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ELYQLRYFQAVAECGTLRGASEQLLVSQSAVSRAITLLEAEIGVQLFTRRGRTNELNRYGQALLVGSRLA QRSVSSAIDNVRELAGVSGGTVALGFLHSLGMQTVPHLIRLHHSRFPQARFELHQRSGQGVLSDLVSGVT DVSLSFPAAFEGYGEIAWQTLFTQQLYAVVSTDHPLAGRRLIRFPELAAYPFVVLDRDHTLRRIVDAACA RHGIDPTPAFEGTDVGTLRGLIGANLGVGVLPQATARPADIIEIAIDDAQLVRPIAIGWIADRCLPSSAV AFRETAFGCYGHRDSAAGV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_4020 | - | - | 100% (300) | LuxR family transcriptional regulator |
| M. ulcerans Agy99 | MUL_2998 | oxyR | 4e-15 | 26.45% (242) | hydrogen peroxide-inducible genes activator, OxyR |
| M. ulcerans Agy99 | MUL_3983 | - | 7e-12 | 26.29% (232) | putative regulatory protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0121 | oxyS | 1e-11 | 26.75% (243) | oxidative stress response regulatory protein OXYS |
| M. gilvum PYR-GCK | Mflv_3565 | - | 2e-30 | 32.38% (281) | LysR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0117 | oxyS | 1e-11 | 26.75% (243) | oxidative stress response regulatory protein OXYS |
| M. leprae Br4923 | MLBr_02041 | oxyR | 2e-17 | 25.78% (287) | putative LysR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_2707 | - | 5e-34 | 33.96% (265) | putative transcriptional regulator |
| M. marinum M | MMAR_4157 | - | 1e-167 | 99.00% (300) | LuxR family transcriptional regulator |
| M. avium 104 | MAV_1538 | - | 1e-32 | 30.69% (277) | transcriptional regulator, LysR family protein |
| M. smegmatis MC2 155 | MSMEG_0104 | - | 2e-37 | 33.80% (287) | transcriptional regulator, LysR family protein |
| M. thermoresistible (build 8) | TH_3504 | - | 4e-13 | 26.03% (219) | PUTATIVE putative transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_3362 | - | 4e-24 | 32.26% (248) | LysR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_4020|M.ulcerans_Agy99 -------MELYQLRYFQAVAECGTLRGASEQLLVSQSAVSRAITLLEAEI
MMAR_4157|M.marinum_M -------MELYQLRYFQAVAECGTLRGASEQLLVSQSAVSRAITLLEAEI
MAB_2707|M.abscessus_ATCC_1997 -------MAEGDYEWYITLAELQNVTAAADQLRLAQPTLTRMLARLERRL
MAV_1538|M.avium_104 -------MAVGDYEWFITLAELQHVTAAAEQLHVAQPTLTRMLARLEQRL
MSMEG_0104|M.smegmatis_MC2_155 -------MHLDELSWFVVLAETEHVTDAAAELGISQPTLSRALARLEDEV
Mflv_3565|M.gilvum_PYR-GCK -------MELRQLEYFVAIVEEGGFTRAASRERVAQPAVSAQIRRLERSV
Mvan_3362|M.vanbaalenii_PYR-1 -------MELRQLEYLVAVVEERSFTKAAQRERVAQPAVSAQIRRLERQV
Mb0121|M.bovis_AF2122/97 -------MLFRQLEYFVAVAQERHFARAAEKCYVSQPALSSAIAKLEREL
Rv0117|M.tuberculosis_H37Rv -------MLFRQLEYFVAVAQERHFARAAEKCYVSQPALSSAIAKLEREL
MLBr_02041|M.leprae_Br4923 MSDKSYQPTIAGLRAFVAVVEKGHFSAAASFLGVRQSTLSQALAALESGL
TH_3504|M.thermoresistible__bu --VPSPKIDLRRLAQFVAVAELGSFTRAAATLHLSQQALSSAVRALENDV
.:.: . *: : * ::: : ** :
MUL_4020|M.ulcerans_Agy99 GVQLFTRRGRTNELNRYGQALLVGSRLAQRSVSSAIDNVRELAGVSGGTV
MMAR_4157|M.marinum_M GVQLFTRRGRTNELNRYGQALLVGSRLAQRSVSSAIDNVRELAGVSGGTV
MAB_2707|M.abscessus_ATCC_1997 GVQLFDRHGKRLALNPFGRIFYQHARRAQLELDSARRAIDDLANPAEGEI
MAV_1538|M.avium_104 GVALFDRHGRRLSLNTYGRIFYEHARRAQLELDSARRAIADLADPAVGEI
MSMEG_0104|M.smegmatis_MC2_155 GVPLFDRVNRRLQLNAYGEILLEHARRTITEMRSATERIAAMRDPDTGLV
Mflv_3565|M.gilvum_PYR-GCK GQPLLTRTSREVRLTRAGEALLPHARAALAAVRDGRAAVDDVAGLLRGSV
Mvan_3362|M.vanbaalenii_PYR-1 GQPLLTRSHRGVRVTPAGAALLPHARAALAAVRDAQAAVDDVANLVRGAV
Mb0121|M.bovis_AF2122/97 NVTLINRGHSFEGLTREGERLVVWAKRILAEHAAFKAEVDAVRSGITGTL
Rv0117|M.tuberculosis_H37Rv NVTLINRGHSFEGLTREGERLVVWAKRILAEHAAFKAEVDAVRSGITGTL
MLBr_02041|M.leprae_Br4923 GVQLIERSTRRVFVTTQGRHLLPRAQAAIEAMDAFTAAAAGESDPLRGGM
TH_3504|M.thermoresistible__bu GADLFTRDGRRISLTTAGRTLLAEGKPLLAAARTVAEHVRQTEAAAQAHY
. *: * :. * : .: .
