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VEQARRRRLRPSPARGAWRPGPAALLPDYLSALQRLAGEREVIFWDQLGCGNSERPSDVDLWTMGRSVAE IDAVVRALGLEAFHIFGNSWGGMLAQQYVLDVPSGAVSLTISNSTASIPRFADSVIRLKAELDPGTQATI DRHEAAGTTHSAEYQSAITTWNETYLCRTLPWPAYLTEAFQNLGPEIFETMFGPSDFRIVGTIRDWDVVD RLAEIALPTLLLAGKYDECSPEDMREMHQRIAGSRFEFFECSAHMPFIEEPDRFDRVMRDLLRSND
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_0358 | pip | - | 100% (276) | proline iminopeptidase PIP |
| M. ulcerans Agy99 | MUL_3195 | - | 9e-06 | 26.42% (265) | hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0863c | pip | 1e-107 | 73.05% (256) | proline iminopeptidase |
| M. gilvum PYR-GCK | Mflv_0527 | - | 9e-09 | 24.58% (240) | 4-carboxymuconolactone decarboxylase |
| M. tuberculosis H37Rv | Rv0840c | pip | 1e-107 | 73.05% (256) | proline iminopeptidase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0349c | - | 1e-07 | 23.35% (257) | putative hydrolase, alpha/beta fold |
| M. marinum M | MMAR_4789 | pip | 1e-143 | 98.39% (248) | proline iminopeptidase Pip |
| M. avium 104 | MAV_0868 | - | 1e-106 | 71.98% (257) | proline imino-peptidase |
| M. smegmatis MC2 155 | MSMEG_2681 | - | 7e-48 | 37.02% (262) | proline imino-peptidase |
| M. thermoresistible (build 8) | TH_4528 | - | 1e-06 | 24.05% (237) | PUTATIVE alpha/beta hydrolase fold |
| M. vanbaalenii PYR-1 | Mvan_2445 | - | 4e-08 | 25.27% (273) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_0358|M.ulcerans_Agy99 -------------MEQARRRRLRPSPARGAWRPGPA----ALLP------
MMAR_4789|M.marinum_M -------------MTKPEATIAVPGGKVWSKRVGGG----SGLPLLVVHG
Mb0863c|M.bovis_AF2122/97 ----------------MEGTIAVPGGRVWFQRIGGG----PGRPLLVVHG
Rv0840c|M.tuberculosis_H37Rv ----------------MEGTIAVPGGRVWFQRIGGG----PGRPLLVVHG
MAV_0868|M.avium_104 -------------------MVAVPGGQVWFQRTGGG----AGLPLLVIHG
MSMEG_2681|M.smegmatis_MC2_155 ---------MLSRMPVSSRTVPFGDHETWVQVTTPENAQPHALPLIVLHG
MAB_0349c|M.abscessus_ATCC_199 ----------MGSAALQDRYLQSCLGGLHVRIGGEG-------PVILFWP
Mflv_0527|M.gilvum_PYR-GCK -------------------MSNPPLTAIHLGGPDDG-------PLLLLGP
TH_4528|M.thermoresistible__bu ------VWSDLQGVAFTQGYLDAGGVRTRYLHAGEA----DKPVLIFLHG
Mvan_2445|M.vanbaalenii_PYR-1 MTERKPNLRPVRELTPTLKFCTIHGYRRAFRVAGSG-------PAILLIH
MUL_0358|M.ulcerans_Agy99 ------DYLSALQRLAGE--REVIFWDQLGCGNSERPSDV--DLWTMGRS
MMAR_4789|M.marinum_M GPGLPHYYLSALQRLAGE--REVIFWDQLGCGNSERPSDV--DLWTMGRS
Mb0863c|M.bovis_AF2122/97 GPGLPHNYLAPLRRLSDE--REVIFWDQLGCGNSACPSDV--DLWTMNRS
Rv0840c|M.tuberculosis_H37Rv GPGLPHNYLAPLRRLSDE--REVIFWDQLGCGNSACPSDV--DLWTMNRS
MAV_0868|M.avium_104 GPGLPHDYLRSLRRLATD--REVIFWDQLGCGNSKCPPNP--GLWTMERS
MSMEG_2681|M.smegmatis_MC2_155 GPGMAHNYVANIAALADETGRTVIHYDQVGCGNSTHLPDAPADFWTPQLF
MAB_0349c|M.abscessus_ATCC_199 SLLMTGSMWAAQAEYFADR-YTVILVDPPGHGDSQSLTRM----FRFEDC
Mflv_0527|M.gilvum_PYR-GCK SLGTTTATLWTGVAQRLVDHVRVVGWDLPGHGRGRR-AHP----FTIADL
