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MRIADRVFVVTGAGNGMGREVALGLARRGAHVAAVDLDEAGLAGTAERARGTGARMSTHVLNVTDRDAVA GLPDAVLDVHGQIDGLVNIAGIAQRFALFTDLEADQIDRVTTVNFLGTVQMCRAFLPVLRQRPEANITNM SSLSALVPFASQVLYSASKAAVQQFSEGLDAELADTNVRVVTVFPGQVSTNLAQNSGVKMLDAGGRRAPV TTPEAAGRKIVTGIAKDRYRVIIGTDAHVLYTLSRLAPRRTARMVAKQIKSVL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2872 | - | - | 100% (263) | short-chain dehydrogenase/reductase SDR |
| M. smegmatis MC2 155 | MSMEG_5053 | - | 2e-35 | 36.33% (256) | short chain alcohol dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4280 | - | 1e-33 | 35.93% (270) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1277c | - | 1e-36 | 38.67% (256) | short-chain type dehydrogenase/reductase |
| M. gilvum PYR-GCK | Mflv_2216 | - | 1e-34 | 39.27% (247) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv1245c | - | 1e-36 | 38.67% (256) | short-chain type dehydrogenase/reductase |
| M. leprae Br4923 | MLBr_00862 | ephD | 1e-34 | 36.70% (267) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3919c | - | 6e-37 | 37.93% (261) | putative short chain dehydrogenase/reductase |
| M. marinum M | MMAR_3259 | ephD | 7e-36 | 37.31% (268) | short-chain dehydrogenase EphD |
| M. avium 104 | MAV_1958 | - | 1e-64 | 48.87% (266) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_2758 | - | 1e-112 | 77.57% (263) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_3574 | ephD | 2e-36 | 37.78% (270) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_4479 | - | 6e-35 | 36.03% (272) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1277c|M.bovis_AF2122/97 --------------------------------------------------
Rv1245c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2216|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4479|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_3919c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_2872|M.smegmatis_MC2_155 --------------------------------------------------
TH_2758|M.thermoresistible__bu --------------------------------------------------
MAV_1958|M.avium_104 --------------------------------------------------
MMAR_3259|M.marinum_M MSATR---QAPQQFVDSAGGVRIAVYEEGNPDGPTVVLVHGFPDSHVLWD
MUL_3574|M.ulcerans_Agy99 MPATK---QAPQQFVDSAGGVRIAVYEEGNPDSPTVVLVHGFPDSHVLWD
MLBr_00862|M.leprae_Br4923 MPATQSIHKVPHQFVESPDGVRLAIYQSGQPEGPAIVLVHGFPDSHVLWD
Mb1277c|M.bovis_AF2122/97 --------------------------------------------------
Rv1245c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2216|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4479|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_3919c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_2872|M.smegmatis_MC2_155 --------------------------------------------------
TH_2758|M.thermoresistible__bu --------------------------------------------------
MAV_1958|M.avium_104 --------------------------------------------------
MMAR_3259|M.marinum_M GVVPRLAERFRILRYDNRGVGLSSAPKAVSAYTTACLADDFAAVIEALSP
MUL_3574|M.ulcerans_Agy99 GVVPRLAERFRILRYDNRGVGLSSAPKAVSAYTTACLADDFAAVIEALSP
MLBr_00862|M.leprae_Br4923 GVVPLLAKRFRIVRYDNRGVGQSSVPKPVSAYTMTRFADDFAAVIDELSP
Mb1277c|M.bovis_AF2122/97 --------------------------------------------------
