVFDSYGPHHRLVFP------
Mvan_4910|M.vanbaalenii_PYR-1 VHG--------------ESVIGQNTLPNTGVYDEYGKHHRIGFP------
Mb3186c|M.bovis_AF2122/97 LH---------------RQTLEPFVPGGGDLDVRQYSRWALRLR------
Rv3161c|M.tuberculosis_H37Rv LH---------------RQTLEPFVPGGGDLDVRQYSRWALRLR------
Mflv_0685|M.gilvum_PYR-GCK THTSVVEIGLF------REPKANKRKDGATYWAGRGGGTTYKLPEGSFED
MAB_4370c|M.abscessus_ATCC_199 SHASALMVMAPQ----GKAPKDEIVHRTGRQYVDPNG-HGAGFP------
MSMEG_5627|M.smegmatis_MC2_155 THPEFNKFGEFKGWAKAQGKHSNIGYDAPKDMEATKSKIRLGTG------
TH_3362|M.thermoresistible__bu LH---------------ANQSPTAYSKAAAEAGFEAPHYRIDGP------
*
MMAR_3964|M.marinum_M ----LNTILELENVPEGQWDPFHH--------------MVVIYALFPNVV
MUL_3820|M.ulcerans_Agy99 ----LNTILELENVPEGQWDPFHH--------------MVVIYALFPNVV
MAV_1644|M.avium_104 ----LNTILELDDIPEDQWNPFHN--------------MVVIYALFPNIV
Mvan_4910|M.vanbaalenii_PYR-1 ----FNWVTNLADDASGSWDPHQN--------------MGVIYWIYPNLI
Mb3186c|M.bovis_AF2122/97 ----VPFTVPVEAKSLQLNEVQKS--------------NLVVLWTFPNSA
Rv3161c|M.tuberculosis_H37Rv ----VPFTVPVEAKSLQLNEVQKS--------------NLVVLWTFPNSA
Mflv_0685|M.gilvum_PYR-GCK RMSYVGYPAEMISRAKATWTEQQQQVVGT------DGFMISAATCFPNIS
MAB_4370c|M.abscessus_ATCC_199 ----VHPKNRFDARVVHQWTDYGALRERLGEARVQGPLTNGHATVFPNLS
MSMEG_5627|M.smegmatis_MC2_155 ----DDPRVSTAEMQMYTWEQTNATTTETLVNAAKRLVDELPEGTPPDKV
TH_3362|M.thermoresistible__bu ----HRLVSTSGVRAWEMSEEMRKPIEDICRSGLFGPWDKPDLGEMPKGL
*.
MMAR_3964|M.marinum_M LSVTIANG------------ELFRIYPGDRPGSSITVHQNSTPLDLSDES
MUL_3820|M.ulcerans_Agy99 LSVTIANG------------ELFRIYPGDRPGSSITVHQNSTPLDLSDES
MAV_1644|M.avium_104 LSVTIANG------------ELFRVYPGDRPGRSITVHQNATPQDLSDES
Mvan_4910|M.vanbaalenii_PYR-1 LANSPIGV------------EIIDILPAGEPTRCSVRHSWMGRVPATTDE
Mb3186c|M.bovis_AF2122/97 LAIAGERV------------VWFGFIP-QSIDRVQVLGGVLTTPELAADA
Rv3161c|M.tuberculosis_H37Rv LAIAGERV------------VWFGFIP-QSIDRVQVLGGVLTTPELAADA
Mflv_0685|M.gilvum_PYR-GCK FVHNWPKVEDGEHVLPFISIRVWQPISENETEVLSWFAVDSDAPEAFKAD
MAB_4370c|M.abscessus_ATCC_199 YLPVNGSV------------RIWHPKGPDKMEVWAWTIVDRSMPEEVRDA
MSMEG_5627|M.smegmatis_MC2_155 LEHWLASARRDDEARG----VIWPTIPADILGQAGTAWQIFPNFQIGQGL
TH_3362|M.thermoresistible__bu NPARCDPWG----------LDSFQLFPNFVILFWGQGWYLTYHYWPTSYN
