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MAVGRRDMAGSPAFSTQEAIRYHAAGWWSDSTLSDAVRRNAECSPHHAAYIDYPASLLTWSEFDCAATNL AEQLAGAGVLPGDRVAVWHGDCAALHALFIAIERCGAVVVGIGARAGIREATQILRAAQVKLLVSDAPRS AAATEVSAQLPVPSGVLVREGKTLRFDGKPVPVAPENGLESELGNERRLGPDDVFLINSTSGTTGAPKCV VHTQNRWHYFHQHAVANGMLTPQDVVLPVIPMPFGFGIWTSHTTPIYLGASAVILDRFTTLAACEAIARH RVTVLCCVSTQLTMLMADHWCRAYDLSSLRVVFAGGEALPYRRATEFEDLTGAAILQFYGSNETGLLSAT TLRDSRERRLRTGGRVVPEMSVRLFDGDRDVTESGRGQPACRGPATSLGYLGGTDHEKLFTRDGWMRMGD ICEIDPDGYLTVTGRTSDFILRGGKNISAGQVEDAALTHPAVAIAAAVSMPDPVFGEKVCLYVELADSQR LDRTELVEHLLALGYSKELLPERLVVVDELPRSSGGKIAKGQLRDDIRARMEAEHERS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_2616 | - | - | 100% (548) | hypothetical protein MMAR_2616 |
| M. marinum M | MMAR_1606 | - | 3e-43 | 29.71% (478) | fatty-acid-CoA ligase |
| M. marinum M | MMAR_3698 | mbtA | 7e-43 | 29.40% (551) | bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2405 | mbtA | 8e-45 | 30.58% (556) | bifunctional salicyl-AMP ligase/salicyl-S-arcp synthetase |
| M. gilvum PYR-GCK | Mflv_4616 | - | 1e-46 | 31.44% (493) | AMP-dependent synthetase and ligase |
| M. tuberculosis H37Rv | Rv2384 | mbtA | 8e-45 | 30.58% (556) | bifunctional salicyl-AMP ligase/salicyl-S-arcp synthetase |
| M. leprae Br4923 | MLBr_02546 | fadD2 | 7e-33 | 26.34% (524) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_2247c | - | 4e-45 | 31.53% (536) | bifunctional salicyl-AMP ligase/salicyl-S-arcp synthetase |
| M. avium 104 | MAV_2995 | - | 0.0 | 73.02% (556) | adenylate-forming enzyme |
| M. smegmatis MC2 155 | MSMEG_4112 | - | 6e-47 | 29.01% (555) | cyclohexanecarboxylate-CoA ligase |
| M. thermoresistible (build 8) | TH_3821 | - | 9e-46 | 31.43% (474) | PUTATIVE putative adenylate-forming enzyme |
| M. ulcerans Agy99 | MUL_3145 | - | 0.0 | 99.36% (470) | hypothetical protein MUL_3145 |
| M. vanbaalenii PYR-1 | Mvan_4966 | - | 1e-50 | 32.82% (515) | AMP-dependent synthetase and ligase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2616|M.marinum_M ---------------MAVGRRDMAGSPAFSTQEAIRYHAAGWWSDSTLSD
MUL_3145|M.ulcerans_Agy99 --------------------------------------------------
MAV_2995|M.avium_104 --------------MMSAGGLHTESSPAFSDEDVARFRAAGWWCDSTLSD
Mb2405|M.bovis_AF2122/97 ------MPPKAADGRRPSPDGGLGGFVPFPADRAASYRAAGYWSGRTLDT
