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TERKPNLRPVRELTPTLKFCTIHGYRRAFRVAGSGPAILLIHGIGDNSTTWSTVQTQLAQRFTVIAPDLL GHGRSDKPRADYSVAAYANGMRDLLSVLDIDDVTVIGHSLGGGVAMQFAYQFPQLVNRLILVGAGGVTKD VNIALRLASLPMGSEALALLRLPLVLPALQVLGRVSGTVFGSTGVGRDIPDMLRILADLPEPTASSAFAR TLRAVVDWRGQVVTMLDRCYLTQSVPVQLIWGDCDAVIPVSHGEMAHAAMPGSRLEVFEGSGHFPFHDDP DRFVEVVEKFIDTSEPAVYDHEYLRGLLRAGISEGTISGPADTRVAVLDAMGADERSAT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2445 | - | - | 100% (340) | alpha/beta hydrolase fold |
| M. vanbaalenii PYR-1 | Mvan_2912 | - | 1e-66 | 45.91% (281) | alpha/beta hydrolase fold |
| M. vanbaalenii PYR-1 | Mvan_4279 | - | 2e-63 | 46.26% (281) | alpha/beta hydrolase fold |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2734 | - | 1e-155 | 76.83% (341) | hydrolase |
| M. gilvum PYR-GCK | Mflv_3952 | - | 1e-170 | 85.29% (340) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv2715 | - | 1e-155 | 76.83% (341) | hydrolase |
| M. leprae Br4923 | MLBr_02297 | - | 2e-09 | 22.46% (276) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_3034 | - | 1e-138 | 72.92% (325) | hydrolase |
| M. marinum M | MMAR_1997 | - | 1e-157 | 78.59% (341) | hydrolase |
| M. avium 104 | MAV_3609 | - | 1e-155 | 77.84% (343) | hydrolase |
| M. smegmatis MC2 155 | MSMEG_4867 | - | 4e-19 | 26.10% (249) | 2-hydroxy-6-ketonona-2,4-dienedoic acid hydrolase |
| M. thermoresistible (build 8) | TH_4528 | - | 2e-19 | 25.86% (263) | PUTATIVE alpha/beta hydrolase fold |
| M. ulcerans Agy99 | MUL_3358 | - | 1e-156 | 78.30% (341) | hydrolase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_2445|M.vanbaalenii_PYR-1 --MTERKPN--LRPVR------------------ELT-PTLKFCTIHG--
Mflv_3952|M.gilvum_PYR-GCK --MTARTPN--LRPVR------------------ELT-PTLRYCTIHG--
Mb2734|M.bovis_AF2122/97 --MTERKRN--LRPVR------------------DVAPPTLQFRTVHG--
Rv2715|M.tuberculosis_H37Rv --MTERKRN--LRPVR------------------DVAPPTLQFRTVHG--
MMAR_1997|M.marinum_M --MTERKRN--LRPVR------------------EVTAPSLQFRTIHG--
MUL_3358|M.ulcerans_Agy99 --MTERKRN--LRPVR------------------EVTAPSLQFRTIHG--
MAV_3609|M.avium_104 --MTERKRKNTLRPVR------------------EVSAPRLEFRTIHG--
MAB_3034|M.abscessus_ATCC_1997 --MNPPPRL--LRPVPDTEHIDGVDGGGDTPSAATSTRPRLAFRTIHG--
MSMEG_4867|M.smegmatis_MC2_155 --MTSTAAAGTASAVEFES----------IWSDLQGVAFSQGYLDVPVGD
