For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
LPGDRVAVWHGDCAALHALFIAIERCGAVVVGIGARAGVREATQILRAAQVKLLVSDAPRSAAATEVSAQ LPVPSGVLVREGKTLRFDGKPVPVAPENGLESELGNERRLGPDDVFLINSTSGTTGAPKCVVHTQNRWHY FHQHAVANGMLTPQDVVLPVIPMPFGFGIWTSHTTPIYLGASAVILDRFTTLAACEAIARHRVTVLCCVS TQLTMLMADHWCRAYDLSSLRVVFAGGEALPYRRATEFEDLTGAAILQFYGSNETGLLSATTLRDSRERR LRTGGRVVPEMSVRLFDGDRDVTASGRGQPGCRGPATSLGYLGGTDHEKLFTRDGWMRMGDICEIDPDGY LTVTGRTSDFILRGGKNISAGQVEDAALTHPAVAIAAAVSMPDPVFGEKVCLYVELADSQRLDRTELVEH LLALGYSKELLPERLVVVDELPRSSGGKIAKGQLRDDIRARMEAEHERS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_3145 | - | - | 100% (470) | hypothetical protein MUL_3145 |
| M. ulcerans Agy99 | MUL_3641 | mbtA | 3e-35 | 32.12% (386) | bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP |
| M. ulcerans Agy99 | MUL_0229 | fadD14 | 4e-32 | 29.14% (477) | acyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2533c | fadD35 | 1e-39 | 29.83% (476) | AMP-binding domain protein |
| M. gilvum PYR-GCK | Mflv_4616 | - | 2e-43 | 31.50% (473) | AMP-dependent synthetase and ligase |
| M. tuberculosis H37Rv | Rv2505c | fadD35 | 1e-39 | 29.83% (476) | AMP-binding domain protein |
| M. leprae Br4923 | MLBr_01051 | xclC | 3e-28 | 27.83% (442) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4377c | - | 2e-39 | 28.06% (474) | AMP-binding domain protein |
| M. marinum M | MMAR_2616 | - | 0.0 | 99.36% (470) | hypothetical protein MMAR_2616 |
| M. avium 104 | MAV_2995 | - | 0.0 | 75.42% (476) | adenylate-forming enzyme |
| M. smegmatis MC2 155 | MSMEG_5649 | - | 2e-40 | 28.93% (484) | acyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_3821 | - | 4e-46 | 31.76% (466) | PUTATIVE putative adenylate-forming enzyme |
| M. vanbaalenii PYR-1 | Mvan_4966 | - | 2e-46 | 34.17% (398) | AMP-dependent synthetase and ligase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2533c|M.bovis_AF2122/97 ------MAAAEVVDPNRLSYDRGPSAPSLLESTIGANLAATAARYGHREA
Rv2505c|M.tuberculosis_H37Rv ------MAAAEVVDPNRLSYDRGPSAPSLLESTIGANLAATAARYGHREA
MAB_4377c|M.abscessus_ATCC_199 ----------------MKAYDAGATLSPIIEETIGENFERIARAHPDVGA
