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RFMGTAATPPATLLSGLFDVLDHHVRTRPDAPALVVTQQRIAVTYATLGRWADDVAAGLTADGLRRGEVI AVVDVNTAEFVVALLAAARIGAVVAPLDPALADAEMTDRLARLGARAVLTGPCEHALGTHRVRVTASRAT VEPTRGATVEPTVRQAVDLGLGPDDALILFTSGTTGRAKMVPWTHANIAASVHGICAAYELGDGDATVAV MPFFHGHGLVAVLLSTLAGGGKVLLPAHGRFSAHTFWADMRDADATWFTAVPTIHQILLQRPDEEHPPLR FVRSCSAPLDPATAEAAERRFGAPMLEAYGMTETTHQAASRRVRTHDPRMSVGPASGAARFQVVRSDGGE CTPAETGEVWVSGPAVVRGYLADPENTAQAFTDGWFRTGDLGALDADGNLQLTGRIKNIINRGGEKISPE HVEGVLTGCDGVFEAVVFAIPDATYGEQVGAAVVPAAAHVSADDILAQCRTGLAPYEVPARLDIVESLPH TAKGAIDRQAVKLLFAH*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5295 | - | - | 100% (508) | acyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_4876 | - | 7e-44 | 33.05% (466) | acyl-CoA synthase |
| M. smegmatis MC2 155 | MSMEG_5649 | - | 9e-42 | 28.08% (495) | acyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0123 | fadD7 | 1e-127 | 50.10% (513) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_4616 | - | 4e-55 | 34.42% (491) | AMP-dependent synthetase and ligase |
| M. tuberculosis H37Rv | Rv0119 | fadD7 | 1e-127 | 50.10% (513) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_02661 | - | 1e-116 | 47.54% (509) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_0596c | - | 7e-44 | 30.14% (491) | fatty-acid-CoA ligase FadD |
| M. marinum M | MMAR_0319 | fadD7 | 1e-130 | 50.29% (523) | fatty-acid-CoA ligase FadD7 |
| M. avium 104 | MAV_5190 | - | 1e-127 | 50.29% (523) | acyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_3626 | - | 6e-73 | 36.22% (497) | PUTATIVE putative fatty-acid-CoA ligase |
| M. ulcerans Agy99 | MUL_4803 | fadD7 | 1e-128 | 49.90% (523) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_0943 | - | 8e-50 | 30.98% (510) | AMP-dependent synthetase and ligase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4616|M.gilvum_PYR-GCK ------------------------------------MDRGIGQWVTKRAF
Mvan_0943|M.vanbaalenii_PYR-1 ------------------------------------MIHNLADIIRVHGR
MAB_0596c|M.abscessus_ATCC_199 -----------------------------MESAQQTPGLTIPAALDQAAA
