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VHAALLAAGVCDVVILDHAPGPPANSQLRPGRVIGAAFDDDTDTWALRTADGATVCGRVVVAACPPVYVP WTPDFAGRNDFRGESFHAGAPDPAFRPAGKRIAVLGTDSNVAHWIDEWADSAASVTVFAQGPRRVVTDLA RHPPQAKRWLLGRIGAKRPRRAPTIAASVIAALTPSGIRTNDGIEHPVDAVIYGTGFTIPEQTVEPTLVG TRGLTIQQAWYPGMEAFLGVAVHGFPNYFFICGPDVAAQISYVAECVDLLQRTASTRIEVLRSSQQVFNE RAQLRPVQPYQPLRAFDLSAGAPEDSGIPNIPNIYDGAATLEIGGVRHAVHVRLAGHLDPIDGNYHWQGT VLDPLPRDTLKQARAGTLTVGERSAAVRVIEQTPWGTHSVAGLGAPPYADSGR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_4425 | - | - | 100% (403) | monooxygenase |
| M. ulcerans Agy99 | MUL_1053 | - | 4e-18 | 25.76% (330) | monooxygenase |
| M. ulcerans Agy99 | MUL_4873 | - | 5e-15 | 25.49% (306) | monooxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0968c | - | 1e-108 | 63.21% (318) | monooxygenase |
| M. gilvum PYR-GCK | Mflv_4608 | - | 2e-14 | 30.71% (127) | FAD dependent oxidoreductase |
| M. tuberculosis H37Rv | Rv0943c | - | 1e-108 | 63.21% (318) | monooxygenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4476c | - | 1e-16 | 29.31% (232) | putative monooxygenase |
| M. marinum M | MMAR_4565 | - | 0.0 | 98.76% (403) | monooxygenase |
| M. avium 104 | MAV_3378 | - | 9e-21 | 25.31% (324) | lipolytic enzyme |
| M. smegmatis MC2 155 | MSMEG_4451 | - | 5e-24 | 27.05% (329) | monooxygenase |
| M. thermoresistible (build 8) | TH_4080 | - | 2e-17 | 21.69% (332) | PUTATIVE conserved hypothetical protein |
| M. vanbaalenii PYR-1 | Mvan_1519 | - | 3e-16 | 32.28% (127) | FAD dependent oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_4451|M.smegmatis_MC2_155 --MSAP-----ASSTPTLP-ASVHTLVVGAGFAGLAAAAAVLREDPRADL
TH_4080|M.thermoresistible__bu MTVTEPSADITPANTPTQPPVRTRALIVGTGFSGLGMAIALQRRG--IDF
Mflv_4608|M.gilvum_PYR-GCK ------------------MSDTTTVLIVGAGFAGLGTAIRLLQQG-IDDF
MAB_4476c|M.abscessus_ATCC_199 ---------------------MTEVLIVGAGFAGLGTAIRLLEKG-IEDF
Mvan_1519|M.vanbaalenii_PYR-1 -------------------MHVHDTLIVGAGFSGLGTAIKLRQAG-VDDI
MAV_3378|M.avium_104 --------------MSSPAVPDHHTLIIGAGFSGIGAAIKLDKAG-LPDY
MUL_4425|M.ulcerans_Agy99 --------------------------------------------------
MMAR_4565|M.marinum_M -------------------------------MTHTPGVARAPRDCHDCHD
Mb0968c|M.bovis_AF2122/97 --------------------------------------------------
Rv0943c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_4451|M.smegmatis_MC2_155 LIIERADEVGGTWRDNTYPGCACDVPTSLYSFSFAPSAKWSHTFARQPEI