MSMEG_5649|M.smegmatis_MC2_155 ----------------MKSYDAGPTGAPVLEETIGANFERIAATYPEHEA
Mflv_4616|M.gilvum_PYR-GCK -----------------------------MDRGIGQWVTKRAFLNGQRTA
MUL_3145|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2616|M.marinum_M -MAVGRRDMAGSPAFSTQEAIRYHAAGWWSDSTLSDAVRRNAECSPHHAA
MAV_2995|M.avium_104 MMSAGGLHTESSPAFSDEDVARFRAAGWWCDSTLSDAVRRNAQRTPERPA
MLBr_01051|M.leprae_Br4923 --------------------------------------MLLASLNPSVVT
TH_3821|M.thermoresistible__bu ------------------------------------------MLEADPDA
Mvan_4966|M.vanbaalenii_PYR-1 --------------------------------MTTLADALRDAARDTPDR
Mb2533c|M.bovis_AF2122/97 LVDMVARRRFNYSELLTDVHRLATGLVRAGIGPGDRVGIWAPNRWEWVLV
Rv2505c|M.tuberculosis_H37Rv LVDMVARRRFNYSELLTDVHRLATGLVRAGIGPGDRVGIWAPNRWEWVLV
MAB_4377c|M.abscessus_ATCC_199 LVDVSGDRRWTYRELDAEINRVARGLMSLGVAAGDRVGIWAPNCAEWVLV
MSMEG_5649|M.smegmatis_MC2_155 LVEVATGRRWTYAELNDEIDATARGLMALGVDKGDRVGIWAPNCAEWIMT
Mflv_4616|M.gilvum_PYR-GCK LVQG--DTSFTYSDFDRRTNQVASSLLRLGVRKGDRVAILLVNSVEFLEV
MUL_3145|M.ulcerans_Agy99 ------------------------------MLPGDRVAVWHGDCAALHAL
MMAR_2616|M.marinum_M YIDYP-ASLLTWSEFDCAATNLAEQLAGAGVLPGDRVAVWHGDCAALHAL
MAV_2995|M.avium_104 YIDHG-GRTFTWHEFDCAASNLAETLAGLGVGPGDRVAVWHGDCAAIHVL
MLBr_01051|M.leprae_Br4923 ATDIADAVCVDGVVLSRSGLVGAATSVAERVGGARLVAVLATPTASTVLA
TH_3821|M.thermoresistible__bu VALIRGDQRWSREQLWELSGRAVAKLRSLGAEPGDAVVAHYDTGAEEMAI
Mvan_4966|M.vanbaalenii_PYR-1 ILLRDDEASLSSAELLSAATNLAHALVRR-MPVGSVVSFAVPNWHEAAVI
. *
Mb2533c|M.bovis_AF2122/97 QYATAEIGAILVTINPAYRVREVEYALRQSGVAMVIAVASFKDADYAAML
Rv2505c|M.tuberculosis_H37Rv QYATAEIGAILVTINPAYRVREVEYALRQSGVAMVIAVASFKDADYAAML
MAB_4377c|M.abscessus_ATCC_199 QYATAKIGAILVNINPAYRTHELAYALNQSGVRTLICAKAFKSSDYVAMA
MSMEG_5649|M.smegmatis_MC2_155 QFAAAKVGAILVNINPAYRTHEVAYVLRQSGVRTLVSASSFKTSDYASMI
Mflv_4616|M.gilvum_PYR-GCK LLGCAKIGAITIPINVRLAGPEIGYILADSGADVFVFHAPLAAAAVSALT
MUL_3145|M.ulcerans_Agy99 FIAIERCGAVVVGIGARAGVREATQILRAAQVKLLVSDAPRSAAATEVSA
MMAR_2616|M.marinum_M FIAIERCGAVVVGIGARAGIREATQILRAAQVKLLVSDAPRSAAATEVSA