TH_3626|M.thermoresistible__bu ---------------------------------MLSQSVHLVSLPDQRAA
Mb0123|M.bovis_AF2122/97 ------------MASD--------------------FGPRIADLVEVAAT
Rv0119|M.tuberculosis_H37Rv ------------MASD--------------------FGPRIADLVEVAAT
MMAR_0319|M.marinum_M ------------MASDSITGGQAVPAHVGTQPCDSAAGPRLADLVELAAA
MUL_4803|M.ulcerans_Agy99 ------------MASDSITGGQAVPAHVGTQPCDSAAGPRLADLVELAAA
MLBr_02661|M.leprae_Br4923 ------------MKSESITSSRAPVEQIDARLTGQFESPSIASLVEAAAI
MAV_5190|M.avium_104 MDRYWTQRNAARHGGSDDTTGKDVAMTSEATPSATAAGPRLADLVEAAAQ
MSMEG_5295|M.smegmatis_MC2_155 ---------MRFMGTAATPP--------------ATLLSGLFDVLDHHVR
:
Mflv_4616|M.gilvum_PYR-GCK LNGQRTALVQGDT--SFTYSDFDRRTNQVASSLLRLGVRKGDRVAILLVN
Mvan_0943|M.vanbaalenii_PYR-1 ERPGAPALVVGDR--TVTYGELDDRSSRAAQAFAQAGVGVGDRVAFVDKN
MAB_0596c|M.abscessus_ATCC_199 RFGERDALYADGS--WLSFSELRARARRFAAALIALGVEHGQRLAIWSPN
TH_3626|M.thermoresistible__bu SAPAAPCLADDTV--ALSNAEFRHAVDSAAAVLRGHGVGAGDVVAVMLPN
Mb0123|M.bovis_AF2122/97 RLPEAPALVVTADRIAISHRDLARLVDELAGQLTRSGLLPGDRVALRMGS
Rv0119|M.tuberculosis_H37Rv RLPEAPALVVTADRIAISHRDLARLVDELAGQLTRSGLLPGDRVALRMGS
MMAR_0319|M.marinum_M RLPEATAVIFTADRVAVSYRDLVRLVDDLAGQLTRAGLRPGERVALRSGS
MUL_4803|M.ulcerans_Agy99 QLSEATAVIFTADRVAVSYRDLVRLVDDLAGQLTRAGLRQGERVALRSGS
MLBr_02661|M.leprae_Br4923 RNPSAPALVVTDNRIVVSYRDLLRLVDDLTVQLALGGLLPGDRVALCAAS
MAV_5190|M.avium_104 RAPRAPALLVASERTPIAYADLVRLVDDLAARLRAAGLAPGDRVGLRAGS
MSMEG_5295|M.smegmatis_MC2_155 TRPDAPALVVTQQRIAVTYATLGRWADDVAAGLTADGLRRGEVIAVVDVN
.: .: : : : *: *: :.. .
Mflv_4616|M.gilvum_PYR-GCK SVEFLEVLLGCAKIGAITIPINVRLAGPEIGYILADSGADVFVFHAPLAA
Mvan_0943|M.vanbaalenii_PYR-1 GAEFFEVTFGLAKVGAVGVPVNWRLAAPEMRHIIADSGAKIVVVGQDFAG
MAB_0596c|M.abscessus_ATCC_199 SWHWPIACLGGQYAGAAVVPMNTRYTVDEATDILQRSHARVLVSVGKFLG
TH_3626|M.thermoresistible__bu TVDLVVTLFAAWRLGAAVTPLNPALSVDESAYQIADAGAKVLVAGGNLPA
Mb0123|M.bovis_AF2122/97 NAEFVVALLAASRADLVVVPLDPALPITEQRVRSQAAGARVVLIDA---D
Rv0119|M.tuberculosis_H37Rv NAEFVVALLAASRADLVVVPLDPALPITEQRVRSQAAGARVVLIDA---D
MMAR_0319|M.marinum_M NLEFVVALLAASRANLIVVPLDPALPVADQRARAGAAGARVVLIDG---T
