For questions or suggestions e-mail us at: ioerger@cs.tamu.edu

M. ulcerans Agy99 MUL_3861 (adhB_1)

annotation: zinc-containing alcohol dehydrogenase NAD dependent AdhB_1
coordinates: 4316070 - 4317224
length: 384

MRSRAAILHDVGEPWSVEEFELDAPRTAEVLVEMSAAGLCHTDDHILKGDMSAPNEVLRSRGLPTMFPTI
GGHEGSGIVREIGPGVTDFVPGDHVVMSFVAVCGQCRWCASGMEYLCDAGIGTLTPGMPTDGTFRHHTAD
GTPLGHLAKVGAFAEHTVVSRDSLVKIDPDLPLAPSALLSCAIPTGYGSAANRAGVRGGDTVVVLGAGGI
GTGAIQGARINGAAQIVAIDPVEFKQKSAYLFGATHGAGSISQAMALVRELTHGVMADSVLVSPSLITAD
DVRDALRLTCKGGTCVLAGMTSQLTRSVNIDLQEFILMNKTLAGTIFGSCNPRADIARLAGLYQSGQLQL
DEMITRRYRLDDINAAYTDLLNGDIVRGIIDFTI
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. ulcerans Agy99MUL_3861adhB_1-100% (384)zinc-containing alcohol dehydrogenase NAD dependent AdhB_1
M. ulcerans Agy99MUL_4872adhDe-15467.19% (384) zinc-type alcohol dehydrogenase AdhD
M. ulcerans Agy99MUL_0470adhB3e-9242.97% (384) zinc-containing alcohol dehydrogenase NAD- dependent AdhB

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0784cadhB2e-9343.08% (383) zinc-containing alcohol dehydrogenase NAD dependant ADHB
M. gilvum PYR-GCKMflv_1486-9e-9846.32% (380) alcohol dehydrogenase
M. tuberculosis H37RvRv0761cadhB2e-9343.08% (383) zinc-containing alcohol dehydrogenase NAD dependent ADHB
M. leprae Br4923MLBr_01784adhE23e-4931.66% (379) putative alcohol dehydrogenase (Zn dependent)
M. abscessus ATCC 19977MAB_2084-1e-8944.76% (382) zinc-type alcohol dehydrogenase AdhD
M. marinum MMMAR_3997adhB_10.097.40% (384) zinc-containing alcohol dehydrogenase NAD dependent AdhB_1
M. avium 104MAV_1614-0.084.64% (384) alcohol dehydrogenase B
M. smegmatis MC2 155MSMEG_3388-2e-9346.32% (380) S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol
M. thermoresistible (build 8)TH_4578-1e-10448.85% (391) PUTATIVE alcohol dehydrogenase B
M. vanbaalenii PYR-1Mvan_5270-3e-9846.58% (380) alcohol dehydrogenase

CLUSTAL 2.0.9 multiple sequence alignment


Mb0784c|M.bovis_AF2122/97           -------------------------------------------MKTKGAL
Rv0761c|M.tuberculosis_H37Rv        -------------------------------------------MKTKGAL
Mflv_1486|M.gilvum_PYR-GCK          -------------------------------------------MKTNAAI
Mvan_5270|M.vanbaalenii_PYR-1       -------------------------------------------MKTNAAI
MAB_2084|M.abscessus_ATCC_1997      -------------------------------------------MKTRAAV
MSMEG_3388|M.smegmatis_MC2_155      MHSDPSHIDLLGPATFTSRDRRPIGFPPLRCSRHKISWKEPSEMKTKAAV
MUL_3861|M.ulcerans_Agy99           -------------------------------------------MRSRAAI
MMAR_3997|M.marinum_M               -------------------------------------------MRSRAAI
MAV_1614|M.avium_104                -------------------------------------------MKSRAAI
TH_4578|M.thermoresistible__bu      -------------------------------------------MRTKAAV
MLBr_01784|M.leprae_Br4923          -----------------------------------------MSQTVRGVI
                                                                                  ...:

