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DRYWTQRNAARHGGSDDTTGKDVAMTSEATPSATAAGPRLADLVEAAAQRAPRAPALLVASERTPIAYAD LVRLVDDLAARLRAAGLAPGDRVGLRAGSNPEFVVALLAASRADLVVAPLDPALPAADQLSRSRAVGARA VLVDRLGEGQTAPESAPCWPVTVTVGPDDSAPTVDLTVTAAPTHDVTAPQGLRDDDAMIMFTGGTTGAPK MVPWTRHNIAASIRSIVAGYGLGPRDATVAVMPLYHGHGLLAALLATLASGGAVLLPARGKFSAHTFWDD IAAVGATWYTAVPTIHQILLERARTEAPRGTHALRFIRSCSAPLTAETAQALQDTFGAPVVCAFGMTEAT HQVSTTAIDGAGHSENPGATPGLVGRSTGPDIRIAGPDGQSLPADTVGEVWLRGATVVRGYLGDPAITAA NFTDGWLHTGDLGTLSAAGDLVVRGRIKELINRGGEKISPERVEGVLAGHPDVLEAAVFGRPDQLYGETV AAVIVTRGSAAPTADELASFCRERLAPFEVPAEFRRAAELPHTAKGSLDRRAVAEQFGESA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_5190 | - | - | 100% (552) | acyl-CoA synthetase |
| M. avium 104 | MAV_5076 | - | 2e-49 | 31.09% (550) | acyl-CoA ligase |
| M. avium 104 | MAV_1912 | - | 9e-45 | 32.21% (506) | acyl-CoA synthase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0123 | fadD7 | 0.0 | 70.80% (524) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_0027 | - | 2e-55 | 32.75% (516) | AMP-dependent synthetase and ligase |
| M. tuberculosis H37Rv | Rv0119 | fadD7 | 0.0 | 70.80% (524) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_02661 | - | 0.0 | 67.57% (518) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4559 | - | 4e-47 | 29.58% (497) | putative long-chain-fatty-acid CoA ligase |
| M. marinum M | MMAR_0319 | fadD7 | 0.0 | 69.43% (543) | fatty-acid-CoA ligase FadD7 |
| M. smegmatis MC2 155 | MSMEG_5295 | - | 1e-126 | 50.29% (523) | acyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_3626 | - | 7e-67 | 33.14% (507) | PUTATIVE putative fatty-acid-CoA ligase |
| M. ulcerans Agy99 | MUL_4803 | fadD7 | 0.0 | 68.32% (543) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_0943 | - | 2e-51 | 31.73% (520) | AMP-dependent synthetase and ligase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0319|M.marinum_M ------------MASDSITGGQAVPAHVGTQPCDSAAGPRLADLVELAAA
MUL_4803|M.ulcerans_Agy99 ------------MASDSITGGQAVPAHVGTQPCDSAAGPRLADLVELAAA
Mb0123|M.bovis_AF2122/97 ------------MASD--------------------FGPRIADLVEVAAT
Rv0119|M.tuberculosis_H37Rv ------------MASD--------------------FGPRIADLVEVAAT
MLBr_02661|M.leprae_Br4923 ------------MKSESITSSRAPVEQIDARLTGQFESPSIASLVEAAAI
MAV_5190|M.avium_104 MDRYWTQRNAARHGGSDDTTGKDVAMTSEATPSATAAGPRLADLVEAAAQ
MSMEG_5295|M.smegmatis_MC2_155 ---------MRFMGTAATPP--------------ATLLSGLFDVLDHHVR
TH_3626|M.thermoresistible__bu ---------------------------------MLSQSVHLVSLPDQRAA
Mflv_0027|M.gilvum_PYR-GCK ------------------------------------MFHNLADIVRSHGR
Mvan_0943|M.vanbaalenii_PYR-1 ------------------------------------MIHNLADIIRVHGR
MAB_4559|M.abscessus_ATCC_1997 --------------------------------------MQFTQWLHRALQ
: .
