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MGLRGLADKVAVVVGGATGIGAATAARLAGEGCRVVIGDVAVDAARQTADRIGAAGGTATQVAFDLADPA SVATLIDCAATTYGGVDLLFNVGADMSTIRADTDVVDIDFDVWDRVMTVSLRGYVAAMKYAIPRMLDRGG GAIVNMSSAAAFQGEPARPAYATAKAGIGALTRHVASRWGKDNIRCNAVAPGFTATETIRSVPQWPELEA AALKRIRGPRVGDPADVAALVAFLLSAEGDWINGQVINIDGGTVLR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4177 | - | - | 100% (256) | putative short-chain type dehydrogenase/reductase y4lA |
| M. avium 104 | MAV_3097 | - | 1e-57 | 44.92% (256) | NAD dependent epimerase/dehydratase family protein |
| M. avium 104 | MAV_0714 | - | 9e-41 | 38.96% (249) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0792 | - | 8e-40 | 38.31% (248) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_3483 | - | 1e-115 | 80.47% (256) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv0769 | - | 3e-40 | 38.71% (248) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_02565 | fabG | 2e-23 | 31.76% (255) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. abscessus ATCC 19977 | MAB_1219 | - | 2e-38 | 37.20% (250) | short chain dehydrogenase |
| M. marinum M | MMAR_0271 | - | 5e-41 | 40.40% (250) | short-chain type dehydrogenase/reductase |
| M. smegmatis MC2 155 | MSMEG_5858 | - | 1e-39 | 38.15% (249) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_3037 | - | 3e-44 | 39.76% (249) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_0478 | - | 3e-39 | 37.75% (249) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_5156 | - | 2e-42 | 38.61% (259) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_4177|M.avium_104 --------------------------------------------------
Mflv_3483|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_0271|M.marinum_M --------------------------------------------------
TH_3037|M.thermoresistible__bu --------------------------------------------------
Mvan_5156|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5858|M.smegmatis_MC2_155 --------------------------------------------------
Mb0792|M.bovis_AF2122/97 --------------------------------------------------
Rv0769|M.tuberculosis_H37Rv --------------------------------------------------
MUL_0478|M.ulcerans_Agy99 --------------------------------------------------
MAB_1219|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 MAPKCSSDLFSQIVSSGPGSFVAKQLGVPRPETLRRYRPSDAPLCGSLLI
MAV_4177|M.avium_104 --------------------------------------------------
Mflv_3483|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_0271|M.marinum_M --------------------------------------------------
TH_3037|M.thermoresistible__bu --------------------------------------------------
Mvan_5156|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5858|M.smegmatis_MC2_155 --------------------------------------------------
Mb0792|M.bovis_AF2122/97 --------------------------------------------------
Rv0769|M.tuberculosis_H37Rv --------------------------------------------------
MUL_0478|M.ulcerans_Agy99 --------------------------------------------------
MAB_1219|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 GGDGRLVEPLRATLEKDYDLVSNNLGGRWTDSFGGLVFDATGITAPAELK
MAV_4177|M.avium_104 --------------------------------------------------
Mflv_3483|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_0271|M.marinum_M --------------------------------------------------
