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MRSRAAILHDVGGPWSVEEFELDTPRTGEVLVEMSAAGLCHTDDHILKGDMSAPNEVLRSRGLPTMFPTI GGHEGSGIVREIGPGVTDFAPGDHVVMSFIAVCGQCRWCASGMEYLCDAGIGTLTPGMPTDGTFRHHTAD GTPLGHLAKVGAFAEHTVVSRDSLVKIDPDLPLAPSALLSCAIPTGYGSAANRAGVRGGDTVVVLGAGGI GTGAIQGARINGAAQIVAVDPVEFKQKSAHLFGATHGAGSISEAMALVRELTHGVMADSVLVSPSLITAD DVRDALRLTRKGGTCVLAGMTSQLTRSVNIDLQEFILMNKTLAGTIFGSCNPRADIARLAGLYQSGQLQL DDMITRRYRLDDINAAYTDLLNGDIVRGIIDFTI
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3997 | adhB_1 | - | 100% (384) | zinc-containing alcohol dehydrogenase NAD dependent AdhB_1 |
| M. marinum M | MMAR_0241 | adhD | e-159 | 69.79% (384) | zinc-type alcohol dehydrogenase AdhD |
| M. marinum M | MMAR_0127 | adhD_1 | 5e-94 | 45.00% (380) | zinc-containing alcohol dehydrogenase NAD- dependent, |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0784c | adhB | 5e-94 | 44.13% (383) | zinc-containing alcohol dehydrogenase NAD dependant ADHB |
| M. gilvum PYR-GCK | Mflv_1486 | - | 1e-100 | 47.63% (380) | alcohol dehydrogenase |
| M. tuberculosis H37Rv | Rv0761c | adhB | 5e-94 | 44.13% (383) | zinc-containing alcohol dehydrogenase NAD dependent ADHB |
| M. leprae Br4923 | MLBr_01784 | adhE2 | 5e-50 | 32.19% (379) | putative alcohol dehydrogenase (Zn dependent) |
| M. abscessus ATCC 19977 | MAB_2084 | - | 1e-90 | 45.29% (382) | zinc-type alcohol dehydrogenase AdhD |
| M. avium 104 | MAV_1614 | - | 0.0 | 85.68% (384) | alcohol dehydrogenase B |
| M. smegmatis MC2 155 | MSMEG_3388 | - | 5e-94 | 47.11% (380) | S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol |
| M. thermoresistible (build 8) | TH_4578 | - | 1e-106 | 49.36% (391) | PUTATIVE alcohol dehydrogenase B |
| M. ulcerans Agy99 | MUL_3861 | adhB_1 | 0.0 | 97.40% (384) | zinc-containing alcohol dehydrogenase NAD dependent AdhB_1 |
| M. vanbaalenii PYR-1 | Mvan_5270 | - | 1e-100 | 47.37% (380) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0784c|M.bovis_AF2122/97 -------------------------------------------MKTKGAL
Rv0761c|M.tuberculosis_H37Rv -------------------------------------------MKTKGAL
Mflv_1486|M.gilvum_PYR-GCK -------------------------------------------MKTNAAI
Mvan_5270|M.vanbaalenii_PYR-1 -------------------------------------------MKTNAAI
MAB_2084|M.abscessus_ATCC_1997 -------------------------------------------MKTRAAV
MSMEG_3388|M.smegmatis_MC2_155 MHSDPSHIDLLGPATFTSRDRRPIGFPPLRCSRHKISWKEPSEMKTKAAV
MMAR_3997|M.marinum_M -------------------------------------------MRSRAAI
MUL_3861|M.ulcerans_Agy99 -------------------------------------------MRSRAAI
MAV_1614|M.avium_104 -------------------------------------------MKSRAAI
TH_4578|M.thermoresistible__bu -------------------------------------------MRTKAAV
MLBr_01784|M.leprae_Br4923 -----------------------------------------MSQTVRGVI
...:
Mb0784c|M.bovis_AF2122/97 IWEFNQPWSVEEIEIGDPRKDEVKIQMEAAGMCRSDHHLVTGDIPMAG--
Rv0761c|M.tuberculosis_H37Rv IWEFNQPWSVEEIEIGDPRKDEVKIQMEAAGMCRSDHHLVTGDIPMAG--
Mflv_1486|M.gilvum_PYR-GCK LWEYGGDWTVEEIDLDPPGDGEVLVSWQATGLCHSDEHIRTGDLPAP---
Mvan_5270|M.vanbaalenii_PYR-1 LWEYGGDWTVEEIDLDPPGDGEVLVSWEATGLCHSDEHIRTGDLPAP---
MAB_2084|M.abscessus_ATCC_1997 LWGLEQKWEVEEVDLDPPGPGEVLVRLAATGLCHSDEHLVTGDLPIP---
MSMEG_3388|M.smegmatis_MC2_155 SLGVNRPFEIMELELDGPKEGEVLLKNVAAGLCHSDLHLTDGDMPPR---
MMAR_3997|M.marinum_M LHDVGGPWSVEEFELDTPRTGEVLVEMSAAGLCHTDDHILKGDMSAPN--
MUL_3861|M.ulcerans_Agy99 LHDVGEPWSVEEFELDAPRTAEVLVEMSAAGLCHTDDHILKGDMSAPN--
MAV_1614|M.avium_104 LHDVGGPWSVEEFELDPPRAGEVLVQMAAAGLCHSDDHILKGDMSAPN--
TH_4578|M.thermoresistible__bu LRGVGVDWEVTEIELDPPRAGEVLVKMAYAGICHSDEHFYTGDSVPSKEM
MLBr_01784|M.leprae_Br4923 SRKKDEPVELVDIVIPDPGPGEAVVDVTACGVCHTDLTYREGGINDR---
: :. : * *. : *:*::* *.
