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HSDPSHIDLLGPATFTSRDRRPIGFPPLRCSRHKISWKEPSEMKTKAAVSLGVNRPFEIMELELDGPKEG EVLLKNVAAGLCHSDLHLTDGDMPPRYPIVGGHEGSAIVEDVGPGVTKVKPGDHVVCSYIPNCGTCRYCA TGRSNLCDMGATILDGRFPDGTFRFHKDGVDYGSLCLLGSFAERTTVSQHSVVKVDEWIPLETAVLVGCG VPAGWGGPVYNNGIRPGDTAVIYGIGGLGINAIQGAVMAGARYVVAVDPVEFKRDMALKFGATHAFATAE EAHEAVREITWGQMADGALIFVGTPDEKVVSDAFNVIGKGGTVSLASLADPAKLTVHVSGMEMTLMEKTI KGCLFGSSNPQYDIVRLLRLYDEGKLKLDELITTRYRLEDINQGYDDLRAGVNIRGVIIHDPEA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3388 | - | - | 100% (415) | S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5866 | - | 6e-97 | 47.01% (368) | alcohol dehydrogenase B |
| M. smegmatis MC2 155 | MSMEG_4167 | - | 8e-96 | 46.09% (371) | alcohol dehydrogenase B |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3113 | adhD | 1e-163 | 73.37% (368) | zinc-type alcohol dehydrogenase AdhD |
| M. gilvum PYR-GCK | Mflv_4588 | - | 1e-105 | 50.82% (366) | alcohol dehydrogenase |
| M. tuberculosis H37Rv | Rv3086 | adhD | 1e-163 | 73.37% (368) | zinc-type alcohol dehydrogenase AdhD |
| M. leprae Br4923 | MLBr_01784 | adhE2 | 9e-48 | 30.81% (370) | putative alcohol dehydrogenase (Zn dependent) |
| M. abscessus ATCC 19977 | MAB_2084 | - | 1e-103 | 48.91% (366) | zinc-type alcohol dehydrogenase AdhD |
| M. marinum M | MMAR_0127 | adhD_1 | 1e-167 | 74.80% (369) | zinc-containing alcohol dehydrogenase NAD- dependent, |
| M. avium 104 | MAV_0705 | - | 1e-96 | 48.10% (368) | alcohol dehydrogenase B |
| M. thermoresistible (build 8) | TH_2499 | - | 1e-107 | 52.16% (370) | PUTATIVE Alcohol dehydrogenase GroES domain protein |
| M. ulcerans Agy99 | MUL_3861 | adhB_1 | 1e-93 | 46.32% (380) | zinc-containing alcohol dehydrogenase NAD dependent AdhB_1 |
| M. vanbaalenii PYR-1 | Mvan_0013 | - | 1e-111 | 54.32% (370) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3113|M.bovis_AF2122/97 -------------------------------------------MKTTAAV
Rv3086|M.tuberculosis_H37Rv -------------------------------------------MKTTAAV
MMAR_0127|M.marinum_M -------------------------------------------MKTTAAV
MSMEG_3388|M.smegmatis_MC2_155 MHSDPSHIDLLGPATFTSRDRRPIGFPPLRCSRHKISWKEPSEMKTKAAV
Mflv_4588|M.gilvum_PYR-GCK -------------------------------------------MKTRAAV
MAB_2084|M.abscessus_ATCC_1997 -------------------------------------------MKTRAAV
Mvan_0013|M.vanbaalenii_PYR-1 -------------------------------------------MKTKAAV