Mb0784c|M.bovis_AF2122/97           IWEFNQPWSVEEIEIGDPRKDEVKIQMEAAGMCRSDHHLVTGDIPMAG--
Rv0761c|M.tuberculosis_H37Rv        IWEFNQPWSVEEIEIGDPRKDEVKIQMEAAGMCRSDHHLVTGDIPMAG--
Mflv_1486|M.gilvum_PYR-GCK          LWEYGGDWTVEEIDLDPPGDGEVLVSWQATGLCHSDEHIRTGDLPAP---
Mvan_5270|M.vanbaalenii_PYR-1       LWEYGGDWTVEEIDLDPPGDGEVLVSWEATGLCHSDEHIRTGDLPAP---
MAB_2084|M.abscessus_ATCC_1997      LWGLEQKWEVEEVDLDPPGPGEVLVRLAATGLCHSDEHLVTGDLPIP---
MSMEG_3388|M.smegmatis_MC2_155      SLGVNRPFEIMELELDGPKEGEVLLKNVAAGLCHSDLHLTDGDMPPR---
MUL_3861|M.ulcerans_Agy99           LHDVGEPWSVEEFELDAPRTAEVLVEMSAAGLCHTDDHILKGDMSAPN--
MMAR_3997|M.marinum_M               LHDVGGPWSVEEFELDTPRTGEVLVEMSAAGLCHTDDHILKGDMSAPN--
MAV_1614|M.avium_104                LHDVGGPWSVEEFELDPPRAGEVLVQMAAAGLCHSDDHILKGDMSAPN--
TH_4578|M.thermoresistible__bu      LRGVGVDWEVTEIELDPPRAGEVLVKMAYAGICHSDEHFYTGDSVPSKEM
MLBr_01784|M.leprae_Br4923          SRKKDEPVELVDIVIPDPGPGEAVVDVTACGVCHTDLTYREGGINDR---
                                             : :. :  *   *. :     *:*::*     *.       

Mb0784c|M.bovis_AF2122/97           --------------FPVLGGHEGAGIVTEVGPGVDDFAPGDHVVLAFIPS
Rv0761c|M.tuberculosis_H37Rv        --------------FPVLGGHEGAGIVTEVGPGVDDFAPGDHVVLAFIPS
Mflv_1486|M.gilvum_PYR-GCK          --------------LPLIGGHEGAGIVREVGAGVVGLAPGDHVVASFLPA
Mvan_5270|M.vanbaalenii_PYR-1       --------------LPLIGGHEGAGIVREVGPGVVGLAPGDHVVASFLPA
MAB_2084|M.abscessus_ATCC_1997      --------------LPVVGGHEGAGTVVECGEGVEDLSEGDSVILTFLPS
MSMEG_3388|M.smegmatis_MC2_155      --------------YPIVGGHEGSAIVEDVGPGVTKVKPGDHVVCSYIPN
MUL_3861|M.ulcerans_Agy99           -EVLRSRGLPT--MFPTIGGHEGSGIVREIGPGVTDFVPGDHVVMSFVAV
MMAR_3997|M.marinum_M               -EVLRSRGLPT--MFPTIGGHEGSGIVREIGPGVTDFAPGDHVVMSFIAV
MAV_1614|M.avium_104                -EVMRSLGLPT--MFPTIGGHEGSGIVREVGEGVTDFAPGDHVVMSFVAV
TH_4578|M.thermoresistible__bu      EEMMRASGVPVPEWFPMLGGHEGAGVVEDVGPEVRTLKPGDHVAVSFLPA
MLBr_01784|M.leprae_Br4923          --------------YPFLLGHEAAGTVEVVGPGVTAVEPGDFVILNWRAV
                                                   * : ***.:. *   *  *  .  ** *   : . 

Mb0784c|M.bovis_AF2122/97           CGKCPSCQAGMRNLCDLGAGLLAGESVTDGSFRIQARG----QNVYPMTL
Rv0761c|M.tuberculosis_H37Rv        CGKCPSCQAGMRNLCDLGAGLLAGESVTDGSFRIQARG----QNVYPMTL
Mflv_1486|M.gilvum_PYR-GCK          CGRCRFCSTGHQNLCDLGAMIMAGTQL-DGTYRRHING----QDVGVMAL
Mvan_5270|M.vanbaalenii_PYR-1       CGRCRFCSTGHQNLCDLGAMIMAGTQL-DGTYRRHVRG----QDVGVMAL
MAB_2084|M.abscessus_ATCC_1997      CGRCSYCARGMGNLCELGAALMMGPQI-DGTYRFHARG----EDVGQMCL
MSMEG_3388|M.smegmatis_MC2_155      CGTCRYCATGRSNLCDMGATILDGRFP-DGTFRFHKDG----VDYGSLCL
MUL_3861|M.ulcerans_Agy99           CGQCRWCASGMEYLCDAGIGTLTPGMPTDGTFRHHTAD---GTPLGHLAK
MMAR_3997|M.marinum_M               CGQCRWCASGMEYLCDAGIGTLTPGMPTDGTFRHHTAD---GTPLGHLAK
MAV_1614|M.avium_104                CGQCRWCASGMEYLCDVGIGTMIPGMPTDGTFRHHTAG---GGNLGHIAK
TH_4578|M.thermoresistible__bu      CGSCRWCASGHTYLCDVGADLYSKRMTTDGTARRHLPDPDGDRDLMAMMQ
MLBr_01784|M.leprae_Br4923          CGQCRACKRGRPSYCFDTFNAQQKMTLIDGTELTPALG------------
                                    ** *  *  *    *             **:      .            