Mb0784c|M.bovis_AF2122/97 --------------FPVLGGHEGAGIVTEVGPGVDDFAPGDHVVLAFIPS
Rv0761c|M.tuberculosis_H37Rv --------------FPVLGGHEGAGIVTEVGPGVDDFAPGDHVVLAFIPS
Mflv_1486|M.gilvum_PYR-GCK --------------LPLIGGHEGAGIVREVGAGVVGLAPGDHVVASFLPA
Mvan_5270|M.vanbaalenii_PYR-1 --------------LPLIGGHEGAGIVREVGPGVVGLAPGDHVVASFLPA
MAB_2084|M.abscessus_ATCC_1997 --------------LPVVGGHEGAGTVVECGEGVEDLSEGDSVILTFLPS
MSMEG_3388|M.smegmatis_MC2_155 --------------YPIVGGHEGSAIVEDVGPGVTKVKPGDHVVCSYIPN
MMAR_3997|M.marinum_M -EVLRSRGLPT--MFPTIGGHEGSGIVREIGPGVTDFAPGDHVVMSFIAV
MUL_3861|M.ulcerans_Agy99 -EVLRSRGLPT--MFPTIGGHEGSGIVREIGPGVTDFVPGDHVVMSFVAV
MAV_1614|M.avium_104 -EVMRSLGLPT--MFPTIGGHEGSGIVREVGEGVTDFAPGDHVVMSFVAV
TH_4578|M.thermoresistible__bu EEMMRASGVPVPEWFPMLGGHEGAGVVEDVGPEVRTLKPGDHVAVSFLPA
MLBr_01784|M.leprae_Br4923 --------------YPFLLGHEAAGTVEVVGPGVTAVEPGDFVILNWRAV
* : ***.:. * * * . ** * : .
Mb0784c|M.bovis_AF2122/97 CGKCPSCQAGMRNLCDLGAGLLAGESVTDGSFRIQARG----QNVYPMTL
Rv0761c|M.tuberculosis_H37Rv CGKCPSCQAGMRNLCDLGAGLLAGESVTDGSFRIQARG----QNVYPMTL
Mflv_1486|M.gilvum_PYR-GCK CGRCRFCSTGHQNLCDLGAMIMAGTQL-DGTYRRHING----QDVGVMAL
Mvan_5270|M.vanbaalenii_PYR-1 CGRCRFCSTGHQNLCDLGAMIMAGTQL-DGTYRRHVRG----QDVGVMAL
MAB_2084|M.abscessus_ATCC_1997 CGRCSYCARGMGNLCELGAALMMGPQI-DGTYRFHARG----EDVGQMCL
MSMEG_3388|M.smegmatis_MC2_155 CGTCRYCATGRSNLCDMGATILDGRFP-DGTFRFHKDG----VDYGSLCL
MMAR_3997|M.marinum_M CGQCRWCASGMEYLCDAGIGTLTPGMPTDGTFRHHTAD---GTPLGHLAK
MUL_3861|M.ulcerans_Agy99 CGQCRWCASGMEYLCDAGIGTLTPGMPTDGTFRHHTAD---GTPLGHLAK
MAV_1614|M.avium_104 CGQCRWCASGMEYLCDVGIGTMIPGMPTDGTFRHHTAG---GGNLGHIAK
TH_4578|M.thermoresistible__bu CGSCRWCASGHTYLCDVGADLYSKRMTTDGTARRHLPDPDGDRDLMAMMQ