TH_4528|M.thermoresistible__bu -----------------------------VWSDLQGVAFTQGYLDAGG--
MLBr_02297|M.leprae_Br4923 MAMSNPSVTRIAGPWH----------------HLDVHANGIRFHVVEAVP
:
Mvan_2445|M.vanbaalenii_PYR-1 --YRRAFRVAGS--GPAILLIHGIGDNSTTWSTVQTQLAQRFTVIAPDLL
Mflv_3952|M.gilvum_PYR-GCK --YRRAYRIAGS--GPAILLIHGIGDNSTTWAGVQTQLAQRFTVIAPDLL
Mb2734|M.bovis_AF2122/97 --YRRAFRIAGS--GPAILLIHGIGDNSTTWNGVHAKLAQRFTVIAPDLL
Rv2715|M.tuberculosis_H37Rv --YRRAFRIAGS--GPAILLIHGIGDNSTTWNGVHAKLAQRFTVIAPDLL
MMAR_1997|M.marinum_M --YKRAFRIAGS--GPAILLIHGIGDNSTTWTGIHAKLAQRFTVIAPDLL
MUL_3358|M.ulcerans_Agy99 --YKRAFRIAGS--GPAILLIHGIGDNSTTWTGIHAKLAQRFTVIAPDLL
MAV_3609|M.avium_104 --YRRAYRIAGS--GPAILLIHGIGDNSTTWNTVQAKLAQRFTVIAPDLL
MAB_3034|M.abscessus_ATCC_1997 --YRRAYRIAGS--GPVLLLIHGIGDNSATWDSVHAQLAEHFTVIAPDLL
MSMEG_4867|M.smegmatis_MC2_155 RKIRTRYLHAGNPQAPALLFLHGSGGHAEAYVRNLAAHAEHFSTWSIDML
TH_4528|M.thermoresistible__bu --VRTRYLHAGEADKPVLIFLHGSGGHAEAYVRNLEAHAEHFSTWSIDML
MLBr_02297|M.leprae_Br4923 TQPAGQDCAPSATARPLVMLLHGFGSFWWSWRHQLRGLTEAR-LVAVDLR
.. * ::::** *. :: :: : *:
Mvan_2445|M.vanbaalenii_PYR-1 GHGRSDKPRADYSVAAYANGMRDLLSVLDIDDVTVIGHSLGGGVAMQFAY
Mflv_3952|M.gilvum_PYR-GCK GHGKSDKPRADYSVAAYANGMRDLLSVLNIDSATVVGHSLGGGVAMQFAY
Mb2734|M.bovis_AF2122/97 GHGQSDKPRADYSVAAYANGMRDLLSVLDIERVTIVGHSLGGGVAMQFAY
Rv2715|M.tuberculosis_H37Rv GHGQSDKPRADYSVAAYANGMRDLLSVLDIERVTIVGHSLGGGVAMQFAY
MMAR_1997|M.marinum_M GHGRSDKPRADYSIAAYANGMRDLLSVLDIERVTIIGHSLGGGVAMQFAY
MUL_3358|M.ulcerans_Agy99 GHGRSDKPRADYSIAAYANGMRDLLSVLDIERVTIIGHSLGGGVAMQFAY
MAV_3609|M.avium_104 GHGQSDKPRADYSVAAYANGMRDLLAVLDIERVTIVGHSLGGGVAMQFAY
MAB_3034|M.abscessus_ATCC_1997 GHGQSDKPRADYSVAAYANGMRDLLAVLDIERVTVVGHSLGGGVAMQFTY
MSMEG_4867|M.smegmatis_MC2_155 GHGYTDKPGHPLEVAHYVDHVIAFLDTIGAQRAHISGESLGGWVAARVAV
TH_4528|M.thermoresistible__bu GHGYTDKPGHPLEVRHYVEHLAAVLDAIGADRAHISGESLGGWVASRFAI
MLBr_02297|M.leprae_Br4923 GYGGSDKPPRGYDGWTLAGDTAGLIRALGHSSATLVGHAEGGLACWATAL
*:* :*** . . .: .:. . . : *.: ** .. :
Mvan_2445|M.vanbaalenii_PYR-1 QFPQLVNRLILVGAGGVTKDVNIALRLASLPMGSEALAL-LRLPLVLPAL
Mflv_3952|M.gilvum_PYR-GCK QFPQLVDRLILVGAGGVTKDVNIALRAASLPMGTEALAL-LRLPLLLPTL
Mb2734|M.bovis_AF2122/97 QFPQLVDRLILVSAGGVTKDVNIVFRLASLPMGSEAMAL-LRLPLVLPAV
Rv2715|M.tuberculosis_H37Rv QFPQLVDRLILVSAGGVTKDVNIVFRLASLPMGSEAMAL-LRLPLVLPAV
