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VASPSNPSLSPRMRELIRHTARIALNPTQQWLDELDRTTLAANPALSDDPALVEIISRANRANLIHFAVA ILRDPGGPVPANFGPEPLRMAQELLNRGLEALAADIYRIAHNVAWERWTDIAFGLTSNPQELRDLLDVAF RSSNDFIDATIAGIPAQLPLEYDALTREVSAQRRKVVEQILGGAPVNRERAEAQLGYLLDRAHTAAIVWS DEPDGDHGQLDQAADAFCTALGCRAPLIVVTNSATRWVWVNDAATPVGDRIQQVLTYAPTVRLVVGNTRR GIEGFRRSHRDAQTTQRMLTRLGAPQRTAHFADTQMVELLTQDLEGVDEFIECTLGEFQSASPVLHAILL TYINQQCNAARTAKALYIHRNTLVHRLETAHRLLPQPVEANIVRIAVALEVLQWRSDRDDDSLRAIT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_3245 | - | - | 100% (417) | transcriptional regulator |
| M. ulcerans Agy99 | MUL_0944 | - | e-130 | 57.29% (398) | transcriptional regulatory protein |
| M. ulcerans Agy99 | MUL_1854 | - | e-114 | 57.40% (331) | transcriptional activator protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2391c | - | 1e-144 | 59.75% (405) | hypothetical protein Mb2391c |
| M. gilvum PYR-GCK | Mflv_4621 | - | 7e-11 | 24.12% (257) | hypothetical protein Mflv_4621 |
| M. tuberculosis H37Rv | Rv2370c | - | 1e-144 | 59.75% (405) | hypothetical protein Rv2370c |
| M. leprae Br4923 | MLBr_01052 | - | 1e-129 | 55.33% (403) | hypothetical protein MLBr_01052 |
| M. abscessus ATCC 19977 | MAB_2657c | - | 2e-61 | 33.58% (405) | hypothetical protein MAB_2657c |
| M. marinum M | MMAR_2099 | - | 0.0 | 98.77% (405) | transcriptional regulator |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_2971 | - | 5e-06 | 25.28% (269) | regulatory protein |
| M. thermoresistible (build 8) | TH_3143 | - | 3e-18 | 27.48% (393) | PUTATIVE putative conserved hypothetical protein |
| M. vanbaalenii PYR-1 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4621|M.gilvum_PYR-GCK --------------------------------------------------
TH_3143|M.thermoresistible__bu --------------------------------------------------
MUL_3245|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2099|M.marinum_M --------------------------------------------------
Mb2391c|M.bovis_AF2122/97 --------------------------------------------------
Rv2370c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01052|M.leprae_Br4923 --------------------------------------------------
MAB_2657c|M.abscessus_ATCC_199 -------------------------------------------------M
MSMEG_2971|M.smegmatis_MC2_155 MLSLSALLADPTLELTLLVPGSPGAVDREVLWLHNTELPDPSPYIRATEL
Mflv_4621|M.gilvum_PYR-GCK --------------MLDSSEVQDTPGHAVHHLFRDLGDLVRELPESIHGL
TH_3143|M.thermoresistible__bu --------------VVVSGYNADDISSTVALIVDRLLENSGEDVERIQRR
