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RELIRHTARIALNPTQQWLDELDRTTLAANPALSDDPALVEIISRANRANLIHFAVAILRDPGGPVPANF GPEPLRMAQELLNRGLEALAADIYRIAHNVAWERWTDIAFGLTSNPQELRDLLDVAFRSSNDFIDATIAG IPAQLPLEYDALTREVSAQRRKVVEQILGGAPVNRERAEAQLGYLLDRAHTAAIVWSDEPDGDHGQLDQA ADAFCTALGCRAPLIVVTNSATRWVWVNDAATPVGDRIQQVLTDAPTVRLAVGNTRRGIEGFRRSHRDAQ TTQRMLTRLGAPQRTAHFADTQMVELLTQDLEGVDEFIECTLGEFQSASPVLHATLLTYINQQCNAARTA KALYIHRNTLVHRLETAHRLLPQPVEANIVHIAVALEVLQWRSDRDGDSLRAIT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_2099 | - | - | 100% (405) | transcriptional regulator |
| M. marinum M | MMAR_2258 | - | e-143 | 59.65% (399) | transcriptional activator protein |
| M. marinum M | MMAR_4242 | - | e-132 | 58.48% (395) | transcriptional regulatory protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1488 | - | 1e-144 | 61.15% (399) | transcriptional activator protein |
| M. gilvum PYR-GCK | Mflv_4621 | - | 2e-12 | 25.00% (260) | hypothetical protein Mflv_4621 |
| M. tuberculosis H37Rv | Rv1453 | - | 1e-144 | 61.15% (399) | transcriptional activator protein |
| M. leprae Br4923 | MLBr_01052 | - | 1e-129 | 55.75% (400) | hypothetical protein MLBr_01052 |
| M. abscessus ATCC 19977 | MAB_2657c | - | 1e-61 | 34.09% (399) | hypothetical protein MAB_2657c |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_2971 | - | 1e-06 | 25.28% (269) | regulatory protein |
| M. thermoresistible (build 8) | TH_3143 | - | 2e-19 | 27.99% (393) | PUTATIVE putative conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_3245 | - | 0.0 | 98.77% (405) | transcriptional regulator |
| M. vanbaalenii PYR-1 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4621|M.gilvum_PYR-GCK --------------------------------------------------
TH_3143|M.thermoresistible__bu --------------------------------------------------
MMAR_2099|M.marinum_M --------------------------------------------------
MUL_3245|M.ulcerans_Agy99 --------------------------------------------------
Mb1488|M.bovis_AF2122/97 --------------------------------------------------
Rv1453|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01052|M.leprae_Br4923 --------------------------------------------------
MAB_2657c|M.abscessus_ATCC_199 -------------------------------------------------M
MSMEG_2971|M.smegmatis_MC2_155 MLSLSALLADPTLELTLLVPGSPGAVDREVLWLHNTELPDPSPYIRATEL
