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HVHDTLIVGAGFSGLGTAIKLRQAGVDDIVIVERGQRVGGTWRDNTYPGVACDIPSLLYSFSFVRNPSWS RAYPTGAEICDHIEDMADQHGLTPLIRFDTEVTGLTFDDQSGAWTVTTKRRKQFRARTVVLASGPLADHR FPEIRGIDSYRGHKIHSASWDHDYDFTGKRVAVIGTGASAVQIVPELVKTAAFVKVFQRTPGWVLPRLDL PMPAAVQALFAKVPATQEIARQALYWGHEASAAALVWNTPMSGLVARLGKAHLRQQVKDPWMRRQLTPDF TPGCKRMLISSDYYPALQRDNCKLIDWPIATLSPAGIRTSDGVEHHLDAIVFATGYDVHLSGPPFPVAGL NGRSLQQEWAGHAEAYKSASAHGYPNLFFMTGPNSGPGHNSLLVYVEGQIAYAVDAITTILNRNLRYLDV RADVQQRHNAQIQRRLTKTTWMSGCHSWYLTADGFNASMYPGFATQYRRQMQFRAEDYTAVA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1519 | - | - | 100% (483) | FAD dependent oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_2059 | - | 3e-98 | 40.29% (484) | putative monooxygenase |
| M. vanbaalenii PYR-1 | Mvan_2671 | - | 3e-88 | 37.63% (497) | cyclohexanone monooxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3075c | - | 1e-98 | 41.03% (468) | monooxygenase |
| M. gilvum PYR-GCK | Mflv_4608 | - | 1e-179 | 62.45% (466) | FAD dependent oxidoreductase |
| M. tuberculosis H37Rv | Rv3049c | - | 1e-98 | 41.03% (468) | monooxygenase |
| M. leprae Br4923 | MLBr_00065 | - | 1e-29 | 28.28% (396) | putative monooxygenase |
| M. abscessus ATCC 19977 | MAB_4476c | - | 0.0 | 63.52% (477) | putative monooxygenase |
| M. marinum M | MMAR_3702 | - | 0.0 | 73.66% (486) | flavin-binding monooxygenase |
| M. avium 104 | MAV_1795 | - | 0.0 | 78.05% (483) | flavin-binding monooxygenase |
| M. smegmatis MC2 155 | MSMEG_4451 | - | 1e-104 | 41.58% (469) | monooxygenase |
| M. thermoresistible (build 8) | TH_4080 | - | 2e-98 | 40.22% (465) | PUTATIVE conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_1880 | - | 1e-103 | 41.81% (464) | monooxygenase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3702|M.marinum_M -----------------MTMAPDHAYATLIVGAGLTGLGAAIRLAEAGLS
MAV_1795|M.avium_104 -------------------MARDHAHAALIIGAGFTGLGAAIRLAEAGV-
Mvan_1519|M.vanbaalenii_PYR-1 ----------------------MHVHDTLIVGAGFSGLGTAIKLRQAGV-
Mflv_4608|M.gilvum_PYR-GCK ---------------------MSDTTTVLIVGAGFAGLGTAIRLLQQGI-
MAB_4476c|M.abscessus_ATCC_199 ------------------------MTEVLIVGAGFAGLGTAIRLLEKGI-
Mb3075c|M.bovis_AF2122/97 ---MSIADTAAKPSTPSPANQPPVRTRAVIIGTGFSGLGMAIALQKQGV-
