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MRSRAAILYGYGHPWTVEEFELDPPRAGEVLLQLSATGLCHSDEHIRRGNLAPPPETLRSFGLPTMSPTI GGHEGSGVVLEVGEGVTRFAPGDHVVTSFIAVCGQCRWCATGMEYLCDTGYGTLAPGMPTDGTFRHHSLD GRDLGHVSKIGPFAEHTVVSADSLVKIDQTFPLVPAALLACAIPTRYGSAARRAQVRGGDIAVVIGAGGI GTAAIQGARIQGATRIIAVDPVEFERKSALTFGATHTAATTDEAVETVRELTRGVMADVVVVSPATIGPA DVAAALSLTRKGGTCVLTGLPDPAMHSIAVGLQDFVLMNKTLCGTVFGSCNPKSDIPLLATMYQSGQLLL DAMITKRYSLHSINDAYADLVAGELIRGVIDFSLS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_4872 | adhD | - | 100% (385) | zinc-type alcohol dehydrogenase AdhD |
| M. ulcerans Agy99 | MUL_3861 | adhB_1 | e-154 | 67.19% (384) | zinc-containing alcohol dehydrogenase NAD dependent AdhB_1 |
| M. ulcerans Agy99 | MUL_0470 | adhB | 1e-85 | 42.45% (384) | zinc-containing alcohol dehydrogenase NAD- dependent AdhB |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3113 | adhD | 1e-92 | 46.05% (380) | zinc-type alcohol dehydrogenase AdhD |
| M. gilvum PYR-GCK | Mflv_1486 | - | 2e-97 | 47.37% (380) | alcohol dehydrogenase |
| M. tuberculosis H37Rv | Rv3086 | adhD | 1e-92 | 46.05% (380) | zinc-type alcohol dehydrogenase AdhD |
| M. leprae Br4923 | MLBr_01784 | adhE2 | 1e-50 | 33.88% (369) | putative alcohol dehydrogenase (Zn dependent) |
| M. abscessus ATCC 19977 | MAB_2084 | - | 2e-94 | 47.12% (382) | zinc-type alcohol dehydrogenase AdhD |
| M. marinum M | MMAR_0241 | adhD | 0.0 | 97.40% (385) | zinc-type alcohol dehydrogenase AdhD |
| M. avium 104 | MAV_1614 | - | 1e-160 | 69.61% (385) | alcohol dehydrogenase B |
| M. smegmatis MC2 155 | MSMEG_3388 | - | 4e-91 | 47.37% (380) | S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol |
| M. thermoresistible (build 8) | TH_4578 | - | 1e-102 | 48.97% (390) | PUTATIVE alcohol dehydrogenase B |
| M. vanbaalenii PYR-1 | Mvan_5270 | - | 4e-97 | 47.11% (380) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_4872|M.ulcerans_Agy99 -------------------------------------------MRSRAAI
MMAR_0241|M.marinum_M -------------------------------------------MRSRAAI
MAV_1614|M.avium_104 -------------------------------------------MKSRAAI
Mb3113|M.bovis_AF2122/97 -------------------------------------------MKTTAAV
Rv3086|M.tuberculosis_H37Rv -------------------------------------------MKTTAAV
MSMEG_3388|M.smegmatis_MC2_155 MHSDPSHIDLLGPATFTSRDRRPIGFPPLRCSRHKISWKEPSEMKTKAAV
Mflv_1486|M.gilvum_PYR-GCK -------------------------------------------MKTNAAI
Mvan_5270|M.vanbaalenii_PYR-1 -------------------------------------------MKTNAAI
MAB_2084|M.abscessus_ATCC_1997 -------------------------------------------MKTRAAV
TH_4578|M.thermoresistible__bu -------------------------------------------MRTKAAV
MLBr_01784|M.leprae_Br4923 -----------------------------------------MSQTVRGVI
..:
MUL_4872|M.ulcerans_Agy99 LYGYGHPWTVEEFELDPPRAGEVLLQLSATGLCHSDEHIRRGNLAPPPET
MMAR_0241|M.marinum_M LYEYGHPWTVEEFELDPPRAGEVLVQLSATGLCHSDEHIRRGNLAPPPET
MAV_1614|M.avium_104 LHDVGGPWSVEEFELDPPRAGEVLVQMAAAGLCHSDDHILKGDMSAPNEV
Mb3113|M.bovis_AF2122/97 LFEAGKPFELMELDLDGPGPGEVLVKYTAAGLCHSDLHLTDGD-------
Rv3086|M.tuberculosis_H37Rv LFEAGKPFELMELDLDGPGPGEVLVKYTAAGLCHSDLHLTDGD-------
MSMEG_3388|M.smegmatis_MC2_155 SLGVNRPFEIMELELDGPKEGEVLLKNVAAGLCHSDLHLTDGD-------
Mflv_1486|M.gilvum_PYR-GCK LWEYGGDWTVEEIDLDPPGDGEVLVSWQATGLCHSDEHIRTGD-------
Mvan_5270|M.vanbaalenii_PYR-1 LWEYGGDWTVEEIDLDPPGDGEVLVSWEATGLCHSDEHIRTGD-------
MAB_2084|M.abscessus_ATCC_1997 LWGLEQKWEVEEVDLDPPGPGEVLVRLAATGLCHSDEHLVTGD-------
TH_4578|M.thermoresistible__bu LRGVGVDWEVTEIELDPPRAGEVLVKMAYAGICHSDEHFYTGDSVPSKEM
MLBr_01784|M.leprae_Br4923 SRKKDEPVELVDIVIPDPGPGEAVVDVTACGVCHTDLTYREGG-------
: :. : * **.:: *:**:* *.