TH_4080|M.thermoresistible__bu LMLEKADDIGGTWRDNTYPGCACDIPSHLYSFSFEPKADWRHLFSYQDEI
Mflv_4608|M.gilvum_PYR-GCK VVLERADEVGGTWRDNTYPGAACDIPSLLYSYGFEQNPDWSRAYSGSAEI
MAB_4476c|M.abscessus_ATCC_199 VILERGDDVGGTWRDNSYPGAACDIPSLLYSYSFEQNPQWSRAYSGGSEI
Mvan_1519|M.vanbaalenii_PYR-1 VIVERGQRVGGTWRDNTYPGVACDIPSLLYSFSFVRNPSWSRAYPTGAEI
MAV_3378|M.avium_104 RVIEAGDGVGGTWHWNTYPGIAVDIPSFSYQFSFEQSRHWSRTYAPGREL
MUL_4425|M.ulcerans_Agy99 ------------MHAALLAAGVCDVVILDHAPGPPANSQLR---------
MMAR_4565|M.marinum_M VVIIGAGSRGRSVHAALLAAGVCDVVILDHAPGLPANSQLR---------
Mb0968c|M.bovis_AF2122/97 ------------------MAGVSEAERRGHR----KLVRFQ---------
Rv0943c|M.tuberculosis_H37Rv ------------------MAGVSEAERRGHR----KLVRFQ---------
. . : :
MSMEG_4451|M.smegmatis_MC2_155 HRYLTSVADQTGLRHHLVTGCELLGAAWDDDEQRWRVRTSLG-MVTATVL
TH_4080|M.thermoresistible__bu QEYLQGVTAKYGLRRYIHFDSLVDRAHWDDTEHRWHVFTADGREYIAQFL
Mflv_4608|M.gilvum_PYR-GCK LGYIKTMVDKYSLSRFIRFGVNVTGLEFDEESALWTAQTADGSQFTARTA
MAB_4476c|M.abscessus_ATCC_199 LGYIQRMVDKHQLRRFIKFGVDVTGLTFDDSTGMWTADTAAGEIFTGRCA
Mvan_1519|M.vanbaalenii_PYR-1 CDHIEDMADQHGLTPLIRFDTEVTGLTFDDQSGAWTVTTKRRKQFRARTV
MAV_3378|M.avium_104 KAYAEHCADKYGIRSRIRFNTKVLAAEFDDEQRLWRVQTDPGGEVTARFL
MUL_4425|M.ulcerans_Agy99 -------------------PGRVIGAAFDDDTDTWALRTADGATVCGRVV
MMAR_4565|M.marinum_M -------------------PGRVIGAAFDDDTDTWAVRTADGATVCGRVV
Mb0968c|M.bovis_AF2122/97 -------------------ARRAIG----------PIR------------
Rv0943c|M.tuberculosis_H37Rv -------------------ARRAIG----------PIR------------
MSMEG_4451|M.smegmatis_MC2_155 VAATGALSTPKLPDVPGLDRFGGTVFHSATWNHDHDLTDERVAVVGTGAS
TH_4080|M.thermoresistible__bu ISCAGALHIPSIPDFPGRDQFAGPAFHSAQWDHSVDLTGKRVAVIGTGAS
Mflv_4608|M.gilvum_PYR-GCK VMASGPLANASLPDIRGLDTFDGHKIHSARWDHDYDMSDKRVAVIGTGAS
MAB_4476c|M.abscessus_ATCC_199 VMAAGPLANVSWPDIRGLDSYTGHKIHSARWDHDYEMSGKHVAVIGTGAS
Mvan_1519|M.vanbaalenii_PYR-1 VLASGPLADHRFPEIRGIDSYRGHKIHSASWDHDYDFTGKRVAVIGTGAS
MAV_3378|M.avium_104 ISACGVLTVPNLPDIDGVDSFAGITMHTARWDHGQDLRGKRVAVIGTGAS
MUL_4425|M.ulcerans_Agy99 VAACPPVYVPWTPDFAGRNDFRGESFHAGAPDPAFRPAGKRIAVLGTDSN
MMAR_4565|M.marinum_M VAACPPVYVPWTPDFAGRNDFRGESFHAGAPDPAFRPAGKRIAVLGTDSN
Mb0968c|M.bovis_AF2122/97 -----PTSAAWDRDFD--------------------PAGKRIAVVGTDAA
Rv0943c|M.tuberculosis_H37Rv -----PTSAAWDRDFD--------------------PAGKRIAVVGTDAA
:. .:::**:**.:
