For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
YSTMQDFPLTITAIMRHGCGVHGSRQVITATGDAYRQTTYREVGQRAAQLANALRGLGISGDQRVATFMW NNAEHLVTYLAVPSMGAVLHTLNIRLFAEQIAYVANEAEDQVVLVDLSLTNLLAPVLPNLDTVHTVIAVG EGDTAALEESGKTVLRYDELLDGQSTEFDWPHIDENSAAAMCYTSGTTGHPKGVVYSHRSSFLHSMATCT ANGIGLGSSDRVLPIVPMFHANAWGLPYAALMAGADLVLPDRHLDARSLVHMVENLRPTRAGAVPTIWND VMHYLEKNPGHDVSSLGLVACGGSAVPESLMRTFEEKYGVQIRQLWGMTETSPLATMAWPPPGTPPDRHW AIRSTQGQPVCGVETRIVDDNGEALPNDGQAVGEVEVRGPWITGAYYLGYDQSEFDSGWLRTGDVGRIDE LGFITLTDRAKDVIKSGGEWISSVELENCLIAHPDVVEAAVVGVPDERWQERPLAVVVRREGATVSAAEL RKFLADRVVRWWLPERWAFADQVPRTSVGKYDKKTIRAGYAESVYQVTDVHN*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_0229 | fadD14 | - | 100% (543) | acyl-CoA synthetase |
| M. ulcerans Agy99 | MUL_4827 | fadD12_2 | 8e-39 | 28.46% (506) | acyl-CoA synthetase |
| M. ulcerans Agy99 | MUL_1191 | fadD2 | 2e-38 | 28.83% (503) | acyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1087 | fadD14 | 0.0 | 84.32% (542) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_4589 | - | 0.0 | 62.26% (530) | acyl-CoA synthetase |
| M. tuberculosis H37Rv | Rv1058 | fadD14 | 0.0 | 84.32% (542) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_02546 | fadD2 | 1e-41 | 28.72% (491) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_2080 | - | 0.0 | 64.79% (534) | acyl-CoA synthetase |
| M. marinum M | MMAR_4412 | fadD14 | 0.0 | 98.16% (543) | medium chain fatty-acid-CoA ligase FadD14 |
| M. avium 104 | MAV_1186 | - | 0.0 | 80.56% (540) | acyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_5291 | - | 0.0 | 72.71% (535) | acyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_2961 | - | 0.0 | 72.22% (540) | PUTATIVE AMP-dependent synthetase and ligase |
| M. vanbaalenii PYR-1 | Mvan_0905 | - | 1e-136 | 48.60% (537) | AMP-dependent synthetase and ligase |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_0229|M.ulcerans_Agy99 ----------------------MYSTMQDFPLTITAIMRHGCGVHGSRQV
MMAR_4412|M.marinum_M ----------------------MYSTMQDFPLTITAIMRHGCGVHGSRQV
Mb1087|M.bovis_AF2122/97 ----------------------MYGTMQDFPLTITAIMRHGCGVHGRRTV