MMAR_3964|M.marinum_M VATGAQAVFDYAHATVRD-----------------------------EDY
MUL_3820|M.ulcerans_Agy99 VATGAQAVFDYAHATVRD-----------------------------EDY
MAV_1644|M.avium_104 VAAGVQAVFDYAHATVRD-----------------------------EDY
Mvan_4910|M.vanbaalenii_PYR-1 MREMYDQVYDSVHAAVVD-----------------------------EDF
Mb3186c|M.bovis_AF2122/97 AATAQTSQFVMAMINDED-----------------------------RLG
Rv3161c|M.tuberculosis_H37Rv AATAQTSQFVMAMINDED-----------------------------RLG
Mflv_0685|M.gilvum_PYR-GCK SYKAYLMCFGSTGMFEQDDVENWVSLTNTAGGSMARRLRLNSRMGLLADD
MAB_4370c|M.abscessus_ATCC_199 QRLYNLRTFGPTGIFEQDDG---------------------------ENW
MSMEG_5627|M.smegmatis_MC2_155 TTALCYSAKPHPSYNPDK---------------------CIFEVATFELF
TH_3362|M.thermoresistible__bu THVFEGNLYFPAARTPRE---------------------------RVAQE
.
MMAR_3964|M.marinum_M RLAETLQTNFESGARQR-LVFGRNEPGLQHRHITWAQALKTPG-------
MUL_3820|M.ulcerans_Agy99 RLAETLQTNLESGARQR-LVFGRNEPGLQHRHITWAQALETPG-------
MAV_1644|M.avium_104 RLVESLQANLESGARDH-LVFGRNEPGLQHRHITWAKALAASTG------
Mvan_4910|M.vanbaalenii_PYR-1 AMLPQCGEGVRHGQHDH-MIIGRNEIGVQHMVKVFAQELGVALS------
Mb3186c|M.bovis_AF2122/97 LEAVQVGAGSRFAERGH-LSS-KEWPGMLAFYRNLAMALVGDHPGAS---
Rv3161c|M.tuberculosis_H37Rv LEAVQVGAGSRFAERGH-LSS-KEWPGMLAFYRNLAMALVGDHPGAS---
Mflv_0685|M.gilvum_PYR-GCK ARVVDTLSSAQFHGPGY-AQLGYNENNQRELLRLWADYLDMPPLRVDPAT
MAB_4370c|M.abscessus_ATCC_199 SEVQSISRGFVTNSVALNYQMGLDSEREDGRHPGLTSELYSDAAGRSFYA
MSMEG_5627|M.smegmatis_MC2_155 PKGQEPRTEWEYTPADSPNWLSVLPQDFSNMAAVQQGMKSMGFPGTKPNP
TH_3362|M.thermoresistible__bu LAAASFKEYGLQDANTLEATQSMIESGVLDDFVLCDQEVLIRHLHKETAD
MMAR_3964|M.marinum_M ----------------------------------
MUL_3820|M.ulcerans_Agy99 ----------------------------------
MAV_1644|M.avium_104 ----------------------------------
Mvan_4910|M.vanbaalenii_PYR-1 ----------------------------------
Mb3186c|M.bovis_AF2122/97 ----------------------------------
Rv3161c|M.tuberculosis_H37Rv ----------------------------------
Mflv_0685|M.gilvum_PYR-GCK VLTDNPQGIEPMVQTNGGAVAGIDSESATTSVTL
MAB_4370c|M.abscessus_ATCC_199 RWRDLMNTKAWHEEHV------------------
MSMEG_5627|M.smegmatis_MC2_155 YRERSTVNLHYQLSKYMGTGEPRDLQENA-----
TH_3362|M.thermoresistible__bu WIDRYERESTGTAAGVAGR---------------