MAV_2995|M.avium_104 FVAIERRGAVIVGIGERAGAREAGAILRNAQPKILLSDQPRSKPAAEVAG
MLBr_01051|M.leprae_Br4923 ITGCLIAGVPVVPVPADIGVVERRHMLTDSGAQAWLGPGPSADSAPDG--
TH_3821|M.thermoresistible__bu ALAASRLGCVFMPIPRRLGARELNYVVGLADPVLVAVQDRDHVGVVENPG
Mvan_4966|M.vanbaalenii_PYR-1 YLGATLAGMVVNPILPSLRERELSFILADAGSRAIFIPQTFGGHDYAAML
. * : * : :
Mb2533c|M.bovis_AF2122/97 AEVGPRCPDLADVILLESDRWDALAG--AEPDLPALQQTAARLDGSDPVN
Rv2505c|M.tuberculosis_H37Rv AEVGPRCPDLADVILLESDRWDALAG--AEPDLPALQQTAARLDGSDPVN
MAB_4377c|M.abscessus_ATCC_199 SQVMPDAPGLRDVVFIGTSDWTELVAGAERVTETALRARMSQLSNTDPIN
MSMEG_5649|M.smegmatis_MC2_155 AEVRPECPDLLDVVFLDNDDWDRLRA--NQVDDAAFHERMATLANTDPIN
Mflv_4616|M.gilvum_PYR-GCK EPG----VRVRHTLRAGGAPADGEIPYTDLLSDGAPAPLDSDVEGRDPAF
MUL_3145|M.ulcerans_Agy99 QLPVPSGVLVREGKTLRFD--GKPVPVAPENGLESELGNERRLGPDDVFL
MMAR_2616|M.marinum_M QLPVPSGVLVREGKTLRFD--GKPVPVAPENGLESELGNERRLGPDDVFL
MAV_2995|M.avium_104 ELRIPALVLT------------QPLDTEPR-----AFDRDCQLGPDDVFL
MLBr_01051|M.leprae_Br4923 ------------------------LPHIPVQLDARSWNRYPEPSPDATAM
TH_3821|M.thermoresistible__bu RAR--------------------VLTLADSLAPTGAEVDPYRWRPGEAAL
Mvan_4966|M.vanbaalenii_PYR-1 DRVVAGLPSPPEVVVVRGE---PRRPALTDLVSEPRDGTLPDLDPAATRM
Mb2533c|M.bovis_AF2122/97 IQYTSGTTAYPKGVTLSHRNILNNGY-LVGELLGYTAQDRICIPVPFYHC
Rv2505c|M.tuberculosis_H37Rv IQYTSGTTAYPKGVTLSHRNILNNGY-LVGELLGYTAQDRICIPVPFYHC
MAB_4377c|M.abscessus_ATCC_199 IQYTSGTTGYPKGATLSHRNVLNNGF-FVAESIQLQAGDRLCIPVPFYHC
MSMEG_5649|M.smegmatis_MC2_155 IQYTSGTTGFPKGATLSHRNILNNGF-FVTELIALGPDDRLCIVPPFYHC
Mflv_4616|M.gilvum_PYR-GCK IMYTSGTTGRPKGAILTHDNLRWNAINVLGAEQGLTGSDVTVAVAPMFHI
MUL_3145|M.ulcerans_Agy99 INSTSGTTGAPKCVVHTQNRWHYFHQ-HAVANGMLTPQDVVLPVIPMPFG
MMAR_2616|M.marinum_M INSTSGTTGAPKCVVHTQNRWHYFHQ-HAVANGMLTPQDVVLPVIPMPFG
MAV_2995|M.avium_104 INSTSGTTGLPKCVVHTQNRWYYFHQ-KAVANGMLTPDDVFLPVIPTPFG
MLBr_01051|M.leprae_Br4923 VIYTSGTTGPPKGVLLSRRAIAVDLD-ALAQAWQWTADDVLVHGLPLFHV
TH_3821|M.thermoresistible__bu VGFTSGSTGHPKGVMHGVPAMEWVAD-LIVERGSLRPGEPICVTGAGAGA
Mvan_4966|M.vanbaalenii_PYR-1 ILYTSGTTGRPKGVLHSHKSLGALIA-QLGRYWRIDPGDTFLVPSPIAHI
: ***:*. ** . : .