MUL_4803|M.ulcerans_Agy99 NLEFVVALLAASRANLIVVPLDPALPVAYQRARAGAAGARVVLIDG---T
MLBr_02661|M.leprae_Br4923 NIEFVVGLLAASRAGLIVVPLDPALPVNEQCIRSQAAGVRVTLVDSLALE
MAV_5190|M.avium_104 NPEFVVALLAASRADLVVAPLDPALPAADQLSRSRAVGARAVLVDR---L
MSMEG_5295|M.smegmatis_MC2_155 TAEFVVALLAAARIGAVVAPLDPALADAEMTDRLARLGARAVLTGP----
. :. . *:: . . :
Mflv_4616|M.gilvum_PYR-GCK AAVSALTEPG-------VRVRHTLRAGGAPADGEIPYTDLLSDGAPAPLD
Mvan_0943|M.vanbaalenii_PYR-1 --HLEAIEDG-------LDADIVVIGDHPRWP---AFDDWVASHPPVDPG
MAB_0596c|M.abscessus_ATCC_199 TDRIEQLDTSSLPDLRHIVRVAVEDGDESGWDAFVAHGDGVSDGDIDTRK
TH_3626|M.thermoresistible__bu PATPVVRPAD------------------------------LKTGHGPVEV
Mb0123|M.bovis_AF2122/97 GPHDRAEPTTR----WWPLTVNVGGDSGPSGGTLSVHLDAATEPNPATST
Rv0119|M.tuberculosis_H37Rv GPHDRAEPTTR----WWPLTVNVGGDSGPSGGTLSVHLDAATEPNPATST
MMAR_0319|M.marinum_M GPGDRDEPAVR----WWPIAVSVARDTG----ILSVHLDAAGEPTAVASA
MUL_4803|M.ulcerans_Agy99 GPGDRDEPAVR----WWPIAVSVARDTG----ILSVHLDAAGEPTAVASA
MLBr_02661|M.leprae_Br4923 GVSDQRAATMR----YWPIAVSYGSVTGASEGSLLVHLDDTAALHPVTST
MAV_5190|M.avium_104 GEGQTAPESAP----CWPVTVTVGPDDS----APTVDLTVTAAPTHDVTA
MSMEG_5295|M.smegmatis_MC2_155 CEHALGTHRVR----VTASRATVEPTRG-----------ATVEPTVRQAV
Mflv_4616|M.gilvum_PYR-GCK SDVEGRDPAFIMYTSGTTGRPKGAILTHDNLRWNAINVLGAEQGLTGSDV
Mvan_0943|M.vanbaalenii_PYR-1 VVTGPDDVVLLMYTSGTTGAPKGVMLSNTNYVYKTGGVAGPWQ-FDADAV
MAB_0596c|M.abscessus_ATCC_199 AAVSSEDISDILFTSGTTGRSKGVLCMHR-QPLAASLAWATYGEFTENDR
TH_3626|M.thermoresistible__bu APPADDRLALLIYTSGTTGRPKGVMLDHANIAAMCASIIEANELTSADS-
Mb0123|M.bovis_AF2122/97 PEGLRPDDAMIMFTGGTTGLPKMVPWTHANIASSVRAIITGYR-LSPRDA
Rv0119|M.tuberculosis_H37Rv PEGLRPDDAMIMFTGGTTGLPKMVPWTHANIASSVRAIITGYR-LSPRDA
MMAR_0319|M.marinum_M PQGLRADDAMIMFTGGTTGLPKMVPWTRANIATSIRSIIAGYR-LSPQDA
MUL_4803|M.ulcerans_Agy99 PQGLRADDAMIMFTGGTTGLPKMVPWTRANIATSIRSIIAGYR-LSPQDA
MLBr_02661|M.leprae_Br4923 PDGLRHDDAMIMFTGGTTGLPKMVPWTDGNIAGSVHAIITAYQ-LGPQDA
MAV_5190|M.avium_104 PQGLRDDDAMIMFTGGTTGAPKMVPWTRHNIAASIRSIVAGYG-LGPRDA
MSMEG_5295|M.smegmatis_MC2_155 DLGLGPDDALILFTSGTTGRAKMVPWTHANIAASVHGICAAYE-LGDGDA
:::*.**** .* .
