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VAVVAGGAGGIGAATSRLFAQHGAQVVIADIDAELAHRTVDEIGGAAWVVGTDVRDADQVSALAQRVLDR YGRLDILVNNVGHWLRHPGNFVDTDPQLWDELYRVNLHHVLLATHAFLPAMIEQHGGAIVNVSSVEGLRG YPEDPVYAAFKAAVIHFTHSLAVQVGNHGVRINAIAPDVTESLQVPYSQWLSDAEQTQWPGWVPVGRMGV PEDQARVILFLACELSAFVTGHTIPTDGGTAAAGGWFRSSRRPDREWTNRPIAP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_3168 | - | - | 100% (264) | short chain dehydrogenase |
| M. ulcerans Agy99 | MUL_0327 | - | 3e-42 | 39.76% (249) | oxidoreductase |
| M. ulcerans Agy99 | MUL_0336 | - | 9e-35 | 35.00% (260) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1385 | fabG | 2e-31 | 34.16% (243) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. gilvum PYR-GCK | Mflv_2424 | - | 3e-39 | 38.40% (250) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv1350 | fabG | 2e-31 | 34.16% (243) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. leprae Br4923 | MLBr_00862 | ephD | 9e-24 | 36.61% (183) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4632 | - | 6e-27 | 33.73% (249) | short chain dehydrogenase |
| M. marinum M | MMAR_2592 | - | 1e-154 | 98.86% (264) | short chain dehydrogenase |
| M. avium 104 | MAV_3012 | - | 1e-123 | 78.65% (267) | short-chain dehydrogenase/reductase SDR |
| M. smegmatis MC2 155 | MSMEG_4850 | - | 2e-41 | 40.08% (252) | short-chain dehydrogenase/reductase SDR |
| M. thermoresistible (build 8) | TH_3505 | - | 3e-44 | 41.34% (254) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_4228 | - | 4e-41 | 38.80% (250) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_3168|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2592|M.marinum_M --------------------------------------------------
MAV_3012|M.avium_104 --------------------------------------------------
Mflv_2424|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4228|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4850|M.smegmatis_MC2_155 --------------------------------------------------
TH_3505|M.thermoresistible__bu --------------------------------------------------
Mb1385|M.bovis_AF2122/97 --------------------------------------------------
Rv1350|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4632|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 MPATQSIHKVPHQFVESPDGVRLAIYQSGQPEGPAIVLVHGFPDSHVLWD
MUL_3168|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2592|M.marinum_M --------------------------------------------------
MAV_3012|M.avium_104 --------------------------------------------------
Mflv_2424|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4228|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4850|M.smegmatis_MC2_155 --------------------------------------------------
TH_3505|M.thermoresistible__bu --------------------------------------------------
Mb1385|M.bovis_AF2122/97 --------------------------------------------------
Rv1350|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4632|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 GVVPLLAKRFRIVRYDNRGVGQSSVPKPVSAYTMTRFADDFAAVIDELSP
MUL_3168|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2592|M.marinum_M --------------------------------------------------
MAV_3012|M.avium_104 --------------------------------------------------
Mflv_2424|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4228|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4850|M.smegmatis_MC2_155 --------------------------------------------------
TH_3505|M.thermoresistible__bu --------------------------------------------------
Mb1385|M.bovis_AF2122/97 --------------------------------------------------
Rv1350|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4632|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DRPVHVLAHDWGSVGVWEYLSRSGASDRVASFTSVSGPSQDQLVDYILSG
