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TGQRLASKRVVITGAASGIGRAAAQLMIGEGARVLIADLDADAAAAAASDIGGNAIGVAANVLDDKSVAA MIDRAVTEFGGIDVLCNHVGGSNPHKDLDLLRLDLDEWDRAMALNARSTVVASRLALPHMIAEGGGSIIN TVSVAGLTGDTLQCAYGASKAAVIRLTQYIATQYGRKGVRCNAVAPGAVMTPALADNVPAAVIDNIRSHN ALDLIGSPEDIGWAMVYLASDESRYMTGQTLVLDGGLTAQSPIAASRRS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2001 | - | - | 100% (260) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_3483 | - | 1e-40 | 35.71% (252) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_4062 | - | 7e-40 | 37.60% (250) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0792 | - | 4e-41 | 39.52% (248) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv0769 | - | 1e-41 | 39.92% (248) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_02565 | fabG | 1e-23 | 32.02% (253) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. abscessus ATCC 19977 | MAB_0833 | - | 4e-34 | 31.73% (249) | Short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_0271 | - | 2e-49 | 38.31% (248) | short-chain type dehydrogenase/reductase |
| M. avium 104 | MAV_4177 | - | 2e-43 | 38.89% (252) | putative short-chain type dehydrogenase/reductase y4lA |
| M. smegmatis MC2 155 | MSMEG_2598 | - | 1e-41 | 37.85% (251) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_3420 | - | 1e-40 | 37.40% (262) | PUTATIVE oxidoreductase, short chain dehydrogenase/reductase |
| M. ulcerans Agy99 | MUL_4844 | - | 2e-49 | 38.71% (248) | short-chain type dehydrogenase/reductase |
| M. vanbaalenii PYR-1 | Mvan_0169 | - | 4e-40 | 35.66% (258) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0792|M.bovis_AF2122/97 --------------------------------------------------
Rv0769|M.tuberculosis_H37Rv --------------------------------------------------
TH_3420|M.thermoresistible__bu --------------------------------------------------
Mvan_0169|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2598|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_2001|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_0271|M.marinum_M --------------------------------------------------
MUL_4844|M.ulcerans_Agy99 --------------------------------------------------
MAV_4177|M.avium_104 --------------------------------------------------
MAB_0833|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 MAPKCSSDLFSQIVSSGPGSFVAKQLGVPRPETLRRYRPSDAPLCGSLLI
Mb0792|M.bovis_AF2122/97 --------------------------------------------------
Rv0769|M.tuberculosis_H37Rv --------------------------------------------------
TH_3420|M.thermoresistible__bu --------------------------------------------------
Mvan_0169|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2598|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_2001|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_0271|M.marinum_M --------------------------------------------------
MUL_4844|M.ulcerans_Agy99 --------------------------------------------------
MAV_4177|M.avium_104 --------------------------------------------------
MAB_0833|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 GGDGRLVEPLRATLEKDYDLVSNNLGGRWTDSFGGLVFDATGITAPAELK
Mb0792|M.bovis_AF2122/97 --------------------------------------------------
Rv0769|M.tuberculosis_H37Rv --------------------------------------------------
TH_3420|M.thermoresistible__bu --------------------------------------------------
Mvan_0169|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2598|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_2001|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_0271|M.marinum_M --------------------------------------------------
MUL_4844|M.ulcerans_Agy99 --------------------------------------------------
MAV_4177|M.avium_104 --------------------------------------------------
MAB_0833|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 GLHNFFTPLLRNLGRCARVVVIGTTPDATTSTDERIAQRALEGFSRSLGK
Mb0792|M.bovis_AF2122/97 --------------------------------------------------
Rv0769|M.tuberculosis_H37Rv --------------------------------------------------
TH_3420|M.thermoresistible__bu --------------------------------------------------
Mvan_0169|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2598|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_2001|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_0271|M.marinum_M --------------------------------------------------
MUL_4844|M.ulcerans_Agy99 --------------------------------------------------
MAV_4177|M.avium_104 --------------------------------------------------
MAB_0833|M.abscessus_ATCC_1997 -------------------------------------------------M
MLBr_02565|M.leprae_Br4923 ELRRGATVALVYLSPDAKPAATGLESTMRFILSAKSAYVNGQVFYVGAAD
Mb0792|M.bovis_AF2122/97 ---------MFDSKVAIVTGAAQGIGQAYAQALAREGASVVVADINADGA
Rv0769|M.tuberculosis_H37Rv ---------MFDSKVAIVTGAAQGIGQAYAQALAREGASVVVADINADGA
TH_3420|M.thermoresistible__bu ---VTERAGELAGKVAVVTGGAAGLGAGLARRFVAEGAKVLIGDVDTGNG
Mvan_0169|M.vanbaalenii_PYR-1 ----MVRA--LPHKIAVITGGASGIGAGTARRFLAEGARVVIADIDRERG
MSMEG_2598|M.smegmatis_MC2_155 ----MDLTQRLAGKVAVITGGASGIGLATGRRLRAEGATVVVGDIDPTTG
Mflv_2001|M.gilvum_PYR-GCK -----MTGQRLASKRVVITGAASGIGRAAAQLMIGEGARVLIADLDADAA
MMAR_0271|M.marinum_M ------MTAELENKVAIITGACGGIGLETSRVLARAGARVVLADLPETDL
MUL_4844|M.ulcerans_Agy99 ------MTAELENKVAIITGACGGIGLETSRVPACAGARVVLADLPETDL
MAV_4177|M.avium_104 -----MGLRGLADKVAVVVGGATGIGAATAARLAGEGCRVVIGDVAVDAA
MAB_0833|M.abscessus_ATCC_1997 NRETFSRLFDLTGRTAIVTGGTRGIGRALAEGYACAGANVVVASRKPEAC
MLBr_02565|M.leprae_Br4923 STPPTNWDRPLENKVAIVTGAARGIGAAIAEVVARDGARVVAIDVESAAE
: : .::.*. *:* . *. *: .