Rv1058|M.tuberculosis_H37Rv ----------------------MYGTMQDFPLTITAIMRHGCGVHGRRTV
MAV_1186|M.avium_104 ----------------------MDGTMQDFPLTITAIMRHGCSVHGARTV
MSMEG_5291|M.smegmatis_MC2_155 --------------------------MQQWPLTITAILRHACGVNGDQTV
TH_2961|M.thermoresistible__bu ----------------------MQSTMQPIPLTVAAIMRYAIEVHGDRTV
MAB_2080|M.abscessus_ATCC_1997 --------------------------MQNVPLTVSAIVQHAAAIHGDSEV
Mflv_4589|M.gilvum_PYR-GCK --------------------------MQDVALTVPAIVAHAAAVHGDREV
Mvan_0905|M.vanbaalenii_PYR-1 ----------------------MLGLMQNRPLVLPHIFHRAERYFGHKQV
MLBr_02546|M.leprae_Br4923 MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVAMRKWGDLAM
: . . . * :
MUL_0229|M.ulcerans_Agy99 ITATGDA-----------YRQTTYREVGQRAAQLANALRGLGISGDQRVA
MMAR_4412|M.marinum_M ITATGDA-----------YRQTTYREVGQRAAQLANALRGLGISGDQRVA
Mb1087|M.bovis_AF2122/97 TTATGEG-----------YRHSSYRDVGQRAGQLANALRRLGVTGDQRVA
Rv1058|M.tuberculosis_H37Rv TTATGEG-----------YRHSSYRDVGQRAGQLANALRRLGVTGDQRVA
MAV_1186|M.avium_104 TTATGDG-----------YRRTSYRELGDRAAQLANALRGLGVTGDQRVA
MSMEG_5291|M.smegmatis_MC2_155 TTATGQGG----------FRTTTYREVGERAAQLAHLLREVGITGDERVG
TH_2961|M.thermoresistible__bu TTATGDGG----------YRHATYADLGREAARLANALRRLGITGDERVA
MAB_2080|M.abscessus_ATCC_1997 VTPTGNG-----------YRRTPYRIVLARVARLANALRSLGVTADQRVA
Mflv_4589|M.gilvum_PYR-GCK LTARGPQQ----------ISGVSYHELGQRAARLANALREIGVRGDERVA
Mvan_0905|M.vanbaalenii_PYR-1 ITATAGGA----------VAMSTVADVCGQVRRLATVFDELGISSDARVA
MLBr_02546|M.leprae_Br4923 LPAMPARRSPHRAALIDEEGTLTYKELDRAAHALANGLIAKGVRGGDGIA
.. . : . ** : *: .. :.
MUL_0229|M.ulcerans_Agy99 TFMWNNAEHLVTYLAVPSMGAVLHTLNIRLFAEQIAYVANEAEDQVVLVD
MMAR_4412|M.marinum_M TFMWNNAEHLVAYLAVPSMGAVLHTLNIRLFAEQIAYVANEAEDQVVLVD
Mb1087|M.bovis_AF2122/97 TFMWNNTEHLVTYFAVPSMGAVLHTLNIRLFPEQIAYVTNEAEDRVILVD
Rv1058|M.tuberculosis_H37Rv TFMWNNTEHLVTYFAVPSMGAVLHTLNIRLFPEQIAYVTNEAEDRVILVD
MAV_1186|M.avium_104 TFMWNNAEHLAAYLAVPSMGAVLHTLNIRLFPEQIAYVANEAGDQVVLVD
MSMEG_5291|M.smegmatis_MC2_155 TFMWNNTEHLTAYLAIPAMGAVLHTLNIRLSPEQIGFIAREAEDRVIITD