MMAR_0319|M.marinum_M RLPEATAVIFTADRVAVSYRDLVRLVDDLAGQLTRAGLRPGERVALRSGS
MUL_4803|M.ulcerans_Agy99 QLSEATAVIFTADRVAVSYRDLVRLVDDLAGQLTRAGLRQGERVALRSGS
Mb0123|M.bovis_AF2122/97 RLPEAPALVVTADRIAISHRDLARLVDELAGQLTRSGLLPGDRVALRMGS
Rv0119|M.tuberculosis_H37Rv RLPEAPALVVTADRIAISHRDLARLVDELAGQLTRSGLLPGDRVALRMGS
MLBr_02661|M.leprae_Br4923 RNPSAPALVVTDNRIVVSYRDLLRLVDDLTVQLALGGLLPGDRVALCAAS
MAV_5190|M.avium_104 RAPRAPALLVASERTPIAYADLVRLVDDLAARLRAAGLAPGDRVGLRAGS
MSMEG_5295|M.smegmatis_MC2_155 TRPDAPALVVTQQRIAVTYATLGRWADDVAAGLTADGLRRGEVIAVVDVN
TH_3626|M.thermoresistible__bu SAPAAP--CLADDTVALSNAEFRHAVDSAAAVLRGHGVGAGDVVAVMLPN
Mflv_0027|M.gilvum_PYR-GCK NRPDAPALIVGDR--TVSYRELDERSNRTAQAFSRTGVGPGDRVAFVERN
Mvan_0943|M.vanbaalenii_PYR-1 ERPGAPALVVGDR--TVTYGELDDRSSRAAQAFAQAGVGVGDRVAFVDKN
MAB_4559|M.abscessus_ATCC_1997 QYPDRLITIDQGR--EHTVEQFADRVARLSAGLRANGVRPGDRVGMLSLN
. : : : : *: *: :.. .
MMAR_0319|M.marinum_M NLEFVVALLAASRANLIVVPLDPALPVADQRARAGAAGARVVLIDG---T
MUL_4803|M.ulcerans_Agy99 NLEFVVALLAASRANLIVVPLDPALPVAYQRARAGAAGARVVLIDG---T
Mb0123|M.bovis_AF2122/97 NAEFVVALLAASRADLVVVPLDPALPITEQRVRSQAAGARVVLIDA---D
Rv0119|M.tuberculosis_H37Rv NAEFVVALLAASRADLVVVPLDPALPITEQRVRSQAAGARVVLIDA---D
MLBr_02661|M.leprae_Br4923 NIEFVVGLLAASRAGLIVVPLDPALPVNEQCIRSQAAGVRVTLVDSLALE
MAV_5190|M.avium_104 NPEFVVALLAASRADLVVAPLDPALPAADQLSRSRAVGARAVLVDR---L
MSMEG_5295|M.smegmatis_MC2_155 TAEFVVALLAAARIGAVVAPLDPALADAEMTDRLARLGARAVLTGP----
TH_3626|M.thermoresistible__bu TVDLVVTLFAAWRLGAAVTPLNPALSVDESAYQIADAGAKVLVAGG----
Mflv_0027|M.gilvum_PYR-GCK GIEFFDVAFGSAKLGAVAVPVNWRLTAPEMRHVIADCGASVVVVGQ---E
Mvan_0943|M.vanbaalenii_PYR-1 GAEFFEVTFGLAKVGAVGVPVNWRLAAPEMRHIIADSGAKIVVVGQ---D
MAB_4559|M.abscessus_ATCC_1997 SDRYIEYLTAVPWLGAALNAVNIRWSLAEIGYSLRESGTRVLLVDD---T
. . . .:: . *. : .
