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KSRAAILHDVGGPWSVEEFELDPPRAGEVLVQMAAAGLCHSDDHILKGDMSAPNEVMRSLGLPTMFPTIG GHEGSGIVREVGEGVTDFAPGDHVVMSFVAVCGQCRWCASGMEYLCDVGIGTMIPGMPTDGTFRHHTAGG GNLGHIAKIGAFAEHTVVSTNSLVKIEQQLPLAPSALLSCAIPTGYGSAANRAGVCGGDAVVVIGAGGIG TGAIQGARISGAAQIVAVDPVEFKQKSALRFGATHSVATIAEALDLVRDLTYGVMADAVVVSPSLITADD VRDALKLTRKGGTCVLTGMTSQLTRSVNIELQDFILMNKTLAGTIFGSCNPRADIARLARLYQTGQLQLD EMITKRYRLDEVNDAYDDLLNGKIVRGIIDFGIA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1614 | - | - | 100% (385) | alcohol dehydrogenase B |
| M. avium 104 | MAV_5214 | - | e-109 | 50.00% (378) | alcohol dehydrogenase B |
| M. avium 104 | MAV_0705 | - | 3e-96 | 45.69% (383) | alcohol dehydrogenase B |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3113 | adhD | 1e-96 | 45.53% (380) | zinc-type alcohol dehydrogenase AdhD |
| M. gilvum PYR-GCK | Mflv_1486 | - | 1e-102 | 48.42% (380) | alcohol dehydrogenase |
| M. tuberculosis H37Rv | Rv3086 | adhD | 1e-96 | 45.53% (380) | zinc-type alcohol dehydrogenase AdhD |
| M. leprae Br4923 | MLBr_01784 | adhE2 | 1e-48 | 32.54% (378) | putative alcohol dehydrogenase (Zn dependent) |
| M. abscessus ATCC 19977 | MAB_2084 | - | 7e-94 | 45.55% (382) | zinc-type alcohol dehydrogenase AdhD |
| M. marinum M | MMAR_3997 | adhB_1 | 0.0 | 85.68% (384) | zinc-containing alcohol dehydrogenase NAD dependent AdhB_1 |
| M. smegmatis MC2 155 | MSMEG_3388 | - | 2e-95 | 46.05% (380) | S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol |
| M. thermoresistible (build 8) | TH_4578 | - | 1e-112 | 52.17% (391) | PUTATIVE alcohol dehydrogenase B |
| M. ulcerans Agy99 | MUL_3861 | adhB_1 | 0.0 | 84.64% (384) | zinc-containing alcohol dehydrogenase NAD dependent AdhB_1 |
| M. vanbaalenii PYR-1 | Mvan_5270 | - | 1e-103 | 48.42% (380) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3113|M.bovis_AF2122/97 -------------------------------------------MKTTAAV
Rv3086|M.tuberculosis_H37Rv -------------------------------------------MKTTAAV
MSMEG_3388|M.smegmatis_MC2_155 MHSDPSHIDLLGPATFTSRDRRPIGFPPLRCSRHKISWKEPSEMKTKAAV
Mflv_1486|M.gilvum_PYR-GCK -------------------------------------------MKTNAAI
Mvan_5270|M.vanbaalenii_PYR-1 -------------------------------------------MKTNAAI
MAB_2084|M.abscessus_ATCC_1997 -------------------------------------------MKTRAAV
MMAR_3997|M.marinum_M -------------------------------------------MRSRAAI
MUL_3861|M.ulcerans_Agy99 -------------------------------------------MRSRAAI
MAV_1614|M.avium_104 -------------------------------------------MKSRAAI
TH_4578|M.thermoresistible__bu -------------------------------------------MRTKAAV
MLBr_01784|M.leprae_Br4923 -----------------------------------------MSQTVRGVI
..:
Mb3113|M.bovis_AF2122/97 LFEAGKPFELMELDLDGPGPGEVLVKYTAAGLCHSDLHLTDGD-------
Rv3086|M.tuberculosis_H37Rv LFEAGKPFELMELDLDGPGPGEVLVKYTAAGLCHSDLHLTDGD-------
MSMEG_3388|M.smegmatis_MC2_155 SLGVNRPFEIMELELDGPKEGEVLLKNVAAGLCHSDLHLTDGD-------
Mflv_1486|M.gilvum_PYR-GCK LWEYGGDWTVEEIDLDPPGDGEVLVSWQATGLCHSDEHIRTGD-------
Mvan_5270|M.vanbaalenii_PYR-1 LWEYGGDWTVEEIDLDPPGDGEVLVSWEATGLCHSDEHIRTGD-------
MAB_2084|M.abscessus_ATCC_1997 LWGLEQKWEVEEVDLDPPGPGEVLVRLAATGLCHSDEHLVTGD-------
MMAR_3997|M.marinum_M LHDVGGPWSVEEFELDTPRTGEVLVEMSAAGLCHTDDHILKGDMSAPN--
MUL_3861|M.ulcerans_Agy99 LHDVGEPWSVEEFELDAPRTAEVLVEMSAAGLCHTDDHILKGDMSAPN--
MAV_1614|M.avium_104 LHDVGGPWSVEEFELDPPRAGEVLVQMAAAGLCHSDDHILKGDMSAPN--
TH_4578|M.thermoresistible__bu LRGVGVDWEVTEIELDPPRAGEVLVKMAYAGICHSDEHFYTGDSVPSKEM
MLBr_01784|M.leprae_Br4923 SRKKDEPVELVDIVIPDPGPGEAVVDVTACGVCHTDLTYREGG-------
: :. : * .*.:: *:**:* *.