MUL_4020|M.ulcerans_Agy99 ALGFLHSLGMQTVPHLIRLHHSRFPQARFELHQ-RSGQGVLSDLVSGVTD
MMAR_4157|M.marinum_M ALGFLHSLGMQTVPHLIRLHHSRFPQARFELHQ-RSGQGVLSDLVSGVTD
MAB_2707|M.abscessus_ATCC_1997 RLGFLHTFGPTLIAGLIAGFATTSPHVRFVLEQ-GAAGSLDDLVATGDLD
MAV_1538|M.avium_104 RLAYLSSFGSTVVPRLIARFKESSPRVTFTLEE-GAAESIADRVRSGGVD
MSMEG_0104|M.smegmatis_MC2_155 RLAFLHSQAGSFVPDLLRRFRAHAPHVQFSLTQ-GAAHDLLERLAGGQVD
Mflv_3565|M.gilvum_PYR-GCK AIGTVT-LHPMNVAHLIAEFHADHPDVEITLGT-ATSDVLIAELGDGRLD
Mvan_3362|M.vanbaalenii_PYR-1 AIGTVT-LHPVDVARLMADFHAEHPGVEITLGT-DTSDVLLAKLEDGRLD
Mb0121|M.bovis_AF2122/97 RLGTVP-TASTTASLVLSAFCSAHPLAKVQVCSRLAATELYRRLREFELD
Rv0117|M.tuberculosis_H37Rv RLGTVP-TASTTASLVLSAFCSAHPLAKVQVCSRLAATELYRRLREFELD
MLBr_02041|M.leprae_Br4923 RLGLIPTVAPYVLPTMLTGLTHRLPTLTLRVVE-DQTEHLLTALREGALD
TH_3504|M.thermoresistible__bu VIGHTPALSGAEAYALIEPAVTAYPSTSFTLRQ-LYPDALTDAVFDGTVQ
:. :: * . : : : :
MUL_4020|M.ulcerans_Agy99 VSLSFPAAFEGYGEIAWQTLFTQQLYAVVSTDHPLAGRRLIRFPELAAYP
MMAR_4157|M.marinum_M VSLSFPAAFEGYGEIAWQTLFTQQLYAVVSTDHPLAGRRLIRFPELAAYP
MAB_2707|M.abscessus_ATCC_1997 VAIVSPRPRR--ANLGWRNLFRQRLGVAVPTDHRLAQAQDVSMVDLADEP
MAV_1538|M.avium_104 IGVVSPRPVE--RTLAWRSLFRQRLGVAVPDGHRFARGAAVSMVDLADEP
MSMEG_0104|M.smegmatis_MC2_155 LAITSPRP----EGFQWRGLYVERLCLAVPRGHRLASRSRITLADAGDEP
Mflv_3565|M.gilvum_PYR-GCK LAIVSIAVDEDLPGLEVAVITDEAVEAAVADGHPLAHRRSLSLEQLSRHP
Mvan_3362|M.vanbaalenii_PYR-1 AAIVSIGADEDPAGLEYEVITDEALEAAVTAQHRLARRKSLSLKQLCEYP
Mb0121|M.bovis_AF2122/97 AVIVHPETQDS-DDVDLVPLYEEQYVLLSPADMLPPGTSTLVWRDAAQLP
Rv0117|M.tuberculosis_H37Rv AVIVHPETQDS-DDVDLVPLYEEQYVLLSPADMLPPGTSTLVWRDAAQLP
MLBr_02041|M.leprae_Br4923 AAMIALPVET--AGIAEIPIYDEDFVLALPPGHPLSGKRRVPTTALAQLP
TH_3504|M.thermoresistible__bu LGLRRGVVPT--PELATAVIGYHRVRVAFVDSHPLAARESVDITELAREQ
: . : . . :
MUL_4020|M.ulcerans_Agy99 FVVLDRD--HTLRRIVDAACARHGIDPTPAFE-GTDVGTLRGLIGANLGV
MMAR_4157|M.marinum_M FVVLDRD--HTLRRIVDAACARHGIDPTLAFE-GTDVGTLRGLIGANLGV
MAB_2707|M.abscessus_ATCC_1997 FVAMHPG--FGMRRLLEELCAAAQFQPRIVLE-SSNLMTVAGLVAAGLGV
MAV_1538|M.avium_104 FVTMHPG--FGMRRLLDELCAAAQFRPRVALQ-APNLTTAASLVAAGLGI
