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LKYPRRRPHKRRRDVHTAHRYPSRPALARMCGERRSQEIHPVERISALGSKPMESAAQPHRIEVGETVCN DGTVIGHTAAGEGPALALLPGWSLTAQIFRHQLAGLSHTWRVLAIDHRGHGRSSTPQLGYHIHRLAADLR TVLQTHQLDQVHLLGHSMGCAVIWSYLELFGTDRLASLLLVDQMPCALRNPAWTGAQALEAGATMDPTGL FAFTDRLRADGDDPRPDFVTEVVSEGIGADELAWPVEQGQTLDRRCAADLIFDVATHDWRGLMAHIGLPT LVLAGDSVNVPIASQRWMWQQIPGAQFARVPGRRGGTHFPFLENPQTFNDVVSQHLCAHRPG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_3195 | - | - | 100% (342) | hydrolase |
| M. ulcerans Agy99 | MUL_2888 | ephB | 4e-12 | 36.75% (117) | epoxide hydrolase EphB |
| M. ulcerans Agy99 | MUL_2488 | hpx | 3e-10 | 35.24% (105) | non-heme haloperoxidase Hpx |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2734 | - | 2e-10 | 24.91% (277) | hydrolase |
| M. gilvum PYR-GCK | Mflv_2561 | - | 4e-14 | 28.41% (271) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv2715 | - | 2e-10 | 24.91% (277) | hydrolase |
| M. leprae Br4923 | MLBr_00862 | ephD | 4e-09 | 32.52% (123) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3034 | - | 3e-09 | 24.73% (275) | hydrolase |
| M. marinum M | MMAR_2566 | - | 1e-169 | 97.59% (290) | hydrolase |
| M. avium 104 | MAV_5175 | - | 5e-14 | 26.81% (276) | non-haem bromoperoxidase BPO-A2 |
| M. smegmatis MC2 155 | MSMEG_3297 | - | 7e-13 | 26.67% (270) | transcriptional regulator, CadC |
| M. thermoresistible (build 8) | TH_0684 | hpx | 1e-12 | 28.67% (279) | POSSIBLE NON-HEME HALOPEROXIDASE HPX |
| M. vanbaalenii PYR-1 | Mvan_1865 | - | 1e-11 | 27.60% (279) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2734|M.bovis_AF2122/97 --------------------------------------------------
Rv2715|M.tuberculosis_H37Rv --------------------------------------------------
MAB_3034|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_3195|M.ulcerans_Agy99 --------------------------------MKYPRRRPHKRRRDVHTA
MMAR_2566|M.marinum_M --------------------------------------------------
Mflv_2561|M.gilvum_PYR-GCK --------------------------------------------------
MAV_5175|M.avium_104 --------------------------------------------------
TH_0684|M.thermoresistible__bu --------------------------------------------------
Mvan_1865|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3297|M.smegmatis_MC2_155 MSLTESRSGRVWAFDEFTLDTEGYELRQGDVAIRVEPQVFDVLVKLVDNH