MMAR_1997|M.marinum_M QFPQLVDRLILVGAGGVTKDVNVVFRLASLPMGAEALAL-LRLPMVLPTV
MUL_3358|M.ulcerans_Agy99 QFPQLVDRLILVGAGGVTKDVNVVFRLASLPMGAEALAL-LRLPMVLPTV
MAV_3609|M.avium_104 QFPHLVERLILVGAGGVTKDVNFVLRWASLPLGSEAIAL-LRLPLVLPAV
MAB_3034|M.abscessus_ATCC_1997 QFPHLVERLILVAPGGVTKDVNIVLRCASLPFIGDALGL-LRLPMAMPML
MSMEG_4867|M.smegmatis_MC2_155 DHPDRVEKLVLNTAGGSQADPEVMKRIITLSMAAAENPT-WDTVQARIKW
TH_4528|M.thermoresistible__bu DRPDRLDRLVLNTAGGSQADPEVMKRIITLSMAAAENPS-WDTVQARITW
MLBr_02297|M.leprae_Br4923 LHPRLVRAIALINSPHPAALRRSMLTHRNQGYALLPTLLRYQLPIWPERL
* : : * . . .
Mvan_2445|M.vanbaalenii_PYR-1 QVLGRVSG--TVFGSTGVGRDIP--------DMLRILADLPEPTASSAFA
Mflv_3952|M.gilvum_PYR-GCK RLLGRVGG--PLLGNTRIGRDIP--------NMLRILADLPEPTASSAFA
Mb2734|M.bovis_AF2122/97 QIAGRIVG--KAIGTTSLGHDLP--------NVLRILDDLPEPTASAAFG
Rv2715|M.tuberculosis_H37Rv QIAGRIVG--KAIGTTSLGHDLP--------NVLRILDDLPEPTASAAFG
MMAR_1997|M.marinum_M QLAGKVLG--MALGSTALGQDLP--------NVLRILDDLPEPTASSAFT
MUL_3358|M.ulcerans_Agy99 QLAGKVLG--MALGSTALGQDLP--------NVLRILDDLPEPTASSAFT
MAV_3609|M.avium_104 QLMGRVLG--TALGSTGLGRDLP--------NVLRILDDLPEPTASAAFS
MAB_3034|M.abscessus_ATCC_1997 RLGGAVAR--ATFGRASMARDIP--------DVLRVLADLPEPRASAAFT
MSMEG_4867|M.smegmatis_MC2_155 LMADKSKDYDDIVASRQRVYRQP--------GFVAAMSDIMALQDPQIRA
TH_4528|M.thermoresistible__bu LMADKSKGYDDIVASRQKIYRQP--------GFVDAMRNIMALQDPEIRA
MLBr_02297|M.leprae_Br4923 LTRNNAAEIERLVRSRSSAKWQACEDFAVTIDHLRIAIQIPAAAHCALEY
. . . . : ::
Mvan_2445|M.vanbaalenii_PYR-1 RTLRAVVDWRGQVVTMLDRCYLTQSVPVQLIWGDCDAVIPVSHGEMAHAA
Mflv_3952|M.gilvum_PYR-GCK RTLRSVVDWRGQVVTMLDRCYLTQSVPVQLIWGSQDSVIPVSHAEMAHTA
Mb2734|M.bovis_AF2122/97 RTLRAVVDWRGQMVTMLDRCYLTEAIPVQIIWGTKDVVLPVRHAHMAHAA
Rv2715|M.tuberculosis_H37Rv RTLRAVVDWRGQMVTMLDRCYLTEAIPVQIIWGTKDVVLPVRHAHMAHAA
MMAR_1997|M.marinum_M RTLRAVVDWRGQIVTMLDRCYLTQAIPVQIIWGSRDAVVPVRHAEMAHAA
MUL_3358|M.ulcerans_Agy99 RTLRAVVDWRGQIVTMLDRCYLTQAIPVQIIWGSRDAVVPVRHAEMAHAA
MAV_3609|M.avium_104 RTLRAVVDWRGQIVTMLDRCYLTEAIPVQIVWGTKDVVVPVRHAWMAHAA
MAB_3034|M.abscessus_ATCC_1997 RTLRAVVDWRGQVVTMLDRCYLTESVPVQLIWGSDDLVIPVSHGHLAHAA
MSMEG_4867|M.smegmatis_MC2_155 RNLLGQAEYG------------SITAPTLVVWTSDDPTADVAEGRRIASM
TH_4528|M.thermoresistible__bu RNLLGPEEYG------------AITAPTLVVWTSDDPTADVDEGKRIASM
MLBr_02297|M.leprae_Br4923 QRWAVRSQLRNEGRKFMKSMSRPFSVPLLHVRGDADPYLLADSVDRTRRY
: : . : * : * .