MUL_4872|M.ulcerans_Agy99 LRSFG-----LPTMSPTIGGHEGSGVVLEVGEGVTRFAPGDHVVTSFIAV
MMAR_0241|M.marinum_M LRSLG-----LPAMSPTIGGHEGSGVVLEVGEGVTRFAPGDHVVTSFIAV
MAV_1614|M.avium_104 MRSLG-----LPTMFPTIGGHEGSGIVREVGEGVTDFAPGDHVVMSFVAV
Mb3113|M.bovis_AF2122/97 ----------LPPRFPIVGGHEGSGVIEEVGAGVTRVKPGDHVVCSFIPN
Rv3086|M.tuberculosis_H37Rv ----------LPPRFPIVGGHEGSGVIEEVGAGVTRVKPGDHVVCSFIPN
MSMEG_3388|M.smegmatis_MC2_155 ----------MPPRYPIVGGHEGSAIVEDVGPGVTKVKPGDHVVCSYIPN
Mflv_1486|M.gilvum_PYR-GCK ----------LPAPLPLIGGHEGAGIVREVGAGVVGLAPGDHVVASFLPA
Mvan_5270|M.vanbaalenii_PYR-1 ----------LPAPLPLIGGHEGAGIVREVGPGVVGLAPGDHVVASFLPA
MAB_2084|M.abscessus_ATCC_1997 ----------LPIPLPVVGGHEGAGTVVECGEGVEDLSEGDSVILTFLPS
TH_4578|M.thermoresistible__bu EEMMRASGVPVPEWFPMLGGHEGAGVVEDVGPEVRTLKPGDHVAVSFLPA
MLBr_01784|M.leprae_Br4923 ----------INDRYPFLLGHEAAGTVEVVGPGVTAVEPGDFVILNWRAV
: * : ***.:. : * * . ** * .: .
MUL_4872|M.ulcerans_Agy99 CGQCRWCATGMEYLCDTGYGTLAPGMPTDGTFRHHSLD---GRDLGHVSK
MMAR_0241|M.marinum_M CGQCRWCATGMEYLCDTGYGTLAPGMPTDGTFRHHSLD---GRDLGHVSK
MAV_1614|M.avium_104 CGQCRWCASGMEYLCDVGIGTMIPGMPTDGTFRHHTAG---GGNLGHIAK
Mb3113|M.bovis_AF2122/97 CGTCRYCCTGRQNLCDMGATILEGCMP-DGSFRFHSQG----TDFGAMCM
Rv3086|M.tuberculosis_H37Rv CGTCRYCCTGRQNLCDMGATILEGCMP-DGSFRFHSQG----TDFGAMCM
MSMEG_3388|M.smegmatis_MC2_155 CGTCRYCATGRSNLCDMGATILDGRFP-DGTFRFHKDG----VDYGSLCL
Mflv_1486|M.gilvum_PYR-GCK CGRCRFCSTGHQNLCDLGAMIMAGTQL-DGTYRRHING----QDVGVMAL
Mvan_5270|M.vanbaalenii_PYR-1 CGRCRFCSTGHQNLCDLGAMIMAGTQL-DGTYRRHVRG----QDVGVMAL
MAB_2084|M.abscessus_ATCC_1997 CGRCSYCARGMGNLCELGAALMMGPQI-DGTYRFHARG----EDVGQMCL
TH_4578|M.thermoresistible__bu CGSCRWCASGHTYLCDVGADLYSKRMTTDGTARRHLPDPDGDRDLMAMMQ