MUL_3245|M.ulcerans_Agy99 ------------MASPSNPSLSPRMRELIRHTARIALNPTQQWLDELDRT
MMAR_2099|M.marinum_M ------------------------MRELIRHTARIALNPTQQWLDELDRT
Mb2391c|M.bovis_AF2122/97 ---------------MVLPKPTPRGRELIRQAAKVALHPTPEWLDELDRA
Rv2370c|M.tuberculosis_H37Rv ---------------MVLPKPTPRGRELIRQAAKVALHPTPEWLDELDRA
MLBr_01052|M.leprae_Br4923 ---------------MARQHPSPRVRELIREGARIALNPTQEWIDQLDRA
MAB_2657c|M.abscessus_ATCC_199 NEGSERVHTQSMTPDQLWPDASEPVRRLIRELAEKMLARSGEVAGDLTAA
MSMEG_2971|M.smegmatis_MC2_155 VLTNGLWRGTVDSTMFVDALLRARAAGVVFGLTEQTPAAPADLVEACSSA
: :
Mflv_4621|M.gilvum_PYR-GCK LIEQV--AELAADQQLKELLSDTVAANVDTWFS-VVRHSIPFDRMESPTA
TH_3143|M.thermoresistible__bu ILADI--DELRSDPRLVELLRSSVAGNVETVLT-VIRYGIDLDRVEPPTA
MUL_3245|M.ulcerans_Agy99 TLAAN--PALSDDPALVEIISRANRANLIHFAVAILRDPGGPVPANFGPE
MMAR_2099|M.marinum_M TLAAN--PALSDDPALVEIISRANRANLIHFAVAILRDPGGPVPANFGPE
Mb2391c|M.bovis_AF2122/97 TLAAH--PSIAADPALATVVSRANRSHLIHFATANLRKPGQPVPANLGPD
Rv2370c|M.tuberculosis_H37Rv TLAAH--PSIAADPALATVVSRANRSHLIHFATANLRKPGQPVPANLGPD
MLBr_01052|M.leprae_Br4923 TFAAN--PAIANDPVLAKVVRRASRAHLVHWATANLRDPGAPVPAHLGPE
MAB_2657c|M.abscessus_ATCC_199 SLEDPRYRTIADDPVIAEVDARLTVSNLKHWLTSNISEPGHRVRPATGSA
MSMEG_2971|M.smegmatis_MC2_155 ELPLATVSIAVPFTAITQAAARIQSDARQAALSKLVRRGNALASSIARGG
: : :
Mflv_4621|M.gilvum_PYR-GCK ALEHARRMAQREVPVNALLR---AYRLGHQYGLNLIIAGLRSADLPPEEK
TH_3143|M.thermoresistible__bu ALEYARRAAQHGIALSALIR---AYRLGQQEMLERILREVRETELDPDLR
MUL_3245|M.ulcerans_Agy99 PLRMAQELLNRGLEALAAD----IYRIAHNVAWERWTDIAFGLTSNPQEL
MMAR_2099|M.marinum_M PLRMAQELLNRGLEALAAD----IYRIAHNVAWERWTDIAFGLTSNPQEL
Mb2391c|M.bovis_AF2122/97 PLRMARDLVRRGLDASALD----VYRVGQNVAWQRWTEIAFGLTTDPQEL
Rv2370c|M.tuberculosis_H37Rv PLRMARDLVRRGLDASALD----VYRVGQNVAWQRWTEIAFGLTTDPQEL
MLBr_01052|M.leprae_Br4923 PLTMARDLVRRGRDVLALD----IYRVGQYTAWRRWMEIAFTLTSDPQEL
MAB_2657c|M.abscessus_ATCC_199 MRTYARDVVLRGLTTDDIQ----SWRAVQRVGWKWWLAACFQVTDDKEQL
MSMEG_2971|M.smegmatis_MC2_155 GAEGILDVLRRDHDLPLLVVDRLGRRLAGDIGDDEDVQVAADALNRHPPP
: *
Mflv_4621|M.gilvum_PYR-GCK LALIEHITRVSFRYIDW-----------MSEQVLETYQTERAEWDERRRS
TH_3143|M.thermoresistible__bu LSVYERISSTSFAYIDW-----------ISQQVSDTYDTERERWLEHRNN
MUL_3245|M.ulcerans_Agy99 RDLLDVAFRSSNDFIDA-----------TIAGIPAQLPLEYDALTREVSA
MMAR_2099|M.marinum_M RDLLDVAFRSSNDFIDA-----------TIAGIPAQLPLEYDALTREVSA
Mb2391c|M.bovis_AF2122/97 HELLTLPFRSASEFIDA-----------TLAGLAAQMQLEYDELTRDVHA
Rv2370c|M.tuberculosis_H37Rv HELLTLPFRSASEFIDA-----------TLAGLAAQMQLEYDELTRDVHA