Mb0784c|M.bovis_AF2122/97           LGTFSPYMVVHRSSVVKIDPSVPFEVACLVGCGVTTGYGSAVRTADVRPG
Rv0761c|M.tuberculosis_H37Rv        LGTFSPYMVVHRSSVVKIDPSVPFEVACLVGCGVTTGYGSAVRTADVRPG
Mflv_1486|M.gilvum_PYR-GCK          VGTFSQYGTVPEASIVKIDDDIPLSRACLLGCGVTTGWGSAVNTADVSPG
Mvan_5270|M.vanbaalenii_PYR-1       VGTFSQYGTVPEASIVKIDDDIPLSRACLLGCGVTTGWGSAVNTADVSPG
MAB_2084|M.abscessus_ATCC_1997      LGTFSEYTVVPQASVVKIDGGIPLDRAALIGCGVTTGYGSAVRTGEVRAG
MSMEG_3388|M.smegmatis_MC2_155      LGSFAERTTVSQHSVVKVDEWIPLETAVLVGCGVPAGWGGPVYNNGIRPG
MUL_3861|M.ulcerans_Agy99           VGAFAEHTVVSRDSLVKIDPDLPLAPSALLSCAIPTGYGSAANRAGVRGG
MMAR_3997|M.marinum_M               VGAFAEHTVVSRDSLVKIDPDLPLAPSALLSCAIPTGYGSAANRAGVRGG
MAV_1614|M.avium_104                IGAFAEHTVVSTNSLVKIEQQLPLAPSALLSCAIPTGYGSAANRAGVCGG
TH_4578|M.thermoresistible__bu      VGTFAEYVVASERSLVKVHDWIPLAAASLVSCGVTTGFGSGSVAAGTQPG
MLBr_01784|M.leprae_Br4923          IGAFADKTLVHSGQCTKVDPAADPAVAGLLGCGVMAGLGAAINTAAVSRD
                                    :*:*:    .   . .*:.       : *:.*.: :* *.         .

Mb0784c|M.bovis_AF2122/97           DDVAIVGLGGVGMAALQGAVSAGARYVFAVEPVEWKRDQALKFGATHVYP
Rv0761c|M.tuberculosis_H37Rv        DDVAIVGLGGVGMAALQGAVSAGARYVFAVEPVEWKRDQALKFGATHVYP
Mflv_1486|M.gilvum_PYR-GCK          DTVVIIGLGGIGSGAIQGARLAGAEKIVVVEPVETKRDLAFRFGATHFVT
Mvan_5270|M.vanbaalenii_PYR-1       DTVVIIGLGGIGSGAIQGARLAGAEKIVVIEPVESKRELAFRFGATHFVT
MAB_2084|M.abscessus_ATCC_1997      DTVVVVGAGGIGMNAIQGARIAGALAIVAVDPVNFKREQASGFGATHTAA
MSMEG_3388|M.smegmatis_MC2_155      DTAVIYGIGGLGINAIQGAVMAGARYVVAVDPVEFKRDMALKFGATHAFA
MUL_3861|M.ulcerans_Agy99           DTVVVLGAGGIGTGAIQGARINGAAQIVAIDPVEFKQKSAYLFGATHGAG
MMAR_3997|M.marinum_M               DTVVVLGAGGIGTGAIQGARINGAAQIVAVDPVEFKQKSAHLFGATHGAG
MAV_1614|M.avium_104                DAVVVIGAGGIGTGAIQGARISGAAQIVAVDPVEFKQKSALRFGATHSVA
TH_4578|M.thermoresistible__bu      DTVVVVGVGGIGMNAVQGARTAGAKHIVAVDPVEFKREIAPTFGATHAVA
MLBr_01784|M.leprae_Br4923          DTVAVIGCGGVGDAAISGAALVGANRIIAVDIDDTKLEWARTFGATHTVN
                                    * ..: * **:*  *:.**   **  :..::  : * . *  *****   