MLBr_00862|M.leprae_Br4923 --------------------------------------------------
Mb2734|M.bovis_AF2122/97 ----------------------------------MTERKRNLRPVRD---
Rv2715|M.tuberculosis_H37Rv ----------------------------------MTERKRNLRPVRD---
MAB_3034|M.abscessus_ATCC_1997 ----------------------------------MNPPPRLLRPVPDTEH
MUL_3195|M.ulcerans_Agy99 HRYPSRPALARMCGERRSQEIHPVERISALGSKPMESAAQPHRIEVG---
MMAR_2566|M.marinum_M ----------------------------------MESAAQPHRIEVG---
Mflv_2561|M.gilvum_PYR-GCK ----------------------------------MTMITAYRGPLRS---
MAV_5175|M.avium_104 ----------------------------------MPDVIAHHGLLKD---
TH_0684|M.thermoresistible__bu ------------------------------------VEQMPPGRVVS---
Mvan_1865|M.vanbaalenii_PYR-1 --------------------MAPGTSTRSRSRGFAPAQALPPGRIVD---
MSMEG_3297|M.smegmatis_MC2_155 HRCVTKEELFDSVWGGRFVGEAALSSRIMAARKALGDDGESQRYIRTVRG
MLBr_00862|M.leprae_Br4923 ----------------------------------MPATQSIHKVPHQ---
Mb2734|M.bovis_AF2122/97 --------------------------VAPPTLQFRTVHGYRRAFRIAGS-
Rv2715|M.tuberculosis_H37Rv --------------------------VAPPTLQFRTVHGYRRAFRIAGS-
MAB_3034|M.abscessus_ATCC_1997 IDGVDG-----------GGDTPSAATSTRPRLAFRTIHGYRRAYRIAGS-
MUL_3195|M.ulcerans_Agy99 --------------------------------ETVCNDGTVIGHTAAGE-
MMAR_2566|M.marinum_M --------------------------------ETVCNDGTVIGHTAAGE-
Mflv_2561|M.gilvum_PYR-GCK --------------------------------TDLHVD------DSGGD-
MAV_5175|M.avium_104 --------------------------------TRLHVD------DTGGP-
TH_0684|M.thermoresistible__bu ---------------------------------VTAPDGVRLHAEVFGPA
Mvan_1865|M.vanbaalenii_PYR-1 ---------------------------------VRSKDGVRLHAEVFGPE
MSMEG_3297|M.smegmatis_MC2_155 RGYQFVGTLSDTAPRDEEPLEIEVPPLRQHIRFCYAADGVRLAYAATGD-
MLBr_00862|M.leprae_Br4923 --------------------------------FVESPDGVRLAIYQSGQP
. *
Mb2734|M.bovis_AF2122/97 -GPAILLIH------GIGDNSTTWNGVHAKLAQR-FTVIAPDLLGHGQSD
Rv2715|M.tuberculosis_H37Rv -GPAILLIH------GIGDNSTTWNGVHAKLAQR-FTVIAPDLLGHGQSD
MAB_3034|M.abscessus_ATCC_1997 -GPVLLLIH------GIGDNSATWDSVHAQLAEH-FTVIAPDLLGHGQSD
MUL_3195|M.ulcerans_Agy99 -GPALALLP------GWSLTAQIFRHQLAGLSHT-WRVLAIDHRGHGRSS
MMAR_2566|M.marinum_M -GPALVLLP------GWSLTAQIFRHQLAGLSRT-WRVLAIDHRGHGRSS