MLBr_01052|M.leprae_Br4923 REILNVSAQSINEYVAA-----------TLEAIATHMQLERDELTRSTHA
MAB_2657c|M.abscessus_ATCC_199 CELIEVTSNSLTTFVDD-----------SIAELAEHVRRVREELAGGSQL
MSMEG_2971|M.smegmatis_MC2_155 LEVALPSGDTASVYLVEGAMGDVDAGLFCLRPLPSLKPLERDALDQAARY
: :: :
Mflv_4621|M.gilvum_PYR-GCK L-----------------RAQAIRDILNGRD-VDLTEASSAMRYFLGATH
TH_3143|M.thermoresistible__bu I-----------------RAVRVREILDSDEPIDIDTASAALGYPLRGRH
MUL_3245|M.ulcerans_Agy99 Q-----------------RRKVVEQILGGAP-VNRERAEAQLGYLLDRAH
MMAR_2099|M.marinum_M Q-----------------RRKVVEQILGGAP-VNRERAEAQLGYLLDRAH
Mb2391c|M.bovis_AF2122/97 E-----------------HRRIVELILDGAP-ISRQSAEAKLGYPLDRSH
Rv2370c|M.tuberculosis_H37Rv E-----------------HRRIVELILDGAP-ISRQSAEAKLGYPLDRSH
MLBr_01052|M.leprae_Br4923 E-----------------RLEVVDLILEGAP-VTQERAEARLGYRLGLTH
MAB_2657c|M.abscessus_ATCC_199 Q-----------------RYATVELLLQGAD-IAPARAEAQLGYALTGSH
MSMEG_2971|M.smegmatis_MC2_155 LSLEVTRQQALQAIESRFSSELLEMVLSGAA-RARDVAERLRAFGIDPSS
: :* . *. : :
Mflv_4621|M.gilvum_PYR-GCK VALMVWLDRDAGADTDEFIAMERFMQHAVSATGAKQS-VYFSIDRLVGCA
TH_3143|M.thermoresistible__bu LALVLWMTR-SDLPGGELLRLERFARAVAEAFQLRNTPLFVAEDTVSGWA
MUL_3245|M.ulcerans_Agy99 TAAIVWSDEPDGDHG----QLDQAADAFCTALGCRAPLIVVTNSATR---
MMAR_2099|M.marinum_M TAAIVWSDEPDGDHG----QLDQAADAFCTALGCRAPLIVVTNSATR---
Mb2391c|M.bovis_AF2122/97 TAAIIWYDDPDDNQN----HLDHTARAFGRALGCPQPLIAVASAATR---
Rv2370c|M.tuberculosis_H37Rv TAAIIWYDDPDDNQN----HLDHTARAFGRALGCPQPLIAVASAATR---
MLBr_01052|M.leprae_Br4923 TAAVIWSDDLDGDHG----YLDQAAEAFSHVVESTQQLIVVASAATR---
MAB_2657c|M.abscessus_ATCC_199 IGAVVWVDS-EKEIA----ALERASEQVMRACGADRRLTVVAGTVAL---
MSMEG_2971|M.smegmatis_MC2_155 ALAVYTVVVGDGAVRPP--GSTDEIEDFFNRHSIPAVVIPGSQDTVVVFG
: :
Mflv_4621|M.gilvum_PYR-GCK WMTV-HRPSDYLSQLRDFVRAQPDGPRLSVGEPLPGIEG--FRRTYRQAE
TH_3143|M.thermoresistible__bu WLAINHVVTEPVRTIRELAETADNGVHVALGTVDDGLEG--FRRSHRRAR
MUL_3245|M.ulcerans_Agy99 WVWVNDAATPVGDRIQQVLTYAP-TVRLVVGNTRRGIEG--FRRSHRDAQ
MMAR_2099|M.marinum_M WVWVNDAATPVGDRIQQVLTDAP-TVRLAVGNTRRGIEG--FRRSHRDAQ
Mb2391c|M.bovis_AF2122/97 WVWVSDAATLDTDRIHQVLDHAP-HARIAVGTTARGIDG--FRRSHRDAL
Rv2370c|M.tuberculosis_H37Rv WVWVSDAATLDTDRIHQVLDHAP-HARIAVGTTARGIDG--FRRSHRDAL
MLBr_01052|M.leprae_Br4923 WVWLADALALDVPEVQKALLNLS-KARVAIGTSSAGIEG--FRRSHLEAL
MAB_2657c|M.abscessus_ATCC_199 WLWIPAKTTPTVAVLMDSLGRRS-GVRVALGRAATGMAG--FRRTHMDAA
MSMEG_2971|M.smegmatis_MC2_155 WHRDMTALVGLAEDLVQTLTARFPADRAVIGVGDLAADASALREPLIRAR
* : . : :* . . :*.. *