Mb0792|M.bovis_AF2122/97 AAVAKQIVADGGTVIHVPVDVSDEDSAKAMVDRAVGAFG-GIDYLVNNAA
Rv0769|M.tuberculosis_H37Rv AAVAKQIVADGGTAIHVPVDVSDEDSAKAMVDRAVGAFG-GIDYLVNNAA
TH_3420|M.thermoresistible__bu AKLAAELGA---DAEFVEADVADLDQVSGLVSTAVERFG-GLHVMVNNAG
Mvan_0169|M.vanbaalenii_PYR-1 EARAAELGP---DCVFKYTDVASRDDVTELVEYAVDRFG-GLDVMMNNAG
MSMEG_2598|M.smegmatis_MC2_155 KAAADEL-----EGLFVPVDVSEQEAVDNLFDTAASTFG-RVDIAFNNAG
Mflv_2001|M.gilvum_PYR-GCK AAAASDIGG---NAIGVAANVLDDKSVAAMIDRAVTEFG-GIDVLCNHVG
MMAR_0271|M.marinum_M AGAAASVGRG---AVHHVVDLTNEVSVRALIDFTIDTFG-RLDIVDNNAA
MUL_4844|M.ulcerans_Agy99 AGAAASVGRG---AVHHVVDLTNEVSVRALIDFTIDTFG-RLDIVDNNAA
MAV_4177|M.avium_104 RQTADRIGAAGGTATQVAFDLADPASVATLIDCAATTYG-GVDLLFNVGA
MAB_0833|M.abscessus_ATCC_1997 TEAVERLRSLGARALGVPTHTGDIHSLEELVRATAEEFG-GIDIVVNNAA
MLBr_02565|M.leprae_Br4923 ALDETANRVG---GTTLSLDVTADDAVDKITEHLHDYQGGHADILVNNAG
. : * . * .
Mb0792|M.bovis_AF2122/97 IYG-GMKLDLLLTVPLDYYKKFMSVNHDGVLVCTRAVYKHMAKRGGGAIV
Rv0769|M.tuberculosis_H37Rv IYG-GMKLDLLLTVPLDYYKKFMSVNHDGVLVCTRAVYKHMAKRGGGAIV
TH_3420|M.thermoresistible__bu IS--GTMHRSLLDDDLADFDRVMRINVRAVMAGTRDAARHMAEHGGGSII
Mvan_0169|M.vanbaalenii_PYR-1 IS--GRMQPELLDDDFADFDRVMRVDLLGVMLGTQIAARHMKDHGGGSII
MSMEG_2598|M.smegmatis_MC2_155 IS--PPEDDLIENTDLPAWQRVQDINLKSVYLSCRAALRHMVPAGKGSII
Mflv_2001|M.gilvum_PYR-GCK GSN-PHKDLDLLRLDLDEWDRAMALNARSTVVASRLALPHMIAEGGGSII
MMAR_0271|M.marinum_M HSD--PADMLVTQMTVDVWDDTFTVNARGTMLMCKYAIPRLISAGGGAIV
MUL_4844|M.ulcerans_Agy99 HSD--PADMLVSQMTVDVWDDTFTVNARGTMLMCKYAIPRLISAGGGAIV
MAV_4177|M.avium_104 DMSTIRADTDVVDIDFDVWDRVMTVSLRGYVAAMKYAIPRMLDRGGGAIV
MAB_0833|M.abscessus_ATCC_1997 NAL----TEPVGAFTVDGWDKSFGVNLRGPVFLVQAALPHLVASPHAAVL
MLBr_02565|M.leprae_Br4923 ITR----DKLLANMDDCRWDAVLEVNLLAPQRLTEGLVGNGSISKGGRVI
: :. :. . . . . ::
Mb0792|M.bovis_AF2122/97 NQSSTAAWLYSNF----YGLAKVGVNGLTQQLARELGGMKIRINAIAPGP
Rv0769|M.tuberculosis_H37Rv NQSSTAAWLYSNF----YGLAKVGVNGLTQQLARELGGMKIRINAIAPGP
TH_3420|M.thermoresistible__bu NLTSIGGIQAGGG-VQTYRASKAAVIQFTKSAAIELAHHEIRVNALAPGN
Mvan_0169|M.vanbaalenii_PYR-1 NTTSIGGIQAGCT-VMTYRAAKAGVIHFTKSAAIDLAQYAIRVNTIAPGG
MSMEG_2598|M.smegmatis_MC2_155 NTASFVAVMGSATSQISYTASKGGVLAMSRELGVQYARQGIRVNALCPGP