Rv2384|M.tuberculosis_H37Rv ------MPPKAADGRRPSPDGGLGGFVPFPADRAASYRAAGYWSGRTLDT
MAB_2247c|M.abscessus_ATCC_199 -----MTQPRSTTTASSAATPALDGFVPFPSVRADEYRRAGYWTGNTVES
Mvan_4966|M.vanbaalenii_PYR-1 --------------------------------------------MTTLAD
MSMEG_4112|M.smegmatis_MC2_155 ---------MTAPTERRLANVLNGQYTPIDDDTAANWRAAGWWENRSIRS
TH_3821|M.thermoresistible__bu --------------------------------------------------
Mflv_4616|M.gilvum_PYR-GCK -------------------------------------------MDRGIGQ
MLBr_02546|M.leprae_Br4923 MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVAMRKWGDLAM
MMAR_2616|M.marinum_M AVRRNAECSPHHAAYIDYP----ASLLTWSEFDCAATNLAEQLAGAGVLP
MUL_3145|M.ulcerans_Agy99 -----------------------------------------------MLP
MAV_2995|M.avium_104 AVRRNAQRTPERPAYIDHG----GRTFTWHEFDCAASNLAETLAGLGVGP
Mb2405|M.bovis_AF2122/97 VLSDAARRWPDRLAVADAGDRPGHGGLSYAELDQRADRAAAALHGLGITP
Rv2384|M.tuberculosis_H37Rv VLSDAARRWPDRLAVADAGDRPGHGGLSYAELDQRADRAAAALHGLGITP
MAB_2247c|M.abscessus_ATCC_199 LLRVSAARRPCHPAVIDE-----HRALSYRELDEAADNAAHAFLRLGIAP
Mvan_4966|M.vanbaalenii_PYR-1 ALRDAARDTPDRILLRDDE-----ASLSSAELLSAATNLAHALVRR-MPV
MSMEG_4112|M.smegmatis_MC2_155 LLADAAQAHPDRIALVGRRADGGRVARTYQEFDRNANQVASVLASLGVRP
TH_3821|M.thermoresistible__bu ----MLEADPDAVALIRGD-----QRWSREQLWELSGRAVAKLRSLGAEP
Mflv_4616|M.gilvum_PYR-GCK WVTKRAFLNGQRTALVQGD-----TSFTYSDFDRRTNQVASSLLRLGVRK
MLBr_02546|M.leprae_Br4923 LPAMPARRSPHRAALIDEE-----GTLTYKELDRAAHALANGLIAKGVRG
MMAR_2616|M.marinum_M GDRVAVWHGDCAALHALFIAIERCGAVVVGIGARAGIREATQILRAAQVK
MUL_3145|M.ulcerans_Agy99 GDRVAVWHGDCAALHALFIAIERCGAVVVGIGARAGVREATQILRAAQVK
MAV_2995|M.avium_104 GDRVAVWHGDCAAIHVLFVAIERRGAVIVGIGERAGAREAGAILRNAQPK
Mb2405|M.bovis_AF2122/97 GDRVLLQLPNGCQFAVALFALLRAGAIPVMCLPGHRAAELGHFAAVSAAT
Rv2384|M.tuberculosis_H37Rv GDRVLLQLPNGCQFAVALFALLRAGAIPVMCLPGHRAAELGHFAAVSAAT
MAB_2247c|M.abscessus_ATCC_199 GDRVLLQLPNRASFAVALFGLMRAGAIPVMCLPGHRAAELSHFIEVADAV
Mvan_4966|M.vanbaalenii_PYR-1 GSVVSFAVPNWHEAAVIYLGATLAGMVVNPILPSLRERELSFILADAGSR
MSMEG_4112|M.smegmatis_MC2_155 DDAVVVMLPNWVEYPEFLFGINELGAIYAGIPVAYGDQQAAAILRRSRAR
TH_3821|M.thermoresistible__bu GDAVVAHYDTGAEEMAIALAASRLGCVFMPIPRRLGARELNYVVGLADPV
Mflv_4616|M.gilvum_PYR-GCK GDRVAILLVNSVEFLEVLLGCAKIGAITIPINVRLAGPEIGYILADSGAD
MLBr_02546|M.leprae_Br4923 GDGIAILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKEVSEREGAK
.. : . * : .
