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VTHTPGVARAPRDCHDCHDVVIIGAGSRGRSVHAALLAAGVCDVVILDHAPGLPANSQLRPGRVIGAAFD DDTDTWAVRTADGATVCGRVVVAACPPVYVPWTPDFAGRNDFRGESFHAGAPDPAFRPAGKRIAVLGTDS NVAHWIDEWADSAASVTVFAQGPRRVVTDLARHPPQAKRWLLGRIGAKRPRRAPTIAASAIAALTPSGIR TNDGIEHPVDAVIYGTGFTIPEQTVEPTLVGTRGLTIQQAWYPGMEAFLGVAVHGFPNYFFLCGPDVAAQ ISYVAECVDLLQRTASTRIEVLRSSQQVFNERAQLRPVQPYQPLRAFDLSAGAPEDTGIPNIPNIYDGAA TLEIGGVRHAVHVRLAGHLDPIDGNYHWQGTVLDPLPRDTLKQARAGTLTVGERSAAVRVIEQTPWGTHS VAGLGAPPYADSGR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4565 | - | - | 100% (434) | monooxygenase |
| M. marinum M | MMAR_0403 | - | 6e-17 | 25.30% (332) | monooxygenase |
| M. marinum M | MMAR_0240 | - | 1e-16 | 25.00% (408) | monoooxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0968c | - | 1e-108 | 63.21% (318) | monooxygenase |
| M. gilvum PYR-GCK | Mflv_3372 | - | 8e-15 | 31.97% (122) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
| M. tuberculosis H37Rv | Rv0943c | - | 1e-108 | 63.21% (318) | monooxygenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4476c | - | 2e-16 | 33.86% (127) | putative monooxygenase |
| M. avium 104 | MAV_3378 | - | 5e-21 | 25.62% (324) | lipolytic enzyme |
| M. smegmatis MC2 155 | MSMEG_4451 | - | 6e-25 | 27.66% (329) | monooxygenase |
| M. thermoresistible (build 8) | TH_4080 | - | 1e-17 | 23.49% (332) | PUTATIVE conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_4425 | - | 0.0 | 98.76% (403) | monooxygenase |
| M. vanbaalenii PYR-1 | Mvan_1519 | - | 3e-16 | 32.28% (127) | FAD dependent oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_4451|M.smegmatis_MC2_155 --MSAP-----ASSTPTLP-ASVHTLVVGAGFAGLAAAAAVLREDPRADL
TH_4080|M.thermoresistible__bu MTVTEPSADITPANTPTQPPVRTRALIVGTGFSGLGMAIALQRRG--IDF
MAB_4476c|M.abscessus_ATCC_199 ---------------------MTEVLIVGAGFAGLGTAIRLLEKG-IEDF
Mvan_1519|M.vanbaalenii_PYR-1 -------------------MHVHDTLIVGAGFSGLGTAIKLRQAG-VDDI
Mflv_3372|M.gilvum_PYR-GCK -----------------MVEPQYDVIVVGAGFGGMGAAIQLKKMG-YENI
MAV_3378|M.avium_104 --------------MSSPAVPDHHTLIIGAGFSGIGAAIKLDKAG-LPDY
MMAR_4565|M.marinum_M -------------------------------MTHTPGVARAPRDCHDCHD
MUL_4425|M.ulcerans_Agy99 --------------------------------------------------
Mb0968c|M.bovis_AF2122/97 --------------------------------------------------
Rv0943c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_4451|M.smegmatis_MC2_155 LIIERADEVGGTWRDNTYPGCACDVPTSLYSFSFAPSAKWSHTFARQPEI