MMAR_0319|M.marinum_M GPGDRDEPAVRWWPIAVSVARDTG----ILSVHLDAAGEPTAVASAPQGL
MUL_4803|M.ulcerans_Agy99 GPGDRDEPAVRWWPIAVSVARDTG----ILSVHLDAAGEPTAVASAPQGL
Mb0123|M.bovis_AF2122/97 GPHDRAEPTTRWWPLTVNVGGDSGPSGGTLSVHLDAATEPNPATSTPEGL
Rv0119|M.tuberculosis_H37Rv GPHDRAEPTTRWWPLTVNVGGDSGPSGGTLSVHLDAATEPNPATSTPEGL
MLBr_02661|M.leprae_Br4923 GVSDQRAATMRYWPIAVSYGSVTGASEGSLLVHLDDTAALHPVTSTPDGL
MAV_5190|M.avium_104 GEGQTAPESAPCWPVTVTVGPDDS----APTVDLTVTAAPTHDVTAPQGL
MSMEG_5295|M.smegmatis_MC2_155 CEHALGTHRVRVTASRATVEPTRG-----------ATVEPTVRQAVDLGL
TH_3626|M.thermoresistible__bu ------NLPAPATPVVRPADLKTG----------------HGPVEVAPPA
Mflv_0027|M.gilvum_PYR-GCK FTGRIEAIADDLDVEVVVIG-----KHRHWPTFDDLLAAAPAVDPGVVTG
Mvan_0943|M.vanbaalenii_PYR-1 FAGHLEAIEDGLDADIVVIG-----DHPRWPAFDDWVASHPPVDPGVVTG
MAB_4559|M.abscessus_ATCC_1997 FKAAAAPLRAACACLETVIYCGAGPAPQDMIGYEDLLASHEPIDD-TRTG
MMAR_0319|M.marinum_M RADDAMIMFTGGTTGLPKMVPWTRANIATSIRSIIAGYRLSPQD-ATVAV
MUL_4803|M.ulcerans_Agy99 RADDAMIMFTGGTTGLPKMVPWTRANIATSIRSIIAGYRLSPQD-ATVAV
Mb0123|M.bovis_AF2122/97 RPDDAMIMFTGGTTGLPKMVPWTHANIASSVRAIITGYRLSPRD-ATVAV
Rv0119|M.tuberculosis_H37Rv RPDDAMIMFTGGTTGLPKMVPWTHANIASSVRAIITGYRLSPRD-ATVAV
MLBr_02661|M.leprae_Br4923 RHDDAMIMFTGGTTGLPKMVPWTDGNIAGSVHAIITAYQLGPQD-ATVVV
MAV_5190|M.avium_104 RDDDAMIMFTGGTTGAPKMVPWTRHNIAASIRSIVAGYGLGPRD-ATVAV
MSMEG_5295|M.smegmatis_MC2_155 GPDDALILFTSGTTGRAKMVPWTHANIAASVHGICAAYELGDGD-ATVAV
TH_3626|M.thermoresistible__bu DDRLALLIYTSGTTGRPKGVMLDHANIAAMCASIIEANELTSAD-SSLLI
Mflv_0027|M.gilvum_PYR-GCK PDDLVFLMYTSGTTGAPKGVMLSNANVVCKTAGVGGPWKFDADS-VSLAV
Mvan_0943|M.vanbaalenii_PYR-1 PDDVVLLMYTSGTTGAPKGVMLSNTNYVYKTGGVAGPWQFDADA-VSLAV
MAB_4559|M.abscessus_ATCC_1997 GDSLLGVFYTGGTTGNPKGVMLSHNNVLASAMGSLSTGNFLTRGGRLLHS
:::*.**** .* * * . : :
MMAR_0319|M.marinum_M MPLYHGHGLMAALLSTLVSGGTVLLPARGKFSAHTFWDDIHVAHATWYTA
MUL_4803|M.ulcerans_Agy99 MPLYHGHGLMAALLSTLVSGGTVLLPARGKFSAHTFWDDIHVAHATWYTA
Mb0123|M.bovis_AF2122/97 MPLYHGHGLIASLLATLASGGAVSLPARGRFSAHTFWDDIKAVGATWYTA
Rv0119|M.tuberculosis_H37Rv MPLYHGHGLIASLLATLASGGAVSLPARGRFSAHTFWDDIKAVGATWYTA
MLBr_02661|M.leprae_Br4923 MPLYHGHGLIAALLSTLASGGVVLLPARARFSARTFWDDIDAVAATWYTA
MAV_5190|M.avium_104 MPLYHGHGLLAALLATLASGGAVLLPARGKFSAHTFWDDIAAVGATWYTA