MMAR_2616|M.marinum_M LLVSDAPRSAAATEVSAQLPVPSGVLVREGKTLRFDGKPVPVAPENGLES
MUL_3145|M.ulcerans_Agy99 LLVSDAPRSAAATEVSAQLPVPSGVLVREGKTLRFDGKPVPVAPENGLES
MAV_2995|M.avium_104 ILLSDQPRSKPAAEVAGELRIPALVLT----------QPLDTEPR-----
Mb2405|M.bovis_AF2122/97 GLVVADVASGFDYRPMARELVADHPTLRHVIVDGDPGPFVSWAQLCAQAG
Rv2384|M.tuberculosis_H37Rv GLVVADVASGFDYRPMARELVADHPTLRHVIVDGDPGPFVSWAQLCAQAG
MAB_2247c|M.abscessus_ATCC_199 GLVIPDSAGGFDYRALAVALSQRHPRLRTVVVEGDAGPFASWTSLLKSVE
Mvan_4966|M.vanbaalenii_PYR-1 AIFIPQTFGGHDYAAMLDRVVAGLPSPPEVVVVRGEPRRPALTDLVS-EP
MSMEG_4112|M.smegmatis_MC2_155 VLVIPRRWRGNNILEQSRRLRDQIPTLQQVIVLDDDGTDLRDGESLWSDH
TH_3821|M.thermoresistible__bu LVAVQDRDHVGVVENPGR------------------ARVLTLADSLAPTG
Mflv_4616|M.gilvum_PYR-GCK VFVFHAPLAAAAVSALTEPGVRVRHTLRAGGAPADGEIPYTDLLSDGAPA
MLBr_02546|M.leprae_Br4923 VIIYDDEYTKVVSKAEPALGKLRALGVNPDEEEPPGSTDETLAELIARSS
.
MMAR_2616|M.marinum_M ELGNE---RRLGPDDVFLINSTSGTTGAPKCVVHTQNRWHYFHQHAVANG
MUL_3145|M.ulcerans_Agy99 ELGNE---RRLGPDDVFLINSTSGTTGAPKCVVHTQNRWHYFHQHAVANG
MAV_2995|M.avium_104 AFDRD---CQLGPDDVFLINSTSGTTGLPKCVVHTQNRWYYFHQKAVANG
Mb2405|M.bovis_AF2122/97 TGSPA---PPADPGSPALLLVSGGTTGMPKLIPRTHDDYVFNATASAALC
Rv2384|M.tuberculosis_H37Rv TGSPA---PPADPGSPALLLVSGGTTGMPKLIPRTHDDYVFNATASAALC
MAB_2247c|M.abscessus_ATCC_199 PQGPL---PTVQTDTPALLLVSGGTTAAPKLIPRTHEDYVYNATQAARVC
Mvan_4966|M.vanbaalenii_PYR-1 RDGTL---PDLDPAATRMILYTSGTTGRPKGVLHSHKSLGALIAQLGRYW
MSMEG_4112|M.smegmatis_MC2_155 AHVAARQFPPPDPGQICYLGFTSGTTGEPKGAMHSHNTLIYSARRQAEHI
TH_3821|M.thermoresistible__bu AEVDP---YRWRPGEAALVGFTSGSTGHPKGVMHGVPAMEWVADLIVERG
Mflv_4616|M.gilvum_PYR-GCK PLDSD-----VEGRDPAFIMYTSGTTGRPKGAILTHDNLRWNAINVLGAE
MLBr_02546|M.leprae_Br4923 SAPAP-----KVRKRASIIILTSGTTGTPKGANRNTPASLAPLGGILSKV
: :.*:*. **
MMAR_2616|M.marinum_M ---MLTPQDVVLPVIPMPFGFGIWTS-HTTPIYLGASAVILDRFTTLAAC
MUL_3145|M.ulcerans_Agy99 ---MLTPQDVVLPVIPMPFGFGIWTS-HTTPIYLGASAVILDRFTTLAAC
MAV_2995|M.avium_104 ---MLTPDDVFLPVIPTPFGFGIWTS-HTTPIHLGATAVILDRFTPAATC
Mb2405|M.bovis_AF2122/97 ---RLSADDVYLVVLAAGHNFPLACPGLLGAMTVGATAVFAPDPSPEAAF