Mflv_4616|M.gilvum_PYR-GCK TVAVAPMFHIGGLGVHTLPLLYVGGTSVILPS--FDPVGTLKAMAESRAT
Mvan_0943|M.vanbaalenii_PYR-1 SLAVMPLFHMAGSG-WALAGLWQGATTVVLRD--VEPAAILDAIARHRIT
MAB_0596c|M.abscessus_ATCC_199 YLCVNPFFHNFGYKAGILACLQTGAALMPQLT--FDPEKAMAAVQEHKIT
TH_3626|M.thermoresistible__bu SLLILPLFHVNGIVVGTLSPLIAGGHVTIAGR--FDPRTFFDRVRRSRPT
Mb0123|M.bovis_AF2122/97 TVAVMPLYHGHGLIASLLATLASGGAVSLPARGRFSAHTFWDDIKAVGAT
Rv0119|M.tuberculosis_H37Rv TVAVMPLYHGHGLIASLLATLASGGAVSLPARGRFSAHTFWDDIKAVGAT
MMAR_0319|M.marinum_M TVAVMPLYHGHGLMAALLSTLVSGGTVLLPARGKFSAHTFWDDIHVAHAT
MUL_4803|M.ulcerans_Agy99 TVAVMPLYHGHGLMAALLSTLVSGGTVLLPARGKFSAHTFWDDIHVAHAT
MLBr_02661|M.leprae_Br4923 TVVVMPLYHGHGLIAALLSTLASGGVVLLPARARFSARTFWDDIDAVAAT
MAV_5190|M.avium_104 TVAVMPLYHGHGLLAALLATLASGGAVLLPARGKFSAHTFWDDIAAVGAT
MSMEG_5295|M.smegmatis_MC2_155 TVAVMPFFHGHGLVAVLLSTLAGGGKVLLPAHGRFSAHTFWADMRDADAT
: : *::* * *. * *. ... : *
Mflv_4616|M.gilvum_PYR-GCK VQFMVPAMWSALTQVPDFD------SYDLSALRLAMGGGAPMPLTVIDFM
Mvan_0943|M.vanbaalenii_PYR-1 NMLLVPAVIQFLLDTDGVA------EVDLSTLRVIVYGASPISDDVLVRG
MAB_0596c|M.abscessus_ATCC_199 VLPGAPTIFQMLLDHPARK------NYDLTSLRYSVTGAAVVPVVLIERM
TH_3626|M.thermoresistible__bu YFSAVPTIYTKLLELPEDP------TVDTSSLRFAACGAAPASAELLQRF
Mb0123|M.bovis_AF2122/97 WYTAVPTIHQILLERSATE----PSGRKPAALRFIRSCSAPLTAQAALAL
Rv0119|M.tuberculosis_H37Rv WYTAVPTIHQILLERSATE----PSGRKPAALRFIRSCSAPLTAQAALAL
MMAR_0319|M.marinum_M WYTAVPTIHQILLERAKTEREADSSGRTRAALRFIRSCSAPLTPETAQAL
MUL_4803|M.ulcerans_Agy99 WYTAVPTIHQILLERAKTEREADSSGRTRAALRFIRSCSGPLTPETAQAL
MLBr_02661|M.leprae_Br4923 WYTAAPAIHRILLELASTQ----SFRSKRAKLRFIRSCSAPLTQETAQAL
MAV_5190|M.avium_104 WYTAVPTIHQILLERARTE-----APRGTHALRFIRSCSAPLTAETAQAL
MSMEG_5295|M.smegmatis_MC2_155 WFTAVPTIHQILLQRPDEE---------HPPLRFVRSCSAPLDPATAEAA
.*:: * : ** ..