Mflv_4621|M.gilvum_PYR-GCK --------------MLDSSEVQDTPGHAVHHLFRDLGDLVRELPESIHGL
TH_3143|M.thermoresistible__bu --------------VVVSGYNADDISSTVALIVDRLLENSGEDVERIQRR
MMAR_2099|M.marinum_M ------------------------MRELIRHTARIALNPTQQWLDELDRT
MUL_3245|M.ulcerans_Agy99 ------------MASPSNPSLSPRMRELIRHTARIALNPTQQWLDELDRT
Mb1488|M.bovis_AF2122/97 ---------------MALRETSPRIHELIREAARIALNPTQEWLDEFDRA
Rv1453|M.tuberculosis_H37Rv ---------------MALRETSPRIHELIREAARIALNPTQEWLDEFDRA
MLBr_01052|M.leprae_Br4923 ---------------MARQHPSPRVRELIREGARIALNPTQEWIDQLDRA
MAB_2657c|M.abscessus_ATCC_199 NEGSERVHTQSMTPDQLWPDASEPVRRLIRELAEKMLARSGEVAGDLTAA
MSMEG_2971|M.smegmatis_MC2_155 VLTNGLWRGTVDSTMFVDALLRARAAGVVFGLTEQTPAAPADLVEACSSA
: :
Mflv_4621|M.gilvum_PYR-GCK LIEQV--AELAADQQLKELLSDTVAANVDTWFS-VVRHSIPFDRMESPTA
TH_3143|M.thermoresistible__bu ILADI--DELRSDPRLVELLRSSVAGNVETVLT-VIRYGIDLDRVEPPTA
MMAR_2099|M.marinum_M TLAAN--PALSDDPALVEIISRANRANLIHFAVAILRDPGGPVPANFGPE
MUL_3245|M.ulcerans_Agy99 TLAAN--PALSDDPALVEIISRANRANLIHFAVAILRDPGGPVPANFGPE
Mb1488|M.bovis_AF2122/97 ILAAN--PSIAADPALATVVKRSNRAHLIHFAAANLRNPGAPVPANLGPE
Rv1453|M.tuberculosis_H37Rv ILAAN--PSIAADPALATVVKRSNRAHLIHFAAANLRNPGAPVPANLGPE
MLBr_01052|M.leprae_Br4923 TFAAN--PAIANDPVLAKVVRRASRAHLVHWATANLRDPGAPVPAHLGPE
MAB_2657c|M.abscessus_ATCC_199 SLEDPRYRTIADDPVIAEVDARLTVSNLKHWLTSNISEPGHRVRPATGSA
MSMEG_2971|M.smegmatis_MC2_155 ELPLATVSIAVPFTAITQAAARIQSDARQAALSKLVRRGNALASSIARGG
: : :
Mflv_4621|M.gilvum_PYR-GCK ALEHARRMAQREVPVNALLR---AYRLGHQYGLNLIIAGLRSADLPPEEK
TH_3143|M.thermoresistible__bu ALEYARRAAQHGIALSALIR---AYRLGQQEMLERILREVRETELDPDLR
MMAR_2099|M.marinum_M PLRMAQELLNRGLEALAAD----IYRIAHNVAWERWTDIAFGLTSNPQEL
MUL_3245|M.ulcerans_Agy99 PLRMAQELLNRGLEALAAD----IYRIAHNVAWERWTDIAFGLTSNPQEL
Mb1488|M.bovis_AF2122/97 PLRMARDLVRVGLDALALD----IYRIGQNVAWRRWTDIAFGLTSDPDEL
Rv1453|M.tuberculosis_H37Rv PLRMARDLVRVGLDALALD----IYRIGQNVAWRRWTDIAFGLTSDPDEL
MLBr_01052|M.leprae_Br4923 PLTMARDLVRRGRDVLALD----IYRVGQYTAWRRWMEIAFTLTSDPQEL
MAB_2657c|M.abscessus_ATCC_199 MRTYARDVVLRGLTTDDIQ----SWRAVQRVGWKWWLAACFQVTDDKEQL
MSMEG_2971|M.smegmatis_MC2_155 GAEGILDVLRRDHDLPLLVVDRLGRRLAGDIGDDEDVQVAADALNRHPPP
*
Mflv_4621|M.gilvum_PYR-GCK LALIEHITRVSFRYIDW-----------MSEQVLETYQTERAEWDERRRS
TH_3143|M.thermoresistible__bu LSVYERISSTSFAYIDW-----------ISQQVSDTYDTERERWLEHRNN
MMAR_2099|M.marinum_M RDLLDVAFRSSNDFIDA-----------TIAGIPAQLPLEYDALTREVSA