Mvan_2445|M.vanbaalenii_PYR-1 MPGSRLEVFEGSGHFPFHDDPDRFVEVVEKFIDTSEPAVYDHEYLRGLLR
Mflv_3952|M.gilvum_PYR-GCK MPGSRLEIFEGAGHFPFHDEPDRFVELVEKFIDSTEPAVYDQEYLRTLLR
Mb2734|M.bovis_AF2122/97 MPGSQLEIFEGSGHFPFHDDPARFIDIVERFMDTTEPAEYDQAALRALLR
Rv2715|M.tuberculosis_H37Rv MPGSQLEIFEGSGHFPFHDDPARFIDIVERFMDTTEPAEYDQAALRALLR
MMAR_1997|M.marinum_M MPGSKLEVFEGSGHFPFHDDPARFIDIVLRFIDSTQPPEYDQAALRELLR
MUL_3358|M.ulcerans_Agy99 MPGSKLEVFEGSGHFPFHDDPARFIDIVLRFIDSTQPPEYDQAALRELLR
MAV_3609|M.avium_104 MPGSRLEIFEGSGHFPFHDDPARFIDVVERFIDSTEPAAYDQEALRRLLR
MAB_3034|M.abscessus_ATCC_1997 MPGSALEIFDKSGHFPFHDDPERFIGIVRQFIASTEPGEYNEDELRRLLR
MSMEG_4867|M.smegmatis_MC2_155 IPGARFEVMPGCGHWPQYEDPATFNALHLDFLLGR---------------
TH_4528|M.thermoresistible__bu IPGARFEVMPGCGHWPQYEDPATFNRLHIDFLLGRS--------------
MLBr_02297|M.leprae_Br4923 APHGRYVSVSDAGHFSHEEAPEEINRYLTRFLKQVHGPRLS---------
* . . .**:. : * : *:
Mvan_2445|M.vanbaalenii_PYR-1 AGISEGTISGPADTRVAVLDAMGADERSAT
Mflv_3952|M.gilvum_PYR-GCK TGTSENTLSGDVDTQVAVLDAIGADERSAT
Mb2734|M.bovis_AF2122/97 RGGGEATVTGSADTRVAVLNAIGSNERSAT
Rv2715|M.tuberculosis_H37Rv RGGGEATVTGSADTRVAVLNAIGSNERSAT
MMAR_1997|M.marinum_M TGGGERTVSGPADTRVAVLSAMGSDERSAT
MUL_3358|M.ulcerans_Agy99 TGGGERTVSDPADTRVAVLSAMGSDERSAT
MAV_3609|M.avium_104 SGGGAQAVTGPAPTRVAVLSAMGSDERSAT
MAB_3034|M.abscessus_ATCC_1997 TGVTEHAISGAARTRMAVLDAMGTDERSAT
MSMEG_4867|M.smegmatis_MC2_155 ------------------------------
TH_4528|M.thermoresistible__bu ------------------------------
MLBr_02297|M.leprae_Br4923 ------------------------------