TH_2499|M.thermoresistible__bu -------------------------------------------MKMNAAV
MAV_0705|M.avium_104 -------------------------------------------MKTKGAL
MUL_3861|M.ulcerans_Agy99 -------------------------------------------MRSRAAI
MLBr_01784|M.leprae_Br4923 -----------------------------------------MSQTVRGVI
..:
Mb3113|M.bovis_AF2122/97 LFEAGKPFELMELDLDGPGPGEVLVKYTAAGLCHSDLHLTDGDLPPR---
Rv3086|M.tuberculosis_H37Rv LFEAGKPFELMELDLDGPGPGEVLVKYTAAGLCHSDLHLTDGDLPPR---
MMAR_0127|M.marinum_M LLEAGKPFEIMELELDGPRVGEVLIKYTAAGLCHSDLHLTDGDLPPR---
MSMEG_3388|M.smegmatis_MC2_155 SLGVNRPFEIMELELDGPKEGEVLLKNVAAGLCHSDLHLTDGDMPPR---
Mflv_4588|M.gilvum_PYR-GCK LWGLGEKWEVDEIELDPPGVDEVLVQLTASGLCHSDEHLVTGDLPFP---
MAB_2084|M.abscessus_ATCC_1997 LWGLEQKWEVEEVDLDPPGPGEVLVRLAATGLCHSDEHLVTGDLPIP---
Mvan_0013|M.vanbaalenii_PYR-1 LWGLHQKWEVEELELDAPRAQEVLVKLTASGLCHSDDHLVTGDMPMN---
TH_2499|M.thermoresistible__bu LWDVNGDWSIEEVELDGPQEGEVLVSFTATGMCHSDHHVRTGDFPAP---
MAV_0705|M.avium_104 IWEFNQPWSIEEIEIGDPQAHEVKIQMEAAGMCHSDHHLVTGGIPMAG--
MUL_3861|M.ulcerans_Agy99 LHDVGEPWSVEEFELDAPRTAEVLVEMSAAGLCHTDDHILKGDMSAPNEV
MLBr_01784|M.leprae_Br4923 SRKKDEPVELVDIVIPDPGPGEAVVDVTACGVCHTDLTYREGGINDR---
.: :. : * *. : * *:**:* *.:
Mb3113|M.bovis_AF2122/97 ---------FPIVGGHEGSGVIEEVGAGVTRVKPGDHVVCSFIPNCGTCR
Rv3086|M.tuberculosis_H37Rv ---------FPIVGGHEGSGVIEEVGAGVTRVKPGDHVVCSFIPNCGTCR
MMAR_0127|M.marinum_M ---------YPIVGGHEGSGVIEEVGPGVSKVKPGDHVVCSFIPNCGTCR
MSMEG_3388|M.smegmatis_MC2_155 ---------YPIVGGHEGSAIVEDVGPGVTKVKPGDHVVCSYIPNCGTCR
Mflv_4588|M.gilvum_PYR-GCK ---------LPVVGGHEGAGTVVEVGAGVEDLAVGDSVILTFLPSCGHCS
MAB_2084|M.abscessus_ATCC_1997 ---------LPVVGGHEGAGTVVECGEGVEDLSEGDSVILTFLPSCGRCS
Mvan_0013|M.vanbaalenii_PYR-1 ---------LPVVGGHEGAGVVVDVGPGVTEVEAGDHVVLSFIPACGRCT
TH_2499|M.thermoresistible__bu ---------LPIIGGHEGAGVVQEVGPGVRDLKPGDHVVASFLPACGRCR
MAV_0705|M.avium_104 ---------FPVLGGHEGAGIVTEVGPGVEDIAPGDHVVLSFIPSCGSCP
MUL_3861|M.ulcerans_Agy99 LRSRGLPTMFPTIGGHEGSGIVREIGPGVTDFVPGDHVVMSFVAVCGQCR
MLBr_01784|M.leprae_Br4923 ---------YPFLLGHEAAGTVEVVGPGVTAVEPGDFVILNWRAVCGQCR
* : ***.:. : * ** . ** *: .: . ** *
Mb3113|M.bovis_AF2122/97 YCCTGRQNLCDMGATILEGCMP-DGSFRFH----SQGTDFGAMCMLGTFA
Rv3086|M.tuberculosis_H37Rv YCCTGRQNLCDMGATILEGCMP-DGSFRFH----SQGTDFGAMCMLGTFA
MMAR_0127|M.marinum_M YCSTGRQNLCDMGATILEGCMS-DGSFRFH----RKGVDFGAMCMLGTFS
MSMEG_3388|M.smegmatis_MC2_155 YCATGRSNLCDMGATILDGRFP-DGTFRFH----KDGVDYGSLCLLGSFA