Mflv_2561|M.gilvum_PYR-GCK -GRPVVLIH------GWPLHSDSWAHQVDALRDAGYRVITYDRRGFGRSD
MAV_5175|M.avium_104 -GRPVLLMH------PWPLSGQSWSAQVPVLHAAGYRVVTYDRRGFGRSD
TH_0684|M.thermoresistible__bu DAPPIVLAH------GITCAIRVWAHQIAELADD-YRVIAFDHRGHGRSS
Mvan_1865|M.vanbaalenii_PYR-1 DGYPIVLAH------GITCSLRVWAYQIAELARD-HRVIAFDHRGHGRSA
MSMEG_3297|M.smegmatis_MC2_155 -GPPLVRAANWMTHLGYDIESPVWQHWVRDLSAH-HRLIRYDERGCGLSD
MLBr_00862|M.leprae_Br4923 EGPAIVLVH------GFPDSHVLWDGVVPLLAKR-FRIVRYDNRGVGQSS
. : : * :: * * * *
Mb2734|M.bovis_AF2122/97 KP--RADYSVAAYANGMRDLLSVLD--IERVTIVGHSLGGGVAMQFAYQF
Rv2715|M.tuberculosis_H37Rv KP--RADYSVAAYANGMRDLLSVLD--IERVTIVGHSLGGGVAMQFAYQF
MAB_3034|M.abscessus_ATCC_1997 KP--RADYSVAAYANGMRDLLAVLD--IERVTVVGHSLGGGVAMQFTYQF
MUL_3195|M.ulcerans_Agy99 TP--QLGYHIHRLAADLRTVLQTHQ--LDQVHLLGHSMGCAVIWSYLELF
MMAR_2566|M.marinum_M TP--QLGYHIHRLAADLRTVLQTHQ--LDQVHLLGHSMGCAVIWSYLELF
Mflv_2561|M.gilvum_PYR-GCK KP--LIGYTYESLSDDLSAVLEELD--LTDVTLVGFSMGGGEVAAYCARK
MAV_5175|M.avium_104 KP--LTGYSYSQLTQDLHTLVESLD--LRDLTLVGSSMGGGEVARYLSTY
TH_0684|M.thermoresistible__bu VPRRRWQYSLDHLASDLDAVLDATLDPGERAVIAGHSMGGIAISSWAERY
Mvan_1865|M.vanbaalenii_PYR-1 IPPRRGGYSLDYLAGDLDAVLEATLAPGERAVIAGHSMGGIAISSWSERL
MSMEG_3297|M.smegmatis_MC2_155 WS--ARDFTFEDWVEDLASVVDALE--LEHFPLLGVSQGGAVAVAYAAKH
MLBr_00862|M.leprae_Br4923 VPKPVSAYTMTRFADDFAAVIDELS-PDRPVHVLAHDWGSVGVWEYLSRS
. : .: :: : . . * :
Mb2734|M.bovis_AF2122/97 PQ---LVDRLILVSAGGVTKDVN-----IVFRLASLPMGSEAMALLRLPL
Rv2715|M.tuberculosis_H37Rv PQ---LVDRLILVSAGGVTKDVN-----IVFRLASLPMGSEAMALLRLPL
MAB_3034|M.abscessus_ATCC_1997 PH---LVERLILVAPGGVTKDVN-----IVLRCASLPFIGDALGLLRLPM
MUL_3195|M.ulcerans_Agy99 GT---DRLASLLLVDQMPCALRN-----PAWTGAQALEAGATMDPTGLFA
MMAR_2566|M.marinum_M GT---DRLASLLLVDQMPCALRN-----PAWTDAQALEAGATMDPAGLFA
Mflv_2561|M.gilvum_PYR-GCK GV---ERIRSVVFASSVTPFMSA-----RKDNPEGPLGKLEAARMAASLT
MAV_5175|M.avium_104 GP---ERVRSVVFASSVTPYLLQ-----TTDNPDGPLTMKDAARATASFV
TH_0684|M.thermoresistible__bu PERVSERAAAVALINTTTGDLLHNVQLLPVPDRFAAVRVRTASAVIKTVA
Mvan_1865|M.vanbaalenii_PYR-1 PHRVEQRADAVALINTTTGDLLRNVNLLPVPPALADVRVRAAGEVLRRFG
MSMEG_3297|M.smegmatis_MC2_155 PD---RVSKLVLCGAYARGRAVR-------AVGEEELRAADLDRELARVG
MLBr_00862|M.leprae_Br4923 GAS--DRVASFTSVSGPSQDQLVDYILSGLRRPWRPRTFARAVSQLFRLT
.