Mb3113|M.bovis_AF2122/97 --------LPPR--FPIVGGHEGSGVIEEVGAGVTRVKPGDHVVCSFIPN
Rv3086|M.tuberculosis_H37Rv --------LPPR--FPIVGGHEGSGVIEEVGAGVTRVKPGDHVVCSFIPN
MSMEG_3388|M.smegmatis_MC2_155 --------MPPR--YPIVGGHEGSAIVEDVGPGVTKVKPGDHVVCSYIPN
Mflv_1486|M.gilvum_PYR-GCK --------LPAP--LPLIGGHEGAGIVREVGAGVVGLAPGDHVVASFLPA
Mvan_5270|M.vanbaalenii_PYR-1 --------LPAP--LPLIGGHEGAGIVREVGPGVVGLAPGDHVVASFLPA
MAB_2084|M.abscessus_ATCC_1997 --------LPIP--LPVVGGHEGAGTVVECGEGVEDLSEGDSVILTFLPS
MMAR_3997|M.marinum_M -EVLRSRGLPT--MFPTIGGHEGSGIVREIGPGVTDFAPGDHVVMSFIAV
MUL_3861|M.ulcerans_Agy99 -EVLRSRGLPT--MFPTIGGHEGSGIVREIGPGVTDFVPGDHVVMSFVAV
MAV_1614|M.avium_104 -EVMRSLGLPT--MFPTIGGHEGSGIVREVGEGVTDFAPGDHVVMSFVAV
TH_4578|M.thermoresistible__bu EEMMRASGVPVPEWFPMLGGHEGAGVVEDVGPEVRTLKPGDHVAVSFLPA
MLBr_01784|M.leprae_Br4923 --------INDR--YPFLLGHEAAGTVEVVGPGVTAVEPGDFVILNWRAV
: * : ***.:. : * * . ** * .: .
Mb3113|M.bovis_AF2122/97 CGTCRYCCTGRQNLCDMGATILEGCMP-DGSFRFHSQG----TDFGAMCM
Rv3086|M.tuberculosis_H37Rv CGTCRYCCTGRQNLCDMGATILEGCMP-DGSFRFHSQG----TDFGAMCM
MSMEG_3388|M.smegmatis_MC2_155 CGTCRYCATGRSNLCDMGATILDGRFP-DGTFRFHKDG----VDYGSLCL
Mflv_1486|M.gilvum_PYR-GCK CGRCRFCSTGHQNLCDLGAMIMAGTQL-DGTYRRHING----QDVGVMAL
Mvan_5270|M.vanbaalenii_PYR-1 CGRCRFCSTGHQNLCDLGAMIMAGTQL-DGTYRRHVRG----QDVGVMAL
MAB_2084|M.abscessus_ATCC_1997 CGRCSYCARGMGNLCELGAALMMGPQI-DGTYRFHARG----EDVGQMCL
MMAR_3997|M.marinum_M CGQCRWCASGMEYLCDAGIGTLTPGMPTDGTFRHHTAD---GTPLGHLAK
MUL_3861|M.ulcerans_Agy99 CGQCRWCASGMEYLCDAGIGTLTPGMPTDGTFRHHTAD---GTPLGHLAK
MAV_1614|M.avium_104 CGQCRWCASGMEYLCDVGIGTMIPGMPTDGTFRHHTAG---GGNLGHIAK
TH_4578|M.thermoresistible__bu CGSCRWCASGHTYLCDVGADLYSKRMTTDGTARRHLPDPDGDRDLMAMMQ