MLBr_01784|M.leprae_Br4923 CGQCRACKRGRPSYCFDTFNAQQKMTLIDGTELTPALG------------
** * * * * **: .
MUL_4872|M.ulcerans_Agy99 IGPFAEHTVVSADSLVKIDQTFPLVPAALLACAIPTRYGSAARRAQVRGG
MMAR_0241|M.marinum_M IGAFAEHTVVSADSLVKIDQTFPLVPAALLACAIPTGYGSAARRAQVRGG
MAV_1614|M.avium_104 IGAFAEHTVVSTNSLVKIEQQLPLAPSALLSCAIPTGYGSAANRAGVCGG
Mb3113|M.bovis_AF2122/97 LGTFAERATVSQHSVVKVDDWLPLETAVLVGCGVPSGWGTAVNAGNLRAG
Rv3086|M.tuberculosis_H37Rv LGTFAERATVSQHSVVKVDDWLPLETAVLVGCGVPSGWGTAVNAGNLRAG
MSMEG_3388|M.smegmatis_MC2_155 LGSFAERTTVSQHSVVKVDEWIPLETAVLVGCGVPAGWGGPVYNNGIRPG
Mflv_1486|M.gilvum_PYR-GCK VGTFSQYGTVPEASIVKIDDDIPLSRACLLGCGVTTGWGSAVNTADVSPG
Mvan_5270|M.vanbaalenii_PYR-1 VGTFSQYGTVPEASIVKIDDDIPLSRACLLGCGVTTGWGSAVNTADVSPG
MAB_2084|M.abscessus_ATCC_1997 LGTFSEYTVVPQASVVKIDGGIPLDRAALIGCGVTTGYGSAVRTGEVRAG
TH_4578|M.thermoresistible__bu VGTFAEYVVASERSLVKVHDWIPLAAASLVSCGVTTGFGSGSVAAGTQPG
MLBr_01784|M.leprae_Br4923 IGAFADKTLVHSGQCTKVDPAADPAVAGLLGCGVMAGLGAAINTAAVSRD
:*.*:: . . .*:. : *:.*.: : * .
MUL_4872|M.ulcerans_Agy99 DIAVVIGAGGIGTAAIQGARIQGATRIIAVDPVEFERKSALTFGATHTAA
MMAR_0241|M.marinum_M DIAVVIGAGGIGTAAIQGARIQGATRIIAVDPVEFKRKSALTFGATHTAA
MAV_1614|M.avium_104 DAVVVIGAGGIGTGAIQGARISGAAQIVAVDPVEFKQKSALRFGATHSVA
Mb3113|M.bovis_AF2122/97 DTAVIYGVGGLGINAVQGATAAGCKYVVVVDPVAFKRETALKFGATHAFA
Rv3086|M.tuberculosis_H37Rv DTAVIYGVGGLGINAVQGATAAGCKYVVVVDPVAFKRETALKFGATHAFA
MSMEG_3388|M.smegmatis_MC2_155 DTAVIYGIGGLGINAIQGAVMAGARYVVAVDPVEFKRDMALKFGATHAFA
Mflv_1486|M.gilvum_PYR-GCK DTVVIIGLGGIGSGAIQGARLAGAEKIVVVEPVETKRDLAFRFGATHFVT
Mvan_5270|M.vanbaalenii_PYR-1 DTVVIIGLGGIGSGAIQGARLAGAEKIVVIEPVESKRELAFRFGATHFVT
MAB_2084|M.abscessus_ATCC_1997 DTVVVVGAGGIGMNAIQGARIAGALAIVAVDPVNFKREQASGFGATHTAA
TH_4578|M.thermoresistible__bu DTVVVVGVGGIGMNAVQGARTAGAKHIVAVDPVEFKREIAPTFGATHAVA
MLBr_01784|M.leprae_Br4923 DTVAVIGCGGVGDAAISGAALVGANRIIAVDIDDTKLEWARTFGATHTVN
* ..: * **:* *:.** *. ::.:: : . * *****
MUL_4872|M.ulcerans_Agy99 TTD-EAVETVRELTRGVMADVVVVSPATIGPADVAAALSLTRKGGTCVLT
MMAR_0241|M.marinum_M TTD-EAVETVRELTRGVMADVVVVSPATIGPADVAAALSLTRKGGTCVLT
MAV_1614|M.avium_104 TIA-EALDLVRDLTYGVMADAVVVSPSLITADDVRDALKLTRKGGTCVLT
Mb3113|M.bovis_AF2122/97 DAA-SAAAKVDELTWGQGADAALILVGTVDDEVVSAATAVIGKGGTVVIT
Rv3086|M.tuberculosis_H37Rv DAA-SAAAKVDELTWGQGADAALILVGTVDDEVVSAATAVIGKGGTVVIT
MSMEG_3388|M.smegmatis_MC2_155 TAE-EAHEAVREITWGQMADGALIFVGTPDEKVVSDAFNVIGKGGTVSLA
Mflv_1486|M.gilvum_PYR-GCK SME-EATALVAELTRGVMADSAILTVGLLAGSMLEEAANIIRKGGAVVMT
Mvan_5270|M.vanbaalenii_PYR-1 SME-EATALVADLTRGVMADSAILTVGLLEGSMLEEAANIIRKGGAVVMT
MAB_2084|M.abscessus_ATCC_1997 SMD-EAWSLVSDMTRGKLADVCILTTDVAEGSYTAEALALVGKRGRVVVT
TH_4578|M.thermoresistible__bu DIG-AALDLVKDITWGVMADRVVLTPGVVPPDMVMAAMMLLRKGGTCVLT
MLBr_01784|M.leprae_Br4923 ALELEVVKTIQDLTSGFGVDVVIDTVGR--PETWKQAFYARDLAGTVVLV
. : ::* * .* : * * :.