Rv2384|M.tuberculosis_H37Rv ---RLSADDVYLVVLAAGHNFPLACPGLLGAMTVGATAVFAPDPSPEAAF
MAB_2247c|M.abscessus_ATCC_199 ---GLTQDDVYLVALPAGHNFPLACPGLLGAISTGATTVFLSDPSPESAF
Mvan_4966|M.vanbaalenii_PYR-1 ---RIDPGDTFLVPSPIAH-IGGSIYAFECPLLLGTQAVLMQRWDPDAAV
MSMEG_4112|M.smegmatis_MC2_155 GTEAFGEPVVNLVASPMGHHTGYVWGGVFTVMLAG-TAVHVDRWDPTWGA
TH_3821|M.thermoresistible__bu ----SLRPGEPICVTGAGAGAPGFTFYTYLGLTRGLPIVKSEKWDPKRVL
Mflv_4616|M.gilvum_PYR-GCK QG---LTGSDVTVAVAPMFHIGGLGVHTLPLLYVGGTSVILPSFDPVGTL
MLBr_02546|M.leprae_Br4923 P---FRAHEVTLLPAPMFHALGYLHA--TLAMFLGSTLVLRRRFKPATVL
: * * .
MMAR_2616|M.marinum_M EAIARHRVTVLCCVSTQLTMLMADHWCRA--YDLSSLRVVFAGGEALPYR
MUL_3145|M.ulcerans_Agy99 EAIARHRVTVLCCVSTQLTMLMADHWCRA--YDLSSLRVVFAGGEALPYR
MAV_2995|M.avium_104 EAIARHGVTVLCCVSTQLTMLMADPASRR--HDLSSLRIVYTGGEALPYR
Mb2405|M.bovis_AF2122/97 AAIERHGVTVTALVPALAKLWAQSCEWEP--VTPKSLRLLQVGGSKLEPE
Rv2384|M.tuberculosis_H37Rv AAIERHGVTVTALVPALAKLWAQSCEWEP--VTPKSLRLLQVGGSKLEPE
MAB_2247c|M.abscessus_ATCC_199 ATIARHRVSVTAVVPSLAQLWAQATAWEP--VLPETLRLLQVGGAKLGAD
Mvan_4966|M.vanbaalenii_PYR-1 ALMLRHRCTHMAGATPFLDGLLAAAERAG--TRLPDLKVFICGGASVPPS
MSMEG_4112|M.smegmatis_MC2_155 QVVREEGVTTFFGAPTFLQDIIR-TELAG--DPACPLRCMVVAGAPVPRN
TH_3821|M.thermoresistible__bu ELMARERCVWSTMVPTMLHMLMTAQRDSGRAYDLSAMRTVSMGGAPMSEE
Mflv_4616|M.gilvum_PYR-GCK KAMAESRATVQFMVPAMWSALTQVPDFDS--YDLSALRLAMGGGAPMPLT
MLBr_02546|M.leprae_Br4923 EDIEKHQATAMVVVPVMLSRILDTLENLETKSDLSSLRVVFVSGSQLGAE
: . .. :: .* :
MMAR_2616|M.marinum_M RATEFEDLTGAAILQFYGSNETGLLSATTLRDSRERRLRTGGR-VVPEMS
MUL_3145|M.ulcerans_Agy99 RATEFEDLTGAAILQFYGSNETGLLSATTLRDSRERRLRTGGR-VVPEMS
MAV_2995|M.avium_104 PAAEFEELTGATILQFYGSNETGMLSATTVHDPRDRRLGTAGR-VVPEMA
Mb2405|M.bovis_AF2122/97 DARRVRTALTPGLQQVFG-MAEGLLNFTRIGDPPEVVEHTQGRPLCPADE
Rv2384|M.tuberculosis_H37Rv DARRVRTALTPGLQQVFG-MAEGLLNFTRIGDPPEVVEHTQGRPLCPADE
MAB_2247c|M.abscessus_ATCC_199 DARAVRESLTQGLQQVFG-MAEGLLCLTQPGDPTDILDNSQGRPMCDADE
Mvan_4966|M.vanbaalenii_PYR-1 LIRRAADYFDKAAVSRVYGSTEVPVTTVGSLDDVDRAADTDGR--PGIAD
MSMEG_4112|M.smegmatis_MC2_155 LPAQAAEALGAYVAPAWGMTECSILTSCTP-DEPDAILRTDGS-VFAGSE