Rv3049c|M.tuberculosis_H37Rv ---MSIADTAAKPSTPSPANQPPVRTRAVIIGTGFSGLGMAIALQKQGV-
MUL_1880|M.ulcerans_Agy99 MTDVVIPSTETTASGEPQAPTPPVKTRAVIIGTGFSGLGMAIALQKQGV-
TH_4080|M.thermoresistible__bu ---MTVTEPSADITPANTPTQPPVRTRALIVGTGFSGLGMAIALQRRGI-
MSMEG_4451|M.smegmatis_MC2_155 -----------MSAPASSTPTLPASVHTLVVGAGFAGLAAAAAVLREDPR
MLBr_00065|M.leprae_Br4923 ----------------MVVMAETEYLDVVIVGAGISGVSAAWHLQDRCPN
.:::*:*::*:. * :
MMAR_3702|M.marinum_M NPDEVVILERGDRVGGTWRDTTYPGASCDIPSLLYSFSFVRNPKWSRTYS
MAV_1795|M.avium_104 --DDIVILERADRVGGTWRDTTYPGASCDVPSLLYSYSFVKNPTWSRTYS
Mvan_1519|M.vanbaalenii_PYR-1 --DDIVIVERGQRVGGTWRDNTYPGVACDIPSLLYSFSFVRNPSWSRAYP
Mflv_4608|M.gilvum_PYR-GCK --DDFVVLERADEVGGTWRDNTYPGAACDIPSLLYSYGFEQNPDWSRAYS
MAB_4476c|M.abscessus_ATCC_199 --EDFVILERGDDVGGTWRDNSYPGAACDIPSLLYSYSFEQNPQWSRAYS
Mb3075c|M.bovis_AF2122/97 ---DFVILEKADDVGGTWRDNTYPGCACDIPSHLYSFSFEPKADWKHLFS
Rv3049c|M.tuberculosis_H37Rv ---DFVILEKADDVGGTWRDNTYPGCACDIPSHLYSFSFEPKADWKHLFS
MUL_1880|M.ulcerans_Agy99 ---DFVILEKSDDVGGTWRDNSYPGCACDIPSHLYSFSFEPKPDWRNPFS
TH_4080|M.thermoresistible__bu ---DFLMLEKADDIGGTWRDNTYPGCACDIPSHLYSFSFEPKADWRHLFS
MSMEG_4451|M.smegmatis_MC2_155 --ADLLIIERADEVGGTWRDNTYPGCACDVPTSLYSFSFAPSAKWSHTFA
MLBr_00065|M.leprae_Br4923 --KSYVILEKRAGMGGTWDLFRYPGIRSDSDMYTLGFRFRPWTKCQAIAD
. :::*: :**** *** .* .: * .
MMAR_3702|M.marinum_M PAAEIYRHIEAMVNRFGIGDRIRFGQRVTGLTFNQDTGIWTATT---QAG
MAV_1795|M.avium_104 PAPEIYRHLEDMADRFDIRRRIRFGHEVSGLAFDEDAGVWTATT---KNR
Mvan_1519|M.vanbaalenii_PYR-1 TGAEICDHIEDMADQHGLTPLIRFDTEVTGLTFDDQSGAWTVTT---KRR
Mflv_4608|M.gilvum_PYR-GCK GSAEILGYIKTMVDKYSLSRFIRFGVNVTGLEFDEESALWTAQT---ADG
MAB_4476c|M.abscessus_ATCC_199 GGSEILGYIQRMVDKHQLRRFIKFGVDVTGLTFDDSTGMWTADT---AAG
Mb3075c|M.bovis_AF2122/97 YWDEILGYLKGVTDKYGLRRYIEFNSLVDRGYWDDDECRWHVFT---ADG
Rv3049c|M.tuberculosis_H37Rv YWDEILGYLKGVTDKYGLRRYIEFNSLVDRGYWDDDECRWHVFT---ADG
MUL_1880|M.ulcerans_Agy99 YQPEIWDYLKGVTEKYGLRRYVEFNSLVDRAYWDDEECRWHVFT---SDG
TH_4080|M.thermoresistible__bu YQDEIQEYLQGVTAKYGLRRYIHFDSLVDRAHWDDTEHRWHVFT---ADG
MSMEG_4451|M.smegmatis_MC2_155 RQPEIHRYLTSVADQTGLRHHLVTGCELLGAAWDDDEQRWRVRT---SLG
MLBr_00065|M.leprae_Br4923 GKP-ILEYIKSTAVMHGIDKYIRLNHKVTGADWSSIENRWTVQVENNGTP
* :: . : : . : :.. * . .