MSMEG_5295|M.smegmatis_MC2_155 MPFFHGHGLVAVLLSTLAGGGKVLLPAHGRFSAHTFWADMRDADATWFTA
TH_3626|M.thermoresistible__bu LPLFHVNGIVVGTLSPLIAGGHVTIAG--RFDPRTFFDRVRRSRPTYFSA
Mflv_0027|M.gilvum_PYR-GCK MPLFHMAGFGWALAGLWEGAVTVVLRD---VDPGAILDAVARHRVTNMLL
Mvan_0943|M.vanbaalenii_PYR-1 MPLFHMAGSGWALAGLWQGATTVVLRD---VEPAAILDAIARHRITNMLL
MAB_4559|M.abscessus_ATCC_1997 APMFHMADFSAVLAGNLSGSTHVIVPS---FSPQGVLDAIVAHDVQDMLL
*::* . . .. * : ... . :
MMAR_0319|M.marinum_M VPTIHQILLERAKTEREADSSGRTRAALRFIRSCSAPLTPETAQALHDEF
MUL_4803|M.ulcerans_Agy99 VPTIHQILLERAKTEREADSSGRTRAALRFIRSCSGPLTPETAQALHDEF
Mb0123|M.bovis_AF2122/97 VPTIHQILLERSATE----PSGRKPAALRFIRSCSAPLTAQAALALQTEF
Rv0119|M.tuberculosis_H37Rv VPTIHQILLERSATE----PSGRKPAALRFIRSCSAPLTAQAALALQTEF
MLBr_02661|M.leprae_Br4923 APAIHRILLELASTQ----SFRSKRAKLRFIRSCSAPLTQETAQALREEF
MAV_5190|M.avium_104 VPTIHQILLERARTE-----APRGTHALRFIRSCSAPLTAETAQALQDTF
MSMEG_5295|M.smegmatis_MC2_155 VPTIHQILLQRPDEE---------HPPLRFVRSCSAPLDPATAEAAERRF
TH_3626|M.thermoresistible__bu VPTIYTKLLELPEDP------TVDTSSLRFAACGAAPASAELLQRFEQRY
Mflv_0027|M.gilvum_PYR-GCK VPAVIQFLLDTTGLD------DTDLSRLRIVVYGASPITDDVLMRGIDRF
Mvan_0943|M.vanbaalenii_PYR-1 VPAVIQFLLDTDGVA------EVDLSTLRVIVYGASPISDDVLVRGIERF
MAB_4559|M.abscessus_ATCC_1997 VPTMIQMLVDHPGAA------QLDLSGIRSITYGASVISEAVLQRATRVF
.*:: *:: :* :. :
MMAR_0319|M.marinum_M S-APVLCAFGMTEATHQVASTGVEGSGCDENPAESTGLVGRSTGPEIRIV
MUL_4803|M.ulcerans_Agy99 S-APVLCAFGMTEATHQVASTGVEGSGCDENPAESTGLVGRSTGPEIRIV
Mb0123|M.bovis_AF2122/97 A-APVVCAFGMTEATHQVTTTQIEGIDQTETPVVSTGLVGRSTGAQIRIV
Rv0119|M.tuberculosis_H37Rv A-APVVCAFGMTEATHQVTTTQIEGIDQTETPVVSTGLVGRSTGAQIRIV
MLBr_02661|M.leprae_Br4923 L-APVICAFGMTEATHQVTTTNIKWFGQGENPTVTNGLVGQSTGVQIRIV
MAV_5190|M.avium_104 G-APVVCAFGMTEATHQVSTTAIDGAGHSENPGATPGLVGRSTGPDIRIA
MSMEG_5295|M.smegmatis_MC2_155 G-APMLEAYGMTETTHQAASRRVR----THDPRMSVGPA--SGAARFQVV
TH_3626|M.thermoresistible__bu G-VPIIEGYGLSEGTCVSTANPLRG------PRKPGTVGLPLPGQQVRIV
Mflv_0027|M.gilvum_PYR-GCK G-GIFAQVYGMTESTGSVTQLDGDEH----LPQLLRSCGRPYPWVQIRVV
Mvan_0943|M.vanbaalenii_PYR-1 G-PIFAQVYGMTETTGSITQLDGPDH----VPALLRSCGRPYPWVQIRIV
MAB_4559|M.abscessus_ATCC_1997 PNARFTQAYGMTEVSPVATLLLPDDHD---DPALLRSAGRAAPHCEVRIV
. :*::* : : * .::.