Rv1245c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2216|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4479|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_3919c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_2872|M.smegmatis_MC2_155 --------------------------------------------------
TH_2758|M.thermoresistible__bu --------------------------------------------------
MAV_1958|M.avium_104 --------------------------------------------------
MMAR_3259|M.marinum_M GQPVHVLGHDWGSVAIWEYLTRSGAADRVASFTSVSGPSQDQLVNYIFGG
MUL_3574|M.ulcerans_Agy99 GQPVHVLGHDWGSVAIWDYLTRSGAADRVASFTSVSGPSQDQLVNYIFGG
MLBr_00862|M.leprae_Br4923 DRPVHVLAHDWGSVGVWEYLSRSGASDRVASFTSVSGPSQDQLVDYILSG
Mb1277c|M.bovis_AF2122/97 --------------------------------------------------
Rv1245c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2216|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4479|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_3919c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_2872|M.smegmatis_MC2_155 --------------------------------------------------
TH_2758|M.thermoresistible__bu --------------------------------------------------
MAV_1958|M.avium_104 --------------------------------------------------
MMAR_3259|M.marinum_M LRQPWRPKTFARALTQALRLSYMALFSVPVLAPLVLRATLSRASVRRNMV
MUL_3574|M.ulcerans_Agy99 LRQPWRPKTFARALTQALRLSYMALFSVPVLAPLVLRATLSRASVRRNMV
MLBr_00862|M.leprae_Br4923 LRRPWRPRTFARAVSQLFRLTYMVLFSIPVLVPMVLWIALSSATIRRTMV
Mb1277c|M.bovis_AF2122/97 --------------------------------------------------
Rv1245c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2216|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4479|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_3919c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_2872|M.smegmatis_MC2_155 --------------------------------------------------
TH_2758|M.thermoresistible__bu --------------------------------------------------
MAV_1958|M.avium_104 --------------------------------------------------
MMAR_3259|M.marinum_M DNLPLDRIHHSDNLASDAANSVKTYPANYFRAFSRQSRTRGVPVIDVPVQ
MUL_3574|M.ulcerans_Agy99 DNLPLDQIHHSDNLASDAANSVKTYPANYFRAFSRQSRTRGVPVIDVPVQ
MLBr_00862|M.leprae_Br4923 DNISTDQIHHSATLARDAAHSVKTYPANYFRAFSGRRRGKGVPVVNVPVQ
Mb1277c|M.bovis_AF2122/97 --------------------------------------------------
Rv1245c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2216|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4479|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_3919c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_2872|M.smegmatis_MC2_155 --------------------------------------------------
TH_2758|M.thermoresistible__bu --------------------------------------------------
MAV_1958|M.avium_104 --------------------------------------------------
MMAR_3259|M.marinum_M LIVNTKDPYVRPYGYDETARWVPRLWRRDIKAGHFSPMSHPQVMAAAVHD
MUL_3574|M.ulcerans_Agy99 LIVNTKDPYVRPYGYDETARWVPRLWRRDIKAGHFSPMSHPQVMAAAVHD
MLBr_00862|M.leprae_Br4923 LIVNTMDRYVRPYGYDATARWVPRLWRRDIKAGHFSPMSHPQVMAAAVHD
Mb1277c|M.bovis_AF2122/97 ----------------------MEGFAGKVAVVTGAGSGIGQALAIELAR
Rv1245c|M.tuberculosis_H37Rv ----------------------MEGFAGKVAVVTGAGSGIGQALAIELAR
Mflv_2216|M.gilvum_PYR-GCK ----------------------MQGFAGKVAVVTGAGSGIGQALAIELGR
Mvan_4479|M.vanbaalenii_PYR-1 ----------------------MEGFAGKVAVVTGAGSGIGQALAIELGR