MMAR_3702|M.marinum_M ERFRARTVILASGPLSDVS--FPDIRGLDRYEGHKIHSARWDHDYDFSGK
MAV_1795|M.avium_104 KKFRARTVVLASGPLSDVS--FPDIRGLDSYRGHKIHSARWDHDYDFAGK
Mvan_1519|M.vanbaalenii_PYR-1 KQFRARTVVLASGPLADHR--FPEIRGIDSYRGHKIHSASWDHDYDFTGK
Mflv_4608|M.gilvum_PYR-GCK SQFTARTAVMASGPLANAS--LPDIRGLDTFDGHKIHSARWDHDYDMSDK
MAB_4476c|M.abscessus_ATCC_199 EIFTGRCAVMAAGPLANVS--WPDIRGLDSYTGHKIHSARWDHDYEMSGK
Mb3075c|M.bovis_AF2122/97 REYVAQFLISGAGALHIPS--FPEIAGRDEFAGPAFHSAQWDHSIDLTGK
Rv3049c|M.tuberculosis_H37Rv REYVAQFLISGAGALHIPS--FPEIAGRDEFAGPAFHSAQWDHSIDLTGK
MUL_1880|M.ulcerans_Agy99 REYVAQFLISGAGALHIPS--SPEIEGREEFAGPAFHSAEWDHSVDLTGK
TH_4080|M.thermoresistible__bu REYIAQFLISCAGALHIPS--IPDFPGRDQFAGPAFHSAQWDHSVDLTGK
MSMEG_4451|M.smegmatis_MC2_155 -MVTATVLVAATGALSTPK--LPDVPGLDRFGGTVFHSATWNHDHDLTDE
MLBr_00065|M.leprae_Br4923 RMISCSFLFLCSGYYNYEQGYAPTFLGSEDFTGPIIHPQHWPEDLDYAAK
. :* * . * : : * :*. * .. : : :
MMAR_3702|M.marinum_M RVAVVGTGASAVQIVPELVNQ-AGFVKVFQRTPCWVLPRLDVATPPAVQA
MAV_1795|M.avium_104 RVAVIGTGASAIQIIPELVKQ-AGFVKVFQRTPCWVLPRLDVATPPAVQA
Mvan_1519|M.vanbaalenii_PYR-1 RVAVIGTGASAVQIVPELVKT-AAFVKVFQRTPGWVLPRLDLPMPAAVQA
Mflv_4608|M.gilvum_PYR-GCK RVAVIGTGASAVQIIPELVKT-ARSVKVFQRTPGWVLPRPDFSHPQWVRT
MAB_4476c|M.abscessus_ATCC_199 HVAVIGTGASGVQIIPELVKT-AARVKVFQRTPGWVLPRLDFQHPDWAQR
Mb3075c|M.bovis_AF2122/97 RVAIVGTGASAIQIVPEIVGQ-VAELQLYQRTPPWVVPRTNEELPVSLRR
Rv3049c|M.tuberculosis_H37Rv RVAIVGTGASAIQIVPEIVGQ-VAELQLYQRTPPWVVPRTNEELPVSLRR
MUL_1880|M.ulcerans_Agy99 RVAIIGAGASAIQIVPEIVEQ-VGELQLYQRTPPWVVPRSNPEIPPALRR
TH_4080|M.thermoresistible__bu RVAVIGTGASAIQIVPEIIDR-VAQLQLYQRTPAWVVPRTNDELPAWLRR
MSMEG_4451|M.smegmatis_MC2_155 RVAVVGTGASAVQFVPEIADR-TAHLTVFQRTPAWVLPRLDRTLGRLERA
MLBr_00065|M.leprae_Br4923 NIVVIGSGATAVTLVPALANSGAKHVTMLQRSPTYIVSQP--AKDKIAAR
.:.::*:**:.: ::* : . : : **:* :::.:
MMAR_3702|M.marinum_M LFTKVPAAQQLARQALFWGHEATAGALVWNTPLTSLVALLGQAHLRGQVK
MAV_1795|M.avium_104 LFAKVPAAQELARQALYWGHEASATALVWDTPLTSLVARLGKAHLRAQVK