TH_4080|M.thermoresistible__bu LMLEKADDIGGTWRDNTYPGCACDIPSHLYSFSFEPKADWRHLFSYQDEI
MAB_4476c|M.abscessus_ATCC_199 VILERGDDVGGTWRDNSYPGAACDIPSLLYSYSFEQNPQWSRAYSGGSEI
Mvan_1519|M.vanbaalenii_PYR-1 VIVERGQRVGGTWRDNTYPGVACDIPSLLYSFSFVRNPSWSRAYPTGAEI
Mflv_3372|M.gilvum_PYR-GCK LIVDREDDLGGTWHVNHYPGLAVDIPSPTYSYWFEPNPYWSRLYAPGSEL
MAV_3378|M.avium_104 RVIEAGDGVGGTWHWNTYPGIAVDIPSFSYQFSFEQSRHWSRTYAPGREL
MMAR_4565|M.marinum_M VVIIGAGSRGRSVHAALLAAGVCDVVILDHAPGLPANSQLR---------
MUL_4425|M.ulcerans_Agy99 ------------MHAALLAAGVCDVVILDHAPGPPANSQLR---------
Mb0968c|M.bovis_AF2122/97 ------------------MAGVSEAERRGHR----KLVRFQ---------
Rv0943c|M.tuberculosis_H37Rv ------------------MAGVSEAERRGHR----KLVRFQ---------
. . : :
MSMEG_4451|M.smegmatis_MC2_155 HRYLTSVADQTGLRHHLVTGCELLGAAWDDDEQRWRVRTSLG-MVTATVL
TH_4080|M.thermoresistible__bu QEYLQGVTAKYGLRRYIHFDSLVDRAHWDDTEHRWHVFTADGREYIAQFL
MAB_4476c|M.abscessus_ATCC_199 LGYIQRMVDKHQLRRFIKFGVDVTGLTFDDSTGMWTADTAAGEIFTGRCA
Mvan_1519|M.vanbaalenii_PYR-1 CDHIEDMADQHGLTPLIRFDTEVTGLTFDDQSGAWTVTTKRRKQFRARTV
Mflv_3372|M.gilvum_PYR-GCK KKYAEHVADKYDVRRHMRFNSPVDGARWDDDTESWQVALSGGETLTAKFL
MAV_3378|M.avium_104 KAYAEHCADKYGIRSRIRFNTKVLAAEFDDEQRLWRVQTDPGGEVTARFL
MMAR_4565|M.marinum_M -------------------PGRVIGAAFDDDTDTWAVRTADGATVCGRVV
MUL_4425|M.ulcerans_Agy99 -------------------PGRVIGAAFDDDTDTWALRTADGATVCGRVV
Mb0968c|M.bovis_AF2122/97 -------------------ARRAIG----------PIR------------
Rv0943c|M.tuberculosis_H37Rv -------------------ARRAIG----------PIR------------
MSMEG_4451|M.smegmatis_MC2_155 VAATGALSTPKLPDVPGLDRFGGTVFHSATWNHDHDLTDERVAVVGTGAS
TH_4080|M.thermoresistible__bu ISCAGALHIPSIPDFPGRDQFAGPAFHSAQWDHSVDLTGKRVAVIGTGAS
MAB_4476c|M.abscessus_ATCC_199 VMAAGPLANVSWPDIRGLDSYTGHKIHSARWDHDYEMSGKHVAVIGTGAS
Mvan_1519|M.vanbaalenii_PYR-1 VLASGPLADHRFPEIRGIDSYRGHKIHSASWDHDYDFTGKRVAVIGTGAS
Mflv_3372|M.gilvum_PYR-GCK ITATGYLSQPRKPEIPGIEDFAGRVLHSMDWDDSYSPAGERVGLIGTGAT
MAV_3378|M.avium_104 ISACGVLTVPNLPDIDGVDSFAGITMHTARWDHGQDLRGKRVAVIGTGAS
MMAR_4565|M.marinum_M VAACPPVYVPWTPDFAGRNDFRGESFHAGAPDPAFRPAGKRIAVLGTDSN
MUL_4425|M.ulcerans_Agy99 VAACPPVYVPWTPDFAGRNDFRGESFHAGAPDPAFRPAGKRIAVLGTDSN
Mb0968c|M.bovis_AF2122/97 -----PTSAAWDRDFD--------------------PAGKRIAVVGTDAA
Rv0943c|M.tuberculosis_H37Rv -----PTSAAWDRDFD--------------------PAGKRIAVVGTDAA
:. .:::.::**.:
MSMEG_4451|M.smegmatis_MC2_155 AVQFVPEIADRTAHLTVFQRTPAWVLPRLDRTLGRLERALYRRIPLSQRL
TH_4080|M.thermoresistible__bu AIQIVPEIIDRVAQLQLYQRTPAWVVPRTNDELPAWLRRALENIPGLRLA
MAB_4476c|M.abscessus_ATCC_199 GVQIIPELVKTAARVKVFQRTPGWVLPRLDFQHPDWAQRVFGSSPAVQNL
Mvan_1519|M.vanbaalenii_PYR-1 AVQIVPELVKTAAFVKVFQRTPGWVLPRLDLPMPAAVQALFAKVPATQEI
Mflv_3372|M.gilvum_PYR-GCK AVQLIPQLSKDAAALTVYQRTPIHVVPKIDFAIPPAMRRILARVPLMQRA
MAV_3378|M.avium_104 AVQVIPEIAPIVSSLTVFQRTPIWCFPKLDVPLP-APARWAMRFPGGKAL
MMAR_4565|M.marinum_M VAHWIDEWADSAASVTVFAQGPRRVVTDLARHPPQAKRWLLGRIGAKRPR
MUL_4425|M.ulcerans_Agy99 VAHWIDEWADSAASVTVFAQGPRRVVTDLARHPPQAKRWLLGRIGAKRPR
Mb0968c|M.bovis_AF2122/97 AAHYISRLSESAASVTVFTQAPRRVVTGVPLWTTRAKRWLRRRTGAEHP-
Rv0943c|M.tuberculosis_H37Rv AAHYISRLSESAASVTVFTQAPRRVVTGVPLWTTRAKRWLRRRTGAEHP-
: : . .: : :: : * .. :
MSMEG_4451|M.smegmatis_MC2_155 VRGMVYIYREGYLAL----LAHLTWLLPLLEIIAKTQLRRQVPDPALRRA
TH_4080|M.thermoresistible__bu LRGGIYALQEALAVG----MTKYPGMLRIGHLLGKWNINRSVKDPQLRAK
MAB_4476c|M.abscessus_ATCC_199 ARQAWYWTHEAAAVG----MVWDTPVTTLIQWIAKANLRRQISDPWVRRQ
Mvan_1519|M.vanbaalenii_PYR-1 ARQALYWGHEASAAA----LVWNTPMSGLVARLGKAHLRQQVKDPWMRRQ
Mflv_3372|M.gilvum_PYR-GCK FRASSDVGLEAMMILSVLNFKYFRKLNSVANWLSRALRFVSIRDKELRAK
MAV_3378|M.avium_104 QRLLSQAYVELTFPISAHYFTVIPLAKRMA-ALGRAYLRRQVRDPAVREQ
MMAR_4565|M.marinum_M RAPTIAASAIAALTP--------SGIRTNDGIEHPVDAVIYGTGFTIPEQ
MUL_4425|M.ulcerans_Agy99 RAPTIAASVIAALTP--------SGIRTNDGIEHPVDAVIYGTGFTIPEQ
Mb0968c|M.bovis_AF2122/97 -AVAWATAAIDALTS--------SGIRTSDGVEHPVDAIIYGTGFAIADQ
Rv0943c|M.tuberculosis_H37Rv -AVAWATAAIDALTS--------SGIRTSDGVEHPVDAIIYGTGFAIADQ
. :
MSMEG_4451|M.smegmatis_MC2_155 LTPDFRIGCKRILLTNDWLPTLARDDVEVVTTALTEVTETGVRDGTGRLH
TH_4080|M.thermoresistible__bu LTPDYRLGCKRILNSSTYYPAVADPRTEVITESIDRITTDGIVTSDGTER
MAB_4476c|M.abscessus_ATCC_199 LTPDFRAGCKRMLMTSDYYAALEKDNCKLITWPIATLSPNGIRTADGIEH
Mvan_1519|M.vanbaalenii_PYR-1 LTPDFTPGCKRMLISSDYYPALQRDNCKLIDWPIATLSPAGIRTSDGVEH
Mflv_3372|M.gilvum_PYR-GCK LTPQYEFGCKRPTYSNSYYRMFTKPNVHLQAAGIDHVEADGIVACDGTKT
MAV_3378|M.avium_104 LTPRYAVGCKRPGFHNGYLATFNRDNVRLVTEPIDKITPDAVATTDGETH
MMAR_4565|M.marinum_M TVEPTLVGTRGLTIQQAWYPGMEA----FLGVAVHGFPNYFFLCGPDVAA
MUL_4425|M.ulcerans_Agy99 TVEPTLVGTRGLTIQQAWYPGMEA----FLGVAVHGFPNYFFICGPDVAA
Mb0968c|M.bovis_AF2122/97 VGDQTLVGAGGVTIRQAWDDGMEP----YLGVAVHGFPNYFFITGPDTAA
Rv0943c|M.tuberculosis_H37Rv VGDQTLVGAGGVTIRQAWDDGMEP----YLGVAVHGFPNYFFITGPDTAA
* . : . : . . .