MAB_3919c|M.abscessus_ATCC_199 ----------------------MKNFDNKVAVITGAGSGIGRSLALALAQ
MSMEG_2872|M.smegmatis_MC2_155 -----------------------MRIADRVFVVTGAGNGMGREVALGLAR
TH_2758|M.thermoresistible__bu -----------------------VRITDRVFVVTGSGNGMGREVAVELGR
MAV_1958|M.avium_104 -----------------------MKIRDKVFVVTGGANGMGRQVALLLVA
MMAR_3259|M.marinum_M FADLVDGKPPSRALLRAQVGRPRKYFGDTLVAVTGAGSGIGRETALAFAR
MUL_3574|M.ulcerans_Agy99 FADLVDGKPPSRALLRAQVGRPRKYFGDTLVAVTGAGSGIGRETALAFAR
MLBr_00862|M.leprae_Br4923 LADLVDGKQPSRALLRAQVGRSRDTFGDTLVSVTGAGSGIGRETALALAR
: . : :**...*:*: *: :
Mb1277c|M.bovis_AF2122/97 SGAKVAISDVDTDGLADTEHRLKAISTPVKTDRLDVTEREAFLAYADAVN
Rv1245c|M.tuberculosis_H37Rv SGAKVAISDVDTDGLADTEHRLKAISTPVKTDRLDVTEREAFLAYADAVN
Mflv_2216|M.gilvum_PYR-GCK SGALVAISDVDTEGLAVTEERLKAIGTHVKSDRLNVTERERFLQYADDVA
Mvan_4479|M.vanbaalenii_PYR-1 SGARVAISDVDTEGLAVTEERLKAIGAQVKSDRLDVTERETFLLYADDVA
MAB_3919c|M.abscessus_ATCC_199 RGARLALSDIDTAGVADTAGRCEKAGATAIPFELDVADRAAVYAHAADVK
MSMEG_2872|M.smegmatis_MC2_155 RGAHVAAVDLDEAGLAGTAERARGTGARMSTHVLNVTDRDAVAGLPDAVL
TH_2758|M.thermoresistible__bu RGAHVAAVDIDREGLAGTAELVRATGARITTHVVDVTDDNAVAALPAAVL
MAV_1958|M.avium_104 KGARVAVVDVDVAGLKETAALTAPQAGRISTHVVDVAERSATSALPDAVV
MMAR_3259|M.marinum_M EGAEVVLSDIDEATVKDTAAEIAARGGVAHPYVLDVSDTEAVEAFADQVS
MUL_3574|M.ulcerans_Agy99 EGAEVVLSDIDEATVKDTAAEIAARGGVAHPYVLDVSDTEAVEAFADQVS
MLBr_00862|M.leprae_Br4923 RGAEVVVSDIDEAAAKNTAAQIVASGGVAYAYALDVSDAAAVEAFAEQVS
** :. *:* * . . ::*:: . *
Mb1277c|M.bovis_AF2122/97 EHFGTVNQIYNNAGIAFT-GDIEVSQFKDIERVMDVDFWGVVNGTKAFLP
Rv1245c|M.tuberculosis_H37Rv EHFGTVNQIYNNAGIAFT-GDIEVSQFKDIERVMDVDFWGVVNGTKAFLP
Mflv_2216|M.gilvum_PYR-GCK EHFGKVHQIYNNAGIAFT-GDIEVSQFKDIERVMDVDFWGVVNGTKAFLP
Mvan_4479|M.vanbaalenii_PYR-1 EHFGSVNQIYNNAGIAFT-GDIEITQFKDIERVMDVDYWGVVNGTKAFLP
MAB_3919c|M.abscessus_ATCC_199 NEFGQVNLVFNNAGVALS-ADVKDMEWDDFDWLMNINFWGVAHGTKAFLP
MSMEG_2872|M.smegmatis_MC2_155 DVHGQIDGLVNIAGIAQRFALFTDLEADQIDRVTTVNFLGTVQMCRAFLP
TH_2758|M.thermoresistible__bu DAHGQVDGLVNIAGIAQRFALFSDLGAEALDRVPVVNFTGTVRMCRAFLP
MAV_1958|M.avium_104 AAHGAVDGLVNVAGIIHRFARLNDLEFGEIERVLNINLYGVLNVTKAFLP
MMAR_3259|M.marinum_M ATHGLPDIVVNNAGVGQA-GRFLDTPAEQFDRVLDVNLGGVVNGCRAFGQ
MUL_3574|M.ulcerans_Agy99 ATHGLPDIVVNNAGVGQA-GRFLDTPAEQFDRVLDVNLGGVVNGCRAFGQ
MLBr_00862|M.leprae_Br4923 AKHGVPDIVVNNAGIGQA-GRFLDTPPEEFDRVLAVNLGGVVNCCRAFGQ
.* . : * **: . . :: : :: *. . :**
Mb1277c|M.bovis_AF2122/97 HLIASGDG-HVINISSVFGLFSAPGQAAYNSAKFAVRGFTEALRQEMALA
Rv1245c|M.tuberculosis_H37Rv HLIASGDG-HVINISSVFGLFSAPGQAAYNSAKFAVRGFTEALRQEMALA
Mflv_2216|M.gilvum_PYR-GCK HLIASGDG-HVVNVSSVFGLFSVPGQGAYNAAKFAVRGFTEALRQEMALA
Mvan_4479|M.vanbaalenii_PYR-1 HLIASGDG-HVVNVSSVFGLFSVPGQAAYNSAKFAVRGFTEALRQEMALA
MAB_3919c|M.abscessus_ATCC_199 HLIESGDG-HIVNVSSVFGLMGIPSQSAYNAAKFAVRGFTESLRQEIRAA
MSMEG_2872|M.smegmatis_MC2_155 VLRQRPEA-NITNMSSLSALVPFASQVLYSASKAAVQQFSEGLDAELADT
TH_2758|M.thermoresistible__bu ILLARPEA-NITNMSSLSALVPFASQLLYSASKAAVKQFSEGLDAELVGT
MAV_1958|M.avium_104 HLLKRPTA-HITIVSSMASYAPVPGQAIYGASKAAVKMLAEGLNSELRDT
MMAR_3259|M.marinum_M RLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATFMFSDCLRAELDAA
MUL_3574|M.ulcerans_Agy99 RLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATFMFSDCLRAELDAA
MLBr_00862|M.leprae_Br4923 RLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMFSDCLRAELDAV
* . :: :**: . . * ::* *. ::: * *: .