MUL_3168|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2592|M.marinum_M --------------------------------------------------
MAV_3012|M.avium_104 --------------------------------------------------
Mflv_2424|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4228|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4850|M.smegmatis_MC2_155 --------------------------------------------------
TH_3505|M.thermoresistible__bu --------------------------------------------------
Mb1385|M.bovis_AF2122/97 --------------------------------------------------
Rv1350|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4632|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LRRPWRPRTFARAVSQLFRLTYMVLFSIPVLVPMVLWIALSSATIRRTMV
MUL_3168|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2592|M.marinum_M --------------------------------------------------
MAV_3012|M.avium_104 --------------------------------------------------
Mflv_2424|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4228|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4850|M.smegmatis_MC2_155 --------------------------------------------------
TH_3505|M.thermoresistible__bu --------------------------------------------------
Mb1385|M.bovis_AF2122/97 --------------------------------------------------
Rv1350|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4632|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DNISTDQIHHSATLARDAAHSVKTYPANYFRAFSGRRRGKGVPVVNVPVQ
MUL_3168|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2592|M.marinum_M --------------------------------------------------
MAV_3012|M.avium_104 --------------------------------------------------
Mflv_2424|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4228|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4850|M.smegmatis_MC2_155 --------------------------------------------------
TH_3505|M.thermoresistible__bu --------------------------------------------------
Mb1385|M.bovis_AF2122/97 --------------------------------------------------
Rv1350|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4632|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LIVNTMDRYVRPYGYDATARWVPRLWRRDIKAGHFSPMSHPQVMAAAVHD
MUL_3168|M.ulcerans_Agy99 -----------------------------MAVVAGGAGGIGAATSRLFAQ
MMAR_2592|M.marinum_M ---------------MDEATPARQLLTDRVAVVTGGAGGIGAATSRLFAQ
MAV_3012|M.avium_104 ---------------MTQHKHFDPLLSDRVAVVTGGGGGIGAATARLFAE
Mflv_2424|M.gilvum_PYR-GCK ----------------MAITASDILLTGRVAVVTGGGAGIGRGIAQGLAA
Mvan_4228|M.vanbaalenii_PYR-1 ----------------MTIAPSDILLTGRVAVVTGGGAGIGKGIAHGLAA
MSMEG_4850|M.smegmatis_MC2_155 ----------------MAINPSDILLTGRVAVVTGGGAGIGRGIAEGLAA
TH_3505|M.thermoresistible__bu ----------------LTIAPADILLTDRVAVVTGGGAGLGRGIAAGFAA
Mb1385|M.bovis_AF2122/97 ---------------------MASLLNARTAVITGGAQGLGLAIGQRFVA
Rv1350|M.tuberculosis_H37Rv ---------------------MASLLNARTAVITGGAQGLGLAIGQRFVA
MAB_4632|M.abscessus_ATCC_1997 ------------------MILDRFKLDGNVAVVTGAGRGLGAAIAEAFAQ
MLBr_00862|M.leprae_Br4923 LADLVDGKQPSRALLRAQVGRSRDTFGDTLVSVTGAGSGIGRETALALAR
. ::*.. *:* . :.
MUL_3168|M.ulcerans_Agy99 HGAQVVIADIDAELAHR---TVDEIGGAAWVVGTDVRDADQVSALAQRVL
MMAR_2592|M.marinum_M HGAQVVIADIDAELAHR---TVDEIGGAAWVVGTDVRDADQVSALAQRVL
MAV_3012|M.avium_104 HGAHVVIADIDAELADETASTIAASGGSAHPITADVRNAAEVTHFARTVL
Mflv_2424|M.gilvum_PYR-GCK FGASVAIWERDPDTCAAAAAAIGGLG-----LEVDVRDAAAVDTALDRTE
Mvan_4228|M.vanbaalenii_PYR-1 FGASVAIWERDPQTCGEAAASVGALG-----LPTDVRDAEAVQAALERTE
MSMEG_4850|M.smegmatis_MC2_155 FGARVAIWERDPETCEAAARAVGGVG-----IVTDVRDADQVDAALAQTT
TH_3505|M.thermoresistible__bu FGARVAIWERDPDSCARTAEEIGALG-----IVTDVRDSAAVSAALRQTT