TH_2961|M.thermoresistible__bu TFQWNNQEHLATYVAVPSMGAVLHTLNIRLFPEQLQFIAYEAQDRVVIVD
MAB_2080|M.abscessus_ATCC_1997 TFQWSNQEHLEAYCAIPSMGAVLHTLNIRLAPEQLAYIANHASDQIVLVD
Mflv_4589|M.gilvum_PYR-GCK TLQWSNQEHLDCYAAVPSMGAVLHTLNLRLPPEQLTWIANHAEDQVIIVD
Mvan_0905|M.vanbaalenii_PYR-1 TFCWNTEEHLALYLAAPCTGRVLHTVNIRLFPEQIAYVVNHARDEIIFVE
MLBr_02546|M.leprae_Br4923 ILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKEVSEREGAKVIIYD
: . .: . . * : :* .: *: : . .::: :
MUL_0229|M.ulcerans_Agy99 LSLTNLLAPVLPNLDTVHTVIAVGEGDTAALEESGKTVLRYDELLDGQST
MMAR_4412|M.marinum_M LSLTNLLAPVLPDLGTVHTVIAVGEGDTAPLEESGKTVLRYDELLDGQPT
Mb1087|M.bovis_AF2122/97 LSLARLLAPVLPKLDTVHTVIAVGEGDTTPLREAGKTVLRFAELIDAESP
Rv1058|M.tuberculosis_H37Rv LSLARLLAPVLPKLDTVHTVIAVGEGDTTPLREAGKTVLRFAELIDAESP
MAV_1186|M.avium_104 ASLVKLLAPVLPGLHTVHTVIVVGDGDTEPLRASGKTVLRYADVIGAEPA
MSMEG_5291|M.smegmatis_MC2_155 SSLIPLLAPVLPLVDSVHTVIVVGDGDLEPLRGADRTVLRYDEAMAGRPT
TH_2961|M.thermoresistible__bu ASLVPLLAPVLPTMETVHTVIVVGAGDLSPLQVPGKQVLRYEEILAAESD
MAB_2080|M.abscessus_ATCC_1997 ASVAPLLARALPAMASVHTVIVTGEGDLAPLQGCGKTVLRYEEVLAGQEE
Mflv_4589|M.gilvum_PYR-GCK GTVLNLLAGALPSMTSVHTVLVTGTGDLAAVQGCGKDVLRYDDVVGAQSS
Mvan_0905|M.vanbaalenii_PYR-1 RSLLSVLWPLADQLPEVRYFVVIDDGTDHEIPDSAR-ILSYSSLL-ADST
MLBr_02546|M.leprae_Br4923 DEYTKVVSKAEPALGKLRALGVNPDEEEPPGSTDETLAELIARSSSAPAP
:: : :: . . .
MUL_0229|M.ulcerans_Agy99 EFD--WPHIDENSAAAMCYTSGTTGHPKGVVYSHRSSFLHSMATCTANGI
MMAR_4412|M.marinum_M EFD--WPHIDENSAAAMCYTSGTTGHPKGVVYSHRSSFLHSMATCTANGI
Mb1087|M.bovis_AF2122/97 DFG--WPQIDENSAAAMCYTSGTTGNPKGVVYSHRSSFLHTMAACTTNGI
Rv1058|M.tuberculosis_H37Rv DFG--WPQIDENSAAAMCYTSGTTGNPKGVVYSHRSSFLHTMAACTTNGI
MAV_1186|M.avium_104 EFD--WPRIDENSAAAMCYTSGTTGNPKGVVYSHRSSFLHTMAACTANGI
MSMEG_5291|M.smegmatis_MC2_155 RFD--WPDIDENSAAAMCYTSGTTGNPKGVVYSHRSSYLHSLNTCTANAL
TH_2961|M.thermoresistible__bu EFD--WPELDENSAAAMCYTSGTTGHPKGVVYSHRSSYLHSTAVCSGNGL
MAB_2080|M.abscessus_ATCC_1997 SFD--WPRLDELSAAAMCYTSGTTGDPKGVVYSHRSTYLHSLTACTANAL
Mflv_4589|M.gilvum_PYR-GCK TFD--WPDVDEQSAAAMCYTSGTTGRPKGVVYSHRSTWLHSQAACTSNAL
Mvan_0905|M.vanbaalenii_PYR-1 PFDGAFVVDDENTAAAMCYTSGTTGNPKGVVYSHRSTVLHSLAALAADVL