MLBr_01784|M.leprae_Br4923 CGQCRACKRGRPSYCFDTFNAQQKMTLIDGTELTPALG------------
** * * * * **: .
Mb3113|M.bovis_AF2122/97 LGTFAERATVSQHSVVKVDDWLPLETAVLVGCGVPSGWGTAVNAGNLRAG
Rv3086|M.tuberculosis_H37Rv LGTFAERATVSQHSVVKVDDWLPLETAVLVGCGVPSGWGTAVNAGNLRAG
MSMEG_3388|M.smegmatis_MC2_155 LGSFAERTTVSQHSVVKVDEWIPLETAVLVGCGVPAGWGGPVYNNGIRPG
Mflv_1486|M.gilvum_PYR-GCK VGTFSQYGTVPEASIVKIDDDIPLSRACLLGCGVTTGWGSAVNTADVSPG
Mvan_5270|M.vanbaalenii_PYR-1 VGTFSQYGTVPEASIVKIDDDIPLSRACLLGCGVTTGWGSAVNTADVSPG
MAB_2084|M.abscessus_ATCC_1997 LGTFSEYTVVPQASVVKIDGGIPLDRAALIGCGVTTGYGSAVRTGEVRAG
MMAR_3997|M.marinum_M VGAFAEHTVVSRDSLVKIDPDLPLAPSALLSCAIPTGYGSAANRAGVRGG
MUL_3861|M.ulcerans_Agy99 VGAFAEHTVVSRDSLVKIDPDLPLAPSALLSCAIPTGYGSAANRAGVRGG
MAV_1614|M.avium_104 IGAFAEHTVVSTNSLVKIEQQLPLAPSALLSCAIPTGYGSAANRAGVCGG
TH_4578|M.thermoresistible__bu VGTFAEYVVASERSLVKVHDWIPLAAASLVSCGVTTGFGSGSVAAGTQPG
MLBr_01784|M.leprae_Br4923 IGAFADKTLVHSGQCTKVDPAADPAVAGLLGCGVMAGLGAAINTAAVSRD
:*:*:: . . .*:. : *:.*.: :* * .
Mb3113|M.bovis_AF2122/97 DTAVIYGVGGLGINAVQGATAAGCKYVVVVDPVAFKRETALKFGATHAFA
Rv3086|M.tuberculosis_H37Rv DTAVIYGVGGLGINAVQGATAAGCKYVVVVDPVAFKRETALKFGATHAFA
MSMEG_3388|M.smegmatis_MC2_155 DTAVIYGIGGLGINAIQGAVMAGARYVVAVDPVEFKRDMALKFGATHAFA
Mflv_1486|M.gilvum_PYR-GCK DTVVIIGLGGIGSGAIQGARLAGAEKIVVVEPVETKRDLAFRFGATHFVT
Mvan_5270|M.vanbaalenii_PYR-1 DTVVIIGLGGIGSGAIQGARLAGAEKIVVIEPVESKRELAFRFGATHFVT
MAB_2084|M.abscessus_ATCC_1997 DTVVVVGAGGIGMNAIQGARIAGALAIVAVDPVNFKREQASGFGATHTAA
MMAR_3997|M.marinum_M DTVVVLGAGGIGTGAIQGARINGAAQIVAVDPVEFKQKSAHLFGATHGAG
MUL_3861|M.ulcerans_Agy99 DTVVVLGAGGIGTGAIQGARINGAAQIVAIDPVEFKQKSAYLFGATHGAG
MAV_1614|M.avium_104 DAVVVIGAGGIGTGAIQGARISGAAQIVAVDPVEFKQKSALRFGATHSVA
TH_4578|M.thermoresistible__bu DTVVVVGVGGIGMNAVQGARTAGAKHIVAVDPVEFKREIAPTFGATHAVA
MLBr_01784|M.leprae_Br4923 DTVAVIGCGGVGDAAISGAALVGANRIIAVDIDDTKLEWARTFGATHTVN
*:..: * **:* *:.** *. ::.:: * . * *****
Mb3113|M.bovis_AF2122/97 DAA-SAAAKVDELTWGQGADAALILVGTVDDEVVSAATAVIGKGGTVVIT
Rv3086|M.tuberculosis_H37Rv DAA-SAAAKVDELTWGQGADAALILVGTVDDEVVSAATAVIGKGGTVVIT
MSMEG_3388|M.smegmatis_MC2_155 TAE-EAHEAVREITWGQMADGALIFVGTPDEKVVSDAFNVIGKGGTVSLA
Mflv_1486|M.gilvum_PYR-GCK SME-EATALVAELTRGVMADSAILTVGLLAGSMLEEAANIIRKGGAVVMT
Mvan_5270|M.vanbaalenii_PYR-1 SME-EATALVADLTRGVMADSAILTVGLLEGSMLEEAANIIRKGGAVVMT
MAB_2084|M.abscessus_ATCC_1997 SMD-EAWSLVSDMTRGKLADVCILTTDVAEGSYTAEALALVGKRGRVVVT
MMAR_3997|M.marinum_M SIS-EAMALVRELTHGVMADSVLVSPSLITADDVRDALRLTRKGGTCVLA
MUL_3861|M.ulcerans_Agy99 SIS-QAMALVRELTHGVMADSVLVSPSLITADDVRDALRLTCKGGTCVLA
MAV_1614|M.avium_104 TIA-EALDLVRDLTYGVMADAVVVSPSLITADDVRDALKLTRKGGTCVLT
TH_4578|M.thermoresistible__bu DIG-AALDLVKDITWGVMADRVVLTPGVVPPDMVMAAMMLLRKGGTCVLT
MLBr_01784|M.leprae_Br4923 ALELEVVKTIQDLTSGFGVDVVIDTVGR--PETWKQAFYARDLAGTVVLV
. : ::* * .* : . . * * :.