MSMEG_4451|M.smegmatis_MC2_155 DVDTIIFATGFTPTEPP--VAHQLTGVTGTTLAAHWAG-SPSAHLGITVP
TH_4080|M.thermoresistible__bu AVDVIVYATGFHVSDSY--KYVQIKGLNGEDIVDRFNREGPMAHRGTAVA
MAB_4476c|M.abscessus_ATCC_199 DVDCIVFATGFDVCKAG--TPFPIAGLDGRKLADEWSG-GAYAYKSVNVS
Mvan_1519|M.vanbaalenii_PYR-1 HLDAIVFATGYDVHLSG--PPFPVAGLNGRSLQQEWAG-HAEAYKSASAH
Mflv_3372|M.gilvum_PYR-GCK QIDTLVLCTGFDLWEAN-IPAIEIIGRDARNLGKWWRDYGFQAYQGVSIP
MAV_3378|M.avium_104 EIDVLILATGFKVMDPDSVPTFAVTGSGGRSLSRFWDEHRLQAYEGVTVP
MMAR_4565|M.marinum_M QISYVAECVDLLQRTAS--TRIEVLRSSQQVFNERAQLRPVQPYQP----
MUL_4425|M.ulcerans_Agy99 QISYVAECVDLLQRTAS--TRIEVLRSSQQVFNERAQLRPVQPYQP----
Mb0968c|M.bovis_AF2122/97 QARCVVECMKLMERTAS--RRIEVRRSSQQVFNERAQLKPAQPHRQT--G
Rv0943c|M.tuberculosis_H37Rv QARCVVECMKLMERTAS--RRIEVRRSSQQVFNERAQLKPAQPHRQT--G
: . . : : .:
MSMEG_4451|M.smegmatis_MC2_155 GFPNLFLMYGPNTNLGHSSIVYMLESQAAYLAAALRVMRAEGLASIDVRP
TH_4080|M.thermoresistible__bu DLPNAYLLLGPNTGLGHNSMVYMIESQINYVIEAIKAVDKAGAQALAPTR
MAB_4476c|M.abscessus_ATCC_199 GYPNLFFTFGPNSGPGHNSALVYMEAQIDYIVQAIGIVRAKDLLTLDVRK
Mvan_1519|M.vanbaalenii_PYR-1 GYPNLFFMTGPNSGPGHNSLLVYVEGQIAYAVDAITTILNRNLRYLDVRA
Mflv_3372|M.gilvum_PYR-GCK SFPNFLSLAGPYASSG-LSFFNTVEYQMRHMDRLFGELKRRNATTFEVTP
MAV_3378|M.avium_104 GFPNLFTVFGPYGYVG-SSYFALIEAQTHHIVRCLKRAQRLGATRVEVSE
MMAR_4565|M.marinum_M -LRAFDLSAGAPEDTGIPNIPNIYDGAATLEIGGVRHAVHVRLAGHLDPI
MUL_4425|M.ulcerans_Agy99 -LRAFDLSAGAPEDSGIPNIPNIYDGAATLEIGGVRHAVHVRLAGHLDPI
Mb0968c|M.bovis_AF2122/97 GLEAFDLSSAATEDD------QTYDGAATLTLAGARFRVRVRLTGHLDPI
Rv0943c|M.tuberculosis_H37Rv GLEAFDLSSAATEDD------QTYDGAATLTLAGARFRVRVRLTGHLDPI
.. :
MSMEG_4451|M.smegmatis_MC2_155 DAERTYNEWINDALTNTVWNSGG---CSSWYLDSRGRNSVMWPTFTFRFR
TH_4080|M.thermoresistible__bu EAQDRYNAELQARLGRSVWNTGG---CRSWYLDEHGNNRVLWGGFTWQYR
MAB_4476c|M.abscessus_ATCC_199 DRQDRFNEDIQRRLGKTTWNSG----CQSWYLTEDGKNTTMFPGFATQFA
Mvan_1519|M.vanbaalenii_PYR-1 DVQQRHNAQIQRRLTKTTWMSG----CHSWYLTADGFNASMYPGFATQYR