MLBr_02546|M.leprae_Br4923 KVR--------KRASIIILTSGTTGTPKGANRNTPASLAPLGGILS--KV
. *: : ****** ***. . :: : :
MUL_0229|M.ulcerans_Agy99 GLGSSDRVLPIVPMFHANAWGLPYAALMAGADLVLPDRHLDARSLVHMVE
MMAR_4412|M.marinum_M GVGSNDRVLPIVPMFHANAWGLPYAALMAGADLVLPDRHLDARSLVHMVE
Mb1087|M.bovis_AF2122/97 GVGSSDKVLPIVPMFHANGWGLPYAALMAGADLVLPDRHLDARSLIHMVE
Rv1058|M.tuberculosis_H37Rv GVGSSDKVLPIVPMFHANGWGLPYAALMAGADLVLPDRHLDARSLIHMVE
MAV_1186|M.avium_104 GIGATDSLLPIVPMFHANAWGLPYAALMAGADLVLPDCHLDPRSLVRMVE
MSMEG_5291|M.smegmatis_MC2_155 DVSCGDVVLPIVPMFHANAWGLPYAALMAGAGLVMPDRFLDGASLIELIE
TH_2961|M.thermoresistible__bu GLGFEDRVLPIVPMFHANAWGLPYAALMAGADLVMPDRYLDAKSLVNLIE
MAB_2080|M.abscessus_ATCC_1997 SVSEADRVLAIVPMFHANAWGLIYAALMSGADLVLPDRYLQAEPLVSIIE
Mflv_4589|M.gilvum_PYR-GCK GIGHDDTVLAIVPMFHANAWGLPYAAMMAGAQLLLPDRFLQAGPLVEMIE
Mvan_0905|M.vanbaalenii_PYR-1 GLSERDVVMPVVPMFHANSWGLPYAALLTGAGVVLPGPNMSPKALLGLLA
MLBr_02546|M.leprae_Br4923 PFRAHEVTLLPAPMFHALGYLHATLAMFLGSTLVLRRR-FKPATVLEDIE
. : : .***** .: *:: *: ::: :. .:: :
MUL_0229|M.ulcerans_Agy99 NLRPTRAGAVPTIWNDVMHYLEKNP-GHDVSSLGLVACGGSAVPESLMRT
MMAR_4412|M.marinum_M NLRPTRAGAVPTIWNDVMHYLEKNP-GHDVSSLGLVACGGSAVPESLMRT
Mb1087|M.bovis_AF2122/97 TLKPTLAGAVPTIWNDVMHYLEKDP-DHDMSSLRLVACGGSAVPESLMRT
Rv1058|M.tuberculosis_H37Rv TLKPTLAGAVPTIWNDVMHYLEKDP-DHDMSSLRLVACGGSAVPESLMRT
MAV_1186|M.avium_104 DLRPTVTGAVPTIWNAVLHHLEDDP-DHDMSSLRLVVCGGSAVPVSLMRT
MSMEG_5291|M.smegmatis_MC2_155 TQRPTLAGAVPTIWNDVLNCLEKSP-GHDISSLRLVACGGSAVPLSLMQA
TH_2961|M.thermoresistible__bu TQRPTVAGAVPTIWNDVLHHLDSEP-DHDISSLRLVGCGGSAVPVSLMQS
MAB_2080|M.abscessus_ATCC_1997 DTRPTVAGAVPTIWNDVDRYLDSHP-ERDISSLRLVACGGSAVPLSLMRA
Mflv_4589|M.gilvum_PYR-GCK AARPTMAGAVPTIWTDVLHYLRDNP-GHDLSSLKMVACGGSAVPRSLMTA
Mvan_0905|M.vanbaalenii_PYR-1 DHRVTVTAGVPTIWMGAAPLLAD----YDLSALRYILCGGSAVPKALSEE
MLBr_02546|M.leprae_Br4923 KHQATAMVVVPVMLSRILDTLENLETKSDLSSLRVVFVSGSQLGAELATR
: * **.: * . *:*:* : .** : *
MUL_0229|M.ulcerans_Agy99 FEEKYGVQIRQLWGMTETSPLATMAWPP---PGTPPDRHWAIRSTQGQPV
MMAR_4412|M.marinum_M FEEKYGVQIRQLWGMTETSPLATMAWPP---PGTPPDRHWAIRSTQGQPV