Mvan_1519|M.vanbaalenii_PYR-1 LFAKVPATQEIARQALYWGHEASAAALVWNTPMSGLVARLGKAHLRQQVK
Mflv_4608|M.gilvum_PYR-GCK AFRRLPRVQNVGRQAWFWGHELMAVGMVWDTPVTTGIQLLAKANLRRQVS
MAB_4476c|M.abscessus_ATCC_199 VFGSSPAVQNLARQAWYWTHEAAAVGMVWDTPVTTLIQWIAKANLRRQIS
Mb3075c|M.bovis_AF2122/97 ALRTVPGLRALLRLGIYWAQEALAYGMTKRPNTLKIIEAYAKYNIRRSVK
Rv3049c|M.tuberculosis_H37Rv ALRTVPGLRALLRLGIYWAQEALAYGMTKRPNTLKIIEAYAKYNIRRSVK
MUL_1880|M.ulcerans_Agy99 AMENVPGLRALARLGIYWAQEALAFGMTKRPNVLKVGEAYAKYNIRRSVK
TH_4080|M.thermoresistible__bu ALENIPGLRLALRGGIYALQEALAVGMTKYPGMLRIGHLLGKWNINRSVK
MSMEG_4451|M.smegmatis_MC2_155 LYRRIPLSQRLVRGMVYIYREGYLALLAHLTWLLPLLEIIAKTQLRRQVP
MLBr_00065|M.leprae_Br4923 LNRWLPDKYAYTAVRWKNILRQSALYGACQKWPQRMRNILLGHVARRLPK
* . . .
MMAR_3702|M.marinum_M DRWLRRQLTPDFRPGCKRMLVS--SDYYPALQRPNCKLIDWPIATLSPVG
MAV_1795|M.avium_104 DPWLRRQLTPDFRPGCKRMLVS--SDYYPALQRDNCKLIDWPIATLSPAG
Mvan_1519|M.vanbaalenii_PYR-1 DPWMRRQLTPDFTPGCKRMLIS--SDYYPALQRDNCKLIDWPIATLSPAG
Mflv_4608|M.gilvum_PYR-GCK DTWLRRQLTPNFRAGCKRMLMS--SDYYPALQRDNCKLVSWPIATLSPNG
MAB_4476c|M.abscessus_ATCC_199 DPWVRRQLTPDFRAGCKRMLMT--SDYYAALEKDNCKLITWPIATLSPNG
Mb3075c|M.bovis_AF2122/97 DRELRRKLTPRYRIGCKRILNS--STYYPAVADPKTELITDRIDRITHDG
Rv3049c|M.tuberculosis_H37Rv DRELRRKLTPRYRIGCKRILNS--STYYPAVADPKTELITDRIDRITHDG
MUL_1880|M.ulcerans_Agy99 DRELRRKLTPHYRIGCKRILNS--SSYYPAVANPKTRLITDRIARITRNG
TH_4080|M.thermoresistible__bu DPQLRAKLTPDYRLGCKRILNS--STYYPAVADPRTEVITESIDRITTDG
MSMEG_4451|M.smegmatis_MC2_155 DPALRRALTPDFRIGCKRILLT--NDWLPTLARDDVEVVTTALTEVTETG
MLBr_00065|M.leprae_Br4923 GYDVQKHFGPHYNPWEQRLCLVPDGDLFRAIRKGTVDMVTDAIDRFTSTG
. :: : * : :*: . :: :: : .: *
MMAR_3702|M.marinum_M IRTSDG----LEHHLDCIVFATGYDVHLTGPPFPVTGIGGRSLADEWAH-
MAV_1795|M.avium_104 IRTSDG----IEHHLDCIVFATGYDVHLTGPPFPVTGLGGRSLAAEWAG-
Mvan_1519|M.vanbaalenii_PYR-1 IRTSDG----VEHHLDAIVFATGYDVHLSGPPFPVAGLNGRSLQQEWAG-
Mflv_4608|M.gilvum_PYR-GCK IRTADG----IEHELDCIVFATGFDVCKAGTPFPIRGAHGRELSDEWSQ-
MAB_4476c|M.abscessus_ATCC_199 IRTADG----IEHDVDCIVFATGFDVCKAGTPFPIAGLDGRKLADEWSG-