TH_3037|M.thermoresistible__bu --------------------------------------------------
Mvan_5156|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5858|M.smegmatis_MC2_155 --------------------------------------------------
Mb0792|M.bovis_AF2122/97 --------------------------------------------------
Rv0769|M.tuberculosis_H37Rv --------------------------------------------------
MUL_0478|M.ulcerans_Agy99 --------------------------------------------------
MAB_1219|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 GLHNFFTPLLRNLGRCARVVVIGTTPDATTSTDERIAQRALEGFSRSLGK
MAV_4177|M.avium_104 --------------------------------------------------
Mflv_3483|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_0271|M.marinum_M --------------------------------------------------
TH_3037|M.thermoresistible__bu --------------------------------------------------
Mvan_5156|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5858|M.smegmatis_MC2_155 --------------------------------------------------
Mb0792|M.bovis_AF2122/97 --------------------------------------------------
Rv0769|M.tuberculosis_H37Rv --------------------------------------------------
MUL_0478|M.ulcerans_Agy99 --------------------------------------------------
MAB_1219|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 ELRRGATVALVYLSPDAKPAATGLESTMRFILSAKSAYVNGQVFYVGAAD
MAV_4177|M.avium_104 -----MGLRGLADKVAVVVGGATGIGAATAARLAGEGCRVVIGDVAVDAA
Mflv_3483|M.gilvum_PYR-GCK -----MGLRGLTGKVAVVAGGATGLGAAAATRLAEEGCRVVVGDVSEDAA
MMAR_0271|M.marinum_M ------MTAELENKVAIITGACGGIGLETSRVLARAGARVVLADLPETDL
TH_3037|M.thermoresistible__bu ---MG----QFDDKVAIVTGAGGGIGQAYAEALAREGAAVVVADINTEGA
Mvan_5156|M.vanbaalenii_PYR-1 ---MGLYGDQFKEKVAIVTGAGGGIGQAYAEALAREGAAVVVADINTEGA
MSMEG_5858|M.smegmatis_MC2_155 ---MGQYGTNFEDKVAIVTGAGGGIGQAYAEALAREGAAVVVADINLEGA
Mb0792|M.bovis_AF2122/97 ---------MFDSKVAIVTGAAQGIGQAYAQALAREGASVVVADINADGA
Rv0769|M.tuberculosis_H37Rv ---------MFDSKVAIVTGAAQGIGQAYAQALAREGASVVVADINADGA
MUL_0478|M.ulcerans_Agy99 ---MG----QFENKVAIVTGAAQGIGQAYADALAREGARVVVADINAEAA
MAB_1219|M.abscessus_ATCC_1997 ---MG----EFDNKVAIVTGAAQGIGEAYAHALAREGAAVVVADINAEMG
MLBr_02565|M.leprae_Br4923 STPPTNWDRPLENKVAIVTGAARGIGAAIAEVVARDGARVVAIDVESAAE
: ***::.*. *:* : :* *. ** *:
MAV_4177|M.avium_104 RQTADRIGAAGGTATQVAFDLADPASVATLIDCAATTYG-GVDLLFNVGA
Mflv_3483|M.gilvum_PYR-GCK THTVRRITEAGGTAVAIAFDLADPSSVAGLFASAVDAFS-DVDLLFNVGA
MMAR_0271|M.marinum_M AGAAASVGRG---AVHHVVDLTNEVSVRALIDFTIDTFG-RLDIVDNNAA
TH_3037|M.thermoresistible__bu QKVADGIKGEGGDALAVPVDVSDPESAEEMAAQTVSEFG-GIDYLVNNAA
Mvan_5156|M.vanbaalenii_PYR-1 QKVADGIKGEGGNALAVRVDVSDPESAKGMAAQTLSEFG-GIDYLVNNAA
MSMEG_5858|M.smegmatis_MC2_155 QKVADAILGEGGNALAVRVDVSDIDSAKDMAAQTLSEFG-GIDYLVNNAA
Mb0792|M.bovis_AF2122/97 AAVAKQIVADGGTVIHVPVDVSDEDSAKAMVDRAVGAFG-GIDYLVNNAA
Rv0769|M.tuberculosis_H37Rv AAVAKQIVADGGTAIHVPVDVSDEDSAKAMVDRAVGAFG-GIDYLVNNAA
MUL_0478|M.ulcerans_Agy99 EKTAKQIVADGGTAIHVPVDVSDEESARAMADRTVSEFG-GIDYLVNNAA
MAB_1219|M.abscessus_ATCC_1997 EGVAKQIVADGGRAIFAGVDVSDPDSAIAMADKAVSEFG-GIDYLVNNAA
MLBr_02565|M.leprae_Br4923 ALDETANRVGG---TTLSLDVTADDAVDKITEHLHDYQGGHADILVNNAG
.*:: :. : . * : * ..
MAV_4177|M.avium_104 DMSTIRADTDVVDIDFDVWDRVMTVSLRGYVAAMKYAIPRMLDRGGGAIV