Mb1087|M.bovis_AF2122/97 FEDKHDVQIRQLWGMTETSPLATMAWPP---PGTPDDQHWAFRITQGQPV
Rv1058|M.tuberculosis_H37Rv FEDKHDVQIRQLWGMTETSPLATMAWPP---PGTPDDQHWAFRITQGQPV
MAV_1186|M.avium_104 FEEKHGVQIRQLWGMTETSPLATMAWPP---PGTPEDQHWAYRGTQGQPV
MSMEG_5291|M.smegmatis_MC2_155 FQERHDVYIQQAWGMTETSPLATVAKPL---PGVTDERHWAMRITQGRPM
TH_2961|M.thermoresistible__bu FEEKFGVQIRQLWGMTETSPVCTLAWPA---PNTPADRHWEVRGSQGRPI
MAB_2080|M.abscessus_ATCC_1997 FEEKYNVPIVQAWGMTETSPLATVARPA---HRADATRRWEMRASQGRPI
Mflv_4589|M.gilvum_PYR-GCK YDELG-IRIVQAWGMTETSPLAAVALPR---DTDTPERSLYLRGTQGRVV
Mvan_0905|M.vanbaalenii_PYR-1 YRQAIGVSITQVWGMTETSPIAAACTPRTQYAELTTQEKAVALARQGQAV
MLBr_02546|M.leprae_Br4923 ALEELGPVIYNMYGSTEIA-FATIAGPK---------DLQINSATVGPVV
: * : :* ** : ..: . * * :
MUL_0229|M.ulcerans_Agy99 CGVETRIVD-DNGEALPNDGQAVGEVEVRGPWITGAYYLGYDQSE--FDS
MMAR_4412|M.marinum_M CGVETRIVD-DNGEALPNDGQAVGEVEVRGPWITGAYYLGYDQSK--FDS
Mb1087|M.bovis_AF2122/97 CGVETRIVD-DDGQVLPNDGNAVGEVEVRGPWIAGSYYGGRDESK--FDS
Rv1058|M.tuberculosis_H37Rv CGVETRIVD-DDGQVLPNDGNAVGEVEVRGPWIAGSYYGGRDESK--FDS
MAV_1186|M.avium_104 CGVQMRIVD-DDGRVLPNDGTAVGEVEVRGPWIAGSYYLGRDDSK--FDS
MSMEG_5291|M.smegmatis_MC2_155 CGVEVRIVD-DAGNPLPSDGKAVGELEVRGPWITGGYYLGRDAEK--FDS
TH_2961|M.thermoresistible__bu CGVEARIVD-DEGNVLPRDNEAVGELEVRGPWITGSYYHDADPSK--FEN
MAB_2080|M.abscessus_ATCC_1997 CGVEIRLRD-DDGKDVPWDGQSVGEIQARGPWITGSYFGDNDTEK--FDE
Mflv_4589|M.gilvum_PYR-GCK AGVQARIVD-DSGAEQPWDGKSVGEIQIRGPWITQSYYEYDSPAV--SPD
Mvan_0905|M.vanbaalenii_PYR-1 PLVDLRLVDPDTGADVPWDNHSTGEVQAAGPWIASSYYNSDDQQSSFTDD
MLBr_02546|M.leprae_Br4923 KGVKVKILD-DSGKEVPRG--QVGRIFVGNAFPFEGYTGGGGKQI---ID
*. :: * * * * . .*.: ..: .* . .
MUL_0229|M.ulcerans_Agy99 GWLRTGDVGRIDELGFITLTDRAKDVIKSGGEWISSVELENCLIAHPDVV
MMAR_4412|M.marinum_M GWLRTGDVGRIDELGFITLTDRAKDVIKSGGEWISSVELENCLIAHPDVV
Mb1087|M.bovis_AF2122/97 GWLRTGDVGRIDEQGFITLTDRAKDVIKSGGEWISSVELENCLIAHPDVL
Rv1058|M.tuberculosis_H37Rv GWLRTGDVGRIDEQGFITLTDRAKDVIKSGGEWISSVELENCLIAHPDVL
MAV_1186|M.avium_104 GWLRTGDVGRIDERGFVTLTDRAKDVIKSGGEWISSVELENCLIGHPDVV
MSMEG_5291|M.smegmatis_MC2_155 GWLRTGDVGVIDELGYVTLTDRAKDVIKSGGEWISSVELENHLIGHPAVL