Mb1385|M.bovis_AF2122/97 EGARVVLGDVNLEATEVAAKRLGGDD-VALAVRCDVTQADDVDILIRTAV
Rv1350|M.tuberculosis_H37Rv EGARVVLGDVNLEATEVAAKRLGGDD-VALAVRCDVTQADDVDILIRTAV
MAB_4632|M.abscessus_ATCC_1997 AGADVLIASRTESQLREVAAKVQAAGRQAEVVVADLSDTEASAALAQKAV
MLBr_00862|M.leprae_Br4923 RGAEVVVSDIDEAAAKNTAAQIVASGGVAYAYALDVSDAAAVEAFAEQVS
** * : . : . *: :: .
MUL_3168|M.ulcerans_Agy99 DRYGRLDILVNNVGHWLRHPGNFVDTDPQLWDELYRVNLHHVLLATHAFL
MMAR_2592|M.marinum_M DRYGRVDILVNNVGHWLRHPGNFVDTDPQLWDELYRVNLHHVLLATHAFL
MAV_3012|M.avium_104 DRYGRIDVLVNNVGHWLRHPGGFADTDPQLWDELYRINLHHVFLVTHAFL
Mflv_2424|M.gilvum_PYR-GCK RELGTVSILVNNAGGTFNSP--LLDTSENGWDALYRSNLRHVLLCTQRVA
Mvan_4228|M.vanbaalenii_PYR-1 RELGTVSILVNNAGGTFNSP--LLETSENGWDALYRSNLRHVLLCTQRVA
MSMEG_4850|M.smegmatis_MC2_155 SELGTVSILVNNAGGVFASP--LLETTENGWDALYKANLRHVLLCTQRVA
TH_3505|M.thermoresistible__bu EQLGSPTILVNNAGGTFSSP--LLETSENGWDALYRANLRHVLLCTQQVG
Mb1385|M.bovis_AF2122/97 ERFGGLDVMVNNAGITRDAT--MRTMTEEQFDQVIAVHLKGTWNGTRLAA
Rv1350|M.tuberculosis_H37Rv ERFGGLDVMVNNAGITRDAT--MRTMTEEQFDQVIAVHLKGTWNGTRLAA
MAB_4632|M.abscessus_ATCC_1997 DRFGRLDVVVNNVGGTMPKP--FLDTTNDDLAEAFSFNVLSGHALLRAAV
MLBr_00862|M.leprae_Br4923 AKHGVPDIVVNNAGIGQAGR--FLDTPPEEFDRVLAVNLGGVVNCCRAFG
. * ::***.* : : :: :
MUL_3168|M.ulcerans_Agy99 PAMIEQHG-GAIVNVSSVEGLRGYPEDPVYAAFKAAVIHFTHSLAVQVGN
MMAR_2592|M.marinum_M PAMIEQHG-GAIVNVSSVEGLRGYPEDPVYAAFKAAVIHFTRSLAVQVGN
MAV_3012|M.avium_104 PTMIDRGA-GAIVNVSSVEGLRGYPEDPVYAAFKAAVIGFTRSLAVQVGN
Mflv_2424|M.gilvum_PYR-GCK RRLVAAEQTGSVINVTSIEGSRAAPGYAAYAAAKAGVVNYTKTASFELAP
Mvan_4228|M.vanbaalenii_PYR-1 RRLVEVGQPGSVINITSIEGSRAAPGYAAYAAAKAGVVNYTKTASFELAP
MSMEG_4850|M.smegmatis_MC2_155 RDMVAAEMPGSIINLTSIEGVRAAPRYAAYSAAKAGVINYTLTAAFELAP
TH_3505|M.thermoresistible__bu RQLVAAGQPGSIVNITSIEGARAAPGYAAYAAAKAGVINYTRTAAFELAP
Mb1385|M.bovis_AF2122/97 AIMRERKR-GAIVNMSSVSGKVGMVGQTNYSAAKAGIVGMTKAAAKELAH
Rv1350|M.tuberculosis_H37Rv AIMRERKR-GAIVNMSSVSGKVGMVGQTNYSAAKAGIVGMTKAAAKELAH
MAB_4632|M.abscessus_ATCC_1997 PHLLKSDN-ASVINITSTMGRLPGRAFLGYCTAKGALAHYTRTAAMDLSP
MLBr_00862|M.leprae_Br4923 QRLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMFSDCLRAELDA
: . ::*::* . *.: *.. : ::
MUL_3168|M.ulcerans_Agy99 HGVRINAIAPDVTESLQVP----YSQWLSDAEQTQ-WPGWVPVGRMGVPE
MMAR_2592|M.marinum_M HGVRINAIAPDVTESLQVP----YSQWLSDAEQTQ-WPGWVPVGRMGVPE
MAV_3012|M.avium_104 HGVRVNAVAPDVTESLQVP----YSQWLSAEEQSQ-WPRWVPVGRMGLPE
Mflv_2424|M.gilvum_PYR-GCK YGIRVNGLAPDLTMTEGL-------QKLAFGELSGTVARMVPMRRAGHVD
Mvan_4228|M.vanbaalenii_PYR-1 HRIRVNALAPDLTMTEGL-------QKLAFGDLSGTMADMVPMRRVGHVD
MSMEG_4850|M.smegmatis_MC2_155 YGIRVNALAPDLTVTDGL-------LALSGGRQPG--GDAIPMKRPGHVD
TH_3505|M.thermoresistible__bu HRIRVNAIAPDIAVTEGL-------QRMSPDGIPPEVGHAIPLGRPGHVD
Mb1385|M.bovis_AF2122/97 LGIRVNAIAPGLIRSAMT--------EAMPQRIWDQKLAEVPMGRAGEPS
Rv1350|M.tuberculosis_H37Rv LGIRVNAIAPGLIRSAMT--------EAMPQRIWDQKLAEVPMGRAGEPS
MAB_4632|M.abscessus_ATCC_1997 R-IRVNGIAPGSILTSAL------EVVAGNDEMRNTLEQNTPLHRLGDPA
MLBr_00862|M.leprae_Br4923 VGVGLTTICPGVIDTNIIQSTRIDTPTAKQERVRDRRGQLDMMFRLRRYG
: :. :.*. : : *
MUL_3168|M.ulcerans_Agy99 DQARVILFLACELSAFVTGHTIPTDGGTAAAGGWFRSSRRPDREWTNRPI
MMAR_2592|M.marinum_M DQARVILFLACELSAFVTGHTIPTDGGTAAAGGWFRSSRRPDREWTNRPI
MAV_3012|M.avium_104 DQARVILFLASDCSSFITGHTIPTDGGTTAAGGWFRSSRRPGREWTNRPA
Mflv_2424|M.gilvum_PYR-GCK EMASAAVFLASDMASYITGQTIHVDGGTEAAGGWYFHPDNGAPTLGPA--
Mvan_4228|M.vanbaalenii_PYR-1 EMASAAVFLASDMAAYITGQTIHVDGGTAAAGGWYFHPETGVPTLGPA--
MSMEG_4850|M.smegmatis_MC2_155 EMAGAAVFLASGMSSYITGQTLHVDGGTQAAGGWYHHPQTGAPTLGPG--
TH_3505|M.thermoresistible__bu EIAGAAVFLASEMSSYITGQTLHVDGGTQAAGGWYHHPRTGAPTLGPGPV
Mb1385|M.bovis_AF2122/97 EVASVAVFLASDLSSYMTGTVLDVTGGRFI--------------------
Rv1350|M.tuberculosis_H37Rv EVASVAVFLASDLSSYMTGTVLDVTGGRFI--------------------
MAB_4632|M.abscessus_ATCC_1997 DIAAAAVYLASPAGSFLTGKVLEVDGGLIAPN-----LDIPLPDLA----
MLBr_00862|M.leprae_Br4923 PDKVADTILSAIKKNKPIRPVAPEAYALYGISRVLPQVLRSTARIRVI--
. *:. . .
MUL_3168|M.ulcerans_Agy99 AP
MMAR_2592|M.marinum_M AP
MAV_3012|M.avium_104 DP
Mflv_2424|M.gilvum_PYR-GCK --
Mvan_4228|M.vanbaalenii_PYR-1 --
MSMEG_4850|M.smegmatis_MC2_155 --
TH_3505|M.thermoresistible__bu R-
Mb1385|M.bovis_AF2122/97 --
Rv1350|M.tuberculosis_H37Rv --
MAB_4632|M.abscessus_ATCC_1997 --
MLBr_00862|M.leprae_Br4923 --