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TAAFWMAVPPEVHSALLSAGPGPGPLQEAATAWASLSVEYASVAEDLAGVLGGVQAQAWQGPSAASYVAA HLPYAAWLTKASADYAVMAAEQEVVAAEYVAALAAMPTLAELAGNHATHAVLLGTNFFGINTIPIALNEA DYARMWVQAATVMSVYQAGSTAALAAAPRGMPAPVVLKAGAAEGDGAVVGGVNRAGAGGGTGLGWIGGAG KQPGFGGGF*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_2247 | - | - | 100% (220) | PPE family protein |
| M. ulcerans Agy99 | MUL_1154 | - | 6e-65 | 63.27% (196) | PPE family protein |
| M. ulcerans Agy99 | MUL_3127 | - | 1e-62 | 60.29% (204) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0294 | PPE4 | 6e-70 | 67.53% (194) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 3e-63 | 61.70% (188) | PPE protein |
| M. tuberculosis H37Rv | Rv0286 | PPE4 | 7e-70 | 67.53% (194) | PPE family protein |
| M. leprae Br4923 | MLBr_01828 | PPE | 2e-54 | 55.43% (184) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0669 | - | 1e-62 | 61.66% (193) | PPE-family protein |
| M. marinum M | MMAR_3005 | - | 3e-98 | 91.54% (201) | PPE family protein |
| M. avium 104 | MAV_2514 | - | 1e-69 | 66.31% (187) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 3e-64 | 63.30% (188) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 2e-63 | 58.65% (208) | PUTATIVE PPE protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 2e-62 | 61.70% (188) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_2247|M.ulcerans_Agy99 ----------MTAAFWMAVPPEVHSALLSAGPGPGPLQEAATAWASLSVE
MMAR_3005|M.marinum_M ----------------MAVPPEVHSALLSAGPGPGPLQEAATAWASLSVE
Mb0294|M.bovis_AF2122/97 ----------MAAPIWMASPPEVHSALLSNGPGPGSLVAAATAWSQLSAE
Rv0286|M.tuberculosis_H37Rv ----------MAAPIWMASPPEVHSALLSNGPGPGSLVAAATAWSQLSAE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
TH_3569|M.thermoresistible__bu ---------MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAE
MAV_2514|M.avium_104 ----------MTAPIWMAFPPEIHSALLSSGPGPGPLLASAGAWSSLSTE
MAB_0669|M.abscessus_ATCC_1997 ----------MTAPIWMAEPPEVHSALLSAGPGPGAVLAAAVQWQEIGNN
MLBr_01828|M.leprae_Br4923 ----------MSAPIWMASPPEVHSALLSRGPGSGPLLVAAEAWRSLSSV
** ***:**::** ***.*.: :. * :.
MUL_2247|M.ulcerans_Agy99 YASVAEDLAGVLGGVQAQAWQGPSAASYVAAHLPYAAWLTKASADYAVMA
MMAR_3005|M.marinum_M YASVAEDLAGVLGGVQAQAWQGPSAASYVAAHLPYAAWLTKASADYAVMA
Mb0294|M.bovis_AF2122/97 YASTAAELSGLLGAVPGWAWQGPSAEWYVAAHLPYVAWLTQASADAAGAA
Rv0286|M.tuberculosis_H37Rv YASTAAELSGLLGAVPGWAWQGPSAEWYVAAHLPYVAWLTQASADAAGAA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
TH_3569|M.thermoresistible__bu YASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATA
MAV_2514|M.avium_104 YAAAASELTALLDEVQAGAWEGPSAAQYAAAHAPYVAWLTQASADSAAMA
MAB_0669|M.abscessus_ATCC_1997 YANTAVELAQVLAGVRAGSWQGPSASEYVAAHLPYLAWLEQAAAESSVIA
MLBr_01828|M.leprae_Br4923 YAEMADELVALLVVVPVSSWDGSAAEAYVIAYLPYLGWLRQASVDSAVMA
** * :* :* * :*:*.:: *. *: ** ** : :. : *
MUL_2247|M.ulcerans_Agy99 AEQEVVAAEYVAALAAMPTLAELAGNHATHAVLLGTNFFGINTIPIALNE