MUL_3245|M.ulcerans_Agy99 RDLLDVAFRSSNDFIDA-----------TIAGIPAQLPLEYDALTREVSA
Mb1488|M.bovis_AF2122/97 HELLDVPFRTANEFVDT-----------TLAGITTEMQLERDKLTRDVPA
Rv1453|M.tuberculosis_H37Rv HELLDVPFRTANEFVDT-----------TLAGITTEMQLERDKLTRDVPA
MLBr_01052|M.leprae_Br4923 REILNVSAQSINEYVAA-----------TLEAIATHMQLERDELTRSTHA
MAB_2657c|M.abscessus_ATCC_199 CELIEVTSNSLTTFVDD-----------SIAELAEHVRRVREELAGGSQL
MSMEG_2971|M.smegmatis_MC2_155 LEVALPSGDTASVYLVEGAMGDVDAGLFCLRPLPSLKPLERDALDQAARY
: :: :
Mflv_4621|M.gilvum_PYR-GCK L-----------------RAQAIRDILNGRD-VDLTEASSAMRYFLGATH
TH_3143|M.thermoresistible__bu I-----------------RAVRVREILDSDEPIDIDTASAALGYPLRGRH
MMAR_2099|M.marinum_M Q-----------------RRKVVEQILGGAP-VNRERAEAQLGYLLDRAH
MUL_3245|M.ulcerans_Agy99 Q-----------------RRKVVEQILGGAP-VNRERAEAQLGYLLDRAH
Mb1488|M.bovis_AF2122/97 E-----------------RRKIVQLLIDGAP-ISREHAEARLGYPLDRSH
Rv1453|M.tuberculosis_H37Rv E-----------------RRKIVQLLIDGAP-ISREHAEARLGYPLDRSH
MLBr_01052|M.leprae_Br4923 E-----------------RLEVVDLILEGAP-VTQERAEARLGYRLGLTH
MAB_2657c|M.abscessus_ATCC_199 Q-----------------RYATVELLLQGAD-IAPARAEAQLGYALTGSH
MSMEG_2971|M.smegmatis_MC2_155 LSLEVTRQQALQAIESRFSSELLEMVLSGAA-RARDVAERLRAFGIDPSS
: :: . *. : :
Mflv_4621|M.gilvum_PYR-GCK VALMVWLDRDAGADTDEFIAMERFMQHAVSATGAKQS-VYFSIDRLVGCA
TH_3143|M.thermoresistible__bu LALVLWMTR-SDLPGGELLRLERFARAVAEAFQLRNTPLFVAEDTVSGWA
MMAR_2099|M.marinum_M TAAIVWSDEPDGDHG----QLDQAADAFCTALGCRAPLIVVTNSATR---
MUL_3245|M.ulcerans_Agy99 TAAIVWSDEPDGDHG----QLDQAADAFCTALGCRAPLIVVTNSATR---
Mb1488|M.bovis_AF2122/97 TAAVIWGDQAQGDHS----HLDRVADAFGHAGGCPHPLVVVAGAATR---
Rv1453|M.tuberculosis_H37Rv TAAVIWGDQAQGDHS----HLDRVADAFGHAGGCPHPLVVVAGAATR---
MLBr_01052|M.leprae_Br4923 TAAVIWSDDLDGDHG----YLDQAAEAFSHVVESTQQLIVVASAATR---
MAB_2657c|M.abscessus_ATCC_199 IGAVVWVDS-EKEIA----ALERASEQVMRACGADRRLTVVAGTVAL---
MSMEG_2971|M.smegmatis_MC2_155 ALAVYTVVVGDGAVRPP--GSTDEIEDFFNRHSIPAVVIPGSQDTVVVFG
: :
Mflv_4621|M.gilvum_PYR-GCK WMTV-HRPSDYLSQLRDFVRAQPDGPRLSVGEPLPGIEG--FRRTYRQAE
TH_3143|M.thermoresistible__bu WLAINHVVTEPVRTIRELAETADNGVHVALGTVDDGLEG--FRRSHRRAR
MMAR_2099|M.marinum_M WVWVNDAATPVGDRIQQVLTDAP-TVRLAVGNTRRGIEG--FRRSHRDAQ
MUL_3245|M.ulcerans_Agy99 WVWVNDAATPVGDRIQQVLTYAP-TVRLVVGNTRRGIEG--FRRSHRDAQ
Mb1488|M.bovis_AF2122/97 WVWVKDAPGFDIDLIHEVLHDIP-DARIAIGATAPGIEG--FRRSHRDAL
Rv1453|M.tuberculosis_H37Rv WVWVKDAPGFDIDLIHEVLHDIP-DARIAIGATAPGIEG--FRRSHRDAL