Mflv_3483|M.gilvum_PYR-GCK DMSTIRFDTDVVDIDLDVWDRVMTVNLRGYAAALKYAIPVMLEGGGGAIV
MMAR_0271|M.marinum_M HSD--PADMLVTQMTVDVWDDTFTVNARGTMLMCKYAIPRLISAGGGAIV
TH_3037|M.thermoresistible__bu IFGGMKLDFLIT-VDWDYYKRFMSVNLDGALVCTRAVYKKMAKRGGGAIV
Mvan_5156|M.vanbaalenii_PYR-1 IFGGMKLDFLIT-VDWDYYKKFMSVNMDGALVCTRAVYRKMAKRGGGAIV
MSMEG_5858|M.smegmatis_MC2_155 IFGGMKLDFLLT-VDWDYYKKFMSVNLDGALVCTRAVYRKMAKRGGGAIV
Mb0792|M.bovis_AF2122/97 IYGGMKLDLLLT-VPLDYYKKFMSVNHDGVLVCTRAVYKHMAKRGGGAIV
Rv0769|M.tuberculosis_H37Rv IYGGMKLDLLLT-VPLDYYKKFMSVNHDGVLVCTRAVYKHMAKRGGGAIV
MUL_0478|M.ulcerans_Agy99 IYGGMKLDLQLT-VPLDYYKKFMSVNHDGVLVCTRAVYKHMAKRGGGAIV
MAB_1219|M.abscessus_ATCC_1997 IYGGMKLDLLLS-VPWDYYKKFMSVNQDGALVCTRAVYKHIAQRGGGAIV
MLBr_02565|M.leprae_Br4923 ITR----DKLLANMDDCRWDAVLEVNLLAPQRLTEGLVGNGSISKGGRVI
* : : :. : *. . . ** ::
MAV_4177|M.avium_104 NMSSAAAFQGEPARPAYATAKAGIGALTRHVASRWGKDNIRCNAVAPGFT
Mflv_3483|M.gilvum_PYR-GCK NMSSAAAFQGEPARPAYATAKAGIGALTRHVASRWGKDGIRCNAVAPGFT
MMAR_0271|M.marinum_M NISSATAHAAYDMSTAYACTKAAIETLTRYVATQYGRHGVRCNAIAPGLV
TH_3037|M.thermoresistible__bu NQSSTAAWLY---SNYYGLAKAGLNSLTQQLATELGGQNIRVNAIAPGPI
Mvan_5156|M.vanbaalenii_PYR-1 NQSSTAAWLY---SNFYGLAKVGINGLTQQLATELGGQNIRVNAIAPGPI
MSMEG_5858|M.smegmatis_MC2_155 NQSSTAAWLY---SNFYGLAKVGINGLTQQLSRELGGQNIRINAIAPGPI
Mb0792|M.bovis_AF2122/97 NQSSTAAWLY---SNFYGLAKVGVNGLTQQLARELGGMKIRINAIAPGPI
Rv0769|M.tuberculosis_H37Rv NQSSTAAWLY---SNFYGLAKVGVNGLTQQLARELGGMKIRINAIAPGPI
MUL_0478|M.ulcerans_Agy99 NQSSTAAWLY---SNFYGLAKVGVNGLTQQLSRELGGMKIRINAIAPGPI
MAB_1219|M.abscessus_ATCC_1997 NQSSTAAWLY---SGFYGLAKVGINGLTQQLSRELGGQKIRINAIAPGPT
MLBr_02565|M.leprae_Br4923 VLSSMAGIAGNRGQTNYATAKAGVIGLTQALAPGLAEKGITINAVAPGFI
** :. *. :*..: **: :: . : **:***
MAV_4177|M.avium_104 ATETIRSVPQWPELEAAALKRIRGPRVGDPADVAALVAFLLSAEGDWING
Mflv_3483|M.gilvum_PYR-GCK ATDTIRAAPQWPELEAGALRRIRGPRVGAPSDVAGLVAFLLSEEGEWING
MMAR_0271|M.marinum_M RTPRLEVGLPQPIVDIFATHHLAG-RIGEPHEIAELVCFLASDRAAFITG
TH_3037|M.thermoresistible__bu DTEANRSTTPKEMVDD-IVKRIPLSRLGEPEDLVGMCLFLLSDQAKWITG
Mvan_5156|M.vanbaalenii_PYR-1 DTEANRTTTPQEMVAD-IVKGIPLSRMGEPEDLVGMLLFLLSDQAKWITG
MSMEG_5858|M.smegmatis_MC2_155 DTEANRTTTPKEMVDD-IVKGIPLSRMGQPEDLVGMCLFLLSDQARWITG
Mb0792|M.bovis_AF2122/97 DTEATRTVTPAELVKN-MVQTIPLSRMGTPEDLVGMCLFLLSDSASWITG
Rv0769|M.tuberculosis_H37Rv DTEATRTVTPAELVKN-MVQTIPLSRMGTPEDLVGMCLFLLSDSASWITG
MUL_0478|M.ulcerans_Agy99 DTEATRTVTPGEFVKD-MVKQIPLSRMGTPEDLVGMCLFLLGDQASRITG
MAB_1219|M.abscessus_ATCC_1997 DTEATRGTVPEQFRSE-LVKNIPLSRMGTVDDMVGMCLFLLSDKASWITG
MLBr_02565|M.leprae_Br4923 ETQMTAAIPLATREVG--RRLNSLLQGGLPVDVAETIAYFAIPASNAVTG
* : : * ::. :: . :.*
MAV_4177|M.avium_104 QVINIDGGTVLR-------------------
Mflv_3483|M.gilvum_PYR-GCK QVVNIDGGTVLR-------------------
MMAR_0271|M.marinum_M QVIAADSGLLAHLPGLPQIRASVAELQSQPS
TH_3037|M.thermoresistible__bu QIFNVDGGQIIR-------------------
Mvan_5156|M.vanbaalenii_PYR-1 QIFNVDGGQIIRS------------------
MSMEG_5858|M.smegmatis_MC2_155 QIFNVDGGQVIRS------------------
Mb0792|M.bovis_AF2122/97 QIFNVDGGQIIRS------------------
Rv0769|M.tuberculosis_H37Rv QIFNVDGGQIIRS------------------
MUL_0478|M.ulcerans_Agy99 QIFNVDGGQIIRS------------------
MAB_1219|M.abscessus_ATCC_1997 QVFNVDGGQIIRS------------------
MLBr_02565|M.leprae_Br4923 NVIRVCGQAMLGA------------------
::. . :