MSMEG_4451|M.smegmatis_MC2_155 AVQFVPEIADRTAHLTVFQRTPAWVLPRLDRTLGRLERALYRRI--PLSQ
TH_4080|M.thermoresistible__bu AIQIVPEIIDRVAQLQLYQRTPAWVVPRTNDELPAWLRRALENI--PGLR
Mflv_4608|M.gilvum_PYR-GCK AVQIIPELVKTARSVKVFQRTPGWVLPRPDFSHPQWVRTAFRRL--PRVQ
MAB_4476c|M.abscessus_ATCC_199 GVQIIPELVKTAARVKVFQRTPGWVLPRLDFQHPDWAQRVFGSS--PAVQ
Mvan_1519|M.vanbaalenii_PYR-1 AVQIVPELVKTAAFVKVFQRTPGWVLPRLDLPMPAAVQALFAKV--PATQ
MAV_3378|M.avium_104 AVQVIPEIAPIVSSLTVFQRTPIWCFPKLDVPLPAPARWAMRFPGGKALQ
MUL_4425|M.ulcerans_Agy99 VAHWIDEWADSAASVTVFAQGPRRVVTDLARHPPQAKRWLLGRIGAKRPR
MMAR_4565|M.marinum_M VAHWIDEWADSAASVTVFAQGPRRVVTDLARHPPQAKRWLLGRIGAKRPR
Mb0968c|M.bovis_AF2122/97 AAHYISRLSESAASVTVFTQAPRRVVTGVPLWTTRAKRWLRRRTGAEHP-
Rv0943c|M.tuberculosis_H37Rv AAHYISRLSESAASVTVFTQAPRRVVTGVPLWTTRAKRWLRRRTGAEHP-
: : . . : :: : * .. :
MSMEG_4451|M.smegmatis_MC2_155 RLVRGMVYIYREGYLALLAHLTWLLPLLEIIAKTQLRRQVPDPALRRALT
TH_4080|M.thermoresistible__bu LALRGGIYALQEALAVGMTKYPGMLRIGHLLGKWNINRSVKDPQLRAKLT
Mflv_4608|M.gilvum_PYR-GCK NVGRQAWFWGHELMAVGMVWDTPVTTGIQLLAKANLRRQVSDTWLRRQLT
MAB_4476c|M.abscessus_ATCC_199 NLARQAWYWTHEAAAVGMVWDTPVTTLIQWIAKANLRRQISDPWVRRQLT
Mvan_1519|M.vanbaalenii_PYR-1 EIARQALYWGHEASAAALVWNTPMSGLVARLGKAHLRQQVKDPWMRRQLT
MAV_3378|M.avium_104 RLLSQAYVELTFPISAHYFTVIPLAKRMAALGRAYLRRQVRDPAVREQLT
MUL_4425|M.ulcerans_Agy99 RAPTIAASVIAALTPSGIRTNDGIEHPVDAVIYG------TGFTIPEQTV
MMAR_4565|M.marinum_M RAPTIAASAIAALTPSGIRTNDGIEHPVDAVIYG------TGFTIPEQTV
Mb0968c|M.bovis_AF2122/97 -AVAWATAAIDALTSSGIRTSDGVEHPVDAIIYG------TGFAIADQVG
Rv0943c|M.tuberculosis_H37Rv -AVAWATAAIDALTSSGIRTSDGVEHPVDAIIYG------TGFAIADQVG
: : . :
MSMEG_4451|M.smegmatis_MC2_155 PDFRIGCKRILLTNDWLPTLARDDVEVVTTALTEVTETGVRDGTGRLHDV
TH_4080|M.thermoresistible__bu PDYRLGCKRILNSSTYYPAVADPRTEVITESIDRITTDGIVTSDGTERAV
Mflv_4608|M.gilvum_PYR-GCK PNFRAGCKRMLMSSDYYPALQRDNCKLVSWPIATLSPNGIRTADGIEHEL
MAB_4476c|M.abscessus_ATCC_199 PDFRAGCKRMLMTSDYYAALEKDNCKLITWPIATLSPNGIRTADGIEHDV
Mvan_1519|M.vanbaalenii_PYR-1 PDFTPGCKRMLISSDYYPALQRDNCKLIDWPIATLSPAGIRTSDGVEHHL
MAV_3378|M.avium_104 PRYAVGCKRPGFHNGYLATFNRDNVRLVTEPIDKITPDAVATTDGETHEI
MUL_4425|M.ulcerans_Agy99 EPTLVGTRGLTIQQAWYPGMEAFLGVAVHGFPNYFFICGPDVAAQISYVA
MMAR_4565|M.marinum_M EPTLVGTRGLTIQQAWYPGMEAFLGVAVHGFPNYFFLCGPDVAAQISYVA
Mb0968c|M.bovis_AF2122/97 DQTLVGAGGVTIRQAWDDGMEPYLGVAVHGFPNYFFITGPDTAAQARCVV
Rv0943c|M.tuberculosis_H37Rv DQTLVGAGGVTIRQAWDDGMEPYLGVAVHGFPNYFFITGPDTAAQARCVV
* . : . : . .