MMAR_3005|M.marinum_M AEQEVVAAEYVAALAAMPTLAELAGNHATHAVLLGTNFFGINTIPIALNE
Mb0294|M.bovis_AF2122/97 AQHEAAAAAYTTALAAMPTLAELAANHVIHTVLVATNFFGINTIPITLNE
Rv0286|M.tuberculosis_H37Rv AQHEAAAAAYTTALAAMPTLAELAANHVIHTVLVATNFFGINTIPITLNE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
TH_3569|M.thermoresistible__bu GRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNE
MAV_2514|M.avium_104 ARQETAATAYTTALAAMPTLGELAANHALHAALVSTNFFGVNTIPIALNE
MAB_0669|M.abscessus_ATCC_1997 AQHETTAAAYNSALAAMPTLAELAANHITHGVLVGTNFFGINTIPIALNE
MLBr_01828|M.leprae_Br4923 AHYETMATAYITTLAMMPTLAELAANRTAHTVLVTTNFFGINTIPIARNE
. :. *: * ::** ***: **: *: * .*: ***:*:*****: .*
MUL_2247|M.ulcerans_Agy99 ADYARMWVQAATVMSVYQAGSTAALAAAPRGMPAPVVLKAGAAEG-----
MMAR_3005|M.marinum_M ADYARMWVQAATVMSVYQAGSTAALAAAPRGMPAPVVLKAGAAEGVSAA-
Mb0294|M.bovis_AF2122/97 ADYVRMWLQAAAVMGLYQAASGAALASAPRTVPAPTVMNPGGGAAS----
Rv0286|M.tuberculosis_H37Rv ADYVRMWLQAAAVMGLYQAASGAALASAPRTVPAPTVMNPGGGAAS----
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
TH_3569|M.thermoresistible__bu ADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGVSEAADAMA
MAV_2514|M.avium_104 ADYSRMWVQAATTMSTYQAVSTTAVASAPQATAAPKIMNAGMSGGSGMSG
MAB_0669|M.abscessus_ATCC_1997 ADYVRMWVQAAATMSAYQATTEAMTSAIPPTQQPPAILSPGGEARSD---
MLBr_01828|M.leprae_Br4923 IDYVRMWVEAAIAMGTYQEVSTVVVDSAPEAIAAPQIMASDALEASSDQP
** ***::** *. ** : . : * .* :: ..
MUL_2247|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3005|M.marinum_M --------ALPAAPADGPSIL-------WILVQIIL------------IL
Mb0294|M.bovis_AF2122/97 ---------TVGAVNPWQWLL-------ALLQQLWN-----AYTGFYGWM
Rv0286|M.tuberculosis_H37Rv ---------TVGAVNPWQWLL-------ALLQQLWN-----AYTGFYGWM
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFDVS-------NIIADIIR-----LYGEVLRFL
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALDLS-------NIIADLIR-----AYGELLRFL
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLDLS-------SIISDLLN-----QYLQGVPGG
TH_3569|M.thermoresistible__bu TTQQIGSQATAADSGTALNLS-------DLIANLLQ-----YYQDYLDQL
MAV_2514|M.avium_104 GNPYIMGTALPQNLQEWLEAL-------FPFNPFSPQGW--SMHPSLSMF
MAB_0669|M.abscessus_ATCC_1997 ---------QSDVPGSPDQIM-------KMLQGFQQ------------WF
MLBr_01828|M.leprae_Br4923 SPTAPSQSPQVQNWLQWLQKIGYTDFYNTLVQPLITSLTNHPFFQGMFSG
MUL_2247|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3005|M.marinum_M LEILYAIVAYTI--ILAFVLPFLILVEAFVFTILGLMFSIFVG-------
Mb0294|M.bovis_AF2122/97 LQLIWQFLQDPIGNSIKIIIAFLTNPIQALITYGPLLFALGYQ-------
Rv0286|M.tuberculosis_H37Rv LQLIWQFLQDPIGNSIKIIIAFLTNPIQALITYGPLLFALGYQ-------
Mflv_0325|M.gilvum_PYR-GCK FEPIFNFLRDPIGNTFALITDFLTNPVQALITWGPFLLAVVYQ-------
Mvan_0415|M.vanbaalenii_PYR-1 FEPIFDFLRDPLGNTIKLITDFLTNPAQALITWGPFLAAVAYQ-------
MSMEG_0619|M.smegmatis_MC2_155 Q-AILDFLKDPLGNLGRLLTDFMTNPAGALATWWPFLFGVAYQ-------
TH_3569|M.thermoresistible__bu FGPIVDFLRDPIGNLFQLIDDFLTNPAGALVTWWPLLFAVAYQ-------