Mb2533c|M.bovis_AF2122/97 FGMVMGNLAATSHGAAMVIPAPGFDPAATLRAVQDERCTSLYGVPTMFIA
Rv2505c|M.tuberculosis_H37Rv FGMVMGNLAATSHGAAMVIPAPGFDPAATLRAVQDERCTSLYGVPTMFIA
MAB_4377c|M.abscessus_ATCC_199 FGMVMGNLGCTTHGATIVMPAPGFDPGRTLEAIERERCVGVYGVPTMFIA
MSMEG_5649|M.smegmatis_MC2_155 FGMVMGTLGAVSHGTTIVIPAPGFDPGITLSAVESEKCTGLYGVPTMFIA
Mflv_4616|M.gilvum_PYR-GCK GGLGVHTLPLLYVGGTSVILPS-FDPVGTLKAMAESRATVQFMVPAMWSA
MUL_3145|M.ulcerans_Agy99 FGIWTSHTTPIYLGASAVILDR-FTTLAACEAIARHRVTVLCCVSTQLTM
MMAR_2616|M.marinum_M FGIWTSHTTPIYLGASAVILDR-FTTLAACEAIARHRVTVLCCVSTQLTM
MAV_2995|M.avium_104 FGIWTSHTTPIHLGATAVILDR-FTPAATCEAIARHGVTVLCCVSTQLTM
MLBr_01051|M.leprae_Br4923 HGLVLGLLGSLRIGNRFVHTGK-PTPTAYAQACSEAGGSLYFGVPTVWSR
TH_3821|M.thermoresistible__bu PGFTFYTYLGLTRGLPIVKSEK-WDPKRVLELMARERCVWSTMVPTMLHM
Mvan_4966|M.vanbaalenii_PYR-1 GGSIYAFECPLLLGTQAVLMQR-WDPDAAVALMLRHRCTHMAGATPFLDG
* * * . ...
Mb2533c|M.bovis_AF2122/97 ELGLP--DFTDYELGSLRTGIMAGAACPVEVMRKVISRMHMPGVSICYGM
Rv2505c|M.tuberculosis_H37Rv ELGLP--DFTDYELGSLRTGIMAGAACPVEVMRKVISRMHMPGVSICYGM
MAB_4377c|M.abscessus_ATCC_199 MLADP--GFAHRDLSTLRTGIMAGSVCPVEVMKRCIDEMHMAGVAIAYGM
MSMEG_5649|M.smegmatis_MC2_155 MLGHP--DFANFDLSSLRTGIMAGSVCPIEVMKRVVADMHMAEVAICYGM
Mflv_4616|M.gilvum_PYR-GCK LTQVP--DFDSYDLSALRLAMGGGAPMPLTVIDFMHQRG--VPFTEGFGM
MUL_3145|M.ulcerans_Agy99 LMADH--WCRAYDLSSLRVVFAGGEALPYRRATEFEDLTG-AAILQFYGS
MMAR_2616|M.marinum_M LMADH--WCRAYDLSSLRVVFAGGEALPYRRATEFEDLTG-AAILQFYGS
MAV_2995|M.avium_104 LMADP--ASRRHDLSSLRIVYTGGEALPYRPAAEFEELTG-ATILQFYGS
MLBr_01051|M.leprae_Br4923 LVADE--AVAR-ALRPARLLVSGSASLPVPVFDRLAHLTG-HRPIERYGS
TH_3821|M.thermoresistible__bu LMTAQRDSGRAYDLSAMRTVSMGGAPMSEEFISEARELMT-FEPLRVYAM
Mvan_4966|M.vanbaalenii_PYR-1 LLAAA--ERAGTRLPDLKVFICGGASVPPSLIRRAADYFDKAAVSRVYGS
* : .. . :.