Mflv_3372|M.gilvum_PYR-GCK EANAKFRDRMSKLLGKTVFGLGDCAGSRSYYFSPSG-ETLVRPASTHQTN
MAV_3378|M.avium_104 EANDRYFAEMMRRRHRQIFWQDSCRLANSYYFDKNG-DVPLRPGTTPEVY
MMAR_4565|M.marinum_M DGNYHWQGTVLDPLPRDTLKQAR---AGTLTVGERSAAVRVIEQTPWGTH
MUL_4425|M.ulcerans_Agy99 DGNYHWQGTVLDPLPRDTLKQAR---AGTLTVGERSAAVRVIEQTPWGTH
Mb0968c|M.bovis_AF2122/97 DGNYHWQGTVFDSLPETSLTHAR---AATLTIGGRSAPARITEQTPWGTH
Rv0943c|M.tuberculosis_H37Rv DGNYHWQGTVFDSLPETSLTHAR---AATLTIGGRSAPARITEQTPWGTH
: : : . . : . . : .
MSMEG_4451|M.smegmatis_MC2_155 ARTRSFDVINYDTLRTRQQIRGVEQRCESQLADADREILAGQIRLAGEDE
TH_4080|M.thermoresistible__bu LATRTLDPAEYRFWG-----------------------------------
MAB_4476c|M.abscessus_ATCC_199 RQLRTVELDDYSFTSGAAAASAAKPPVDASIG------------------
Mvan_1519|M.vanbaalenii_PYR-1 RQMQ-FRAEDYTAVA-----------------------------------
Mflv_3372|M.gilvum_PYR-GCK RENDTFPLTDYTFA------------------------------------
MAV_3378|M.avium_104 WRSRRFDLDDYRFTG-----------------------------------
MMAR_4565|M.marinum_M SVAG-LGAPPYADSGR----------------------------------
MUL_4425|M.ulcerans_Agy99 SVAG-LGAPPYADSGR----------------------------------
Mb0968c|M.bovis_AF2122/97 SVAG-VGPPPYARSGPASATT-----------------------------
Rv0943c|M.tuberculosis_H37Rv SVAG-VGPPPYARSGPASATT-----------------------------
. *
MSMEG_4451|M.smegmatis_MC2_155 SVTPSTLRTVRRDQRYMTRGRIHAEVADLLDRTVAMNGE
TH_4080|M.thermoresistible__bu ---------------------------------------
MAB_4476c|M.abscessus_ATCC_199 ---------------------------------------
Mvan_1519|M.vanbaalenii_PYR-1 ---------------------------------------
Mflv_3372|M.gilvum_PYR-GCK ---------------------------------------
MAV_3378|M.avium_104 ---------------------------------------
MMAR_4565|M.marinum_M ---------------------------------------
MUL_4425|M.ulcerans_Agy99 ---------------------------------------
Mb0968c|M.bovis_AF2122/97 ---------------------------------------
Rv0943c|M.tuberculosis_H37Rv ---------------------------------------