Mb3113|M.bovis_AF2122/97 GLADPAKLTVHVSGTDLTLHEKTIKGSLFGSCNPQYDIVRLLRLYDAGQL
Rv3086|M.tuberculosis_H37Rv GLADPAKLTVHVSGTDLTLHEKTIKGSLFGSCNPQYDIVRLLRLYDAGQL
MSMEG_3388|M.smegmatis_MC2_155 SLADPAKLTVHVSGMEMTLMEKTIKGCLFGSSNPQYDIVRLLRLYDEGKL
Mflv_1486|M.gilvum_PYR-GCK ALSTMADNQPTLGMMMFTLFQKRLLGSLYGEANPRADIPRLLSLYREGKL
Mvan_5270|M.vanbaalenii_PYR-1 ALSTMADNQPTLGMMMFTLFQKRLLGSLYGEANPRADIPRLLSLYREGKL
MAB_2084|M.abscessus_ATCC_1997 AIGHPDESSISGSLLEMTLYEKQIRGALYGSSNAPHDIPRLVELYSAGLL
MMAR_3997|M.marinum_M GMTSQLTRSVNIDLQEFILMNKTLAGTIFGSCNPRADIARLAGLYQSGQL
MUL_3861|M.ulcerans_Agy99 GMTSQLTRSVNIDLQEFILMNKTLAGTIFGSCNPRADIARLAGLYQSGQL
MAV_1614|M.avium_104 GMTSQLTRSVNIELQDFILMNKTLAGTIFGSCNPRADIARLARLYQTGQL
TH_4578|M.thermoresistible__bu GMAKVSDLNVPLSLPDMVSSCKTLKGVLYGEMNPRDAMPKLLSMYEAGTL
MLBr_01784|M.leprae_Br4923 GVPTP-DMRLDMPLLDFFSHGGSLKSSWYGDCLPERDFPTLVDLYLQGRL
.: : : . :*. . : * :* * *
Mb3113|M.bovis_AF2122/97 MLDELVTTTYNLEQVNQGYQDLRDGKNIRGVIVH----
Rv3086|M.tuberculosis_H37Rv MLDELVTTTYNLEQVNQGYQDLRDGKNIRGVIVH----
MSMEG_3388|M.smegmatis_MC2_155 KLDELITTRYRLEDINQGYDDLRAGVNIRGVIIHDPEA
Mflv_1486|M.gilvum_PYR-GCK LLDETVTHEYKLAEVNEGYEDMREGRNIRGVILHDH--
Mvan_5270|M.vanbaalenii_PYR-1 LLDETVTHEYKLAEVNEGYEDMRAGRNIRGVILHDH--
MAB_2084|M.abscessus_ATCC_1997 KLDELVTREYSLDQINEGYQDMRSGRNIRGLVRF----
MMAR_3997|M.marinum_M QLDDMITRRYRLDDINAAYTDLLNGDIVRGIIDFTI--
MUL_3861|M.ulcerans_Agy99 QLDEMITRRYRLDDINAAYTDLLNGDIVRGIIDFTI--
MAV_1614|M.avium_104 QLDEMITKRYRLDEVNDAYDDLLNGKIVRGIIDFGIA-
TH_4578|M.thermoresistible__bu KLDELITNRYKLDDINEAMRDLRAGKNIRGVIAFD---
MLBr_01784|M.leprae_Br4923 PLGKFVSERIGLGDVEEAFHKIHGGKVLRSVVML----
*.. :: * ::: . .: * :*.::