Mb0784c|M.bovis_AF2122/97           DIN-AALMGIAEVTYGLMAQKVIITVGKLDGADVDSYLTITAKGGTCVLT
Rv0761c|M.tuberculosis_H37Rv        DIN-AALMGIAEVTYGLMAQKVIITVGKLDGADVDSYLTITAKGGTCVLT
Mflv_1486|M.gilvum_PYR-GCK          SME-EATALVAELTRGVMADSAILTVGLLAGSMLEEAANIIRKGGAVVMT
Mvan_5270|M.vanbaalenii_PYR-1       SME-EATALVADLTRGVMADSAILTVGLLEGSMLEEAANIIRKGGAVVMT
MAB_2084|M.abscessus_ATCC_1997      SMD-EAWSLVSDMTRGKLADVCILTTDVAEGSYTAEALALVGKRGRVVVT
MSMEG_3388|M.smegmatis_MC2_155      TAE-EAHEAVREITWGQMADGALIFVGTPDEKVVSDAFNVIGKGGTVSLA
MUL_3861|M.ulcerans_Agy99           SIS-QAMALVRELTHGVMADSVLVSPSLITADDVRDALRLTCKGGTCVLA
MMAR_3997|M.marinum_M               SIS-EAMALVRELTHGVMADSVLVSPSLITADDVRDALRLTRKGGTCVLA
MAV_1614|M.avium_104                TIA-EALDLVRDLTYGVMADAVVVSPSLITADDVRDALKLTRKGGTCVLT
TH_4578|M.thermoresistible__bu      DIG-AALDLVKDITWGVMADRVVLTPGVVPPDMVMAAMMLLRKGGTCVLT
MLBr_01784|M.leprae_Br4923          ALELEVVKTIQDLTSGFGVDVVIDTVGRPE--TWKQAFYARDLAGTVVLV
                                         .   : ::* *  .:  :   .                 *   :.

Mb0784c|M.bovis_AF2122/97           AIGSLVDTQVTLNLAMLTLLQKNIQGTIFGGGNPHYDIPKLLSMYKAGKL
Rv0761c|M.tuberculosis_H37Rv        AIGSLVDTQVTLNLAMLTLLQKNIQGTIFGGGNPHYDIPKLLSMYKAGKL
Mflv_1486|M.gilvum_PYR-GCK          ALSTMADNQPTLGMMMFTLFQKRLLGSLYGEANPRADIPRLLSLYREGKL
Mvan_5270|M.vanbaalenii_PYR-1       ALSTMADNQPTLGMMMFTLFQKRLLGSLYGEANPRADIPRLLSLYREGKL
MAB_2084|M.abscessus_ATCC_1997      AIGHPDESSISGSLLEMTLYEKQIRGALYGSSNAPHDIPRLVELYSAGLL
MSMEG_3388|M.smegmatis_MC2_155      SLADPAKLTVHVSGMEMTLMEKTIKGCLFGSSNPQYDIVRLLRLYDEGKL
MUL_3861|M.ulcerans_Agy99           GMTSQLTRSVNIDLQEFILMNKTLAGTIFGSCNPRADIARLAGLYQSGQL
MMAR_3997|M.marinum_M               GMTSQLTRSVNIDLQEFILMNKTLAGTIFGSCNPRADIARLAGLYQSGQL
MAV_1614|M.avium_104                GMTSQLTRSVNIELQDFILMNKTLAGTIFGSCNPRADIARLARLYQTGQL
TH_4578|M.thermoresistible__bu      GMAKVSDLNVPLSLPDMVSSCKTLKGVLYGEMNPRDAMPKLLSMYEAGTL
MLBr_01784|M.leprae_Br4923          GVPTP-DMRLDMPLLDFFSHGGSLKSSWYGDCLPERDFPTLVDLYLQGRL
                                    .:              :      : .  :*   .   :  *  :*  * *

Mb0784c|M.bovis_AF2122/97           NLDDMVTTAYKLEQINDGYQDMLNGKNIRGVIRYTDDDR
Rv0761c|M.tuberculosis_H37Rv        NLDDMVTTAYKLEQINDGYQDMLNGKNIRGVIRYTDDDR
Mflv_1486|M.gilvum_PYR-GCK          LLDETVTHEYKLAEVNEGYEDMREGRNIRGVILHDH---
Mvan_5270|M.vanbaalenii_PYR-1       LLDETVTHEYKLAEVNEGYEDMRAGRNIRGVILHDH---
MAB_2084|M.abscessus_ATCC_1997      KLDELVTREYSLDQINEGYQDMRSGRNIRGLVRF-----
MSMEG_3388|M.smegmatis_MC2_155      KLDELITTRYRLEDINQGYDDLRAGVNIRGVIIHDPEA-
MUL_3861|M.ulcerans_Agy99           QLDEMITRRYRLDDINAAYTDLLNGDIVRGIIDFTI---
MMAR_3997|M.marinum_M               QLDDMITRRYRLDDINAAYTDLLNGDIVRGIIDFTI---
MAV_1614|M.avium_104                QLDEMITKRYRLDEVNDAYDDLLNGKIVRGIIDFGIA--
TH_4578|M.thermoresistible__bu      KLDELITNRYKLDDINEAMRDLRAGKNIRGVIAFD----
MLBr_01784|M.leprae_Br4923          PLGKFVSERIGLGDVEEAFHKIHGGKVLRSVVML-----
                                     *.. ::    * ::: .  .:  *  :*.::