Mflv_4616|M.gilvum_PYR-GCK HQR--GVPFTEGFGMTETAPMVSVLDAAN-ITTRAGSIGRVAM----HVD
Mvan_0943|M.vanbaalenii_PYR-1 IERF-GPIFAQVYGMTETTGSITQLDGPDHVPALLRSCGRPYP----WVQ
MAB_0596c|M.abscessus_ATCC_199 QSELDFDLVLTAYGLTETQGFATICRSDDDAVTVATTCGRPML----GYE
TH_3626|M.thermoresistible__bu EQRY-GVPIIEGYGLSEGTCVSTAN--PLRGPRKPGTVGLPLP----GQQ
Mb0123|M.bovis_AF2122/97 QTEF-AAPVVCAFGMTEATHQVTTTQIEGIDQTETPVVSTGLVGRSTGAQ
Rv0119|M.tuberculosis_H37Rv QTEF-AAPVVCAFGMTEATHQVTTTQIEGIDQTETPVVSTGLVGRSTGAQ
MMAR_0319|M.marinum_M HDEF-SAPVLCAFGMTEATHQVASTGVEGSGCDENPAESTGLVGRSTGPE
MUL_4803|M.ulcerans_Agy99 HDEF-SAPVLCAFGMTEATHQVASTGVEGSGCDENPAESTGLVGRSTGPE
MLBr_02661|M.leprae_Br4923 REEF-LAPVICAFGMTEATHQVTTTNIKWFGQGENPTVTNGLVGQSTGVQ
MAV_5190|M.avium_104 QDTF-GAPVVCAFGMTEATHQVSTTAIDGAGHSENPGATPGLVGRSTGPD
MSMEG_5295|M.smegmatis_MC2_155 ERRF-GAPMLEAYGMTETTHQAASRRVR----THDPRMSVGPA--SGAAR
. :*::* :
Mflv_4616|M.gilvum_PYR-GCK ARIVDADDRDVPADTVGELLVRGPNVFVGYWMKPATTAEAFRG-GWFHTG
Mvan_0943|M.vanbaalenii_PYR-1 IRIVDETGADAVAGTVGEVWTRSEQNMLGYWNNPDATASTLTADGWLKTG
MAB_0596c|M.abscessus_ATCC_199 LRIDGAEK----PGDEGEVLLRSANVMKGYLDDPKATAEAIDDDGWLHTG
TH_3626|M.thermoresistible__bu VRIVDAEGRTLGANEIGEVLIAGPTVMRGYLNRPEETAKTLVD-GWLRTG
Mb0123|M.bovis_AF2122/97 IRIVGSDGLPLPAGAVGEIWLRGTTVVRGYLGDPTITAANFTD-GWLRTG
Rv0119|M.tuberculosis_H37Rv IRIVGSDGLPLPAGAVGEIWLRGTTVVRGYLGDPTITAANFTD-GWLRTG
MMAR_0319|M.marinum_M IRIVGPDGHPVGPGAVGEVWLHGPTVVRGYLGDPKITAANFTD-GWLRTG
MUL_4803|M.ulcerans_Agy99 IRIVGPDGHPVGPGAVGEVWLHGPTVVRGYLGDPKITAANFTD-GWLRTG
MLBr_02661|M.leprae_Br4923 IRIVGSDGQPLPPDTVGEVWLRGSTVVRGYLGDPAITAANFTH-GWLRTG
MAV_5190|M.avium_104 IRIAGPDGQSLPADTVGEVWLRGATVVRGYLGDPAITAANFTD-GWLHTG
MSMEG_5295|M.smegmatis_MC2_155 FQVVRSDGGECTPAETGEVWVSGPAVVRGYLADPENTAQAFTD-GWFRTG
:: . **: . . ** * ** : **::**
Mflv_4616|M.gilvum_PYR-GCK DLGRIDADGYITLVDRKKDMIISGGENVYPIEVEQVLFRHPGVLDAAVVG
Mvan_0943|M.vanbaalenii_PYR-1 DAGYVDDDGYLFLHDRIKDMIVSGGENVYPVEVENVLMTHPAVADAAVIG
MAB_0596c|M.abscessus_ATCC_199 DIGKLDARGNLTITDRLKDMYICGGFNVYPAEIEQVLMRLDGVADVAVIG
TH_3626|M.thermoresistible__bu DIGYLDDDGYLVLVDRAKDMIIRGGENIYPKEIEAVAHRLPEISEVAVVG
Mb0123|M.bovis_AF2122/97 DLGSLSAAGDLSIRGRIKELINRGGEKISPERVEGVLASHPNVMEAAVFG
Rv0119|M.tuberculosis_H37Rv DLGSLSAAGDLSIRGRIKELINRGGEKISPERVEGVLASHPNVMEAAVFG
MMAR_0319|M.marinum_M DLGTLSQAGDLSIRGRIKELINRGGEKISPERVEGVLASHPGVLENAVFG
MUL_4803|M.ulcerans_Agy99 DLGTLSQAGDLSIRGRIKELINRGGEKISPERVEGVLASHPGVQENAVFG
MLBr_02661|M.leprae_Br4923 DLGSLSVTGDLRIRGRIKELINRSGEKISPERVEGVLASHHNVMEVAVFG
MAV_5190|M.avium_104 DLGTLSAAGDLVVRGRIKELINRGGEKISPERVEGVLAGHPDVLEAAVFG
MSMEG_5295|M.smegmatis_MC2_155 DLGALDADGNLQLTGRIKNIINRGGEKISPEHVEGVLTGCDGVFEAVVFA
* * :. * : : .* *:: .* :: * .:* * : : .*..