MSMEG_4451|M.smegmatis_MC2_155 DTIIFATGFTPTEPP--VAHQLTGVTGTTLAAHWAG-SPSAHLGITVPGF
TH_4080|M.thermoresistible__bu DVIVYATGFHVSDSY--KYVQIKGLNGEDIVDRFNREGPMAHRGTAVADL
Mflv_4608|M.gilvum_PYR-GCK DCIVFATGFDVCKAG--TPFPIRGAHGRELSDEWSQ-GAYAYRSVTVAGY
MAB_4476c|M.abscessus_ATCC_199 DCIVFATGFDVCKAG--TPFPIAGLDGRKLADEWSG-GAYAYKSVNVSGY
Mvan_1519|M.vanbaalenii_PYR-1 DAIVFATGYDVHLSG--PPFPVAGLNGRSLQQEWAG-HAEAYKSASAHGY
MAV_3378|M.avium_104 DVLILATGFKVMDPDSVPTFAVTGSGGRSLSRFWDEHRLQAYEGVTVPGF
MUL_4425|M.ulcerans_Agy99 ECVDLLQRTAS------TRIEVLRSSQQVFNERAQLRPVQPYQP-----L
MMAR_4565|M.marinum_M ECVDLLQRTAS------TRIEVLRSSQQVFNERAQLRPVQPYQP-----L
Mb0968c|M.bovis_AF2122/97 ECMKLMERTAS------RRIEVRRSSQQVFNERAQLKPAQPHRQT--GGL
Rv0943c|M.tuberculosis_H37Rv ECMKLMERTAS------RRIEVRRSSQQVFNERAQLKPAQPHRQT--GGL
: : : : .:
MSMEG_4451|M.smegmatis_MC2_155 PNLFLMYGPNTNLGHSSIVYMLESQAAYLAAALRVMRAEGLASIDVRPDA
TH_4080|M.thermoresistible__bu PNAYLLLGPNTGLGHNSMVYMIESQINYVIEAIKAVDKAGAQALAPTREA
Mflv_4608|M.gilvum_PYR-GCK PNLFFTFGPNSGPGHNSALVYMEAEINYIVKAIGAIIANDLSTLEVREDR
MAB_4476c|M.abscessus_ATCC_199 PNLFFTFGPNSGPGHNSALVYMEAQIDYIVQAIGIVRAKDLLTLDVRKDR
Mvan_1519|M.vanbaalenii_PYR-1 PNLFFMTGPNSGPGHNSLLVYVEGQIAYAVDAITTILNRNLRYLDVRADV
MAV_3378|M.avium_104 PNLFTVFGPYGYVG-SSYFALIEAQTHHIVRCLKRAQRLGATRVEVSEEA
MUL_4425|M.ulcerans_Agy99 RAFDLSAGAPEDSGIPNIPNIYDGAATLEIGGVRHAVHVRLAGHLDPIDG
MMAR_4565|M.marinum_M RAFDLSAGAPEDTGIPNIPNIYDGAATLEIGGVRHAVHVRLAGHLDPIDG
Mb0968c|M.bovis_AF2122/97 EAFDLSSAATEDD------QTYDGAATLTLAGARFRVRVRLTGHLDPIDG
Rv0943c|M.tuberculosis_H37Rv EAFDLSSAATEDD------QTYDGAATLTLAGARFRVRVRLTGHLDPIDG
.. :. :
MSMEG_4451|M.smegmatis_MC2_155 ERTYNEWINDALT-NTVWNSGG--CSSWYLDSRGRNSVMWPTFTFRFRAR
TH_4080|M.thermoresistible__bu QDRYNAELQARLG-RSVWNTGG--CRSWYLDEHGNNRVLWGGFTWQYRLA
Mflv_4608|M.gilvum_PYR-GCK QNNYHGEVQQRLG-STTWNSG---CKSWYLTNDGYNGTMYPGFATQFKRA
MAB_4476c|M.abscessus_ATCC_199 QDRFNEDIQRRLG-KTTWNSG---CQSWYLTEDGKNTTMFPGFATQFARQ