MAV_2514|M.avium_104 LSRVETLIPMYAHNPAQLLETIVMLALQFVIHRTLYLIWLILYN------
MAB_0669|M.abscessus_ATCC_1997 EKMGFNPATSAVLAVIMLFLYDLLWYPYYASYLLPFLIPALSG-------
MLBr_01828|M.leprae_Br4923 FDPWLPSLGNPLSFLSPFNIAFALGTPMDIGSYVGYLSQTFAFIGADLAA
MUL_2247|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3005|M.marinum_M ---------------------------------------------FLGLL
Mb0294|M.bovis_AF2122/97 ------------------------------------IFFNLVGWPTWGMI
Rv0286|M.tuberculosis_H37Rv ------------------------------------IFFNLVGWPTWGMI
Mflv_0325|M.gilvum_PYR-GCK ------------------------------------AVSWVGASILYPSL
Mvan_0415|M.vanbaalenii_PYR-1 ------------------------------------AVSWVGASILYPSL
MSMEG_0619|M.smegmatis_MC2_155 ------------------------------------VFFNLVGWPTWGMI
TH_3569|M.thermoresistible__bu ------------------------------------VFTNLVGWPTWAMI
MAV_2514|M.avium_104 ---------------------------------PAGLLSFFLSNPVYTLA
MAB_0669|M.abscessus_ATCC_1997 ---------------------------------------LSGLAALMHLR
MLBr_01828|M.leprae_Br4923 AFASGNPVTIGFTLLFTTIEAIGTIITDTIALVKTMIEQSFVLLPMILPL
MUL_2247|M.ulcerans_Agy99 --------------DGAVVGG-----------------------------
MMAR_3005|M.marinum_M FGPPLLTIAAPLLLNGAVIGLSTGVPVSLATALPIGIPAYLADQSRRGEL
Mb0294|M.bovis_AF2122/97 LSSPFLLP-AGLGLGLAAIAFLPIVLAP-AVIPPASTPLAAAAVAAGSVW
Rv0286|M.tuberculosis_H37Rv LSSPFLLP-AGLGLGLAAIAFLPIVLAP-AVIPPASTPLAAAAVAAGSVW
Mflv_0325|M.gilvum_PYR-GCK FLLPLLAT-TLAIVAGVGQHLLSLLNTP-PAEEAAEEPAPAQSAPSRPDQ
Mvan_0415|M.vanbaalenii_PYR-1 LLLPLVAT-TLAIVLGVGAYLLENLPAP-AEDAPAEEPAASSPAPTRADQ
MSMEG_0619|M.smegmatis_MC2_155 FASPFLIP-ALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAPRTD
TH_3569|M.thermoresistible__bu LASPVLIP-LAITLGVAGLVMIADQAQP-----PAEEAAPEEDVAAP---
MAV_2514|M.avium_104 LTTPLLIVPAGAAGGLAGLTGLAAVPAPTLTPPVSPSTIPVTDAPPPPTV
MAB_0669|M.abscessus_ATCC_1997 PAAPGPVPAAALSPGDRPIRRPTQHVEPNLAALPLPTSSVVPSGGSSVPV
MLBr_01828|M.leprae_Br4923 LTAPLAVATAGAAGSFAGLSELAGLVGVAPPGLPSAPPVAAVAPVVPPSM
MUL_2247|M.ulcerans_Agy99 -------------------VNRAGAGG-----------------------
MMAR_3005|M.marinum_M ------------GDAGQDQVVFVGARGGMAPSLAESTA------------
Mb0294|M.bovis_AF2122/97 PAVSMAVTGAGTAGAATPAAGAAPS-AGAAPAPAAPAT---ASFAYAVGG
Rv0286|M.tuberculosis_H37Rv PAVSMAVTGAGTAGAATPAAGAAPS-AGAAPAPAAPAT---ASFAYAVGG
Mflv_0325|M.gilvum_PYR-GCK QSFPATMSAPPPPSGAPIAANTVSAGSPPAPGAPAAAA---ATFVPYVVA
Mvan_0415|M.vanbaalenii_PYR-1 PSPAIAVSAPPPPSSAAATVGTVATGTAPAPGAPAAAT---ASFVPYAVA
MSMEG_0619|M.smegmatis_MC2_155 QPLAVGISPAGVPGSAATAAAPAPAPAGTTVAAPAPAA---ATFVPYAVA
TH_3569|M.thermoresistible__bu ----------------VRAEPQNPLPLTXXX-------------------
MAV_2514|M.avium_104 GAAPIMGTASSPGAAPMPALPEAAATPGAPPTPPPTIVGPETSFTAQAFV
MAB_0669|M.abscessus_ATCC_1997 S----------TPTAPAHTVSSVPAPSAAISYAIPGLVP-----------
MLBr_01828|M.leprae_Br4923 PTLASIPTPTPMPAPAASTAPVVTPPGPPPVTAPPSVTGAGVESFGYLVG
MUL_2247|M.ulcerans_Agy99 -------------------------GTGLGWIG-----------------