Mflv_4588|M.gilvum_PYR-GCK YCARGMGNLCDMGAAIMMGPQI-DGTYRFH----ARGEDVGQMCLLGTFS
MAB_2084|M.abscessus_ATCC_1997 YCARGMGNLCELGAALMMGPQI-DGTYRFH----ARGEDVGQMCLLGTFS
Mvan_0013|M.vanbaalenii_PYR-1 ECARGRSNLCVYGAAIVAGPQL-DGTFRFHGSSGGRAYDIGQMCVLGTFS
TH_2499|M.thermoresistible__bu WCATGRSNLCDLGAMLLAGTQL-DGTYRRH---LPDGRDVGVALLLGTFA
MAV_0705|M.avium_104 TCQAGMRNLCDLGAGLLGGEAVSDGTFRIQ----ARGQNVYPMTLLGTFS
MUL_3861|M.ulcerans_Agy99 WCASGMEYLCDAGIGTLTPGMPTDGTFRHHT---ADGTPLGHLAKVGAFA
MLBr_01784|M.leprae_Br4923 ACKRGRPSYCFDTFNAQQKMTL------------IDGTELTPALGIGAFA
* * * . :*:*:
Mb3113|M.bovis_AF2122/97 ERATVSQHSVVKVDDWLPLETAVLVGCGVPSGWGTAVNAGNLRAGDTAVI
Rv3086|M.tuberculosis_H37Rv ERATVSQHSVVKVDDWLPLETAVLVGCGVPSGWGTAVNAGNLRAGDTAVI
MMAR_0127|M.marinum_M ERATISQHSVVKIDDWLPLTTAVLVGCGVPTGWGTSVYAGGVRPGDTTVI
MSMEG_3388|M.smegmatis_MC2_155 ERTTVSQHSVVKVDEWIPLETAVLVGCGVPAGWGGPVYNNGIRPGDTAVI
Mflv_4588|M.gilvum_PYR-GCK EYTVVPKASLVKVDHGTPLDKAALIGCGVTTGYGSAVRTGEVRAGDTVVV
MAB_2084|M.abscessus_ATCC_1997 EYTVVPQASVVKIDGGIPLDRAALIGCGVTTGYGSAVRTGEVRAGDTVVV
Mvan_0013|M.vanbaalenii_PYR-1 EYTVVPIASVVKVDNDIPLDKAALVGCGVTTGYGAAVRTGEAADGDTVVV
TH_2499|M.thermoresistible__bu QYGVVSEASLVKIDDDLPLTRACLIGCGVTTGWGSAVNTAKVQPGDTVVV
MAV_0705|M.avium_104 PYMVVHRSSVVKIDPSIPFEVAALVGCGVTTGYGSAVRTADIRPGQDVAI
MUL_3861|M.ulcerans_Agy99 EHTVVSRDSLVKIDPDLPLAPSALLSCAIPTGYGSAANRAGVRGGDTVVV
MLBr_01784|M.leprae_Br4923 DKTLVHSGQCTKVDPAADPAVAGLLGCGVMAGLGAAINTAAVSRDDTVAV
: . .*:* : *:.*.: :* * . .: ..:
Mb3113|M.bovis_AF2122/97 YGVGGLGINAVQGATAAGCKYVVVVDPVAFKRETALKFGATHAF-ADAAS
Rv3086|M.tuberculosis_H37Rv YGVGGLGINAVQGATAAGCKYVVVVDPVAFKRETALKFGATHAF-ADAAS
MMAR_0127|M.marinum_M YGAGGLGINAVQGAVSAGAKHVVVVDPVAFKRDTALKFGATHAF-PDAAS
MSMEG_3388|M.smegmatis_MC2_155 YGIGGLGINAIQGAVMAGARYVVAVDPVEFKRDMALKFGATHAF-ATAEE
Mflv_4588|M.gilvum_PYR-GCK IGAGGIGMNAIQGARIAGALTIVAVDPVEFKREQAGGFGATHAV-ATIDE
MAB_2084|M.abscessus_ATCC_1997 VGAGGIGMNAIQGARIAGALAIVAVDPVNFKREQASGFGATHTA-ASMDE
Mvan_0013|M.vanbaalenii_PYR-1 MGVGGLGINAIQGAAIAGARNVVALDPVAYKRERSFEFGATHAA-ADVAE
TH_2499|M.thermoresistible__bu IGFGGVGSGAVQGARLAGAEKIVVVDIVEDKRAKALEFGATHFV-TSMAE
MAV_0705|M.avium_104 VGVGGVGMAALQGAVNAGARYIFAIDPVEWKRDQALKFGATHVY-PDIMA
MUL_3861|M.ulcerans_Agy99 LGAGGIGTGAIQGARINGAAQIVAIDPVEFKQKSAYLFGATHGA-GSISQ
MLBr_01784|M.leprae_Br4923 IGCGGVGDAAISGAALVGANRIIAVDIDDTKLEWARTFGATHTVNALELE
* **:* *:.** *. :..:* * : *****
Mb3113|M.bovis_AF2122/97 AAAKVDELTWGQGADAALILVGTVDDEVVSAATAVIGKGGTVVITGLADP