Mb2734|M.bovis_AF2122/97 VLPAVQIAGRIVGKAIGTTSLGHDLPNVLRILD-DLPEPTASAAFGRTLR
Rv2715|M.tuberculosis_H37Rv VLPAVQIAGRIVGKAIGTTSLGHDLPNVLRILD-DLPEPTASAAFGRTLR
MAB_3034|M.abscessus_ATCC_1997 AMPMLRLGGAVARATFGRASMARDIPDVLRVLA-DLPEPRASAAFTRTLR
MUL_3195|M.ulcerans_Agy99 FTDRLRADGDDPRPDFVTEVVSEGIG--ADELA-WPVEQGQTLDRRCAAD
MMAR_2566|M.marinum_M FTDRLRADGDDPRPDFVTEVVSEGIG--AHELA-WLVEQGQTLDRRCAAD
Mflv_2561|M.gilvum_PYR-GCK TDQ--DAFFEQFMTDVFSADGELQVT--EQERQ-EALSMCGDADKPATLA
MAV_5175|M.avium_104 KDQ--DAFYDHQMTEFFSANGQLRVS--PATRA-EALRLCKQAGKEASLA
TH_0684|M.thermoresistible__bu GMP-ARLAAVPSRYVVSMMAVGRDADPAITNFVHELFTETPPAARDGWAR
Mvan_1865|M.vanbaalenii_PYR-1 GVPLVRAVDRPNRRFVSSIAVGRDADPAIADFVFELFNSTSPAGRGGWAR
MSMEG_3297|M.smegmatis_MC2_155 WGRDDPAFRQVFAAQFLPEGSRADWDAFDQLQR-------RTTDAQNAVR
MLBr_00862|M.leprae_Br4923 YMVLFSIPVLVPMVLWIALSSATIRRTMVDNISTDQIHHSATLARDAAHS
Mb2734|M.bovis_AF2122/97 AVVDWRGQM----VTMLDRCYLTEAIPVQIIWGTKDVVLPVRH-AHMAHA
Rv2715|M.tuberculosis_H37Rv AVVDWRGQM----VTMLDRCYLTEAIPVQIIWGTKDVVLPVRH-AHMAHA
MAB_3034|M.abscessus_ATCC_1997 AVVDWRGQV----VTMLDRCYLTESVPVQLIWGSDDLVIPVSH-GHLAHA
MUL_3195|M.ulcerans_Agy99 LIFDVAT-------HDWRGLMAHIGLPTLVLAGDS-VNVPIAS-QRWMWQ
MMAR_2566|M.marinum_M LIFDVAT-------HDWRGLMAHIGLPTLVLAGDS-VNVPIAS-QRWMWR
Mflv_2561|M.gilvum_PYR-GCK CMAAFGG-------TDFREDLPKVTVPSLVIHGDSDATVPFEGSGKRTYE
MAV_5175|M.avium_104 CMAAWAN-------TDFRPDLTRVSVPALIIHGEGDESVPLAGSARRTHR
TH_0684|M.thermoresistible__bu TLVDAMG--------PRHIGLHNLTVPTLVIGSDRDRLLPLVSSRRIAEA
Mvan_1865|M.vanbaalenii_PYR-1 VLVDHLG--------PRHIALKNLTVPTLVIGSTKDRLLPMASARRIAAT
MSMEG_3297|M.smegmatis_MC2_155 FLDQFAQ-------IDVLDVAGQVECPTLVMHAQDDLRVPMRF-GEELAM
MLBr_00862|M.leprae_Br4923 VKTYPANYFRAFSGRRRGKGVPVVNVPVQLIVNTMDRYVRPYGYDATARW
* :: :
Mb2734|M.bovis_AF2122/97 AMPGSQLEIFEG---SGHFPFHDDPARFIDIVERFMDTTEPAEYDQAALR
Rv2715|M.tuberculosis_H37Rv AMPGSQLEIFEG---SGHFPFHDDPARFIDIVERFMDTTEPAEYDQAALR
MAB_3034|M.abscessus_ATCC_1997 AMPGSALEIFDK---SGHFPFHDDPERFIGIVRQFIASTEPGEYNEDELR
MUL_3195|M.ulcerans_Agy99 QIPGAQFARVPGRRGGTHFPFLENPQTFNDVVSQHLCAHRPG--------
MMAR_2566|M.marinum_M QIPGAQFARVPGRRGGTHFPFLENPQTFNDVVSQHLCAHRPG--------
Mflv_2561|M.gilvum_PYR-GCK LLPDGRLHVIAG---GPHGIPVSHADEFNAVLLEFLEQDFADGRGR----
MAV_5175|M.avium_104 AIPGSRLCVIAD---GPHGCHISHAQEFNAALLDFLAA------------
TH_0684|M.thermoresistible__bu APNLFDFVELPG----GHCAILECPDRVNDHLRALAAAAADARRATS---
Mvan_1865|M.vanbaalenii_PYR-1 APNLARFVEVPG----GHCAILERPDDVNDHLRWLVRSVTGQGDATGATG
MSMEG_3297|M.smegmatis_MC2_155 LIPQSRFVALPS-----NNHLLTGTEPAWAIFCHELEAFLAEP-------
MLBr_00862|M.leprae_Br4923 VPRLWRRDIKAG-----HFSPMSHPQVMAAAVHDLADLVDGKQPSRALLR
: . .