Mb3075c|M.bovis_AF2122/97 IVTADGTGREVFREADVIVYATGFHVTDSYTYVQIKGRHGEDLVDRWNRE
Rv3049c|M.tuberculosis_H37Rv IVTADGTGREVFREADVIVYATGFHVTDSYTYVQIKGRHGEDLVDRWNRE
MUL_1880|M.ulcerans_Agy99 IVTADG----VEHQADVIVYATGFHVTDSYTYVQIKGQHGEDLVDRWNRE
TH_4080|M.thermoresistible__bu IVTSDG----TERAVDVIVYATGFHVSDSYKYVQIKGLNGEDIVDRFNRE
MSMEG_4451|M.smegmatis_MC2_155 VRDGTG----RLHDVDTIIFATGFTPTEPPVAHQLTGVTGTTLAAHWAG-
MLBr_00065|M.leprae_Br4923 IRLKSG----NELRADIIVTATGLNLQLFGGAVATVDGQPVDLAQ-----
: * * *: *** . :
MMAR_3702|M.marinum_M GAQAYKSINAHGYPNLFFMTGPNSG---PGHNSLLVYIEGQLDYAVRAIT
MAV_1795|M.avium_104 GAQAYKSINVHGYPNLFVMTGPNSG---PGHNSLLVYIEGQLDYAVRGIT
Mvan_1519|M.vanbaalenii_PYR-1 HAEAYKSASAHGYPNLFFMTGPNSG---PGHNSLLVYVEGQIAYAVDAIT
Mflv_4608|M.gilvum_PYR-GCK GAYAYRSVTVAGYPNLFFTFGPNSG---PGHNSALVYMEAEINYIVKAIG
MAB_4476c|M.abscessus_ATCC_199 GAYAYKSVNVSGYPNLFFTFGPNSG---PGHNSALVYMEAQIDYIVQAIG
Mb3075c|M.bovis_AF2122/97 GIGAHRGITVANMPNLFFLLGPNTG---LGHNSVVFMIESQIHYVADAIA
Rv3049c|M.tuberculosis_H37Rv GIGAHRGITVANMPNLFFLLGPNTG---LGHNSVVFMIESQIHYVADAIA
MUL_1880|M.ulcerans_Agy99 GIGAHRGIAVADVPNLFFLLGPNTG---LGHNSVVFMIESQIHYVADAIA
TH_4080|M.thermoresistible__bu GPMAHRGTAVADLPNAYLLLGPNTG---LGHNSMVYMIESQINYVIEAIK
MSMEG_4451|M.smegmatis_MC2_155 SPSAHLGITVPGFPNLFLMYGPNTN---LGHSSIVYMLESQAAYLAAALR
MLBr_00065|M.leprae_Br4923 -TMSYKGMMLSGLPNMIYTVGYTNASWTLKADLVSEFFCRLLNYMNANDF
:: . . ** * .. . . *
MMAR_3702|M.marinum_M TILDERLRYLDVRADVQRRYNERIQRRLAKTTWMSG-CRSWYLTKEGFNG
MAV_1795|M.avium_104 TILNDDLRYLDVREEVQRRHNEAIQRRLTKTTWMSG-CRSWYLTKDGFNG
Mvan_1519|M.vanbaalenii_PYR-1 TILNRNLRYLDVRADVQQRHNAQIQRRLTKTTWMSG-CHSWYLTADGFNA
Mflv_4608|M.gilvum_PYR-GCK AIIANDLSTLEVREDRQNNYHGEVQQRLGSTTWNSG-CKSWYLTNDGYNG
MAB_4476c|M.abscessus_ATCC_199 IVRAKDLLTLDVRKDRQDRFNEDIQRRLGKTTWNSG-CQSWYLTEDGKNT
Mb3075c|M.bovis_AF2122/97 KCDRMGVQALAPTREAQDRFNQELQRRLAGSVWNSGGCRSWYLDEHGKNT
Rv3049c|M.tuberculosis_H37Rv KCDRMGVQALAPTREAQDRFNQELQRRLAGSVWNSGGCRSWYLDEHGKNT
MUL_1880|M.ulcerans_Agy99 KCDKRGAQALAPTRAAQDRFNEELQRRLAGSVWNSGGCSSWYLDEHGRNT
