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AGVSEAERRGHRKLVRFQARRAIGPIRPTSAAWDRDFDPAGKRIAVVGTDAAAAHYISRLSESAASVTVF TQAPRRVVTGVPLWTTRAKRWLRRRTGAEHPAVAWATAAIDALTSSGIRTSDGVEHPVDAIIYGTGFAIA DQVGDQTLVGAGGVTIRQAWDDGMEPYLGVAVHGFPNYFFITGPDTAAQARCVVECMKLMERTASRRIEV RRSSQQVFNERAQLKPAQPHRQTGGLEAFDLSSAATEDDQTYDGAATLTLAGARFRVRVRLTGHLDPIDG NYHWQGTVFDSLPETSLTHARAATLTIGGRSAPARITEQTPWGTHSVAGVGPPPYARSGPASATT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0943c | - | - | 100% (346) | PROBABLE MONOOXYGENASE |
| M. tuberculosis H37Rv | Rv1393c | - | 3e-15 | 32.23% (121) | monoxygenase |
| M. tuberculosis H37Rv | Rv0892 | - | 2e-12 | 30.94% (139) | monooxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0968c | - | 0.0 | 100.00% (346) | monooxygenase |
| M. gilvum PYR-GCK | Mflv_4608 | - | 6e-18 | 27.14% (280) | FAD dependent oxidoreductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2073 | - | 8e-20 | 26.79% (280) | putative monooxygenase |
| M. marinum M | MMAR_4565 | - | 1e-108 | 63.21% (318) | monooxygenase |
| M. avium 104 | MAV_5119 | - | 2e-20 | 28.68% (265) | lipolytic enzyme |
| M. smegmatis MC2 155 | MSMEG_5549 | - | 8e-20 | 51.04% (96) | hypothetical protein MSMEG_5549 |
| M. thermoresistible (build 8) | TH_3452 | - | 1e-18 | 28.68% (272) | PUTATIVE lipolytic enzyme |
| M. ulcerans Agy99 | MUL_4425 | - | 1e-108 | 63.21% (318) | monooxygenase |
| M. vanbaalenii PYR-1 | Mvan_2243 | - | 3e-17 | 26.91% (275) | cyclohexanone monooxygenase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0943c|M.tuberculosis_H37Rv -------------------------------------MAGVSEAERRGHR
Mb0968c|M.bovis_AF2122/97 -------------------------------------MAGVSEAERRGHR
MMAR_4565|M.marinum_M MTHTPGVARAPRDCHDCHDVVIIGAGSRGRSVHAALLAAGVCDVVILDHA
MUL_4425|M.ulcerans_Agy99 -------------------------------MHAALLAAGVCDVVILDHA
MAV_5119|M.avium_104 ---------MPADPMSELSIGIIGAGPGGLALGILLSQAGFDDFTIFDRE
TH_3452|M.thermoresistible__bu ---------MARN----LSVGIIGAGPGGIALGIFLRRAGFTDFTIFDRE
Mvan_2243|M.vanbaalenii_PYR-1 ---------MTTSMAKTFSVAIIGAGPGGLALGIFLRKAGFTDFTIFDRE
Mflv_4608|M.gilvum_PYR-GCK -------------MSDTTTVLIVGAGFAGLGTAIRLLQQGIDDFVVLERA
MAB_2073|M.abscessus_ATCC_1997 -------------MTGTTTTLIVGAGFAGIGTAIRLLQEGTDDFVILERS
MSMEG_5549|M.smegmatis_MC2_155 ----------------------MTTSVRSAATRDEYAERLLKGSVKRSYA
Rv0943c|M.tuberculosis_H37Rv ----KLVRFQARR-------------------------------------