MMAR_0319|M.marinum_M GPDGHPVGPGAVGEVWLHGPTVVRGYLGDPKITAANFT-DGWLRTGDLGT
MUL_4803|M.ulcerans_Agy99 GPDGHPVGPGAVGEVWLHGPTVVRGYLGDPKITAANFT-DGWLRTGDLGT
Mb0123|M.bovis_AF2122/97 GSDGLPLPAGAVGEIWLRGTTVVRGYLGDPTITAANFT-DGWLRTGDLGS
Rv0119|M.tuberculosis_H37Rv GSDGLPLPAGAVGEIWLRGTTVVRGYLGDPTITAANFT-DGWLRTGDLGS
MLBr_02661|M.leprae_Br4923 GSDGQPLPPDTVGEVWLRGSTVVRGYLGDPAITAANFT-HGWLRTGDLGS
MAV_5190|M.avium_104 GPDGQSLPADTVGEVWLRGATVVRGYLGDPAITAANFT-DGWLHTGDLGT
MSMEG_5295|M.smegmatis_MC2_155 RSDGGECTPAETGEVWVSGPAVVRGYLADPENTAQAFT-DGWFRTGDLGA
TH_3626|M.thermoresistible__bu DAEGRTLGANEIGEVLIAGPTVMRGYLNRPEETAKTLV-DGWLRTGDIGY
Mflv_0027|M.gilvum_PYR-GCK DPTGRDVAPGTVGEVWTRSDQNMLGYWNNPEATAATLTPDGWLRTGDAGY
Mvan_0943|M.vanbaalenii_PYR-1 DETGADAVAGTVGEVWTRSEQNMLGYWNNPDATASTLTADGWLKTGDAGY
MAB_4559|M.abscessus_ATCC_1997 DPDDNEVPRGEIGEVIVKGDNVMLGYWELPEESAAAIR-DGWMHTGDAGR
. **: . : ** * :* : .**::*** *
MMAR_0319|M.marinum_M LSQAGDLSIRGRIKELINRGGEKISPERVEGVLASHPGVLENAVFGVPDA
MUL_4803|M.ulcerans_Agy99 LSQAGDLSIRGRIKELINRGGEKISPERVEGVLASHPGVQENAVFGVPDA
Mb0123|M.bovis_AF2122/97 LSAAGDLSIRGRIKELINRGGEKISPERVEGVLASHPNVMEAAVFGVPHQ
Rv0119|M.tuberculosis_H37Rv LSAAGDLSIRGRIKELINRGGEKISPERVEGVLASHPNVMEAAVFGVPHQ
MLBr_02661|M.leprae_Br4923 LSVTGDLRIRGRIKELINRSGEKISPERVEGVLASHHNVMEVAVFGDPDK
MAV_5190|M.avium_104 LSAAGDLVVRGRIKELINRGGEKISPERVEGVLAGHPDVLEAAVFGRPDQ
MSMEG_5295|M.smegmatis_MC2_155 LDADGNLQLTGRIKNIINRGGEKISPEHVEGVLTGCDGVFEAVVFAIPDA
TH_3626|M.thermoresistible__bu LDDDGYLVLVDRAKDMIIRGGENIYPKEIEAVAHRLPEISEVAVVGRPHP
Mflv_0027|M.gilvum_PYR-GCK LDRDGYLYLHDRIKDMIVSGAENVYPAEVENVLMTHPAVTDVAVIGIPDT
Mvan_0943|M.vanbaalenii_PYR-1 VDDDGYLFLHDRIKDMIVSGGENVYPVEVENVLMTHPAVADAAVIGVPDR
MAB_4559|M.abscessus_ATCC_1997 MDDRGYVYIVDRIKDMVVTGGENVYSAEVENALAKHPAVAACAVIGIPDE
:. * : : .* *::: ..*:: . .:* . : .*.. *.