MLBr_01784|M.leprae_Br4923 CGQCRACKRGRPSYCFDTFNAQQKMTLIDGTELTPALG------------
** * * * * **: .
Mb0784c|M.bovis_AF2122/97 LGTFSPYMVVHRSSVVKIDPSVPFEVACLVGCGVTTGYGSAVRTADVRPG
Rv0761c|M.tuberculosis_H37Rv LGTFSPYMVVHRSSVVKIDPSVPFEVACLVGCGVTTGYGSAVRTADVRPG
Mflv_1486|M.gilvum_PYR-GCK VGTFSQYGTVPEASIVKIDDDIPLSRACLLGCGVTTGWGSAVNTADVSPG
Mvan_5270|M.vanbaalenii_PYR-1 VGTFSQYGTVPEASIVKIDDDIPLSRACLLGCGVTTGWGSAVNTADVSPG
MAB_2084|M.abscessus_ATCC_1997 LGTFSEYTVVPQASVVKIDGGIPLDRAALIGCGVTTGYGSAVRTGEVRAG
MSMEG_3388|M.smegmatis_MC2_155 LGSFAERTTVSQHSVVKVDEWIPLETAVLVGCGVPAGWGGPVYNNGIRPG
MMAR_3997|M.marinum_M VGAFAEHTVVSRDSLVKIDPDLPLAPSALLSCAIPTGYGSAANRAGVRGG
MUL_3861|M.ulcerans_Agy99 VGAFAEHTVVSRDSLVKIDPDLPLAPSALLSCAIPTGYGSAANRAGVRGG
MAV_1614|M.avium_104 IGAFAEHTVVSTNSLVKIEQQLPLAPSALLSCAIPTGYGSAANRAGVCGG
TH_4578|M.thermoresistible__bu VGTFAEYVVASERSLVKVHDWIPLAAASLVSCGVTTGFGSGSVAAGTQPG
MLBr_01784|M.leprae_Br4923 IGAFADKTLVHSGQCTKVDPAADPAVAGLLGCGVMAGLGAAINTAAVSRD
:*:*: . . .*:. : *:.*.: :* *. .
Mb0784c|M.bovis_AF2122/97 DDVAIVGLGGVGMAALQGAVSAGARYVFAVEPVEWKRDQALKFGATHVYP
Rv0761c|M.tuberculosis_H37Rv DDVAIVGLGGVGMAALQGAVSAGARYVFAVEPVEWKRDQALKFGATHVYP
Mflv_1486|M.gilvum_PYR-GCK DTVVIIGLGGIGSGAIQGARLAGAEKIVVVEPVETKRDLAFRFGATHFVT
Mvan_5270|M.vanbaalenii_PYR-1 DTVVIIGLGGIGSGAIQGARLAGAEKIVVIEPVESKRELAFRFGATHFVT
MAB_2084|M.abscessus_ATCC_1997 DTVVVVGAGGIGMNAIQGARIAGALAIVAVDPVNFKREQASGFGATHTAA
MSMEG_3388|M.smegmatis_MC2_155 DTAVIYGIGGLGINAIQGAVMAGARYVVAVDPVEFKRDMALKFGATHAFA
MMAR_3997|M.marinum_M DTVVVLGAGGIGTGAIQGARINGAAQIVAVDPVEFKQKSAHLFGATHGAG
MUL_3861|M.ulcerans_Agy99 DTVVVLGAGGIGTGAIQGARINGAAQIVAIDPVEFKQKSAYLFGATHGAG
MAV_1614|M.avium_104 DAVVVIGAGGIGTGAIQGARISGAAQIVAVDPVEFKQKSALRFGATHSVA
TH_4578|M.thermoresistible__bu DTVVVVGVGGIGMNAVQGARTAGAKHIVAVDPVEFKREIAPTFGATHAVA
MLBr_01784|M.leprae_Br4923 DTVAVIGCGGVGDAAISGAALVGANRIIAVDIDDTKLEWARTFGATHTVN
* ..: * **:* *:.** ** :..:: : * . * *****
Mb0784c|M.bovis_AF2122/97 DIN-AALMGIAEVTYGLMAQKVIITVGKLDGADVDSYLTITAKGGTCVLT
Rv0761c|M.tuberculosis_H37Rv DIN-AALMGIAEVTYGLMAQKVIITVGKLDGADVDSYLTITAKGGTCVLT
Mflv_1486|M.gilvum_PYR-GCK SME-EATALVAELTRGVMADSAILTVGLLAGSMLEEAANIIRKGGAVVMT
Mvan_5270|M.vanbaalenii_PYR-1 SME-EATALVADLTRGVMADSAILTVGLLEGSMLEEAANIIRKGGAVVMT
MAB_2084|M.abscessus_ATCC_1997 SMD-EAWSLVSDMTRGKLADVCILTTDVAEGSYTAEALALVGKRGRVVVT
MSMEG_3388|M.smegmatis_MC2_155 TAE-EAHEAVREITWGQMADGALIFVGTPDEKVVSDAFNVIGKGGTVSLA
MMAR_3997|M.marinum_M SIS-EAMALVRELTHGVMADSVLVSPSLITADDVRDALRLTRKGGTCVLA
MUL_3861|M.ulcerans_Agy99 SIS-QAMALVRELTHGVMADSVLVSPSLITADDVRDALRLTCKGGTCVLA
MAV_1614|M.avium_104 TIA-EALDLVRDLTYGVMADAVVVSPSLITADDVRDALKLTRKGGTCVLT
TH_4578|M.thermoresistible__bu DIG-AALDLVKDITWGVMADRVVLTPGVVPPDMVMAAMMLLRKGGTCVLT
MLBr_01784|M.leprae_Br4923 ALELEVVKTIQDLTSGFGVDVVIDTVGRPE--TWKQAFYARDLAGTVVLV
. : ::* * .: : . * :.