MUL_4872|M.ulcerans_Agy99 GLPDPAMHSIAVGLQDFVLMNKTLCGTVFGSCNPKSDIPLLATMYQSGQL
MMAR_0241|M.marinum_M GLPAPAMHSIAVGLQDFVLMNKTLCGTVFGSCNPKSDIPLLATMYQSGQL
MAV_1614|M.avium_104 GMTSQLTRSVNIELQDFILMNKTLAGTIFGSCNPRADIARLARLYQTGQL
Mb3113|M.bovis_AF2122/97 GLADPAKLTVHVSGTDLTLHEKTIKGSLFGSCNPQYDIVRLLRLYDAGQL
Rv3086|M.tuberculosis_H37Rv GLADPAKLTVHVSGTDLTLHEKTIKGSLFGSCNPQYDIVRLLRLYDAGQL
MSMEG_3388|M.smegmatis_MC2_155 SLADPAKLTVHVSGMEMTLMEKTIKGCLFGSSNPQYDIVRLLRLYDEGKL
Mflv_1486|M.gilvum_PYR-GCK ALSTMADNQPTLGMMMFTLFQKRLLGSLYGEANPRADIPRLLSLYREGKL
Mvan_5270|M.vanbaalenii_PYR-1 ALSTMADNQPTLGMMMFTLFQKRLLGSLYGEANPRADIPRLLSLYREGKL
MAB_2084|M.abscessus_ATCC_1997 AIGHPDESSISGSLLEMTLYEKQIRGALYGSSNAPHDIPRLVELYSAGLL
TH_4578|M.thermoresistible__bu GMAKVSDLNVPLSLPDMVSSCKTLKGVLYGEMNPRDAMPKLLSMYEAGTL
MLBr_01784|M.leprae_Br4923 GVPTP-DMRLDMPLLDFFSHGGSLKSSWYGDCLPERDFPTLVDLYLQGRL
.: : : . :*. . : * :* * *
MUL_4872|M.ulcerans_Agy99 LLDAMITKRYSLHSINDAYADLVAGELIRGVIDFSLS-
MMAR_0241|M.marinum_M LLDEMITKRYSLDSINDAYADLVAGELIRGVIDFSLS-
MAV_1614|M.avium_104 QLDEMITKRYRLDEVNDAYDDLLNGKIVRGIIDFGIA-
Mb3113|M.bovis_AF2122/97 MLDELVTTTYNLEQVNQGYQDLRDGKNIRGVIVH----
Rv3086|M.tuberculosis_H37Rv MLDELVTTTYNLEQVNQGYQDLRDGKNIRGVIVH----
MSMEG_3388|M.smegmatis_MC2_155 KLDELITTRYRLEDINQGYDDLRAGVNIRGVIIHDPEA
Mflv_1486|M.gilvum_PYR-GCK LLDETVTHEYKLAEVNEGYEDMREGRNIRGVILHDH--
Mvan_5270|M.vanbaalenii_PYR-1 LLDETVTHEYKLAEVNEGYEDMRAGRNIRGVILHDH--
MAB_2084|M.abscessus_ATCC_1997 KLDELVTREYSLDQINEGYQDMRSGRNIRGLVRF----
TH_4578|M.thermoresistible__bu KLDELITNRYKLDDINEAMRDLRAGKNIRGVIAFD---
MLBr_01784|M.leprae_Br4923 PLGKFVSERIGLGDVEEAFHKIHGGKVLRSVVML----
*. :: * .:::. .: * :*.::