TH_3821|M.thermoresistible__bu FISEARELMTFEPLRVYAMAECMMHSHSRADDPIEIRNGMDGR-PGPGAE
Mflv_4616|M.gilvum_PYR-GCK -VIDFMHQRGVPFTEGFGMTETAPMVSVLDAANITTRAGSIGR-VAMHVD
MLBr_02546|M.leprae_Br4923 LATRALEELGPVIYNMYG-STEIAFATIAGPKDLQINSATVGP-VVKGVK
*
MMAR_2616|M.marinum_M VRLFDGDRDVTESGR-GQPACRGPATSLGYLGG-TDHEKLFTRDGWMRMG
MUL_3145|M.ulcerans_Agy99 VRLFDGDRDVTASGR-GQPGCRGPATSLGYLGG-TDHEKLFTRDGWMRMG
MAV_2995|M.avium_104 VRLFDGDTDVTATGR-GQPACRGPATSLGYLGG-TDHDKLFTRDGWMRMG
Mb2405|M.bovis_AF2122/97 LRIVNADGEPVGPGEEGELLVRGPYTLNGYFAAERDNERCFDPDGFYRSG
Rv2384|M.tuberculosis_H37Rv LRIVNADGEPVGPGEEGELLVRGPYTLNGYFAAERDNERCFDPDGFYRSG
MAB_2247c|M.abscessus_ATCC_199 VRIVDEDGADVPAGETGELLVRGPYTLNGYYRADADNMRSFTVDGFYRSG
Mvan_4966|M.vanbaalenii_PYR-1 VTLVDG-----------EIRARGPQMLTGYLHP-EDNSESFDAEGFFRTG
MSMEG_4112|M.smegmatis_MC2_155 VKIVDDTGAAVAAGVVGDLLMRGPGVVYGYYDRPDATRDAYLPGLWFKTG
TH_3821|M.thermoresistible__bu IATYDSEGRRLPTGETGEIGMRGPSLMLGYLGDAPGSLP-LTSDGFFLSG
Mflv_4616|M.gilvum_PYR-GCK ARIVDADDRDVPADTVGELLVRGPNVFVGYWMKPATTAEAFRGG-WFHTG
MLBr_02546|M.leprae_Br4923 VKILDDSGKEVPRGQVGRIFVGNAFPFEGYTGG----GGKQIIDGLLSSG
: .. ** *
MMAR_2616|M.marinum_M DICEIDPDGYLTVTGRTSDFILRGGKNISAGQVEDAALTHPAVAIAAAVS
MUL_3145|M.ulcerans_Agy99 DICEIDPDGYLTVTGRTSDFILRGGKNISAGQVEDAALTHPAVAIAAAVS
MAV_2995|M.avium_104 DICEIDADGYLRVTGRTSDFILRGGKNISASQVEDAAMTHPAVAIAAAVA
Mb2405|M.bovis_AF2122/97 DLVRRRDDGNLVVTGRVKDVICRAGETIAASDLEEQLLSHPAIFSAAAVG
Rv2384|M.tuberculosis_H37Rv DLVRRRDDGNLVVTGRVKDVICRAGETIAASDLEEQLLSHPAIFSAAAVG
MAB_2247c|M.abscessus_ATCC_199 DRVRALPGGYLEVTGRIKDVILRGGESIAALDLESHLQTHPAVYAAAAVG
Mvan_4966|M.vanbaalenii_PYR-1 DLGHLTDDGYLVVTGRAKDLIIRNGENISPKEVEDILVTHPQIAEIAIVG
MSMEG_4112|M.smegmatis_MC2_155 DRADVDENGWLRLRGRSKDIIIRGGENIPVTDVESAIFDHPDVLNAAVIG
TH_3821|M.thermoresistible__bu DLGRVEDNGCIKVVGRLKDMIIRGGYNIDPGEVEELLRAHPEVRDVAIVG
Mflv_4616|M.gilvum_PYR-GCK DLGRIDADGYITLVDRKKDMIISGGENVYPIEVEQVLFRHPGVLDAAVVG
MLBr_02546|M.leprae_Br4923 DVGYFDEHDLLYISGRDDEMIVSGGENVFPAEVEDLISGHPEVVEATAIG
* . : : .* .:.* * .: ::*. ** : : :.