Mb0968c|M.bovis_AF2122/97 ----KLVRFQARR-------------------------------------
MMAR_4565|M.marinum_M PGLPANSQLRPGR-------------------------------------
MUL_4425|M.ulcerans_Agy99 PGPPANSQLRPGR-------------------------------------
MAV_5119|M.avium_104 DGVGGTWRINTYPGLACDVKSHLYSYSFDLNAHWSRLWSGQPEILDYFQR
TH_3452|M.thermoresistible__bu DGVGGTWRINTYPGLACDVKSHLYSYSFELNSEWTRLWPAQPEILRYFER
Mvan_2243|M.vanbaalenii_PYR-1 DGVGGTWRINTYPGLACDVKSHLYSYSFDLNAHWSRMWSGQEEILQYFER
Mflv_4608|M.gilvum_PYR-GCK DEVGGTWRDNTYPGAACDIPSLLYSYGFEQNPDWSRAYSGSAEILGYIKT
MAB_2073|M.abscessus_ATCC_1997 NRVGGTWRDNTYPGAACDIPSLLYSYSFEPNPGWTHTYSGSAEILEYIDT
MSMEG_5549|M.smegmatis_MC2_155 PVVDIEWDTPLEP-------------------------------------
Rv0943c|M.tuberculosis_H37Rv ----------------AIG----------PIR-----------------P
Mb0968c|M.bovis_AF2122/97 ----------------AIG----------PIR-----------------P
MMAR_4565|M.marinum_M ----------------VIGAAFDDDTDTWAVRTADGATVCGRVVVAACPP
MUL_4425|M.ulcerans_Agy99 ----------------VIGAAFDDDTDTWALRTADGATVCGRVVVAACPP
MAV_5119|M.avium_104 CADKYGLGPHLRLGTEIRSAHWDADTQRWRLTTASGHRHHFDVVVSAVGL
TH_3452|M.thermoresistible__bu CAQRHRLGPHLRLNTEITSARWNPTSRQWMLTTGAGEQHNFDVVVSAVGM
Mvan_2243|M.vanbaalenii_PYR-1 CAQRYRLPDNLQLNTEIVSARWGSETRTWTLTTAGGEEHTFDIVVSAIGL
Mflv_4608|M.gilvum_PYR-GCK MVDKYSLSRFIRFGVNVTGLEFDEESALWTAQTADGSQFTARTAVMASGP
MAB_2073|M.abscessus_ATCC_1997 IVTKYDLARFIQFDTDVTALEFDEGAGIWVADTADGKRYQARSVVMASGP
MSMEG_5549|M.smegmatis_MC2_155 ----------------------DKFFLPPKLVSLYGTPLWESMSREQQIE
Rv0943c|M.tuberculosis_H37Rv TSAAWDRDFD--------------------PAGKRIAVVGTDAAAAHYIS
Mb0968c|M.bovis_AF2122/97 TSAAWDRDFD--------------------PAGKRIAVVGTDAAAAHYIS
MMAR_4565|M.marinum_M VYVPWTPDFAGRNDFRGESFHAGAPDPAFRPAGKRIAVLGTDSNVAHWID
MUL_4425|M.ulcerans_Agy99 VYVPWTPDFAGRNDFRGESFHAGAPDPAFRPAGKRIAVLGTDSNVAHWID
MAV_5119|M.avium_104 FTRPLLPELVEEEPFTGTVMHSARWDHSIPLHGKRIAVLGTGSTASQLIP
TH_3452|M.thermoresistible__bu FTRPVMPDLVEEEPFTGTLMHSARWDHGIDLHGKRIAVLGTGSTASQLIP
Mvan_2243|M.vanbaalenii_PYR-1 FTQPVMPDLVDEEPFTGTVMHTARWDHSVDLRDARVAVLGTGSTAAQLVP
Mflv_4608|M.gilvum_PYR-GCK LANASLPDIRGLDTFDGHKIHSARWDHDYDMSDKRVAVIGTGASAVQIIP
MAB_2073|M.abscessus_ATCC_1997 LADASFPDIRGIDSYEGKKIHSARWDQGYDLGDKRVAVIGTGASAVQILP
MSMEG_5549|M.smegmatis_MC2_155 LSRQELANTLSAGIWFENILN-------QALLRKMMHQDPTARATHYELT
: : * . :