Mb2533c|M.bovis_AF2122/97 TETSPVSTQTRADDSVDRRVGTVGRVGPHLEIKVVDPATG-ETVPRGVVG
Rv2505c|M.tuberculosis_H37Rv TETSPVSTQTRADDSVDRRVGTVGRVGPHLEIKVVDPATG-ETVPRGVVG
MAB_4377c|M.abscessus_ATCC_199 TETSPVSCQTLFDDDLDRRTATVGRAHPHIEIKIVDPNSG-ETVQRGQSG
MSMEG_5649|M.smegmatis_MC2_155 TETSPVSCQTLIDDDLDRRTATIGRAHPHVEIKIIDPDTG-ETVERGQPG
Mflv_4616|M.gilvum_PYR-GCK TETAPMVSVLDAAN-ITTRAGSIGRVAMHVDARIVDADD--RDVPADTVG
MUL_3145|M.ulcerans_Agy99 NETG-LLSATTLRDSRERRLRTGGRVVPEMSVRLFDGDR---DVTASGRG
MMAR_2616|M.marinum_M NETG-LLSATTLRDSRERRLRTGGRVVPEMSVRLFDGDR---DVTESGRG
MAV_2995|M.avium_104 NETG-MLSATTVHDPRDRRLGTAGRVVPEMAVRLFDGDT---DVTATGRG
MLBr_01051|M.leprae_Br4923 TESLITLSTLADGE---RRAGWVGLPLAGVQTRLVDESGGPVPYDGETVG
TH_3821|M.thermoresistible__bu AECM-MHSHSRADDPIEIRNGMDGRPGPGAEIATYDSEGR--RLPTGETG
Mvan_4966|M.vanbaalenii_PYR-1 TEVP--VTTVGSLDDVDRAADTDGRPG-IADVTLVDGEIR----------
* : * *
Mb2533c|M.bovis_AF2122/97 EFCTRGYSVMAGYWNDPQKTAEVIDADGWMHTGDLAEMDPSGYVRIAGR-
Rv2505c|M.tuberculosis_H37Rv EFCTRGYSVMAGYWNDPQKTAEVIDADGWMHTGDLAEMDPSGYVRIAGR-
MAB_4377c|M.abscessus_ATCC_199 ELCTRGYSVMLGYWNDEAHTREVLDTDGWMHTGDLAVMRDDGYCTIIGR-
MSMEG_5649|M.smegmatis_MC2_155 EFCTRGYSVMLGYWNDDEKTREAVDADGWMHTGDLAVMREDGYCTIVGR-
Mflv_4616|M.gilvum_PYR-GCK ELLVRGPNVFVGYWMKPATTAEAFRG-GWFHTGDLGRIDADGYITLVDR-
MUL_3145|M.ulcerans_Agy99 QPGCRGPATSLGYLGG-TDHEKLFTRDGWMRMGDICEIDPDGYLTVTGR-
MMAR_2616|M.marinum_M QPACRGPATSLGYLGG-TDHEKLFTRDGWMRMGDICEIDPDGYLTVTGR-
MAV_2995|M.avium_104 QPACRGPATSLGYLGG-TDHDKLFTRDGWMRMGDICEIDADGYLRVTGR-
MLBr_01051|M.leprae_Br4923 RLQVRSPTMFGGYLNRPEATAEAFDEDGWYRTGDVAVVDSGGMHRIVGRE
TH_3821|M.thermoresistible__bu EIGMRGPSLMLGYLGD-APGSLPLTSDGFFLSGDLGRVEDNGCIKVVGR-
Mvan_4966|M.vanbaalenii_PYR-1 ---ARGPQMLTGYLHP-EDNSESFDAEGFFRTGDLGHLTDDGYLVVTGR-
*. ** . *: **: : .* : .*
Mb2533c|M.bovis_AF2122/97 IKDLVVRGGENISPREIEELLHTHPDIVDGHVIGVPDAKYGEELMAVVKL
Rv2505c|M.tuberculosis_H37Rv IKDLVVRGGENISPREIEELLHTHPDIVDGHVIGVPDAKYGEELMAVVKL
MAB_4377c|M.abscessus_ATCC_199 LKDMVIRGGENIYPREIEEFLLTHPDIEDVHVVGVPDEKYGEELCAWVRM
MSMEG_5649|M.smegmatis_MC2_155 IKDMVIRGGENIYPREIEEFLYTHPDIDDAQVIGVPDERYGEEICAWIRM
Mflv_4616|M.gilvum_PYR-GCK KKDMIISGGENVYPIEVEQVLFRHPGVLDAAVVGGPDDKWGERVVAVVVA
MUL_3145|M.ulcerans_Agy99 TSDFILRGGKNISAGQVEDAALTHPAVAIAAAVSMPDPVFGEKVCLYVEL
MMAR_2616|M.marinum_M TSDFILRGGKNISAGQVEDAALTHPAVAIAAAVSMPDPVFGEKVCLYVEL
MAV_2995|M.avium_104 TSDFILRGGKNISASQVEDAAMTHPAVAIAAAVAMPDPVFGEKVCLYAEL
MLBr_01051|M.leprae_Br4923 SVDLIKLGGYRIGAGEIEMALLGHPDVREVAVVGLPDEDLGQRIVAFVVG
TH_3821|M.thermoresistible__bu LKDMIIRGGYNIDPGEVEELLRAHPEVRDVAIVGYPDPVYGERACAVLWT
Mvan_4966|M.vanbaalenii_PYR-1 AKDLIIRNGENISPKEVEDILVTHPQIAEIAIVGIPDLRTGERACAVIVA
*:: .* .: . ::* ** : :. ** *:.