Mflv_4621|M.gilvum_PYR-GCK QARVVAVAADGSSRHRIVAARDPGVALASMLM--TDDATLKEWIHDVLGP
TH_3143|M.thermoresistible__bu DARKVAAAS--AIPPRITAADDYGISVSALLT--ENLADTRRWVLDTLGP
MUL_3245|M.ulcerans_Agy99 TTQRMLTRLG----APQRTAHFADTQMVELLT--QDLEGVDEFIECTLGE
MMAR_2099|M.marinum_M TTQRMLTRLG----APQRTAHFADTQMVELLT--QDLEGVDEFIECTLGE
Mb2391c|M.bovis_AF2122/97 ATQRMLARLR----SQQRLAFFADIHMIAVLT--ENPDSAADFITSTLGD
Rv2370c|M.tuberculosis_H37Rv ATQRMLARLR----SQQRLAFFADIHMIAVLT--ENPDSAADFITSTLGD
MLBr_01052|M.leprae_Br4923 TAQRTLARLK----SHQQVAFFADVQLVSLIT--QNPEDAKEFITSTLGD
MAB_2657c|M.abscessus_ATCC_199 AAQRLLARLG----SPLSVVRYEDVHLMDLLS--ADPASADQFVTDVLGE
MSMEG_2971|M.smegmatis_MC2_155 ETCHVLRRRT----TEPKVGTYADIGTHRMLLGLHDRSVLRRFADDILGP
: . :: : : **
Mflv_4621|M.gilvum_PYR-GCK LAQNTASD-QRLRDTLRVFLRAGSSFKAAANELQIHANTVKYRVNRALER
TH_3143|M.thermoresistible__bu LASDTAND-ARLRETLLVFLHVGSSYTAAAERLLLHPNSVRYRVNRAVER
MUL_3245|M.ulcerans_Agy99 FQSASP----VLHAILLTYINQQCNAARTAKALYIHRNTLVHRLETAHRL
MMAR_2099|M.marinum_M FQSASP----VLHATLLTYINQQCNAARTAKALYIHRNTLVHRLETAHRL
Mb2391c|M.bovis_AF2122/97 LESASP----QLLTTVLTYINEQCNASRAAHVLHTHRNTLLRRLETAQRL
Rv2370c|M.tuberculosis_H37Rv LESASP----QLLTTVLTYINEQCNASRAAHVLHTHRNTLLRRLETAQRL
MLBr_01052|M.leprae_Br4923 FESASP----ALQQTLLTFINEQCNASRAAKRLFTHRNTLLRRIESAEKL
MAB_2657c|M.abscessus_ATCC_199 FQSASP----VLHQTVLTYVEEALNRTSTAERLYTHRNTIDRRLARVDEL
MSMEG_2971|M.smegmatis_MC2_155 LDQHDEQYGTALVRTLRTFLANDGHWAKTATELYVHVNTLRNRIARISEL
: . * : .:: :* * * *:: *: .
Mflv_4621|M.gilvum_PYR-GCK RGRPIAAERLDVEVALLMCYWLGEVALNPTQALGRS--------------
TH_3143|M.thermoresistible__bu RARPIGEDRLEVELALLACRHFQQAVLQPAD-------------------
MUL_3245|M.ulcerans_Agy99 LPQPVEANIVRIAVALEVLQWRSDRDD---------------------DS
MMAR_2099|M.marinum_M LPQPVEANIVHIAVALEVLQWRSDRDG---------------------DS
Mb2391c|M.bovis_AF2122/97 LPRPLDHTIIQVAVAISALQWRGSQTSDPVETPVEGITSPPPESLGRRRS
Rv2370c|M.tuberculosis_H37Rv LPRPLDHTIIQVAVAISALQWRGSQTSDPVETPVEGITSPPPESLGRRRS
MLBr_01052|M.leprae_Br4923 LPRPLDHTSVHIAVALEALQWRGDQTN----------TSGP--RAGRNDG
MAB_2657c|M.abscessus_ATCC_199 LPKPFARNPIEVAAALTLLRVRAGR-------------------------
MSMEG_2971|M.smegmatis_MC2_155 TGRDVARLEDRVDLFLALEADALG--------------------------
: . : :
Mflv_4621|M.gilvum_PYR-GCK -------
TH_3143|M.thermoresistible__bu -------
MUL_3245|M.ulcerans_Agy99 LRAIT--
MMAR_2099|M.marinum_M LRAIT--
Mb2391c|M.bovis_AF2122/97 RLAQLER
Rv2370c|M.tuberculosis_H37Rv RLAQLER
MLBr_01052|M.leprae_Br4923 VPA----
MAB_2657c|M.abscessus_ATCC_199 -------
MSMEG_2971|M.smegmatis_MC2_155 -------