Rv0943c|M.tuberculosis_H37Rv RLSESAASVTVFTQAPRRVVTGVPLWTTRAKRWLRRRTGAEHP----AVA
Mb0968c|M.bovis_AF2122/97 RLSESAASVTVFTQAPRRVVTGVPLWTTRAKRWLRRRTGAEHP----AVA
MMAR_4565|M.marinum_M EWADSAASVTVFAQGPRRVVTDLARHPPQAKRWLLGRIGAKRPRR--APT
MUL_4425|M.ulcerans_Agy99 EWADSAASVTVFAQGPRRVVTDLARHPPQAKRWLLGRIGAKRPRR--APT
MAV_5119|M.avium_104 ELAKVAERVYSVQRSPTWILPKPDRPYTRWERWAFAHLPLAKKLYRTRLW
TH_3452|M.thermoresistible__bu ELAKIADRVYSVQRSPTWILPKPDRPYSDRERWVFRHVPFAKRIYRTRLW
Mvan_2243|M.vanbaalenii_PYR-1 EVAKQAAKVYSVQRSPTWVLPKPDREYTGREKWMFAHIPLAKKIYRTRLW
Mflv_4608|M.gilvum_PYR-GCK ELVKTARSVKVFQRTPGWVLPRPDFSHPQWVRTAFRRLPRVQNVGRQAWF
MAB_2073|M.abscessus_ATCC_1997 ELVKSAASVKVFQRTPGWVLPRVNLKHPAWARSTFKQLPVSEQALRDAWF
MSMEG_5549|M.smegmatis_MC2_155 ELGDETRHMVMFGRAIERIGAKPVRPRLYQRMIINTLPFFFRGSVLWVAA
. . : : . : : . .
Rv0943c|M.tuberculosis_H37Rv WATAAIDALTSSGIRTSDGVEHPVDAIIYGTG--FAIADQVGDQTLVG--
Mb0968c|M.bovis_AF2122/97 WATAAIDALTSSGIRTSDGVEHPVDAIIYGTG--FAIADQVGDQTLVG--
MMAR_4565|M.marinum_M IAASAIAALTPSGIRTNDGIEHPVDAVIYGTG--FTIPEQTVEPTLVG--
MUL_4425|M.ulcerans_Agy99 IAASVIAALTPSGIRTNDGIEHPVDAVIYGTG--FTIPEQTVEPTLVG--
MAV_5119|M.avium_104 LRSESNISVIEHGSEKTGQFTNIALGLLEASVPDEELRRKLTPDHPMG--
TH_3452|M.thermoresistible__bu LRSEANISVIEDGSEKTEEFKAIALKMLEATVPDEEMRRRLTPDHPLG--
Mvan_2243|M.vanbaalenii_PYR-1 LRSESNISVIENGSDKTEEFKGIALRTLEATVADDELRAKLTPTHPLG--
Mflv_4608|M.gilvum_PYR-GCK WGHELMAVGMVWDTPVTTGIQLLAKANLRRQVSDTWLRRQLTPNFRAG--
MAB_2073|M.abscessus_ATCC_1997 WAHEVMAVGMVWNTAATSAIQLAAKAHLRRQVKDPWLRRQLTPHFRPG--
MSMEG_5549|M.smegmatis_MC2_155 LIGEEIFDSLQRQMMDDPELQPFVQRVMRIHVTEEARHIQFARDGLRKRT
. . : :
Rv0943c|M.tuberculosis_H37Rv AGGVTIRQAWDDGMEP----YLGVAVHGFPNYFFITGPDTAAQARCVVEC
Mb0968c|M.bovis_AF2122/97 AGGVTIRQAWDDGMEP----YLGVAVHGFPNYFFITGPDTAAQARCVVEC
MMAR_4565|M.marinum_M TRGLTIQQAWYPGMEA----FLGVAVHGFPNYFFLCGPDVAAQISYVAEC
MUL_4425|M.ulcerans_Agy99 TRGLTIQQAWYPGMEA----FLGVAVHGFPNYFFICGPDVAAQISYVAEC
MAV_5119|M.avium_104 CKRLVFSSDYLPALTRPNVEVLTSPARSLRRRSLVTEDGTEREVDLVVCA
TH_3452|M.thermoresistible__bu CKRLVFSSDYLAALMRPNVEVVSSPARALRGDTLITEDGTERRVDVVVCA
Mvan_2243|M.vanbaalenii_PYR-1 CKRLVFATDYLQTLTQPHVEVVSSPARSLRSRSLVTEDGTELDVDVVLCA
Mflv_4608|M.gilvum_PYR-GCK CKRMLMSSDYYPALQRDNCKLVSWPIATLSPNGIRTADGIEHELDCIVFA
MAB_2073|M.abscessus_ATCC_1997 CKRMLMTSDYYPALQSDNCKLISWPIATLSPNGVRTADGVEHEVDCIVFA
MSMEG_5549|M.smegmatis_MC2_155 SDMGWPTRVWVSNLNGLGGLFFRHLFSHPIQYRRAGLDGRAGRRLARASA
: : . . .