TH_4528|M.thermoresistible__bu SGGHAEAYVRNLEAHAEH--FSTWSIDMLGHGYTDKPGHP----LEVRHY
Mvan_2445|M.vanbaalenii_PYR-1 GIGDNSTTWSTVQTQLAQR-FTVIAPDLLGHGRSDKPRAD----YSVAAY
. * * *
MUL_0358|M.ulcerans_Agy99 VAEIDAVVRALGLEAFHIFGNSWGGMLAQQYVLDVPSG-AVSLTISNSTA
MMAR_4789|M.marinum_M VAEMDAVVRALGLEAFHIFGNSWGGMLAQQYVLDVPSG-AVSLTISNSTA
Mb0863c|M.bovis_AF2122/97 VAEMATVAEALALTRFHIFSHSWGGMLAQQYVLDKAPD-AVSLTIANSTA
Rv0840c|M.tuberculosis_H37Rv VAEMATVAEALALTRFHIFSHSWGGMLAQQYVLDKAPD-AVSLTIANSTA
MAV_0868|M.avium_104 VAEVDAVVRALRLDRFHLFGNSWGGMLAQQYVLDAAPAGAASLTISNSIA
MSMEG_2681|M.smegmatis_MC2_155 VDEFHAVCTALGIERYHVLGQSWGGMLGAEIAVRQPSG-LVSLAICNSPA
MAB_0349c|M.abscessus_ATCC_199 AHAITQILDSLGIERAHVVGNSWGGMIGGTFTAMYPHR-AGASVLMNATA
Mflv_0527|M.gilvum_PYR-GCK AAAVLVIADDLNVETFHYAGDSVGGCVGLQLLLDAPQRVSSATLLCTG--
TH_4528|M.thermoresistible__bu VEHLAAVLDAIGADRAHISGESLGGWVASRFAIDRPDR-LDRLVLNTAGG
Mvan_2445|M.vanbaalenii_PYR-1 ANGMRDLLSVLDIDDVTVIGHSLGGGVAMQFAYQFPQL--VNRLILVGAG
. . : : ..* ** :. . : .
MUL_0358|M.ulcerans_Agy99 SIPRFADSVIRLKAELDPGTQATIDRHEAAGTTHSAEYQSAITTWNETYL
MMAR_4789|M.marinum_M SIPRFADNVIRLKAELDPGTQATIDRHEAAGTTHSAEYQSAITTWNETHL
Mb0863c|M.bovis_AF2122/97 SIPEFSASLVSLKSCLDVATRSAIDRHEAAGTTHSAEYQAAIRTWNETYL
Rv0840c|M.tuberculosis_H37Rv SIPEFSASLVSLKSCLDVATRSAIDRHEAAGTTHSAEYQAAIRTWNETYL
MAV_0868|M.avium_104 SIPQFGKMVARLKSELDPATQAAIDRHEAAGTTHDPEYQAAIRTWNETYL
MSMEG_2681|M.smegmatis_MC2_155 SMRLWSEAAGDLRAQLPAETRAALDRHEAAGTITHPDYLQAAAEFYRRHV
MAB_0349c|M.abscessus_ATCC_199 SR-------ASMRQRVEFRLLTEIVR--ILGRFREPLTTRAVKAFVGPTI
Mflv_0527|M.gilvum_PYR-GCK ---------AAIGTPDGWLARAATVR----AGGVDTMLTGAAERWFAPGF
TH_4528|M.thermoresistible__bu SQ---ADPEVMKRIITLSMAAAENPSWDTVQARITWLMADKSKGYDDIVA
Mvan_2445|M.vanbaalenii_PYR-1 GVTKDVNIALRLASLPMGSEALALLRLPLVLPALQVLGRVSGTVFGSTGV
:
MUL_0358|M.ulcerans_Agy99 CRTLP-WPAYLTEAFQNLGPE--IFETMFGPSDFRIVGTIRDWDVVDR-L
MMAR_4789|M.marinum_M CRTLP-WPAYLTEAFQNLGPE--IFETMFGPSDFRIVGTIRDWDVVDR-L
Mb0863c|M.bovis_AF2122/97 CRTRP-WPRELTEAFANMGTE--IFETMFGPSDFRIVGNVRDWDVVDR-L
Rv0840c|M.tuberculosis_H37Rv CRTRP-WPRELTEAFANMGTE--IFETMFGPSDFRIVGNVRDWDVVDR-L
MAV_0868|M.avium_104 CRVRP-WPRDLEDAFRKMSAE--VFETMFGASDFHIVGTVRDWDVFDR-L
MSMEG_2681|M.smegmatis_MC2_155 CRVVP-TPQDFADSVAQMEAEPTVYHTMNGPNEFHVVGTLGDWSVIDR-L
MAB_0349c|M.abscessus_ATCC_199 MRERPHVEQSIRAELRDLRVDS-VYWAVNSVVPARP-------DQREL-L
Mflv_0527|M.gilvum_PYR-GCK VDREPGTASALLDALSHTDAES----------YAQVCEALAVFDVTDR-L
TH_4528|M.thermoresistible__bu SRQKIYRQPGFVDAMRNIMALQ------------DPEIRARNLLGPEE-Y
Mvan_2445|M.vanbaalenii_PYR-1 GRDIPDMLRILADLPEPTASS-----AFARTLRAVVDWRGQVVTMLDRCY
: :
MUL_0358|M.ulcerans_Agy99 AEIALPTLLLAGKYDECSP-EDMREMHQRIAGSRFEFFECSAHMPFIEEP
MMAR_4789|M.marinum_M AEIALPTLLLAGKYDECSP-EDMREMHQRIAGSRFEFFECSAHMPFIEEP
Mb0863c|M.bovis_AF2122/97 ADIAVPTLLVVGRFDECSP-EHMREMQGRIAGSRLEFFESSSHMPFIEEP