TH_2961|M.thermoresistible__bu GWLRTGDVGRMDAQSYITLTDRAKDVIKSGGEWISSVELENHLIGHPKVR
MAB_2080|M.abscessus_ATCC_1997 GWLRTGDVGKIDAEGYLTLTDRSKDVIKSGGEWISSVELENTLIGHPAVY
Mflv_4589|M.gilvum_PYR-GCK GWLCTGDVGTISADAFITLTDRAKDVIKSGGEWISSVELENELAAHPAVR
Mvan_0905|M.vanbaalenii_PYR-1 GWLRTGDVGVCDEFGSLLLVDRTKDLVKSGGEWISSVQLENEIMAHPKVS
MLBr_02546|M.leprae_Br4923 GLLSSGDVGYFDEHDLLYISGRDDEMIVSGGENVFPAEVEDLISGHPEVV
* * :**** . : : .* .::: **** : ..::*: : .** *
MUL_0229|M.ulcerans_Agy99 EAAVVGVPDERWQERPLAVVVRREGATVSAAELRKFLADRVVRWWLPERW
MMAR_4412|M.marinum_M EAAVVGVPDERWQERPLAVVVRREGATVSAAELRKFLADRVVRWWLPERW
Mb1087|M.bovis_AF2122/97 EAAVVGVPDERWQERPLAVVVVREGATVSAGDLRAFLADKVVRWWLPERW
Rv1058|M.tuberculosis_H37Rv EAAVVGVPDERWQERPLAVVVVREGATVSAGDLRAFLADKVVRWWLPERW
MAV_1186|M.avium_104 EAAVVGVPDERWEERPLAVVVVKDGASVDADQLRKFLADKVVRWWLPERW
MSMEG_5291|M.smegmatis_MC2_155 EAAVVGVPDERWQERPLAVVVLHEGSSADPGELREFLADKVVRWWLPERW
TH_2961|M.thermoresistible__bu EAAVVGVPDDRWQERPLAAVVLHEGQQATPEELREFLSDKVVRWWLPERW
MAB_2080|M.abscessus_ATCC_1997 EAAVVGVADDKWQERPLALVVVHPGTDVDIDQLRSFLADKVAKWWIPERW
Mflv_4589|M.gilvum_PYR-GCK TATVIGVPDDKWQERPLAVVVLAADCTATAAELTEFLRARVAKWWLPERW
Mvan_0905|M.vanbaalenii_PYR-1 EAAVIAIPHERWVERPLACVVVKQGESMTTEEVIRHLSARVAKWWLPDAV
MLBr_02546|M.leprae_Br4923 EATAIGVDDKEWGARLRAFVVKKQDATIDEDAIKAYVRDHLARYKVPREV
*:.:.: ...* * * ** . : .: ::.:: :*
MUL_0229|M.ulcerans_Agy99 AFADQVPRTSVGKYDKKTIRAGYAESVYQVTDVHN
MMAR_4412|M.marinum_M AFADQVPRTSVGKYDKKTIRAGYAEGVYQVTEVHN
Mb1087|M.bovis_AF2122/97 AFVDEIPRTSVGKYDKKAIRSRYAEGAYQITEVHT
Rv1058|M.tuberculosis_H37Rv AFVDEIPRTSVGKYDKKAIRSRYAEGAYQITEVHT
MAV_1186|M.avium_104 TFVDEIPRTSVGKYDKKAVRSRYADGGYRVIEARD
MSMEG_5291|M.smegmatis_MC2_155 AFVDQVPRTSVGKYDKKTIRARHAEGAYEVIHL--
TH_2961|M.thermoresistible__bu TFVEEIPRTSVGKYDKKTIRARYADGAYQVTHLGG
MAB_2080|M.abscessus_ATCC_1997 SFVSDIPRTSVGKYDKKAIRARHSAGEYLIEIETS
Mflv_4589|M.gilvum_PYR-GCK AFVADVPLTSTGKFDKKKLRSQHADGDLAVETLA-
Mvan_0905|M.vanbaalenii_PYR-1 EFIDAVPKTSVGKFSKKTLRARFENYRFPDQGAPV
MLBr_02546|M.leprae_Br4923 IFLEELPRNPTGKVLKRELRDFEVH----------
* :* ...** *: :*