Rv0943c|M.tuberculosis_H37Rv MKLMERTASRRIEVR-RSSQQVFNERAQLKPAQPHRQTGGLEAFDLSSAA
Mb0968c|M.bovis_AF2122/97 MKLMERTASRRIEVR-RSSQQVFNERAQLKPAQPHRQTGGLEAFDLSSAA
MMAR_4565|M.marinum_M VDLLQRTASTRIEVL-RSSQQVFNERAQLRPVQPYQP---LRAFDLSAGA
MUL_4425|M.ulcerans_Agy99 VDLLQRTASTRIEVL-RSSQQVFNERAQLRPVQPYQP---LRAFDLSAGA
MAV_5119|M.avium_104 TGYAAADYLGELDVTGEHGVTLREVWRDGAYAYLGMAVPGFPNFFMLYGP
TH_3452|M.thermoresistible__bu TGYAAADYLGQIEVVGERQRSLREVWRDGAYAYLGMTVPGFPNFFMLYGP
Mvan_2243|M.vanbaalenii_PYR-1 TGYAAADYLGQIEVRGADDALLSDTWRDGAFAYLGMAVPGYPNFFMLYGP
Mflv_4608|M.gilvum_PYR-GCK TGFDVCKAGTPFPIRGAHGRELSDEWSQGAYAYRSVTVAGYPNLFFTFGP
MAB_2073|M.abscessus_ATCC_1997 TGFDVCKRGTPFPISGLGGRKLGDEWSQGRYAFKSVSVAGYPNLFFTFGP
MSMEG_5549|M.smegmatis_MC2_155 HRHEVQVAGFAPLAAFLEEVGLMGRIGRRMWRRSGFLPQDHTPTVRHRGI
: .