MSMEG_0104|M.smegmatis_MC2_155 FVGLAPG--FGLRQLTEELCAEAGITPHVVFE-ATEIPTMEGLVAAGFGV
Mflv_3565|M.gilvum_PYR-GCK LISLPAG--TGLRTRLDTACAAAGLRPRIAFE-ATSPAELAELARHGLGV
Mvan_3362|M.vanbaalenii_PYR-1 VISLPAG--TGLRSRLDDACAAAGLRPRIAFE-ATSPLELADLARHGLGV
Mb0121|M.bovis_AF2122/97 LALLTAD--MRDRQVIDAAFADHAVSAIPQVE-TDSVASLFAQVATGNWA
Rv0117|M.tuberculosis_H37Rv LALLTAD--MRDRQVIDAAFADHAVSAIPQVE-TDSVASLFAQVATGNWA
MLBr_02041|M.leprae_Br4923 LLLLDEG--HCLRDQTLDICRKSGVQAELANTRAASLATAVQCVTGGLGV
TH_3504|M.thermoresistible__bu VALWAPPGTSYYSDFLMGACRRAGFEPDYVVSRVQGAATVAAPLTTG-GI
. . . .
MUL_4020|M.ulcerans_Agy99 GVLP------QATA--RPADIIEIAIDDAQLVRPIAIGWIADRCLPSSAV
MMAR_4157|M.marinum_M GVLP------QATA--RPADIIEIAIDDAQLVRPIAIGWIADRCLPSSAV
MAB_2707|M.abscessus_ATCC_1997 TVLP------VDAT-TYPPDLRMLRLIDADAHRDVGIVWSSGQPLSRPVR
MAV_1538|M.avium_104 SLVP------IDGS-SYPSGVSVKPLADADAYRDVGMIWDSGRPLPRSAR
MSMEG_0104|M.smegmatis_MC2_155 AVVP------VPHAGRAEPGAEYIALAQASAKRQLGLAWPADRPLPPAAE
Mflv_3565|M.gilvum_PYR-GCK AILP------QSMA-RGGSGLHALRLAPELRGRLVWAWRADGANPAARVL
Mvan_3362|M.vanbaalenii_PYR-1 AILP------RSMA-RGSAGLHPLRLSPELRGRLVWAWRTDISGPAARLL
Mb0121|M.bovis_AF2122/97 SIVPHTWLWAMPMSGPTGGEIRAVELVDPVLKAQIALATNALGPGSPVAR
Rv0117|M.tuberculosis_H37Rv SIVPHTWLWAMPMSGPTGGEIRAVELVDPVLKAQIALATNALGPGSPVAR
MLBr_02041|M.leprae_Br4923 TLLP----QSAAPVESVRSKLGLAQFAAPCPGRRIGLAFRSASGRSASYR
TH_3504|M.thermoresistible__bu AFVT------AAAGPTMNGRVQVVDLTPPLLVPVQALWQR------HTLS
.:. :
MUL_4020|M.ulcerans_Agy99 AFRETAFGCYGHRDSAAGV-------
MMAR_4157|M.marinum_M AFRETALGCYGHRVSAAGV-------
MAB_2707|M.abscessus_ATCC_1997 NFISHAVAST----------------
MAV_1538|M.avium_104 DFIAGAAAVGHGGW------------
MSMEG_0104|M.smegmatis_MC2_155 RFAQFVIRTTHDVE------------
Mflv_3565|M.gilvum_PYR-GCK GERARAMAVSPGSGAPAVVPGA----
Mvan_3362|M.vanbaalenii_PYR-1 NARARAMIAATG--TPAVIPGA----
Mb0121|M.bovis_AF2122/97 ALITCAQALALNEFFDTQLRGITRRR
Rv0117|M.tuberculosis_H37Rv ALITCAQALALNEFFDTQLRGITRRR
MLBr_02041|M.leprae_Br4923 QIAKIIGELISTEHHVRLVA------
TH_3504|M.thermoresistible__bu AIRDRILEGLG---------------