Mvan_1519|M.vanbaalenii_PYR-1 QQRHNAQIQRRLT-KTTWMSG---CHSWYLTADGFNASMYPGFATQYRRQ
MAV_3378|M.avium_104 NDRYFAEMMRRRHRQIFWQDSCRLANSYYFDKNG-DVPLRPGTTPEVYWR
MUL_4425|M.ulcerans_Agy99 NYHWQGTVLDPLPRDTLKQAR---AGTLTVGERSAAVRVIEQTPWGTHSV
MMAR_4565|M.marinum_M NYHWQGTVLDPLPRDTLKQAR---AGTLTVGERSAAVRVIEQTPWGTHSV
Mb0968c|M.bovis_AF2122/97 NYHWQGTVFDSLPETSLTHAR---AATLTIGGRSAPARITEQTPWGTHSV
Rv0943c|M.tuberculosis_H37Rv NYHWQGTVFDSLPETSLTHAR---AATLTIGGRSAPARITEQTPWGTHSV
: : . : . . : .
MSMEG_4451|M.smegmatis_MC2_155 TRSFDVINYDTLRTRQQIRGVEQRCESQLADADREILAGQIRLAGEDESV
TH_4080|M.thermoresistible__bu TRTLDPAEYRFWG-------------------------------------
Mflv_4608|M.gilvum_PYR-GCK LSKVDMGDYVTTPTTARTEHHPTEHAQNGSNVAKVAQGRKAKVAQGRKSA
MAB_4476c|M.abscessus_ATCC_199 LRTVELDDYSFT---------------SGAAAASAAKPP-----------
Mvan_1519|M.vanbaalenii_PYR-1 MQ-FRAEDYTAVA-------------------------------------
MAV_3378|M.avium_104 SRRFDLDDYRFTG-------------------------------------
MUL_4425|M.ulcerans_Agy99 AG-LGAPPYADSGR------------------------------------
MMAR_4565|M.marinum_M AG-LGAPPYADSGR------------------------------------
Mb0968c|M.bovis_AF2122/97 AG-VGPPPYARSGPASATT-------------------------------
Rv0943c|M.tuberculosis_H37Rv AG-VGPPPYARSGPASATT-------------------------------
. *
MSMEG_4451|M.smegmatis_MC2_155 TPSTLRTVRRDQRYMTRGRIHAEVADLLDRTVAMNGE
TH_4080|M.thermoresistible__bu -------------------------------------
Mflv_4608|M.gilvum_PYR-GCK GALPTRSDVKADILDVGVGKVPPKRAASRVRKDA---
MAB_4476c|M.abscessus_ATCC_199 -------------VDASIG------------------
Mvan_1519|M.vanbaalenii_PYR-1 -------------------------------------
MAV_3378|M.avium_104 -------------------------------------
MUL_4425|M.ulcerans_Agy99 -------------------------------------
MMAR_4565|M.marinum_M -------------------------------------
Mb0968c|M.bovis_AF2122/97 -------------------------------------
Rv0943c|M.tuberculosis_H37Rv -------------------------------------