Rv0840c|M.tuberculosis_H37Rv ADIAVPTLLVVGRFDECSP-EHMREMQGRIAGSRLEFFESSSHMPFIEEP
MAV_0868|M.avium_104 GEIAVPTLVLAGRYDECVP-EHMWEMHRRIPGSRFELFESSAHMPFIEEP
MSMEG_2681|M.smegmatis_MC2_155 PDVTAPVLVIAGEHDEATP-KTWQPFVDHIPDVRSHVFPGTSHCTHLEKP
MAB_0349c|M.abscessus_ATCC_199 GRITTPILVIAGREDPTFPVAETELMAEAIPGAELVIMENTGHLAALERP
Mflv_0527|M.gilvum_PYR-GCK SEIVTPVLAVAGSADSPTPPESLRRIASDVKDGDVVVLEGVGHLAPAEAP
TH_4528|M.thermoresistible__bu GAITAPTLVVWTSDDPTADVDEGKRIASMIPGARFEVMPGCGHWPQYEDP
Mvan_2445|M.vanbaalenii_PYR-1 LTQSVPVQLIWGDCDAVIPVSHGEMAHAAMPGSRLEVFEGSGHFPFHDDP
* : * : . .: .* . : *
MUL_0358|M.ulcerans_Agy99 DRFDRVMRDLLRSND-----------------------------------
MMAR_4789|M.marinum_M DRFDRVMRDFLRSND-----------------------------------
Mb0863c|M.bovis_AF2122/97 ARFDRVMREFLRLHDI----------------------------------
Rv0840c|M.tuberculosis_H37Rv ARFDRVMREFLRLHDI----------------------------------
MAV_0868|M.avium_104 EKFDAVMRDFLRLHD-----------------------------------
MSMEG_2681|M.smegmatis_MC2_155 EEFRAVVAQFLHQHDLAADARV----------------------------
MAB_0349c|M.abscessus_ATCC_199 EEVNALIDDFLKRHPIED--------------------------------
Mflv_0527|M.gilvum_PYR-GCK ERVAGLIAEIVGVPQPPSKTLEDVHRAGMAVRREVLGHAHVDRAVAGTTD
TH_4528|M.thermoresistible__bu ATFNRLHIDFLLGRS-----------------------------------
Mvan_2445|M.vanbaalenii_PYR-1 DRFVEVVEKFIDTSEPAVYDHEYLRGLLRAGISEGTISGPADTRVAVLDA
. : .::
MUL_0358|M.ulcerans_Agy99 --------------------------------------------------
MMAR_4789|M.marinum_M --------------------------------------------------
Mb0863c|M.bovis_AF2122/97 --------------------------------------------------
Rv0840c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_0868|M.avium_104 --------------------------------------------------
MSMEG_2681|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0349c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_0527|M.gilvum_PYR-GCK LTADFQHMITQYAWGSIWTRPGLDFRSRSMITLTALVARGHHEELAMHLR
TH_4528|M.thermoresistible__bu --------------------------------------------------
Mvan_2445|M.vanbaalenii_PYR-1 MGADERSAT-----------------------------------------
MUL_0358|M.ulcerans_Agy99 --------------------------------------------------
MMAR_4789|M.marinum_M --------------------------------------------------
Mb0863c|M.bovis_AF2122/97 --------------------------------------------------
Rv0840c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_0868|M.avium_104 --------------------------------------------------
MSMEG_2681|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0349c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_0527|M.gilvum_PYR-GCK AARRNGLSNDEIKELLLQTAIYCGVPDANSAFRIAAEVLPEFDEHPGAPS
TH_4528|M.thermoresistible__bu --------------------------------------------------
Mvan_2445|M.vanbaalenii_PYR-1 --------------------------------------------------