MMAR_0319|M.marinum_M LYGEAVAAVIVPREPAP-TAQELTEFCREKLASFEIPATFQMASELPHTA
MUL_4803|M.ulcerans_Agy99 LYGEAVAAVIVPREPAP-TAQELTEFCREKLASFEIPATFQMASELPHTA
Mb0123|M.bovis_AF2122/97 LYGEAVAAVIVPRESAPPTREELVQFCRERLAAFEIPASFQEASGLPHTA
Rv0119|M.tuberculosis_H37Rv LYGEAVAAVIVPRESAPPTREELVQFCRERLAAFEIPASFQEASGLPHTA
MLBr_02661|M.leprae_Br4923 VYGETVTAVIVPREVIAPTPSELAVFCRDRLAAFEVPTRFQEASALPHTA
MAV_5190|M.avium_104 LYGETVAAVIVTRGSAAPTADELASFCRERLAPFEVPAEFRRAAELPHTA
MSMEG_5295|M.smegmatis_MC2_155 TYGEQVGAAVVP-AAAHVSADDILAQCRTGLAPYEVPARLDIVESLPHTA
TH_3626|M.thermoresistible__bu LYGEVPVMYVAAAPGAVVDTDAVRRHLAVSLAKYKQPVAIRVLDVLPKNA
Mflv_0027|M.gilvum_PYR-GCK RWGEAVKAVVVAG--APVTEAELIAFAREQLAGFKLPKSVDFVDALPRNP
Mvan_0943|M.vanbaalenii_PYR-1 RWGEAVKAVVVAARGAQLTEAELIAFARDRIGGFKLPKSVDFVDVLPRNP
MAB_4559|M.abscessus_ATCC_1997 QWGERVHAVVVKQAQSECCDGDLQEHCREHIANYKVPRSFEFVDELPLSG
:** :. : :. :: * . ** .
MMAR_0319|M.marinum_M KGSLDRRAVAQQFGGQA-----
MUL_4803|M.ulcerans_Agy99 KGSLDRRAVAQQFGGQA-----
Mb0123|M.bovis_AF2122/97 KGSLDRRAVAERFGHSV-----
Rv0119|M.tuberculosis_H37Rv KGSLDRRAVAERFGHSV-----
MLBr_02661|M.leprae_Br4923 KGSLDRRAVAEQFAHRG-----
MAV_5190|M.avium_104 KGSLDRRAVAEQFGESA-----
MSMEG_5295|M.smegmatis_MC2_155 KGAIDRQAVKLLFAH-------
TH_3626|M.thermoresistible__bu VGKIDKPAIRTLDATATQTA--
Mflv_0027|M.gilvum_PYR-GCK SGKLLKRQLREPYWTDEDRHIG
Mvan_0943|M.vanbaalenii_PYR-1 SGKLLKRALREPYWDGADRHIG
MAB_4559|M.abscessus_ATCC_1997 AGKILKRVLRQKYWESRDAGVS
* : : :