Mb0784c|M.bovis_AF2122/97 AIGSLVDTQVTLNLAMLTLLQKNIQGTIFGGGNPHYDIPKLLSMYKAGKL
Rv0761c|M.tuberculosis_H37Rv AIGSLVDTQVTLNLAMLTLLQKNIQGTIFGGGNPHYDIPKLLSMYKAGKL
Mflv_1486|M.gilvum_PYR-GCK ALSTMADNQPTLGMMMFTLFQKRLLGSLYGEANPRADIPRLLSLYREGKL
Mvan_5270|M.vanbaalenii_PYR-1 ALSTMADNQPTLGMMMFTLFQKRLLGSLYGEANPRADIPRLLSLYREGKL
MAB_2084|M.abscessus_ATCC_1997 AIGHPDESSISGSLLEMTLYEKQIRGALYGSSNAPHDIPRLVELYSAGLL
MSMEG_3388|M.smegmatis_MC2_155 SLADPAKLTVHVSGMEMTLMEKTIKGCLFGSSNPQYDIVRLLRLYDEGKL
MMAR_3997|M.marinum_M GMTSQLTRSVNIDLQEFILMNKTLAGTIFGSCNPRADIARLAGLYQSGQL
MUL_3861|M.ulcerans_Agy99 GMTSQLTRSVNIDLQEFILMNKTLAGTIFGSCNPRADIARLAGLYQSGQL
MAV_1614|M.avium_104 GMTSQLTRSVNIELQDFILMNKTLAGTIFGSCNPRADIARLARLYQTGQL
TH_4578|M.thermoresistible__bu GMAKVSDLNVPLSLPDMVSSCKTLKGVLYGEMNPRDAMPKLLSMYEAGTL
MLBr_01784|M.leprae_Br4923 GVPTP-DMRLDMPLLDFFSHGGSLKSSWYGDCLPERDFPTLVDLYLQGRL
.: : : . :* . : * :* * *
Mb0784c|M.bovis_AF2122/97 NLDDMVTTAYKLEQINDGYQDMLNGKNIRGVIRYTDDDR
Rv0761c|M.tuberculosis_H37Rv NLDDMVTTAYKLEQINDGYQDMLNGKNIRGVIRYTDDDR
Mflv_1486|M.gilvum_PYR-GCK LLDETVTHEYKLAEVNEGYEDMREGRNIRGVILHDH---
Mvan_5270|M.vanbaalenii_PYR-1 LLDETVTHEYKLAEVNEGYEDMRAGRNIRGVILHDH---
MAB_2084|M.abscessus_ATCC_1997 KLDELVTREYSLDQINEGYQDMRSGRNIRGLVRF-----
MSMEG_3388|M.smegmatis_MC2_155 KLDELITTRYRLEDINQGYDDLRAGVNIRGVIIHDPEA-
MMAR_3997|M.marinum_M QLDDMITRRYRLDDINAAYTDLLNGDIVRGIIDFTI---
MUL_3861|M.ulcerans_Agy99 QLDEMITRRYRLDDINAAYTDLLNGDIVRGIIDFTI---
MAV_1614|M.avium_104 QLDEMITKRYRLDEVNDAYDDLLNGKIVRGIIDFGIA--
TH_4578|M.thermoresistible__bu KLDELITNRYKLDDINEAMRDLRAGKNIRGVIAFD----
MLBr_01784|M.leprae_Br4923 PLGKFVSERIGLGDVEEAFHKIHGGKVLRSVVML-----
*.. :: * ::: . .: * :*.::