TH_4080|M.thermoresistible__bu AVDKAGAQALAPTREAQDRYNAELQARLGRSVWNTGGCRSWYLDEHGNNR
MSMEG_4451|M.smegmatis_MC2_155 VMRAEGLASIDVRPDAERTYNEWINDALTNTVWNSGGCSSWYLDSRGRNS
MLBr_00065|M.leprae_Br4923 DTVAVEYPGSDVEERPFMDFTPGYVLRSLDALPKQGSRTPWRLNQNYLRD
. : * .* * .
MMAR_3702|M.marinum_M SMFPGFASEYLCQMRDFRYGHYHAVAQ--------------DAGSLVTST
MAV_1795|M.avium_104 SMYPGFATQYLRQMSDFRYQDYQAVAR--------------RARTPAASS
Mvan_1519|M.vanbaalenii_PYR-1 SMYPGFATQYRRQMQ-FRAEDYTAVA------------------------
Mflv_4608|M.gilvum_PYR-GCK TMYPGFATQFKRALSKVDMGDYVTTPTTARTE--HHPTEHAQNGSNVAKV
MAB_4476c|M.abscessus_ATCC_199 TMFPGFATQFARQLRTVELDDYSFT-----------------SGAAAASA
Mb3075c|M.bovis_AF2122/97 VLWCGYTWQYWLTTRSVNPAEYRFFGIGN------------GLSSDRATV
Rv3049c|M.tuberculosis_H37Rv VLWCGYTWQYWLTTRSVNPAEYRFFGIGN------------GLSSDRATV
MUL_1880|M.ulcerans_Agy99 VLWCGYTWQYWLATRSVKPEEYQFFKAG-----------------AKSSV
TH_4080|M.thermoresistible__bu VLWGGFTWQYRLATRTLDPAEYRFWG------------------------
MSMEG_4451|M.smegmatis_MC2_155 VMWPTFTFRFRARTRSFDVINYDTLRTRQQIRGVEQRCESQLADADREIL
MLBr_00065|M.leprae_Br4923 IRLIRRGKVADEGLLFAKKTTPVTV-------------------------
MMAR_3702|M.marinum_M A-------------------------------------------------
MAV_1795|M.avium_104 A-------------------------------------------------
Mvan_1519|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4608|M.gilvum_PYR-GCK AQGRKAKVAQGRKSAGALPTRSDVKADILDVGVGKVPPKRAASRVRKDA-
MAB_4476c|M.abscessus_ATCC_199 AKPP------------------------VDASIG----------------
Mb3075c|M.bovis_AF2122/97 AAAN----------------------------------------------
Rv3049c|M.tuberculosis_H37Rv AAAN----------------------------------------------
MUL_1880|M.ulcerans_Agy99 NG------------------------------------------------
TH_4080|M.thermoresistible__bu --------------------------------------------------
MSMEG_4451|M.smegmatis_MC2_155 AGQIRLAGEDESVTPSTLRTVRRDQRYMTRGRIHAEVADLLDRTVAMNGE
MLBr_00065|M.leprae_Br4923 --------------------------------------------------