Mflv_4616|M.gilvum_PYR-GCK GPDDKWGERVVAVVVADPAAEQEPSADELIAWCRERLAHFKCPREVHLLP
Mvan_0943|M.vanbaalenii_PYR-1 VPDRRWGEAVKAVVVAARGAQ--LTEAELIAFARDRIGGFKLPKSVDFVD
MAB_0596c|M.abscessus_ATCC_199 VPDARLGEVGKAYIVLKPGAT--LNADSVIEYSAKHVANFKKPRFVDFLD
TH_3626|M.thermoresistible__bu RPHPLYGEVPVMYVAAAPGAV--VDTDAVRRHLAVSLAKYKQPVAIRVLD
Mb0123|M.bovis_AF2122/97 VPHQLYGEAVAAVIVPRESAPP--TREELVQFCRERLAAFEIPASFQEAS
Rv0119|M.tuberculosis_H37Rv VPHQLYGEAVAAVIVPRESAPP--TREELVQFCRERLAAFEIPASFQEAS
MMAR_0319|M.marinum_M VPDALYGEAVAAVIVPREPAP---TAQELTEFCREKLASFEIPATFQMAS
MUL_4803|M.ulcerans_Agy99 VPDALYGEAVAAVIVPREPAP---TAQELTEFCREKLASFEIPATFQMAS
MLBr_02661|M.leprae_Br4923 DPDKVYGETVTAVIVPREVIAP--TPSELAVFCRDRLAAFEVPTRFQEAS
MAV_5190|M.avium_104 RPDQLYGETVAAVIVTRGSAAP--TADELASFCRERLAPFEVPAEFRRAA
MSMEG_5295|M.smegmatis_MC2_155 IPDATYGEQVGAAVVP-AAAHV--SADDILAQCRTGLAPYEVPARLDIVE
*. ** :. : :. :: * .
Mflv_4616|M.gilvum_PYR-GCK ELPRNATGKLLKTELRKRFTGVEGGVVQR-
Mvan_0943|M.vanbaalenii_PYR-1 VLPRNPSGKLLKRALREPYWDGADRHIG--
MAB_0596c|M.abscessus_ATCC_199 ELPRNLGGKVVKPTLRAMHGEQRRAQKESS
TH_3626|M.thermoresistible__bu VLPKNAVGKIDKPAIRTLDATATQTA----
Mb0123|M.bovis_AF2122/97 GLPHTAKGSLDRRAVAERFGHSV-------
Rv0119|M.tuberculosis_H37Rv GLPHTAKGSLDRRAVAERFGHSV-------
MMAR_0319|M.marinum_M ELPHTAKGSLDRRAVAQQFGGQA-------
MUL_4803|M.ulcerans_Agy99 ELPHTAKGSLDRRAVAQQFGGQA-------
MLBr_02661|M.leprae_Br4923 ALPHTAKGSLDRRAVAEQFAHRG-------
MAV_5190|M.avium_104 ELPHTAKGSLDRRAVAEQFGESA-------
MSMEG_5295|M.smegmatis_MC2_155 SLPHTAKGAIDRQAVKLLFAH---------
**:. * : : :