Mb2533c|M.bovis_AF2122/97 R-------NDA-PELTIERLREYCMGRIARFKIPRYLWIVDEFPMTVTGK
Rv2505c|M.tuberculosis_H37Rv R-------NDA-PELTIERLREYCMGRIARFKIPRYLWIVDEFPMTVTGK
MAB_4377c|M.abscessus_ATCC_199 R-------PDR-VVIDAVAIRAFASGRLAHYKIPRYVHVVESFPMTVTGK
MSMEG_5649|M.smegmatis_MC2_155 K-------PGR-PPLDADKVREFASGKLAHYKIPRYVHVVDEFPMTVTGK
Mflv_4616|M.gilvum_PYR-GCK D-------PAAEQEPSADELIAWCRERLAHFKCPREVHLLPELPRNATGK
MUL_3145|M.ulcerans_Agy99 A--------DSQRLDRTELVEHLLALGYSKELLPERLVVVDELPRSSGGK
MMAR_2616|M.marinum_M A--------DSQRLDRTELVEHLLALGYSKELLPERLVVVDELPRSSGGK
MAV_2995|M.avium_104 AGPATDPATDPATLDLADLTEHLLAQGFSKELLPERLVVVDELPRSSGGK
MLBr_01051|M.leprae_Br4923 A-----------EALDADELINYVAQQLSIHKRPREVRFVDALPRNAMGK
TH_3821|M.thermoresistible__bu DG---------VVLGLSDIAEFLLERNLSKDKIPEMVVCRDELPQSPDGK
Mvan_4966|M.vanbaalenii_PYR-1 A--------DSAAPDVAEIRDFLVARGVAKFKAPERVVVVDALPKNDAGK
: *. : :* . **
Mb2533c|M.bovis_AF2122/97 VRKVEMRQQALEYLRGQQ-------
Rv2505c|M.tuberculosis_H37Rv VRKVEMRQQALEYLRGQQ-------
MAB_4377c|M.abscessus_ATCC_199 VRKIEMRQQTIQIFGLPEPGRTDEQ
MSMEG_5649|M.smegmatis_MC2_155 IRKVQMREETVALLGLEA-------
Mflv_4616|M.gilvum_PYR-GCK LLKTELRKRFTGVEGGVVQR-----
MUL_3145|M.ulcerans_Agy99 IAKGQLRDDIRARMEAEHERS----
MMAR_2616|M.marinum_M IAKGQLRDDIRARMEAEHERS----
MAV_2995|M.avium_104 VAKGRLREDIRARMEAGDERS----
MLBr_01051|M.leprae_Br4923 VLKKQLLFEG---------------
TH_3821|M.thermoresistible__bu ILKGQLRAEIAALVATRSG------
Mvan_4966|M.vanbaalenii_PYR-1 VLKHAIRAVLLEKPREGEP------
: * :