MLBr_01052|M.leprae_Br4923 WVWLADALALDVPEVQKALLNLS-KARVAIGTSSAGIEG--FRRSHLEAL
MAB_2657c|M.abscessus_ATCC_199 WLWIPAKTTPTVAVLMDSLGRRS-GVRVALGRAATGMAG--FRRTHMDAA
MSMEG_2971|M.smegmatis_MC2_155 WHRDMTALVGLAEDLVQTLTARFPADRAVIGVGDLAADASALREPLIRAR
* : . : :* . . :*.. *
Mflv_4621|M.gilvum_PYR-GCK QARVVAVAADGSSRHRIVAARDPGVALASMLMTDDATLKEWIHDVLGPLA
TH_3143|M.thermoresistible__bu DARKVAAAS--AIPPRITAADDYGISVSALLTENLADTRRWVLDTLGPLA
MMAR_2099|M.marinum_M TTQRMLTRLG--APQRTAHFAD--TQMVELLTQDLEGVDEFIECTLGEFQ
MUL_3245|M.ulcerans_Agy99 TTQRMLTRLG--APQRTAHFAD--TQMVELLTQDLEGVDEFIECTLGEFQ
Mb1488|M.bovis_AF2122/97 TTARMIIRLE--SPHRVAFFTD--VEMVALLTENAEGADDFIQRTLGNLE
Rv1453|M.tuberculosis_H37Rv TTARMIIRLE--SPHRVAFFTD--VEMVALLTENAEGADDFIQRTLGNLE
MLBr_01052|M.leprae_Br4923 TAQRTLARLK--SHQQVAFFAD--VQLVSLITQNPEDAKEFITSTLGDFE
MAB_2657c|M.abscessus_ATCC_199 AAQRLLARLG--SPLSVVRYED--VHLMDLLSADPASADQFVTDVLGEFQ
MSMEG_2971|M.smegmatis_MC2_155 ETCHVLRRRT--TEPKVGTYADIGTHRMLLGLHDRSVLRRFADDILGPLD
: * : : : ** :
Mflv_4621|M.gilvum_PYR-GCK QNTASD-QRLRDTLRVFLRAGSSFKAAANELQIHANTVKYRVNRALERRG
TH_3143|M.thermoresistible__bu SDTAND-ARLRETLLVFLHVGSSYTAAAERLLLHPNSVRYRVNRAVERRA
MMAR_2099|M.marinum_M SASP----VLHATLLTYINQQCNAARTAKALYIHRNTLVHRLETAHRLLP
MUL_3245|M.ulcerans_Agy99 SASP----VLHAILLTYINQQCNAARTAKALYIHRNTLVHRLETAHRLLP
Mb1488|M.bovis_AF2122/97 SASP----ALKTTLLTFINQQCNASRAARLLFTHRNTLMNRLETAQRLLP
Rv1453|M.tuberculosis_H37Rv SASP----ALKTTLLTFINQQCNASRAARLLFTHRNTLMNRLETAQRLLP
MLBr_01052|M.leprae_Br4923 SASP----ALQQTLLTFINEQCNASRAAKRLFTHRNTLLRRIESAEKLLP
MAB_2657c|M.abscessus_ATCC_199 SASP----VLHQTVLTYVEEALNRTSTAERLYTHRNTIDRRLARVDELLP
MSMEG_2971|M.smegmatis_MC2_155 QHDEQYGTALVRTLRTFLANDGHWAKTATELYVHVNTLRNRIARISELTG
. * : .:: :* * * *:: *: .
Mflv_4621|M.gilvum_PYR-GCK RPIAAERLDVEVALLMCYWLGEVALNPTQALGRS------
TH_3143|M.thermoresistible__bu RPIGEDRLEVELALLACRHFQQAVLQPAD-----------
MMAR_2099|M.marinum_M QPVEANIVHIAVALEVLQWRSDRDGDSLRAIT--------
MUL_3245|M.ulcerans_Agy99 QPVEANIVRIAVALEVLQWRSDRDDDSLRAIT--------
Mb1488|M.bovis_AF2122/97 RPLADTTIHVAVALEAQQWREKQTSDP-PAKKESNGTKMR
Rv1453|M.tuberculosis_H37Rv RPLADTTIHVAVALEAQQWREKPTSDP-PAKKESNGTKMR
MLBr_01052|M.leprae_Br4923 RPLDHTSVHIAVALEALQWRGDQTNTSGPRAGRNDGVPA-
MAB_2657c|M.abscessus_ATCC_199 KPFARNPIEVAAALTLLRVRAGR-----------------
MSMEG_2971|M.smegmatis_MC2_155 RDVARLEDRVDLFLALEADALG------------------
: . : *