Rv3086|M.tuberculosis_H37Rv AAAKVDELTWGQGADAALILVGTVDDEVVSAATAVIGKGGTVVITGLADP
MMAR_0127|M.marinum_M AAAKVNEITWGQGADQALILVGTVDTEVVSAAAAVIGKGGTVVITGLANP
MSMEG_3388|M.smegmatis_MC2_155 AHEAVREITWGQMADGALIFVGTPDEKVVSDAFNVIGKGGTVSLASLADP
Mflv_4588|M.gilvum_PYR-GCK AWSLISDITRGKLADVCVLTTDVAEGAYTAEALSLVGKRGRVVITAIGHP
MAB_2084|M.abscessus_ATCC_1997 AWSLVSDMTRGKLADVCILTTDVAEGSYTAEALALVGKRGRVVVTAIGHP
Mvan_0013|M.vanbaalenii_PYR-1 AQALITDLTRGTMADVCVVTTDSAEGAYVAQALSLVGKRGRVVMTAIPHP
TH_2499|M.thermoresistible__bu ATALVGDLTRGVMADSAILTVGLVEGPMIGECIDIIRKGGAVVLTGIAAL
MAV_0705|M.avium_104 AMAGMAEVTYGLMAHKVVVTVGELQGADVDNYLNITQKGGTCVLTAIGSL
MUL_3861|M.ulcerans_Agy99 AMALVRELTHGVMADSVLVSPSLITADDVRDALRLTCKGGTCVLAGMTSQ
MLBr_01784|M.leprae_Br4923 VVKTIQDLTSGFGVDVVIDTVGRPE--TWKQAFYARDLAGTVVLVGVPTP
. : ::* * .. : . * :..:
Mb3113|M.bovis_AF2122/97 AKLTVHVSGTDLTLHEKTIKGSLFGSCNPQYDIVRLLRLYDAGQLMLDEL
Rv3086|M.tuberculosis_H37Rv AKLTVHVSGTDLTLHEKTIKGSLFGSCNPQYDIVRLLRLYDAGQLMLDEL
MMAR_0127|M.marinum_M EKLTVQLSGLDLTLNEKTIKGTLFGSANPQYDIVRLLRLYDAGQLKLDEL
MSMEG_3388|M.smegmatis_MC2_155 AKLTVHVSGMEMTLMEKTIKGCLFGSSNPQYDIVRLLRLYDEGKLKLDEL
Mflv_4588|M.gilvum_PYR-GCK EDTSMSGSLLELTLYEKQIRGALYGSSNAAHDIPRLVELYNSGQLKLDEL
MAB_2084|M.abscessus_ATCC_1997 DESSISGSLLEMTLYEKQIRGALYGSSNAPHDIPRLVELYSAGLLKLDEL
Mvan_0013|M.vanbaalenii_PYR-1 TDTVVDMSLFDLTLYEKQVRGCLFGSSNPRLDIPRLLDLYGSGRLKLDEL
TH_2499|M.thermoresistible__bu ADVTPTLPMAMFTLFQKRLLGSLYGEANPRADIPRLLSLYREGKLLLDET
MAV_0705|M.avium_104 LDTNVTLNLAMLTLMQKNLQGTIFGGGNPQYDIPQLLSMYKAGKLNLDDM
MUL_3861|M.ulcerans_Agy99 LTRSVNIDLQEFILMNKTLAGTIFGSCNPRADIARLAGLYQSGQLQLDEM
MLBr_01784|M.leprae_Br4923 -DMRLDMPLLDFFSHGGSLKSSWYGDCLPERDFPTLVDLYLQGRLPLGKF
: : . :* . *: * :* * * *..
Mb3113|M.bovis_AF2122/97 VTTTYNLEQVNQGYQDLRDGKNIRGVIVH-----
Rv3086|M.tuberculosis_H37Rv VTTTYNLEQVNQGYQDLRDGKNIRGVIVH-----
MMAR_0127|M.marinum_M ITTQYRLEDVNQGYQDLRDGKNIRGVIVHD----
MSMEG_3388|M.smegmatis_MC2_155 ITTRYRLEDINQGYDDLRAGVNIRGVIIHDPEA-
Mflv_4588|M.gilvum_PYR-GCK ITREYTLDEINEGYDDMRSGRNIRGLIRF-----
MAB_2084|M.abscessus_ATCC_1997 VTREYSLDQINEGYQDMRSGRNIRGLVRF-----
Mvan_0013|M.vanbaalenii_PYR-1 ITREYTLEEINQGYEDMHNGRNLRGVIRF-----
TH_2499|M.thermoresistible__bu VTHEYKLHDINQGYDDMLAGRIIRGVIVHDHS--
MAV_0705|M.avium_104 ITRQYRLEQINDGYQDMLDGKNIRGVIRYTDADR
MUL_3861|M.ulcerans_Agy99 ITRRYRLDDINAAYTDLLNGDIVRGIIDFTI---
MLBr_01784|M.leprae_Br4923 VSERIGLGDVEEAFHKIHGGKVLRSVVML-----
:: * ::: .: .: * :*.::