MMAR_3005|M.marinum_M ----------------------PAPAAGLASAGSAVPASNPASAV-----
Mb0294|M.bovis_AF2122/97 S----GDWGPSLGPTVGGRGGIKAPAATVPAAAAAAATRGQSRARRRRRS
Rv0286|M.tuberculosis_H37Rv S----GDWGPSLGPTVGGRGGIKAPAATVPAAAAAAATRGQSRARRRRRS
Mflv_0325|M.gilvum_PYR-GCK G----RDPYEGFSPTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQ
Mvan_0415|M.vanbaalenii_PYR-1 G----RDPGTGFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQ
MSMEG_0619|M.smegmatis_MC2_155 N----RDPGEGFTPTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKK
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAV_2514|M.avium_104 SPYLVGVLGAATESSVSGKNCRPAADATAAAAAAPAPTAADRQTLRRRRN
MAB_0669|M.abscessus_ATCC_1997 -------PGVSFGPKSTEKSSESAVDTVAAVAAARGAVAAQARRRLRGKN
MLBr_01828|M.leprae_Br4923 R-------LPSTARGVVGTSVRQQSSAPDRIEAPDAAATPQEQARSRWRR
MUL_2247|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3005|M.marinum_M --------------------------------------ASERGADMSNFA
Mb0294|M.bovis_AF2122/97 ----ELRDYGDEFLD--MDSDSGFGPSTG-DHGAQ---ASERGAGTLGFA
Rv0286|M.tuberculosis_H37Rv ----ELRDYGDEFLD--MDSDSGFGPSTG-DHGAQ---ASERGAGTLGFA
Mflv_0325|M.gilvum_PYR-GCK KEEIKGRGYADAYAD--YEELPDDGPPEQPAPRVT---ASTRGAGPMGFA
Mvan_0415|M.vanbaalenii_PYR-1 KDEIAGRAYADAYAD--YEPEPDDEPPVRQEPRIA---ATERGAGPMGFA
MSMEG_0619|M.smegmatis_MC2_155 GAQIEERGYADAYMD--YEE-PDEDPAPQPEPRVR---ASERGSDAMGFT
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAV_2514|M.avium_104 APSRVDRGYRYEFLDPEADTEPDERAAADIAPQPNSSLTSERGAGRLGIT
MAB_0669|M.abscessus_ATCC_1997 KAEAGGRRHEYLEET--------AGMGATATADVPAYAATGRGTGPLGFA
MLBr_01828|M.leprae_Br4923 ------RAKVTPFDS---------SGSPNPKAAPT---ASDQGAGTLGLA
MUL_2247|M.ulcerans_Agy99 -----GAGKQPG---------FGGGF------------------------
MMAR_3005|M.marinum_M GTSAKGSTVRPAGLMMLGGSEFEGGLREPMLPATW---------------
Mb0294|M.bovis_AF2122/97 GTATKERRVRAVGLTALAGDEFGNGPRMPMVPGTWEQGSNEPEAPDG-SG
Rv0286|M.tuberculosis_H37Rv GTATKERRVRAVGLTALAGDEFGNGPRMPMVPGTWEQGSNEPEAPDG-SG
Mflv_0325|M.gilvum_PYR-GCK GTVSRGD-EQAGGLTTLAGDSFGGGPREPMLPGTWDPDATDDRHTDGRDG
Mvan_0415|M.vanbaalenii_PYR-1 GTVSRDA-AQAGGLTTLPGDPFGGGPKAPMLPGTWDPDTEPD------ER
MSMEG_0619|M.smegmatis_MC2_155 GTVTRHD-VTAAGLTTLTGDTFDDRPVTPMLPGTWDGDENPA------PS
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAV_2514|M.avium_104 -TVTGRR---ASGLARLAGDAFGGAPTVPMMPGSWRPATG----------
MAB_0669|M.abscessus_ATCC_1997 GTAPAAASTHVAATVRLSSD--EARQVIPMLPSTWDADGGDQN-------
MLBr_01828|M.leprae_Br4923 GTARQASSGPATGLVTLSNGTFSDSPRAPMLPRTWGADPTFCYNAADIGP
MUL_2247|M.ulcerans_Agy99 ------------
MMAR_3005|M.marinum_M ------------
Mb0294|M.bovis_AF2122/97 RGGGDGLPHDSK
Rv0286|M.tuberculosis_H37Rv RGGGDGLPHDSK
Mflv_0325|M.gilvum_PYR-GCK HDGHDGKEKP--
Mvan_0415|M.vanbaalenii_PYR-1 HNHHDGKDSQ--
MSMEG_0619|M.smegmatis_MC2_155 PDDPEGGPRR--
TH_3569|M.thermoresistible__bu ------------
MAV_2514|M.avium_104 ------------
MAB_0669|M.abscessus_ATCC_1997 ------------
MLBr_01828|M.leprae_Br4923 AGGWDDE-----