Mflv_2001|M.gilvum_PYR-GCK NTVSVAGLT-GDTLQCAYGASKAAVIRLTQYIATQYGRKGVRCNAVAPGA
MMAR_0271|M.marinum_M NISSATAHAAYDMS-TAYACTKAAIETLTRYVATQYGRHGVRCNAIAPGL
MUL_4844|M.ulcerans_Agy99 NISSATAHAAYDMS-TAYSCTKAAIETLTRYVATQYGRHGVRCNAIAPGL
MAV_4177|M.avium_104 NMSSAAAFQGEPAR-PAYATAKAGIGALTRHVASRWGKDNIRCNAVAPGF
MAB_0833|M.abscessus_ATCC_1997 NVVSVGAFMFGQG-VSMYSAAKAALVSYTRSAAAELASRGVRVNALAPGA
MLBr_02565|M.leprae_Br4923 VLSSMAGIAGNRG-QTNYATAKAGVIGLTQALAPGLAEKGITINAVAPGF
* . * :* .: :: . . : *::.**
Mb0792|M.bovis_AF2122/97 IDTEATRTVTPAELVKN---MVQTI--------PLSRMGTPEDLVGMCLF
Rv0769|M.tuberculosis_H37Rv IDTEATRTVTPAELVKN---MVQTI--------PLSRMGTPEDLVGMCLF
TH_3420|M.thermoresistible__bu IRTAIVRKSATGADLERLERFEARIRQQMRDDRPLKREGTVEDVAEAALY
Mvan_0169|M.vanbaalenii_PYR-1 IPTAILS-AATGVDESDELGTTAAIRKEIAAERPLKMTASVDDIAAAAAY
MSMEG_2598|M.smegmatis_MC2_155 VNTPLLQ-ELFAKDPERAARRLVHI--------PLGRFAEPEELAAAVAF
Mflv_2001|M.gilvum_PYR-GCK VMTPALADNVPAAVIDN---IRSHN--------ALDLIGSPEDIGWAMVY
MMAR_0271|M.marinum_M VRTPRLEVGLPQPIVDIFATHHLAG-----------RIGEPHEIAELVCF
MUL_4844|M.ulcerans_Agy99 VRTPRLEVGLPQPIVDIFATHHLAG-----------LIGEPHEIAELVCF
MAV_4177|M.avium_104 TATETIRSVPQWPELEAAALKRIRGP----------RVGDPADVAALVAF
MAB_0833|M.abscessus_ATCC_1997 IDTDMVRKTPPAEVERMANTNHLKR------------LGLPDEMVGTALL
MLBr_02565|M.leprae_Br4923 IETQMTAAIPLATREVGRRLNSLLQG------------GLPVDVAETIAY
* . ::
Mb0792|M.bovis_AF2122/97 LLSDSASWITGQIFNVDGGQIIRS------------------
Rv0769|M.tuberculosis_H37Rv LLSDSASWITGQIFNVDGGQIIRS------------------
TH_3420|M.thermoresistible__bu FAGDRSRYVTGTVLPIDGGTVAG---KVIARKSHAE------
Mvan_0169|M.vanbaalenii_PYR-1 LGSEDARYVTGVVLPVDGGMTAGNPRNPLRDLMIAAH-----
MSMEG_2598|M.smegmatis_MC2_155 LASDDASFITGSTFLVDGGISSA----YVTPL----------
Mflv_2001|M.gilvum_PYR-GCK LASDESRYMTGQTLVLDGGLTAQS---PIAASRRS-------
MMAR_0271|M.marinum_M LASDRAAFITGQVIAADSGLLAHLPGLPQIRASVAELQSQPS
MUL_4844|M.ulcerans_Agy99 LASDRAAFITGQVIAADSGLLAHLPGLPQIRASVAELQSQPS
MAV_4177|M.avium_104 LLSAEGDWINGQVINIDGGTVLR-------------------
MAB_0833|M.abscessus_ATCC_1997 LTSDAGSYITGQTIIADGGLVAR-------------------
MLBr_02565|M.leprae_Br4923 FAIPASNAVTGNVIRVCGQAMLGA------------------
: . :.* : .