Mb2734|M.bovis_AF2122/97 ALLRRGGGEATVTGSADTRVAVLNAIGSNERSAT----------------
Rv2715|M.tuberculosis_H37Rv ALLRRGGGEATVTGSADTRVAVLNAIGSNERSAT----------------
MAB_3034|M.abscessus_ATCC_1997 RLLRTGVTEHAISGAARTRMAVLDAMGTDERSAT----------------
MUL_3195|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2566|M.marinum_M --------------------------------------------------
Mflv_2561|M.gilvum_PYR-GCK --------------------------------------------------
MAV_5175|M.avium_104 --------------------------------------------------
TH_0684|M.thermoresistible__bu --------------------------------------------------
Mvan_1865|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3297|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 AQVGRSRDTFGDTLVSVTGAGSGIGRETALALARRGAEVVVSDIDEAAAK
Mb2734|M.bovis_AF2122/97 --------------------------------------------------
Rv2715|M.tuberculosis_H37Rv --------------------------------------------------
MAB_3034|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_3195|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2566|M.marinum_M --------------------------------------------------
Mflv_2561|M.gilvum_PYR-GCK --------------------------------------------------
MAV_5175|M.avium_104 --------------------------------------------------
TH_0684|M.thermoresistible__bu --------------------------------------------------
Mvan_1865|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3297|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 NTAAQIVASGGVAYAYALDVSDAAAVEAFAEQVSAKHGVPDIVVNNAGIG
Mb2734|M.bovis_AF2122/97 --------------------------------------------------
Rv2715|M.tuberculosis_H37Rv --------------------------------------------------
MAB_3034|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_3195|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2566|M.marinum_M --------------------------------------------------
Mflv_2561|M.gilvum_PYR-GCK --------------------------------------------------
MAV_5175|M.avium_104 --------------------------------------------------
TH_0684|M.thermoresistible__bu --------------------------------------------------
Mvan_1865|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3297|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 QAGRFLDTPPEEFDRVLAVNLGGVVNCCRAFGQRLVERGTGGHIVNVSSM
Mb2734|M.bovis_AF2122/97 --------------------------------------------------
Rv2715|M.tuberculosis_H37Rv --------------------------------------------------
MAB_3034|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_3195|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2566|M.marinum_M --------------------------------------------------
Mflv_2561|M.gilvum_PYR-GCK --------------------------------------------------
MAV_5175|M.avium_104 --------------------------------------------------
TH_0684|M.thermoresistible__bu --------------------------------------------------
Mvan_1865|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3297|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 AAYAPLQSLSAYCTSKAATYMFSDCLRAELDAVGVGLTTICPGVIDTNII
Mb2734|M.bovis_AF2122/97 --------------------------------------------------
Rv2715|M.tuberculosis_H37Rv --------------------------------------------------
MAB_3034|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_3195|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2566|M.marinum_M --------------------------------------------------
Mflv_2561|M.gilvum_PYR-GCK --------------------------------------------------
MAV_5175|M.avium_104 --------------------------------------------------
TH_0684|M.thermoresistible__bu --------------------------------------------------
Mvan_1865|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3297|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 QSTRIDTPTAKQERVRDRRGQLDMMFRLRRYGPDKVADTILSAIKKNKPI
Mb2734|M.bovis_AF2122/97 ------------------------------
Rv2715|M.tuberculosis_H37Rv ------------------------------
MAB_3034|M.abscessus_ATCC_1997 ------------------------------
MUL_3195|M.ulcerans_Agy99 ------------------------------
MMAR_2566|M.marinum_M ------------------------------
Mflv_2561|M.gilvum_PYR-GCK ------------------------------
MAV_5175|M.avium_104 ------------------------------
TH_0684|M.thermoresistible__bu ------------------------------
Mvan_1865|M.vanbaalenii_PYR-1 ------------------------------
MSMEG_3297|M.smegmatis_MC2_155 ------------------------------
MLBr_00862|M.leprae_Br4923 RPVAPEAYALYGISRVLPQVLRSTARIRVI