Mb1277c|M.bovis_AF2122/97 GHPVKVTTVHPGGVKTAIARNAT-------AAEGLDQAELAETFDKRVAH
Rv1245c|M.tuberculosis_H37Rv GHPVKVTTVHPGGVKTAIARNAT-------AAEGLDQAELAETFDKRVAH
Mflv_2216|M.gilvum_PYR-GCK GHPVKVSCVHPGGIKTAIARNAG-------AAEGLDAEELAKTFDKKLAS
Mvan_4479|M.vanbaalenii_PYR-1 GHPVKVSCVHPGGIKTAIARNAS-------AAEGLDAEELAKAFDKKLAS
MAB_3919c|M.abscessus_ATCC_199 KFPVGVTCVHPGGIKTNIASSARG------IPDGVDRETVRKGF-QLMAI
MSMEG_2872|M.smegmatis_MC2_155 --NVRVVTVFPGQVSTNLAQNSG-----------VKMLD---AGGRRAPV
TH_2758|M.thermoresistible__bu --DVRVVTVFPGNVATELAKNSG-----------VEMLD---AGSRRVYA
MAV_1958|M.avium_104 --NVRVSVVFPGAVKTDIAVNSG-----------AMTPDENEATARSMRM
MMAR_3259|M.marinum_M D--VGLTTICPGVINTNIVNTTRFDAPPGKGGDQVDGRRGQIDKMFALRS
MUL_3574|M.ulcerans_Agy99 D--VGLTTICPGVINTNIVNTTRFDAPPGKGGDQLDGRRGQIDKMFALRS
MLBr_00862|M.leprae_Br4923 G--VGLTTICPGVIDTNIIQSTRIDTPTAKQ-ERVRDRRGQLDMMFRLRR
* : : ** : * : .:
Mb1277c|M.bovis_AF2122/97 LSPQRAAQIILTGVAKNKARVLVGVDAKVLDLVVRLTGSGYQRIFP----
Rv1245c|M.tuberculosis_H37Rv LSPQRAAQIILTGVAKNKARVLVGVDAKVLDLVVRLTGSGYQRIFP----
Mflv_2216|M.gilvum_PYR-GCK TTPEKAAQVILDGVRKNKARILIGNDAKMFEIAIRALGAGYQSVFP----
Mvan_4479|M.vanbaalenii_PYR-1 TTPEKAAKIILDGVRKNRARILVGNDAKVFDVVVRVLGAGYQSLFP----
MAB_3919c|M.abscessus_ATCC_199 TRPDSAARIILRGVEKNRPRVLIGPDARVFDAIPRIIGPRYEDLMAPFYG
MSMEG_2872|M.smegmatis_MC2_155 TTPEAAGRKIVTGIAKDRYRVIIGTDAHVLYTLSRLAPRRTARMVAK---
TH_2758|M.thermoresistible__bu TSPEAAGRKIVAGIARDRYRVIIGADAHVLHALARIAPRRTARLVAR---
MAV_1958|M.avium_104 LPSTVAAAKIVRGIEKDSRRVFVGLDALLLDKLNRLTPASAAKLIWS---
MMAR_3259|M.marinum_M YGPDKVAKAIVSAVKKNKPIRPVAPEAYALYGISRVLPPALRSTAR----
MUL_3574|M.ulcerans_Agy99 YGPDKVAKAIVSAVKKNKPIRPVAPEAYALYGISRVLPPALRSTAR----
MLBr_00862|M.leprae_Br4923 YGPDKVADTILSAIKKNKPIRPVAPEAYALYGISRVLPQVLRSTAR----
. .. *: .: :: :. :* : *
Mb1277c|M.bovis_AF2122/97 --------IITGRLIPRPR---
Rv1245c|M.tuberculosis_H37Rv --------IITGRLIPRPR---
Mflv_2216|M.gilvum_PYR-GCK --------KVVARLTPPAK---
Mvan_4479|M.vanbaalenii_PYR-1 --------KAVARLTPPAK---
MAB_3919c|M.abscessus_ATCC_199 MGRYGIGKKIAGRFGIEL----
MSMEG_2872|M.smegmatis_MC2_155 --------QIKSVL--------
TH_2758|M.thermoresistible__bu --------QITSVLREQ-----
MAV_1958|M.avium_104 --------QMRDVLPPAGQSLR
MMAR_3259|M.marinum_M ---------MRVI---------
MUL_3574|M.ulcerans_Agy99 ---------MRVI---------
MLBr_00862|M.leprae_Br4923 ---------IRVI---------