MMAR_2616|M.marinum_M MPDPVFGEKVCLYVELA--------DSQRLDRTELVEHLLALGYSKELLP
MUL_3145|M.ulcerans_Agy99 MPDPVFGEKVCLYVELA--------DSQRLDRTELVEHLLALGYSKELLP
MAV_2995|M.avium_104 MPDPVFGEKVCLYAELAGPATDPATDPATLDLADLTEHLLAQGFSKELLP
Mb2405|M.bovis_AF2122/97 LPDQYLGEKICAAVVFA---------GAPITLAELNGYLDRRGVAAHTRP
Rv2384|M.tuberculosis_H37Rv LPDQYLGEKICAAVVFA---------GAPITLAELNGYLDRRGVAAHTRP
MAB_2247c|M.abscessus_ATCC_199 LPDQYLGEIVCAAIVFK---------GKPVAAAELNQHLQARGAATHSRV
Mvan_4966|M.vanbaalenii_PYR-1 IPDLRTGERACAVIVAAD--------SAAPDVAEIRDFLVARGVAKFKAP
MSMEG_4112|M.smegmatis_MC2_155 LPDERLGERVCAVLVTKSG-------CPELTVDTLGEYLLGQGLSKHYLP
TH_3821|M.thermoresistible__bu YPDPVYGERACAVLWTDG---------VVLGLSDIAEFLLERNLSKDKIP
Mflv_4616|M.gilvum_PYR-GCK GPDDKWGERVVAVVVADP------AAEQEPSADELIAWCRER-LAHFKCP
MLBr_02546|M.leprae_Br4923 VDDKEWGARLRAFVVKKQ--------DATIDEDAIKAYVRDH-LARYKVP
* * : :
MMAR_2616|M.marinum_M ERLVVVDELPRSSGGKIAKGQLRDDIRARMEAEHERS--
MUL_3145|M.ulcerans_Agy99 ERLVVVDELPRSSGGKIAKGQLRDDIRARMEAEHERS--
MAV_2995|M.avium_104 ERLVVVDELPRSSGGKVAKGRLREDIRARMEAGDERS--
Mb2405|M.bovis_AF2122/97 DQLVAMPALPTTPIGKIDKRAIVRQLGIATGPVTTQRCH
Rv2384|M.tuberculosis_H37Rv DQLVAMPALPTTPIGKIDKRAIVRQLGIATGPVTTQRCH
MAB_2247c|M.abscessus_ATCC_199 DKLVAVSALPLTAVGKIDKRALLASL---TG--------
Mvan_4966|M.vanbaalenii_PYR-1 ERVVVVDALPKNDAGKVLKHAIRAVLLEKPREGEP----
MSMEG_4112|M.smegmatis_MC2_155 EKVVHLDELPMTPSGKIQKFKLREQYS------------
TH_3821|M.thermoresistible__bu EMVVCRDELPQSPDGKILKGQLRAEIAALVATRSG----
Mflv_4616|M.gilvum_PYR-GCK REVHLLPELPRNATGKLLKTELRKRFTGVEGGVVQR---
MLBr_02546|M.leprae_Br4923 REVIFLEELPRNPTGKVLKRELRDFEVH-----------
: ** . **: * :