Rv0943c|M.tuberculosis_H37Rv TEDD------QTYDGAATLTLAGARFRVRVRLTGHLDPIDGNYHWQGTVF
Mb0968c|M.bovis_AF2122/97 TEDD------QTYDGAATLTLAGARFRVRVRLTGHLDPIDGNYHWQGTVF
MMAR_4565|M.marinum_M PEDTGIPNIPNIYDGAATLEIGGVRHAVHVRLAGHLDPIDGNYHWQGTVL
MUL_4425|M.ulcerans_Agy99 PEDSGIPNIPNIYDGAATLEIGGVRHAVHVRLAGHLDPIDGNYHWQGTVL
MAV_5119|M.avium_104 NTNVGSNSVIFVLEAQARYIVRALKYLRRHRRRYIAVRPAALADFVAKID
TH_3452|M.thermoresistible__bu NTNVGSNSVLFILEAQARYVVKALKRLRRRDTSYIAVRPDTAAAFLAKVD
Mvan_2243|M.vanbaalenii_PYR-1 NTNVGSNSVIFMLEAQAHYIVRALKYMRRKNRSYIEVRSDVMTRFLERID
Mflv_4608|M.gilvum_PYR-GCK NSGPGHNSALVYMEAEINYIVKAIGAIIANDLSTLEVREDRQNNYHGEVQ
MAB_2073|M.abscessus_ATCC_1997 NSGPGHNSALVYMEAVIDYVVKAIKLLQQNDIGTLDVREDRQGRYHSEIQ
MSMEG_5549|M.smegmatis_MC2_155 AAGTEPAIDEDVYDGFAVLDNGDRDSRVRVRLTGHLDPIDGRYHWQGSIL
. :. : :
Rv0943c|M.tuberculosis_H37Rv DSLPETSLTHARAATLTIGGRSAPARITEQTPWGTHSVAGVGPPPYARSG
Mb0968c|M.bovis_AF2122/97 DSLPETSLTHARAATLTIGGRSAPARITEQTPWGTHSVAGVGPPPYARSG
MMAR_4565|M.marinum_M DPLPRDTLKQARAGTLTVGERSAAVRVIEQTPWGTHSVAGLGAPPYADSG
MUL_4425|M.ulcerans_Agy99 DPLPRDTLKQARAGTLTVGERSAAVRVIEQTPWGTHSVAGLGAPPYADSG
MAV_5119|M.avium_104 RWMVGTVWTTQCSNYFRAPNGRVVTQWPRSARAFWSMTRRFRPADYRFQA
TH_3452|M.thermoresistible__bu QWMQGKVWSTQCNNYFRAPNGRVVTQWPRSARAFWAMTRRFRSADYLFEP
Mvan_2243|M.vanbaalenii_PYR-1 TWMQGTVWLTRCSNYFRAPNGRVVTQWPRSARTFWGLTRRFNPGDYGFDA
Mflv_4608|M.gilvum_PYR-GCK QRLGSTTWNSGCKSWYLTNDGYNGTMYPGFATQFKRALSKVDMGDYVTTP
MAB_2073|M.abscessus_ATCC_1997 RRLRRTTWNSGCSSWYLTEDGYNGTMYPGFATQFMRELSRLDPRDYVIT-
MSMEG_5549|M.smegmatis_MC2_155 D---ADMVAGTGPVRLTIGQRSADARIVERTAQSTYTIAGVGEPPFTLAE
. : . :
Rv0943c|M.tuberculosis_H37Rv PASATT--------------------------------------------
Mb0968c|M.bovis_AF2122/97 PASATT--------------------------------------------
MMAR_4565|M.marinum_M R-------------------------------------------------
MUL_4425|M.ulcerans_Agy99 R-------------------------------------------------
MAV_5119|M.avium_104 P--AVRVPAP---------ASEADAR------------------------
TH_3452|M.thermoresistible__bu APDMSEVSAD---------ARPVASR------------------------
Mvan_2243|M.vanbaalenii_PYR-1 PSSRSRIRVG---------AQTSVKQP-----------------------
Mflv_4608|M.gilvum_PYR-GCK TTARTEHHPTEHAQNGSNVAKVAQGRKAKVAQGRKSAGALPTRSDVKADI
MAB_2073|M.abscessus_ATCC_1997 --RRDDAH-----------LRLTQ--------------------------
MSMEG_5549|M.smegmatis_MC2_155 --------------------------------------------------
Rv0943c|M.tuberculosis_H37Rv ---------------------
Mb0968c|M.bovis_AF2122/97 ---------------------
MMAR_4565|M.marinum_M ---------------------
MUL_4425|M.ulcerans_Agy99 ---------------------
MAV_5119|M.avium_104 ---------------------
TH_3452|M.thermoresistible__bu ---------------------
Mvan_2243|M.vanbaalenii_PYR-1 ---------------------
Mflv_4608|M.gilvum_PYR-GCK LDVGVGKVPPKRAASRVRKDA
MAB_2073|M.abscessus_ATCC_1997 ---------------------
MSMEG_5549|M.smegmatis_MC2_155 ---------------------